TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 420.504 | Formula: C24H28N4O3
H donors: 3 H acceptors: 3 LogP: 2.54 Rotable bonds: 12
Rule of 5 violations (Lipinski): 1
SMILES: CCN(C(=O)CCCc1c[nH]c2c1cccc2)CC(=O)Nc1ccc(cc1)NC(=O)C
InChi: 1S/C24H28N4O3/c1-3-28(16-23(30)27-20-13-11-19(12-14-20)26-17(2)29)24(31)10-6-7-18-15-25-22-9-5-4-8-21(18)22/h4-5,8-9,11-15,25H,3,6-7,10,16H2,1-2H3,(H,26,29)(H,27,30)
InChiKey: WEGUFNNSSXBSCG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Schistosoma mansoni	adenoreceptor	0.0044	0.6568	0.5111
Trichomonas vaginalis	aldo/keto reductase, putative	0.0033	0.298	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0044	0.6568	0.6568
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0044	0.6568	0.5111
Echinococcus granulosus	g protein coupled receptor	0.0044	0.6568	0.6568
Entamoeba histolytica	aldose reductase, putative	0.0033	0.298	0.5
Schistosoma mansoni	amine GPCR	0.0044	0.6568	0.5111
Echinococcus multilocularis	g-protein coupled receptor	0.0044	0.6568	0.6568
Schistosoma mansoni	myosin xvIII	0.0044	0.6568	0.5111
Schistosoma mansoni	neuropeptide F-like receptor	0.0044	0.6568	0.5111
Brugia malayi	hypothetical protein	0.0044	0.6568	0.5111
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0033	0.298	0.298
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Brugia malayi	G-protein coupled receptor	0.0044	0.6568	0.5111
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0044	0.6568	0.5111
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0044	0.6568	0.6568
Schistosoma mansoni	biogenic amine receptor	0.0044	0.6568	0.5111
Echinococcus granulosus	7tm_1 domain containing protein	0.0044	0.6568	0.6568
Brugia malayi	AKH receptor	0.0044	0.6568	0.5111
Schistosoma mansoni	histamine h1 receptor	0.0044	0.6568	0.5111
Loa Loa (eye worm)	G-protein coupled receptor	0.0044	0.6568	0.5111
Schistosoma mansoni	neuropeptide receptor	0.0044	0.6568	0.5111
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0044	0.6568	0.6568
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0044	0.6568	0.6568
Schistosoma mansoni	hypothetical protein	0.0044	0.6568	0.5111
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0033	0.298	0.298
Echinococcus granulosus	neuropeptide receptor	0.0044	0.6568	0.6568
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0044	0.6568	0.5111
Leishmania major	aldehyde reductase, putative,oxidoreductase, putative	0.0033	0.298	0.5
Loa Loa (eye worm)	G-protein coupled receptor	0.0044	0.6568	0.5111
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0033	0.298	0.298
Brugia malayi	putative neuropeptide receptor NPR1	0.0044	0.6568	0.5111
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0044	0.6568	0.6568
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0033	0.298	0.298
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0044	0.6568	0.6568
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Echinococcus multilocularis	g protein coupled receptor	0.0044	0.6568	0.6568
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0044	0.6568	0.5111
Brugia malayi	hypothetical protein	0.0044	0.6568	0.5111
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0044	0.6568	0.5111
Trichomonas vaginalis	aldo-keto reductase, putative	0.0033	0.298	0.5
Onchocerca volvulus		0.0044	0.6568	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Trichomonas vaginalis	aldo/keto reductase, putative	0.0033	0.298	0.5
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Echinococcus granulosus	hypothetical protein	0.0033	0.298	0.298
Echinococcus granulosus	rhodopsin orphan GPCR	0.0044	0.6568	0.6568
Schistosoma mansoni	biogenic amine receptor	0.0044	0.6568	0.5111
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.6568	0.5111
Mycobacterium leprae	PROBABLE OXIDOREDUCTASE	0.0033	0.298	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	1	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0044	0.6568	0.6568
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0033	0.298	0.298
Echinococcus granulosus	tm gpcr rhodopsin	0.0044	0.6568	0.6568
