Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | retinoic acid receptor RXR | 0.3178 | 1 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.1472 | 0.1408 | 0.5 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.1324 | 0.0664 | 1 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.303 | 0.9256 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.1324 | 0.0664 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | < 0.006 ug ml-1 | In vitro antibacterial activity was determined against Staphylococcus aureus 209P NIHJ JCI. | ChEMBL. | 10673091 |
MIC (functional) | = 0.025 ug ml-1 | In vitro antibacterial activity was determined against Escherichia coli NIHJ JC2. | ChEMBL. | 10673091 |
MIC (functional) | = 0.025 ug ml-1 | In vitro antibacterial activity was determined against Escherichia coli NIHJ JC2. | ChEMBL. | 10673091 |
MIC (functional) | = 1.56 ug ml-1 | In vitro antibacterial activity was determined against Pseudomonas aeruginosa AK109. | ChEMBL. | 10673091 |
MIC (functional) | = 3.13 ug ml-1 | In vitro antibacterial activity was determined against methicillin-resistant Staphylococcus aureus pMS520/Smith. | ChEMBL. | 10673091 |
MIC (functional) | = 6.25 ug ml-1 | In vitro antibacterial activity was determined against methicillin-resistant Staphylococcus epidermidis MB5181. | ChEMBL. | 10673091 |
MIC (functional) | = 12.5 ug ml-1 | In vitro antibacterial activity was determined against ceftazidime- resistant Pseudomonas aeruginosa AKR17. | ChEMBL. | 10673091 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.