Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | tumor protein p53 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | tumor protein p63 | Get druggable targets OG5_140038 | All targets in OG5_140038 |
Echinococcus granulosus | tumor protein p63 | Get druggable targets OG5_140038 | All targets in OG5_140038 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | acetylcholinesterase | 0.2796 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.2796 | 1 | 1 |
Onchocerca volvulus | 0.0472 | 0.027 | 0.5 | |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0472 | 0.027 | 0.027 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.2796 | 1 | 1 |
Onchocerca volvulus | 0.0472 | 0.027 | 0.5 | |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0472 | 0.027 | 0.027 |
Onchocerca volvulus | 0.0472 | 0.027 | 0.5 | |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0472 | 0.027 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.2796 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0472 | 0.027 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2796 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0472 | 0.027 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.2796 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.2796 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.2796 | 1 | 1 |
Onchocerca volvulus | 0.0472 | 0.027 | 0.5 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0472 | 0.027 | 0.5 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0472 | 0.027 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.2796 | 1 | 1 |
Echinococcus granulosus | neuroligin | 0.0472 | 0.027 | 0.027 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0472 | 0.027 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.2796 | 1 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0472 | 0.027 | 0.027 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0472 | 0.027 | 0.027 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0472 | 0.027 | 0.027 |
Onchocerca volvulus | 0.0472 | 0.027 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.2796 | 1 | 1 |
Echinococcus multilocularis | neuroligin | 0.0472 | 0.027 | 0.027 |
Loa Loa (eye worm) | carboxylesterase | 0.2796 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0472 | 0.027 | 0.027 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.02 um | PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53 Null Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 50.1187 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.