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	1	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0044	0.6568	0.6568
Loa Loa (eye worm)	neuropeptide F receptor	0.0044	0.6568	0.5111
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0044	0.6568	0.6568
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0044	0.6568	0.6568
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0044	0.6568	0.5111
Leishmania major	prostaglandin f synthase, putative	0.0033	0.298	0.5
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Schistosoma mansoni	amine GPCR	0.0044	0.6568	0.5111
Onchocerca volvulus		0.0044	0.6568	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Schistosoma mansoni	neuropeptide receptor	0.0044	0.6568	0.5111
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0033	0.298	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.6568	0.5111
Schistosoma mansoni	hypothetical protein	0.0044	0.6568	0.5111
Echinococcus granulosus	aldo keto reductase	0.0033	0.298	0.298
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0044	0.6568	0.5111
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Onchocerca volvulus		0.0044	0.6568	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0044	0.6568	0.5111
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0033	0.298	0.5
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0044	0.6568	0.5111
Echinococcus multilocularis	neuropeptide Y receptor	0.0044	0.6568	0.6568
Brugia malayi	hypothetical protein	0.0044	0.6568	0.5111
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0044	0.6568	0.5111
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0033	0.298	0.298
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0044	0.6568	0.6568
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0044	0.6568	0.6568
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	1	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0044	0.6568	0.6568
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0044	0.6568	0.5111
Schistosoma mansoni	neuropeptide F-like receptor	0.0044	0.6568	0.5111
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0044	0.6568	0.6568
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0033	0.298	0.298
Echinococcus multilocularis	neuropeptides capa receptor	0.0044	0.6568	0.6568
Brugia malayi	Melatonin receptor type 1A	0.0044	0.6568	0.5111
Trypanosoma brucei	prostaglandin f synthase	0.0033	0.298	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.0044	0.6568	0.6568
Echinococcus granulosus	somatostatin receptor	0.0044	0.6568	0.6568
Echinococcus granulosus	serotonin receptor	0.0044	0.6568	0.6568
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0033	0.298	0.298
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.6568	0.5111
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0033	0.298	0.298
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.6568	0.5111
Brugia malayi	sulfakinin receptor protein	0.0044	0.6568	0.5111
Brugia malayi	hypothetical protein	0.0044	0.6568	0.5111
Echinococcus granulosus	allatostatin A receptor	0.0044	0.6568	0.6568
Echinococcus granulosus	sex peptide receptor	0.0044	0.6568	0.6568
Echinococcus multilocularis	aldo keto reductase	0.0033	0.298	0.298
Brugia malayi	ORL1-like opioid receptor	0.0044	0.6568	0.5111
Schistosoma mansoni	opsin-like receptor	0.0044	0.6568	0.5111
Onchocerca volvulus		0.0044	0.6568	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0044	0.6568	0.6568
Schistosoma mansoni	amine GPCR	0.0044	0.6568	0.5111
Echinococcus granulosus	g-protein coupled receptor	0.0044	0.6568	0.6568
Trichomonas vaginalis	aldo-keto reductase, putative	0.0033	0.298	0.5
Echinococcus multilocularis	g protein coupled receptor	0.0044	0.6568	0.6568
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0044	0.6568	0.6568
Echinococcus granulosus	g protein coupled receptor	0.0044	0.6568	0.6568
Echinococcus multilocularis	aldo keto reductase	0.0033	0.298	0.298
Echinococcus multilocularis	dro:myosuppressin receptor	0.0044	0.6568	0.6568
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Echinococcus multilocularis	orexin receptor type 2	0.0044	0.6568	0.6568
