Detailed information for compound 1325310

Basic information

Technical information
  • TDR Targets ID: 1325310
  • Name: (4-oxo-1,2,3-benzotriazin-3-yl)methyl 2-(2,4- dichlorophenoxy)propanoate
  • MW: 394.209 | Formula: C17H13Cl2N3O4
  • H donors: 0 H acceptors: 2 LogP: 4.91 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(Oc1ccc(cc1Cl)Cl)C)OCn1nnc2c(c1=O)cccc2
  • InChi: 1S/C17H13Cl2N3O4/c1-10(26-15-7-6-11(18)8-13(15)19)17(24)25-9-22-16(23)12-4-2-3-5-14(12)20-21-22/h2-8,10H,9H2,1H3
  • InChiKey: HHQLHXVVDAMVEM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(2,4-dichlorophenoxy)propanoic acid (4-oxo-1,2,3-benzotriazin-3-yl)methyl ester
  • 2-(2,4-dichlorophenoxy)propionic acid (4-keto-1,2,3-benzotriazin-3-yl)methyl ester
  • MLS000534634
  • SMR000142071
  • Oprea1_608127
  • (4-oxo-1,2,3-benzotriazin-3(4H)-yl)methyl 2-(2,4-dichlorophenoxy)propanoate

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0069 0.0978
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0147 0.0454 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.0337 0.031
Brugia malayi cysteinyl tRNA synthetase protein 1 0.0039 0.0041 0.0558
Loa Loa (eye worm) beta-lactamase 0.0043 0.006 0.0844
Echinococcus granulosus leucyl tRNA synthetase 0.0039 0.0041 0.0133
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.006 0.0668
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0147 0.0454 1
Plasmodium falciparum cysteine--tRNA ligase 0.0039 0.0041 0.072
Onchocerca volvulus 0.003 0.0009 0.0063
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.0293 0.0266
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0146 0.0453 0.146
Leishmania major hypothetical protein, conserved 0.0043 0.006 0.1143
Mycobacterium leprae Probable lipase LipE 0.0043 0.006 0.0032
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0118 0.0091
Mycobacterium ulcerans undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase 0.0166 0.0528 0.0519
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0118 0.0372
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.0293 0.0266
Schistosoma mansoni hypothetical protein 0.0038 0.004 0.0115
Mycobacterium tuberculosis Conserved protein 0.0043 0.006 0.0032
Brugia malayi Dihydrofolate reductase 0.0042 0.0056 0.0783
Mycobacterium tuberculosis Probable reductase 0.0104 0.0293 0.0266
Giardia lamblia Cysteinyl-tRNA synthetase 0.0039 0.0041 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.0955 0.093
Trichomonas vaginalis esterase, putative 0.0043 0.006 0.0668
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0069 0.1343
Schistosoma mansoni UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.003 0.0009 0.0016
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0107 0.1562
Loa Loa (eye worm) hypothetical protein 0.0043 0.006 0.0844
Echinococcus multilocularis UDP N acetylglucosamine dolichyl phosphate 0.003 0.0009 0.0016
Wolbachia endosymbiont of Brugia malayi phospho-N-acetylmuramoyl-pentapeptide-transferase 0.0719 0.2641 1
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.006 0.0668
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.0293 0.0266
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.0664 1
Echinococcus multilocularis dihydrofolate reductase 0.0042 0.0056 0.0168
Plasmodium vivax cysteine--tRNA ligase, putative 0.0039 0.0041 0.082
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.006 0.0181
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.006 0.1143
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.004 0.0538
Mycobacterium leprae ProbableUPD-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide)pyrophosphoryl-undecaprenol-N-acetylglucosamine transferase MurG 0.0122 0.0358 0.0331
Onchocerca volvulus 0.0043 0.006 0.0726
Mycobacterium ulcerans glycosyltransferase 0.0035 0.0028 0.0019
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0147 0.0454 1
Mycobacterium tuberculosis Probable UPD-N-acetylglucosamine-N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol-N-acetylglucosamine transferase MurG 0.0122 0.0358 0.0331
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0118 0.2542
Mycobacterium tuberculosis Hypothetical protein 0.005 0.0083 0.0055
Loa Loa (eye worm) solute carrier family 6 member 4 0.0146 0.0453 0.6803
Echinococcus multilocularis cysteinyl tRNA synthetase 0.0039 0.0041 0.012
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0069 0.0223
Echinococcus granulosus UDP N acetylglucosamine dolichyl phosphate 0.003 0.0009 0.0029
Onchocerca volvulus 0.0104 0.0291 0.3748
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0069 0.021
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.006 0.0194
