Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 22.8 uM | Compound was evaluated for inhibition of contraction in guinea pig ileum induced by leukotriene D4 (LTD4). | ChEMBL. | 7608912 |
Kb (functional) | = 5.25 nM | Compound was evaluated for antihistaminic activity against isolated guinea pig ileum. | ChEMBL. | 7608912 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.