Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polymerase (DNA directed), eta | Starlite/ChEMBL | No references |
Homo sapiens | adrenergic, beta, receptor kinase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0.117 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.117 | 0.1904 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.4237 | 0.4237 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.117 | 0.117 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0.117 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.117 | 0.1904 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.0012 | 0.0028 | 0.0028 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.117 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0012 | 0.0028 | 0.0028 |
Leishmania major | DNA polymerase eta, putative | 0.0038 | 0.2635 | 0.4775 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0023 | 0.117 | 0.117 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.0012 | 0.0028 | 0.0066 |
Echinococcus multilocularis | dna polymerase kappa | 0.0023 | 0.117 | 0.117 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0023 | 0.117 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.117 | 0.1904 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0023 | 0.117 | 0.117 |
Trypanosoma brucei | unspecified product | 0.0023 | 0.117 | 0.1904 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0.117 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.117 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.117 | 0.1904 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0023 | 0.117 | 0.117 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0.117 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.117 | 0.1904 |
Loa Loa (eye worm) | AGC/GRK/BARK protein kinase | 0.0112 | 1 | 1 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0038 | 0.2635 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.117 | 0.1904 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0054 | 0.4237 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0054 | 0.4237 | 0.4237 |
Echinococcus granulosus | dna polymerase kappa | 0.0023 | 0.117 | 0.117 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0038 | 0.2635 | 0.4775 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.117 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.117 | 0.1904 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.117 | 0.1904 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0023 | 0.117 | 0.117 |
Echinococcus granulosus | dna polymerase eta | 0.0054 | 0.4237 | 0.4237 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0112 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0.117 | 0.1904 |
Schistosoma mansoni | DNA polymerase eta | 0.0054 | 0.4237 | 0.4237 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0.117 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.117 | 0.1904 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0.117 | 0.5 |
Echinococcus multilocularis | G protein coupled receptor kinase 1 | 0.01 | 0.8846 | 0.8846 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.117 | 0.2761 |
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.0112 | 1 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0054 | 0.4237 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0.117 | 0.1904 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0112 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0054 | 0.4237 | 1 |
Echinococcus granulosus | G protein coupled receptor kinase 1 | 0.01 | 0.8846 | 0.8846 |
Leishmania major | DNA polymerase eta, putative | 0.0054 | 0.4237 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 7.058 uM | PUBCHEM_BIOASSAY: Dose Response of inhibitors of GRK2 binding with RNA aptamer, Powder Set1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488855] | ChEMBL. | No reference |
Potency (functional) | 3.1623 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 26.6795 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 59.7279 uM | PubChem BioAssay. qHTS for Inhibitors of Polymerase Kappa: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 63.0957 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | = 79.4328 um | PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] | ChEMBL. | No reference |
Potency (functional) | 84.9214 uM | PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.