Loa Loa (eye worm) hypothetical protein 0.0043 0.006 0.0844
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0104 0.0291 0.0264
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.006 0.1143
Mycobacterium tuberculosis Conserved protein 0.0043 0.006 0.0032
Schistosoma mansoni dihydrofolate reductase 0.0042 0.0056 0.0168
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.006 0.0032
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.006 0.0032
Loa Loa (eye worm) glutathione reductase 0.0046 0.0069 0.0978
Mycobacterium ulcerans hypothetical protein 0.0043 0.006 0.0051
Chlamydia trachomatis phospho-N-acetylmuramoyl-pentapeptide-transferase 0.0273 0.0938 1
Onchocerca volvulus 0.0043 0.006 0.0726
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.006 0.0051
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0004 0.0013
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.006 0.0181
Echinococcus granulosus dihydrofolate reductase 0.0042 0.0056 0.0181
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0039 0.0041 0.072
Mycobacterium ulcerans lipase LipD 0.0043 0.006 0.0051
Loa Loa (eye worm) hypothetical protein 0.0146 0.0453 0.6803
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0042 0.0056 0.0028
Loa Loa (eye worm) hypothetical protein 0.0043 0.006 0.0844
Plasmodium falciparum glutathione reductase 0.0046 0.0069 0.1343
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0147 0.0454 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0118 0.011
Leishmania major trypanothione reductase 0.0046 0.0069 0.1343
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.006 0.1143
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.006 0.0032
Brugia malayi glutathione reductase 0.0046 0.0069 0.0978
Trypanosoma brucei cysteinyl-tRNA synthetase, putative 0.0039 0.0041 0.072
Treponema pallidum undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase 0.0166 0.0528 0.5427
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.0337 0.031
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0083 0.097
Onchocerca volvulus 0.0146 0.0453 0.5858
Brugia malayi Pre-SET motif family protein 0.0202 0.0664 1
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0118 0.0372
Plasmodium vivax hypothetical protein, conserved 0.0043 0.006 0.1239
Brugia malayi beta-lactamase family protein 0.0043 0.006 0.0844
Wolbachia endosymbiont of Brugia malayi UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase 0.0166 0.0528 0.1872
Echinococcus granulosus thymidylate synthase 0.0104 0.0291 0.0946
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.0293 0.0266
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.006 0.0668
Mycobacterium tuberculosis Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX 0.0719 0.2641 0.2621
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.3079 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0118 0.2461
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0039 0.0041 0.012
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.3079 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.006 0.0051
Echinococcus multilocularis thymidylate synthase 0.0104 0.0291 0.0934
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.006 0.0181
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0069 0.1436
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0118 0.011
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0042 0.0056 0.0028
Trichomonas vaginalis set domain proteins, putative 0.0229 0.0771 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.006 0.0668
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.006 0.0032
Loa Loa (eye worm) cysteinyl tRNA synthetase 1 0.0039 0.0041 0.0558
Loa Loa (eye worm) hypothetical protein 0.0043 0.006 0.0844
Entamoeba histolytica cysteinyl-tRNA synthetase, putative 0.0039 0.0041 1
Chlamydia trachomatis dihydrofolate reductase 0.0042 0.0056 0.0165
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.006 0.0032
Plasmodium vivax N-acetylglucosamine-1-phosphate transferase, putative 0.003 0.0009 0.0107
Loa Loa (eye worm) hypothetical protein 0.0043 0.006 0.0844
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0042 0.0056 0.0047
Trypanosoma cruzi cysteinyl-tRNA synthetase, putative 0.0039 0.0041 0.072
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0118 0.011
Mycobacterium tuberculosis Cysteine:1D-myo-inosityl 2-amino-2-deoxy--D-glucopyranoside ligase MshC 0.2644 1 1
Plasmodium falciparum thioredoxin reductase 0.0046 0.0069 0.1343
Plasmodium vivax glutathione reductase, putative 0.0046 0.0069 0.1436
Loa Loa (eye worm) hypothetical protein 0.0056 0.0107 0.1562
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.0337 0.031
