Detailed information for compound 1325767

Basic information

Technical information
  • TDR Targets ID: 1325767
  • Name: methyl 3-[[2-[(3-cyano-5-hydroxy-7-oxo-4H-thi eno[4,5-b]pyridin-2-yl)sulfanyl]acetyl]amino] -4-methylbenzoate
  • MW: 429.47 | Formula: C19H15N3O5S2
  • H donors: 3 H acceptors: 6 LogP: 3.27 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1ccc(c(c1)NC(=O)CSc1sc2c(c1C#N)nc(cc2O)O)C
  • InChi: 1S/C19H15N3O5S2/c1-9-3-4-10(18(26)27-2)5-12(9)21-15(25)8-28-19-11(7-20)16-17(29-19)13(23)6-14(24)22-16/h3-6H,8H2,1-2H3,(H,21,25)(H2,22,23,24)
  • InChiKey: AGSXMVTYUYQHJD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • methyl 3-[[2-[(3-cyano-5-hydroxy-7-oxo-4H-thieno[4,5-b]pyridin-2-yl)sulfanyl]acetyl]amino]-4-methyl-benzoate
  • 3-[[2-[(3-cyano-5-hydroxy-7-oxo-4H-thieno[4,5-b]pyridin-2-yl)thio]-1-oxoethyl]amino]-4-methylbenzoic acid methyl ester
  • 3-[[2-[(3-cyano-5-hydroxy-7-keto-4H-thieno[4,5-b]pyridin-2-yl)thio]acetyl]amino]-4-methyl-benzoic acid methyl ester
  • methyl 3-[2-[(3-cyano-5-hydroxy-7-oxo-4H-thieno[4,5-b]pyridin-2-yl)sulfanyl]ethanoylamino]-4-methyl-benzoate
  • ASN 14403792

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL No references
Homo sapiens polo-like kinase 1 Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) Get druggable targets OG5_127075 All targets in OG5_127075
Toxoplasma gondii Dullard family phosphatase domain-containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Babesia bovis Dullard-like phosphatase domain containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium falciparum NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Giardia lamblia Nuclear LIM interactor-interacting factor 1 Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma congolense hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Candida albicans Plasma membrane Sodium Response 1 Get druggable targets OG5_127075 All targets in OG5_127075
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium berghei NLI interacting factor-like phosphatase Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania donovani dullard-like phosphatase domain containing protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus multilocularis Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania major hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) Get druggable targets OG5_127075 All targets in OG5_127075
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Plasmodium vivax NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Neospora caninum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium knowlesi NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva nuclear LIM interactor-interacting factor 1, putative Get druggable targets OG5_127075 All targets in OG5_127075
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum CTD small phosphatase-like protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans Plasma membrane Sodium Response 1 Get druggable targets OG5_127075 All targets in OG5_127075
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus CTD small phosphatase protein like Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma congolense TFIIF-stimulated CTD phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium yoelii NLI interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus Carboxy terminal domain RNA polymerase II Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K01090 protein phosphatase [EC3.1.3.16], putative Get druggable targets OG5_127075 All targets in OG5_127075
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei NLI interacting factor-like phosphatase Get druggable targets OG5_127075 All targets in OG5_127075
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium yoelii NLI interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei TFIIF-stimulated CTD phosphatase, putative CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 260 aa 263 aa 27.0 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.1675 1
Trypanosoma brucei chrX additional, unordered contigs 0.0014 0.0361 0.0927
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0015 0.038 0.0433
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0015 0.038 0.038
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.1675 1
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0015 0.038 0.038
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0989 0.2537
Brugia malayi Pre-SET motif family protein 0.0251 0.8768 1
Echinococcus multilocularis dna polymerase kappa 0.0047 0.1502 0.2403
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.1502 0.3855
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1808 0.2984
Entamoeba histolytica recQ family helicase, putative 0.0015 0.0397 0.102
Trypanosoma brucei hypothetical protein, conserved 0.0014 0.0361 0.0927
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0114 0.3896 0.6234
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0015 0.038 0.2267
Trypanosoma brucei hypothetical protein, conserved 0.0014 0.0361 0.0927
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0361 0.0927
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.008 0.2677 0.4283
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3896 0.3896
