Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | Rap guanine nucleotide exchange factor (GEF) 3 | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0011 | 0.0146 | 0.0156 |
Trypanosoma cruzi | guanine nucleotide releasing protein, putative | 0.0008 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0008 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3273 | 0.3495 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0 | 0.5 |
Schistosoma mansoni | dep domain containing protein | 0.0011 | 0.0146 | 0.0156 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0011 | 0.0146 | 0.0156 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0146 | 0.0146 |
Trypanosoma cruzi | hypothetical protein | 0.0008 | 0 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3273 | 0.3273 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0011 | 0.0146 | 0.0156 |
Schistosoma mansoni | fyve finger-containing phosphoinositide kinase fyv1 | 0.0011 | 0.0146 | 0.0156 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0 | 0.5 |
Brugia malayi | regulator of G-protein signaling egl-10 | 0.0011 | 0.0146 | 0.0146 |
Trichomonas vaginalis | guanine nucleotide exchange factor, putative | 0.0008 | 0 | 0.5 |
Onchocerca volvulus | Segment polarity protein dishevelled homolog | 0.0011 | 0.0146 | 0.0146 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0011 | 0.0146 | 0.0156 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3273 | 0.3273 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0146 | 0.0146 |
Echinococcus granulosus | segment polarity protein dishevelled | 0.0011 | 0.0146 | 0.0156 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.9364 | 1 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0011 | 0.0146 | 0.5 |
Schistosoma mansoni | dishevelled | 0.0011 | 0.0146 | 0.0156 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0218 | 1 | 1 |
Brugia malayi | DIX domain containing protein | 0.0011 | 0.0146 | 0.0146 |
Trichomonas vaginalis | ras GTP exchange factor, son of sevenless, putative | 0.0008 | 0 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3273 | 0.3495 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3273 | 0.3495 |
Echinococcus multilocularis | regulator of G protein signaling 7 | 0.0011 | 0.0146 | 0.0156 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3273 | 0.3273 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3273 | 0.3495 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.9364 | 1 |
Echinococcus multilocularis | Pleckstrin G protein, interacting region | 0.0011 | 0.0146 | 0.0156 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0011 | 0.0146 | 0.0146 |
Echinococcus granulosus | regulator of G protein signaling 7 | 0.0011 | 0.0146 | 0.0156 |
Brugia malayi | Domain found in Dishevelled, Egl-10, and Pleckstrin family protein | 0.0011 | 0.0146 | 0.0146 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3273 | 0.3273 |
Echinococcus multilocularis | segment polarity protein dishevelled | 0.0011 | 0.0146 | 0.0156 |
Trypanosoma cruzi | hypothetical protein | 0.0008 | 0 | 0.5 |
Trichomonas vaginalis | ras GTP exchange factor, putative | 0.0008 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3273 | 0.3495 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0218 | 1 | 1 |
Schistosoma mansoni | dishevelled | 0.0011 | 0.0146 | 0.0156 |
Loa Loa (eye worm) | G protein signaling regulator EGL-10 | 0.0011 | 0.0146 | 0.0146 |
Brugia malayi | hypothetical protein | 0.0011 | 0.0146 | 0.0146 |
Schistosoma mansoni | regulator of G protein signaling | 0.0011 | 0.0146 | 0.0156 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0 | 0.5 |
Onchocerca volvulus | 0.0011 | 0.0146 | 0.0146 | |
Loa Loa (eye worm) | DIX domain-containing protein | 0.0011 | 0.0146 | 0.0146 |
Schistosoma mansoni | z-protein (S1r protein) | 0.0011 | 0.0146 | 0.0156 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0146 | 0.0146 |
Echinococcus granulosus | geminin | 0.0205 | 0.9364 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3273 | 0.3273 |
Echinococcus multilocularis | geminin | 0.0205 | 0.9364 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3273 | 0.3495 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3273 | 0.3495 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0 | 0.5 |
Echinococcus granulosus | Pleckstrin G protein interacting region | 0.0011 | 0.0146 | 0.0156 |
Brugia malayi | hypothetical protein | 0.0011 | 0.0146 | 0.0146 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3273 | 0.3273 |
Trichomonas vaginalis | ras GTP exchange factor, putative | 0.0008 | 0 | 0.5 |
Entamoeba histolytica | Ras guanine nucleotide exchange factor, putative | 0.0008 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 3.9811 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 4.1475 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 7.9433 uM | PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.