Echinococcus granulosus	fmrfamide receptor	0.0044	0.6568	0.6568
Echinococcus multilocularis	serotonin receptor	0.0044	0.6568	0.6568
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0033	0.298	0.298
Onchocerca volvulus		0.0044	0.6568	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0044	0.6568	1
Echinococcus multilocularis	neuropeptide receptor	0.0044	0.6568	0.6568
Echinococcus granulosus	aldo keto reductase	0.0033	0.298	0.298
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Echinococcus granulosus	tm gpcr rhodopsin	0.0044	0.6568	0.6568
Entamoeba histolytica	aldose reductase, putative	0.0033	0.298	0.5
Schistosoma mansoni	biogenic amine receptor	0.0044	0.6568	0.5111
Schistosoma mansoni	neuropeptide f receptor 76f	0.0044	0.6568	0.5111
Echinococcus multilocularis	sex peptide receptor	0.0044	0.6568	0.6568
Echinococcus granulosus	neuropeptide s receptor	0.0044	0.6568	0.6568
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0044	0.6568	0.6568
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0033	0.298	0.298
Schistosoma mansoni	hypothetical protein	0.0044	0.6568	0.5111
Trichomonas vaginalis	aldo-keto reductase, putative	0.0033	0.298	0.5
Echinococcus multilocularis	allatostatin A receptor	0.0044	0.6568	0.6568
Trichomonas vaginalis	aldo-keto reductase, putative	0.0033	0.298	0.5
Brugia malayi	hypothetical protein	0.0044	0.6568	0.5111
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0044	0.6568	0.6568
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0033	0.298	0.298
Trichomonas vaginalis	aldo-keto reductase, putative	0.0033	0.298	0.5
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0044	0.6568	0.6568
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0044	0.6568	0.6568
Echinococcus granulosus	G protein coupled receptor 139	0.0044	0.6568	0.6568
Echinococcus multilocularis	aldo keto reductase	0.0033	0.298	0.298
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0044	0.6568	0.6568
Echinococcus multilocularis	neuropeptide receptor A26	0.0044	0.6568	0.6568
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.6568	0.5111
Onchocerca volvulus		0.0044	0.6568	1
Schistosoma mansoni	neuropeptide receptor	0.0044	0.6568	0.5111
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0044	0.6568	0.5111
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0044	0.6568	0.6568
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0044	0.6568	0.5111
Onchocerca volvulus		0.0044	0.6568	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0044	0.6568	0.6568
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Onchocerca volvulus		0.0044	0.6568	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Brugia malayi	G protein-coupled receptor F59B2.13	0.0044	0.6568	0.5111
Echinococcus multilocularis	fmrfamide receptor	0.0044	0.6568	0.6568
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.6568	0.5111
Trichomonas vaginalis	aldo-keto reductase, putative	0.0033	0.298	0.5
Schistosoma mansoni	amine GPCR	0.0044	0.6568	0.5111
Mycobacterium tuberculosis	Probable oxidoreductase	0.0033	0.298	0.5
Brugia malayi	GnHR receptor homolog	0.0044	0.6568	0.5111
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Echinococcus granulosus	tm gpcr rhodopsin	0.0044	0.6568	0.6568
Trichomonas vaginalis	dihydrodiol dehydrogenase, putative	0.0033	0.298	0.5
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0044	0.6568	0.5111
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0044	0.6568	0.6568
Echinococcus granulosus	rhodopsin orphan GPCR	0.0044	0.6568	0.6568
Echinococcus granulosus	neuropeptide Y receptor	0.0044	0.6568	0.6568
Schistosoma mansoni	opsin-like receptor	0.0044	0.6568	0.5111
Schistosoma mansoni	neuropeptide receptor	0.0044	0.6568	0.5111
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0044	0.6568	0.5111
Onchocerca volvulus		0.0044	0.6568	1
Entamoeba histolytica	aldose reductase, putative	0.0033	0.298	0.5
Brugia malayi	Dopamine receptor protein 1	0.0044	0.6568	0.5111
Echinococcus granulosus	orexin receptor type 2	0.0044	0.6568	0.6568