Trypanosoma brucei unspecified product 0.0032 0.0989 0.2537
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0989 0.2537
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.1127 0.186
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0015 0.038 0.038
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.1808 0.2062
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.108 0.1728
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0047 0.1502 0.2479
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1808 0.2893
Entamoeba histolytica deoxycytidyl transferase, putative 0.0047 0.1502 0.3855
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0047 0.1502 0.2403
Treponema pallidum ATP-dependent DNA helicase 0.0006 0.0064 0.5
Echinococcus multilocularis muscleblind protein 0.018 0.625 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0114 0.3896 0.4444
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.008 0.2677 0.3053
Trypanosoma brucei polo-like protein kinase 0.0114 0.3896 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.1127 0.1804
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0273 0.0311
Echinococcus granulosus CTD small phosphatase protein like 0.0015 0.038 0.0607
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.008 0.2677 0.6871
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.606 0.9696
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.1502 0.3855
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0006 0.0064 0.0165
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0012 0.0273 0.0436
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3896 0.3896
Echinococcus multilocularis 0.0015 0.038 0.0607
Trichomonas vaginalis dullard protein, putative 0.0015 0.038 0.038
Trypanosoma brucei DNA damage repair protein, putative 0.0014 0.0361 0.0927
Plasmodium vivax DNA repair protein REV1, putative 0.0014 0.0361 0.2157
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0015 0.038 0.0974
Mycobacterium tuberculosis Conserved hypothetical protein 0.0047 0.1502 0.5
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0047 0.1502 0.2403
Echinococcus granulosus transcription factor Dp 1 0.0046 0.1485 0.2377
Loa Loa (eye worm) hypothetical protein 0.018 0.625 0.7128
Entamoeba histolytica ankyrin repeat protein, putative 0.0004 0.00000005359 0.00000013754
Trichomonas vaginalis DNA polymerase eta, putative 0.0047 0.1502 0.1502
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.1502 0.3855
Trypanosoma brucei DNA damage repair protein, putative 0.0014 0.0361 0.0927
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.066 0.1089
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0006 0.0064 0.0165
Trypanosoma brucei DNA polymerase eta, putative 0.0077 0.2594 0.6657
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0273 0.0311
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.1852 0.1852
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.5886 0.9417
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0397 0.102
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0014 0.0361 0.2157
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0047 0.1502 0.1713
Leishmania major hypothetical protein, conserved 0.0015 0.038 0.0974
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0014 0.0361 0.2157
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.1502 0.3855
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0114 0.3896 0.4444
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.606 1
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0015 0.038 0.0607
Plasmodium falciparum bromodomain protein 1 0.0004 0.00000005359 0.00000035201
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.3896 1
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0012 0.0273 0.179
Entamoeba histolytica serine/threonine protein kinase, putative 0.0114 0.3896 1
Echinococcus multilocularis global transcription activator snf2l2 0.0004 0.00000000017512 0.0000000002802
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3896 0.3896
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.2677 0.6871
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.1127 0.186
Trichomonas vaginalis set domain proteins, putative 0.0286 1 1
Giardia lamblia Sgs1 DNA helicase, putative 0.0012 0.0273 0.0699
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.1127 0.1804
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.0752 0.4938
Leishmania major DNA polymerase eta, putative 0.0045 0.1453 0.3729
Echinococcus granulosus dna polymerase eta 0.0077 0.2594 0.415
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.1502 0.3855
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0361 0.0927
Brugia malayi BRM protein 0.0004 0.00000000017512 0.00000000019974
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0989 0.2537
Onchocerca volvulus 0.0036 0.1127 0.1127
Entamoeba histolytica recQ family helicase, putative 0.0006 0.0056 0.0144
Giardia lamblia DNA damage repair protein 0.0014 0.0361 0.0927
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0114 0.3896 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.1127 0.186
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0004 0.00000000017512 0.0000000010458