Echinococcus multilocularis serotonin transporter 0.0146 0.0453 0.146
Mycobacterium leprae conserved hypothetical protein 0.0043 0.006 0.0032
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0107 0.1562
Schistosoma mansoni UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.003 0.0009 0.0016
Schistosoma mansoni cysteinyl-tRNA synthetase 0.0039 0.0041 0.012
Trypanosoma brucei trypanothione reductase 0.0046 0.0069 0.1343
Loa Loa (eye worm) hypothetical protein 0.0038 0.004 0.0538
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0147 0.0454 1
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.005 0.0083 0.1662
Loa Loa (eye worm) serotonin transporter b 0.0146 0.0453 0.6803
Mycobacterium ulcerans thymidylate synthase 0.0104 0.0291 0.0283
Onchocerca volvulus 0.0229 0.0771 1
Leishmania major cysteinyl-tRNA synthetase, putative 0.0039 0.0041 0.072
Toxoplasma gondii ABC1 family protein 0.0043 0.006 0.1239
Echinococcus granulosus microtubule associated protein 2 0.0833 0.3079 1
Loa Loa (eye worm) dihydrofolate reductase 0.0042 0.0056 0.0783
Treponema pallidum sodium- and chloride- dependent transporter 0.0146 0.0453 0.4594
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.0337 0.031
Brugia malayi beta-lactamase family protein 0.0043 0.006 0.0844
Echinococcus granulosus serotonin transporter 0.0146 0.0453 0.1471
Schistosoma mansoni sodium/chloride dependent transporter 0.0146 0.0453 0.146
Trichomonas vaginalis cysteinyl-tRNA synthetase, putative 0.0039 0.0041 0.0421
Chlamydia trachomatis UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase 0.0166 0.0528 0.5427
Loa Loa (eye worm) hypothetical protein 0.0043 0.006 0.0844
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.0039 0.0041 0.0032
Onchocerca volvulus 0.0039 0.0041 0.0481
Loa Loa (eye worm) norepinephrine transporter 0.0146 0.0453 0.6803
Mycobacterium leprae Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX 0.0719 0.2641 0.2621
Echinococcus granulosus cysteinyl tRNA synthetase 0.0039 0.0041 0.0133
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.006 0.0032
Brugia malayi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.003 0.0009 0.0073
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0069 0.0041
Loa Loa (eye worm) hypothetical protein 0.0039 0.0041 0.0558
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0147 0.0454 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.006 0.0844
Mycobacterium tuberculosis Conserved protein 0.0043 0.006 0.0032
Brugia malayi dihydrofolate reductase family protein 0.0042 0.0056 0.0783
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.006 0.0844
Loa Loa (eye worm) thymidylate synthase 0.0104 0.0291 0.4353
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0073
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.0293 0.0266
Treponema pallidum phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) 0.0273 0.0938 1
Onchocerca volvulus 0.0043 0.006 0.0726
Loa Loa (eye worm) hypothetical protein 0.0146 0.0453 0.6803
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.006 0.0032
Loa Loa (eye worm) hypothetical protein 0.0146 0.0453 0.6803
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0104 0.0291 0.0934
Brugia malayi hypothetical protein 0.005 0.0083 0.1193
Toxoplasma gondii thioredoxin reductase 0.0046 0.0069 0.1436
Mycobacterium ulcerans phospho-N-acetylmuramoyl-pentapeptide-transferase 0.0719 0.2641 0.2635
Brugia malayi thymidylate synthase 0.0104 0.0291 0.4353
Plasmodium falciparum cysteine--tRNA ligase 0.0039 0.0041 0.072
Brugia malayi beta-lactamase 0.0043 0.006 0.0844
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.006 0.0668
Brugia malayi Thioredoxin reductase 0.0046 0.0069 0.0978
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0104 0.0291 0.0264
Mycobacterium ulcerans beta-lactamase 0.0043 0.006 0.0051
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0107 0.1562
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0118 0.0384
Mycobacterium ulcerans cysteinyl-tRNA synthetase 0.2644 1 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0146 0.0453 0.6803
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.0293 0.0266
Toxoplasma gondii cysteine-tRNA synthetase (CysRS) 0.0039 0.0041 0.082
Toxoplasma gondii glycosyl transferase, group 4 family protein 0.003 0.0009 0.0107
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0118 0.0372

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.7079 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (binding) = 7.9433 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (binding) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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