Echinococcus granulosus	7TM GPCR rhodopsin	0.0044	0.6568	0.6568
Brugia malayi	G protein-coupled receptor	0.0044	0.6568	0.5111
Brugia malayi	follicle stimulating hormone receptor	0.0044	0.6568	0.5111
Echinococcus granulosus	neuropeptides capa receptor	0.0044	0.6568	0.6568
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.6568	0.5111
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Echinococcus multilocularis	neuropeptide receptor	0.0044	0.6568	0.6568
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Echinococcus granulosus	rhodopsin orphan GPCR	0.0044	0.6568	0.6568
Trichomonas vaginalis	aldo-keto reductase, putative	0.0033	0.298	0.5
Echinococcus granulosus	dro:myosuppressin receptor	0.0044	0.6568	0.6568
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0044	0.6568	0.5111
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0033	0.298	0.298
Onchocerca volvulus		0.0044	0.6568	1
Trypanosoma cruzi	aldo/keto reductase, putative	0.0033	0.298	0.5
Brugia malayi	hypothetical protein	0.0044	0.6568	0.5111
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0044	0.6568	0.6568
Brugia malayi	hypothetical protein	0.0044	0.6568	0.5111
Trichomonas vaginalis	aldo-keto reductase, putative	0.0033	0.298	0.5
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Echinococcus multilocularis	g protein coupled receptor	0.0044	0.6568	0.6568
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0033	0.298	0.298
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0044	0.6568	0.6568
Brugia malayi	larval opioid receptor	0.0044	0.6568	0.5111
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0055	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0044	0.6568	0.6568
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0033	0.298	0.298
Echinococcus multilocularis	aldo keto reductase	0.0033	0.298	0.298
Echinococcus granulosus	neuropeptide receptor A26	0.0044	0.6568	0.6568
Brugia malayi	Dopamine receptor	0.0044	0.6568	0.5111
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	1	1
Brugia malayi	neuropeptide F receptor	0.0044	0.6568	0.5111
Schistosoma mansoni	growth hormone secretagogue receptor	0.0044	0.6568	0.5111
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0044	0.6568	0.6568
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0044	0.6568	0.6568
Loa Loa (eye worm)	neuropeptide F receptor	0.0044	0.6568	0.5111
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0044	0.6568	0.5111
Brugia malayi	neuropeptide F receptor	0.0044	0.6568	0.5111
Onchocerca volvulus		0.0044	0.6568	1
Schistosoma mansoni	amine GPCR	0.0044	0.6568	0.5111
Echinococcus granulosus	neuropeptide FF receptor 2	0.0044	0.6568	0.6568
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0044	0.6568	0.6568
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.6568	0.5111
Echinococcus granulosus	biogenic amine 5HT receptor	0.0044	0.6568	0.6568
Trichomonas vaginalis	aldo-keto reductase, putative	0.0033	0.298	0.5
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0044	0.6568	0.5111
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0044	0.6568	0.5111
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0044	0.6568	0.6568
Trypanosoma brucei	aldo-keto reductase, putative	0.0033	0.298	0.5
Echinococcus multilocularis	neuropeptide s receptor	0.0044	0.6568	0.6568
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0044	0.6568	0.5111
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0044	0.6568	0.5111
Onchocerca volvulus		0.0044	0.6568	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0044	0.6568	0.6568
Trichomonas vaginalis	aldo-keto reductase, putative	0.0033	0.298	0.5
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Brugia malayi	Dopamine receptor protein 2	0.0044	0.6568	0.5111
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0044	0.6568	0.5111
Echinococcus multilocularis	somatostatin receptor	0.0044	0.6568	0.6568
Onchocerca volvulus		0.0044	0.6568	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0044	0.6568	0.5111
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0044	0.6568	0.6568