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.1502 0.3855
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3896 0.3896
Trypanosoma brucei unspecified product 0.0032 0.0989 0.2537
Trichomonas vaginalis DNA helicase recq, putative 0.0015 0.0397 0.0397
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0361 0.0927
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.008 0.2677 0.4418
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0273 0.1627
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1808 0.2984
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1808 0.2893
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.1502 0.3855
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.0877 0.0877
Echinococcus multilocularis bloom syndrome protein 0.0029 0.0877 0.1403
Loa Loa (eye worm) RecQ helicase 0.0029 0.0877 0.1
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0012 0.0273 0.0436
Trichomonas vaginalis dullard protein, putative 0.0015 0.038 0.038
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.1127 0.1804
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0015 0.038 0.0974
Echinococcus multilocularis transcription factor Dp 1 0.0046 0.1485 0.2377
Loa Loa (eye worm) BRM protein 0.0004 0.00000000017512 0.00000000019974
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3896 0.3896
Loa Loa (eye worm) hypothetical protein 0.0014 0.0361 0.0412
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.1453 0.3729
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.1502 1
Trypanosoma cruzi DNA damage repair protein, putative 0.0014 0.0361 0.0927
Giardia lamblia Transcription regulatory protein SNF2 0.0004 0.00000000017512 0.00000000044947
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3896 0.3896
Leishmania major DNA polymerase kappa, putative 0.0014 0.0361 0.0927
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.1502 0.3855
Trichomonas vaginalis lymphoid specific helicase, putative 0.0004 0.00000000017512 0.00000000017512
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.1502 0.3855
Plasmodium falciparum DNA repair protein REV1, putative 0.0014 0.0361 0.2373
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0047 0.1502 0.1502
Loa Loa (eye worm) hypothetical protein 0.018 0.625 0.7128
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.2677 0.6871
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.1808 0.2893
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.1675 0.1675
Schistosoma mansoni blooms syndrome DNA helicase 0.0006 0.0064 0.0106
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0012 0.0273 0.0436
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.606 0.6911
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.0877 0.0877
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0015 0.038 0.2493
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.3896 0.643
Brugia malayi Pre-SET motif family protein 0.0036 0.1127 0.1286
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.1522 0.3907
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.1502 0.3855
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0006 0.0064 0.0384
Leishmania major DNA polymerase eta, putative 0.0077 0.2594 0.6657
Loa Loa (eye worm) hypothetical protein 0.0036 0.1127 0.1286
Loa Loa (eye worm) hypothetical protein 0.0012 0.0273 0.0311
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0397 0.102
Trypanosoma cruzi DNA polymerase eta, putative 0.0077 0.2594 0.6657
Loa Loa (eye worm) hypothetical protein 0.0006 0.0064 0.0073
Plasmodium vivax hypothetical protein, conserved 0.0004 0.00000005359 0.00000032002
Trichomonas vaginalis CAMK family protein kinase 0.0114 0.3896 0.3896
Toxoplasma gondii bromodomain-containing protein 0.0004 0.00000005359 0.00000032002
Giardia lamblia Kinase, PLK 0.0114 0.3896 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0397 0.102
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0047 0.1502 0.5
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0047 0.1502 0.3855
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0006 0.0056 0.0335
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0015 0.038 0.0607
Onchocerca volvulus Serine\/threonine kinase homolog 0.0114 0.3896 0.3896
Echinococcus granulosus dna polymerase kappa 0.0047 0.1502 0.2403
Loa Loa (eye worm) hypothetical protein 0.0146 0.5027 0.5733
Brugia malayi polk-prov protein 0.0014 0.0361 0.0412
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.0877 0.1
Echinococcus multilocularis dna polymerase eta 0.0077 0.2594 0.415
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.1675 0.2679
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0015 0.038 0.038
Trypanosoma cruzi DNA damage repair protein, putative 0.0014 0.0361 0.0927
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0535 0.3196
Schistosoma mansoni DNA helicase recq1 0.0012 0.0273 0.045
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0012 0.0273 0.0311
Schistosoma mansoni DNA polymerase eta 0.0077 0.2594 0.428
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.1502 1
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0015 0.038 0.2267
Schistosoma mansoni hypothetical protein 0.0015 0.0373 0.0616