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Onchocerca volvulus		0.0044	0.6568	1
Brugia malayi	Serotonin receptor	0.0044	0.6568	0.5111
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0033	0.298	0.298
Echinococcus multilocularis	neuropeptides capa receptor	0.0044	0.6568	0.6568
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0044	0.6568	0.5111
Trichomonas vaginalis	aldo-keto reductase, putative	0.0033	0.298	0.5
Brugia malayi	hypothetical protein	0.0044	0.6568	0.5111
Brugia malayi	hypothetical protein	0.0044	0.6568	0.5111
Onchocerca volvulus		0.0044	0.6568	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Giardia lamblia	Aldose reductase	0.0033	0.298	0.5
Leishmania major	aldo-keto reductase-like protein	0.0033	0.298	0.5
Brugia malayi	Serotonin receptor	0.0044	0.6568	0.5111
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	1	1
Loa Loa (eye worm)	TYRA-2 protein	0.0044	0.6568	0.5111
Leishmania major	prostaglandin f2-alpha synthase/D-arabinose dehydrogenase	0.0033	0.298	0.5
Mycobacterium ulcerans	oxidoreductase	0.0033	0.298	0.5
Echinococcus granulosus	g protein coupled receptor	0.0044	0.6568	0.6568
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0033	0.298	0.298
Echinococcus granulosus	hypothetical protein	0.0044	0.6568	0.6568
Echinococcus granulosus	aldo keto reductase	0.0033	0.298	0.298
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0044	0.6568	0.5111
Echinococcus granulosus	neuropeptide Y receptor	0.0044	0.6568	0.6568
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0044	0.6568	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0044	0.6568	0.6568
Toxoplasma gondii	aldose reductase, putative	0.0033	0.298	0.5
Loa Loa (eye worm)	melatonin receptor type 1A	0.0044	0.6568	0.5111
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Echinococcus granulosus	neuropeptides capa receptor	0.0044	0.6568	0.6568
Brugia malayi	putative neuropeptide receptor	0.0044	0.6568	0.5111
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0044	0.6568	0.5111
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Echinococcus multilocularis	serotonin receptor	0.0044	0.6568	0.6568
Echinococcus multilocularis	fmrfamide receptor	0.0044	0.6568	0.6568
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Giardia lamblia	Aldose reductase	0.0033	0.298	0.5
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0044	0.6568	0.5111
Trichomonas vaginalis	aldo-keto reductase, putative	0.0033	0.298	0.5
Onchocerca volvulus		0.0044	0.6568	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0044	0.6568	0.6568
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0044	0.6568	0.6568
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0055	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0044	0.6568	0.6568
Brugia malayi	RE15519p	0.0044	0.6568	0.5111
Brugia malayi	G-protein coupled receptor	0.0044	0.6568	0.5111
Echinococcus granulosus	neuropeptide receptor	0.0044	0.6568	0.6568
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0033	0.298	0.298
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Schistosoma mansoni	opsin-like receptor	0.0044	0.6568	0.5111
Trypanosoma cruzi	aldo-keto reductase	0.0033	0.298	0.5
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0044	0.6568	0.6568
Loa Loa (eye worm)	hypothetical protein	0.0044	0.6568	0.5111
Schistosoma mansoni	hypothetical protein	0.0044	0.6568	0.5111
Brugia malayi	hypothetical protein	0.0044	0.6568	0.5111
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0044	0.6568	0.5111
Echinococcus granulosus	aldo keto reductase family 1 member B4	0.0033	0.298	0.298
Echinococcus multilocularis	aldo keto reductase family 1, member B4	0.0033	0.298	0.298
Echinococcus granulosus	rhodopsin orphan GPCR	0.0044	0.6568	0.6568
Onchocerca volvulus		0.0044	0.6568	1
Trichomonas vaginalis	aldo/keto reductase, putative	0.0033	0.298	0.5
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0055	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	10 uM	PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1455157

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1326013