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.1808 0.2984
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.8768 1
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0005 0.0022 0.0022
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0273 0.1627
Trypanosoma cruzi polo-like protein kinase, putative 0.0114 0.3896 1
Echinococcus multilocularis muscleblind protein 1 0.018 0.625 1
Trichomonas vaginalis CAMK family protein kinase 0.0056 0.1852 0.1852
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0012 0.0273 0.0436
Schistosoma mansoni kinase 0.0058 0.1905 0.3144
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.1808 0.2062
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0015 0.038 0.0626
Loa Loa (eye worm) hypothetical protein 0.0015 0.038 0.0433
Trypanosoma brucei unspecified product 0.0047 0.1502 0.3855
Giardia lamblia DINP protein human, muc B family 0.0047 0.1502 0.3855
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.1522 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.008 0.2677 0.4283
Trichomonas vaginalis histone acetyltransferase gcn5, putative 0.0005 0.0022 0.0022
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.1127 0.6731
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.008 0.2677 0.3053
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.002 0.0543 0.3245
Leishmania major DNA polymerase kappa, putative 0.0047 0.1502 0.3855
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.1808 0.2893
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.1502 0.3855
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0015 0.038 0.0974
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0045 0.1453 0.8677
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0015 0.038 0.0626
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0015 0.038 0.2267
Echinococcus granulosus bloom syndrome protein 0.0029 0.0877 0.1403
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.1522 0.3907
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.1502 0.3855
Entamoeba histolytica recQ family DNA helicase 0.0006 0.0064 0.0165
Schistosoma mansoni DNA polymerase IV / kappa 0.0014 0.0361 0.0596
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.1127 0.186
Plasmodium vivax SET domain containing protein 0.0006 0.0047 0.0281
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.1502 0.3855
Trichomonas vaginalis dullard protein, putative 0.0015 0.038 0.038
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0361 0.0927
Leishmania major DNA damage repair protein, putative 0.0014 0.0361 0.0927
Schistosoma mansoni DNA helicase recq5 0.0012 0.0273 0.045
Brugia malayi ImpB/MucB/SamB family protein 0.0077 0.2594 0.2958
Brugia malayi ImpB/MucB/SamB family protein 0.0047 0.1502 0.1713
Echinococcus granulosus muscleblind protein 0.018 0.625 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.0373 0.0425
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.038 0.0974
Plasmodium vivax SET domain protein, putative 0.0036 0.1127 0.6731
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0114 0.3896 0.6234
Loa Loa (eye worm) acetyltransferase 0.0175 0.606 0.6911
Toxoplasma gondii histone lysine methyltransferase SET1 0.0006 0.0047 0.0281
Loa Loa (eye worm) hypothetical protein 0.0077 0.2594 0.2958
Brugia malayi Muscleblind-like protein 0.018 0.625 0.7128
Schistosoma mansoni terminal deoxycytidyl transferase 0.0047 0.1502 0.2479
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.1502 0.3855
Schistosoma mansoni helicase 0.0004 0.00000000017512 0.000000000289
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.008 0.2677 0.6871
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.1675 0.1675
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.1502 0.3855
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.1502 0.3855
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.1502 0.3855
Echinococcus granulosus global transcription activator snf2l2 0.0004 0.00000000017512 0.0000000002802
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.1675 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.008 0.2677 0.6871

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 3.037 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493091, AID493120] ChEMBL. No reference
Potency (functional) 5.6234 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 9.285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (binding) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 13.3714 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 15.8489 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM). (Class of assay: confirmatory) [Related pubchem assays: 593 (Fluorescein region spectral profiling screen), 2386 (Probe Development Summary for Inhibitors of Bloom's syndrome helicase (BLM)), 594 (Rhodamine region spectral profiling screen), 2364 (qHTS Validation Assay for Inhibitors of Bloom's syndrome helicase (BLM))] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 44.6684 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 59.7279 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Kappa: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 84.9214 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.