TDR Targets

Basic information

Technical information

TDR Targets ID: 1326202
Name: N-(1-adamantyl)-4-bromo-N,1-dimethylpyrazole- 3-carboxamide
MW: 352.269 | Formula: C16H22BrN3O
H donors: 0 H acceptors: 2 LogP: 3.39 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CN(C12CC3CC(C2)CC(C1)C3)C(=O)c1nn(cc1Br)C
InChi: 1S/C16H22BrN3O/c1-19-9-13(17)14(18-19)15(21)20(2)16-6-10-3-11(7-16)5-12(4-10)8-16/h9-12H,3-8H2,1-2H3
InChiKey: IQFOSGXZNIGHDE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(1-adamantyl)-4-bromo-N,1-dimethyl-pyrazole-3-carboxamide
N-(1-adamantyl)-4-bromo-N,1-dimethyl-3-pyrazolecarboxamide
N-(1-adamantyl)-4-bromo-N,1-dimethyl-1H-pyrazole-3-carboxamide
SMR000115072
ZINC04652452
MLS000546790
Oprea1_580471

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	muscleblind-like splicing regulator 1	Starlite/ChEMBL	No references
Homo sapiens	ATPase family, AAA domain containing 5	Starlite/ChEMBL	No references
Homo sapiens	TAR DNA binding protein	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132352	All targets in OG5_132352
Loa Loa (eye worm)	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma japonicum	TAR DNA-binding protein 43, putative	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	muscleblind protein	Get druggable targets OG5_132352	All targets in OG5_132352
Brugia malayi	Muscleblind-like protein	Get druggable targets OG5_132352	All targets in OG5_132352
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_132352	All targets in OG5_132352
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	tar DNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	Get druggable targets OG5_139225	All targets in OG5_139225
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Schistosoma mansoni	tar DNA-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	RNA recognition motif domain containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	Get druggable targets OG5_132461	All targets in OG5_132461
Brugia malayi	TAR-binding protein	Get druggable targets OG5_132461	All targets in OG5_132461
Echinococcus granulosus	muscleblind protein	Get druggable targets OG5_132352	All targets in OG5_132352
Echinococcus multilocularis	muscleblind protein 1	Get druggable targets OG5_132352	All targets in OG5_132352

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	carboxylesterase, LipT	0.0074	0.0171	0.5
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0248	0.1375	0.1367
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0248	0.1375	0.5154
Brugia malayi	TAR-binding protein	0.0076	0.0191	0.0716
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.005	0.001	0.001
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0076	0.0191	0.0191
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Brugia malayi	hypothetical protein	0.0286	0.1635	0.6127
Brugia malayi	follicle stimulating hormone receptor	0.005	0.001	0.0036
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Loa Loa (eye worm)	serotonin transporter b	0.0371	0.2224	0.2224
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Brugia malayi	Dopamine receptor protein 1	0.005	0.001	0.0036
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.1497	1	1
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0191	0.0182
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Echinococcus multilocularis	acetylcholinesterase	0.0435	0.2668	0.2661
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0314	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0171	0.0171
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0074	0.0171	0.0161
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.005	0.001	0.001
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.005	0.001	0.0036
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0094	0.0314	0.1178
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0191	0.0182
Onchocerca volvulus		0.0074	0.0171	0.0727
Loa Loa (eye worm)	norepinephrine transporter	0.0371	0.2224	0.2224
Brugia malayi	hypothetical protein	0.005	0.001	0.0036
Loa Loa (eye worm)	acetylcholinesterase 1	0.0435	0.2668	0.2668
Brugia malayi	Carboxylesterase family protein	0.0074	0.0171	0.0639
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0074	0.0171	0.0161
Brugia malayi	RNA binding protein	0.0076	0.0191	0.0716
Loa Loa (eye worm)	MH2 domain-containing protein	0.0144	0.0658	0.0658
Onchocerca volvulus		0.0094	0.0314	0.1376
Echinococcus granulosus	acetylcholinesterase	0.0435	0.2668	0.2661
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Brugia malayi	hypothetical protein	0.005	0.001	0.0036
Schistosoma mansoni	BC026374 protein (S09 family)	0.0074	0.0171	0.0161
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.005	0.001	0.0036
Plasmodium falciparum	amino acid transporter, putative	0.0248	0.1375	0.5
Loa Loa (eye worm)	hypothetical protein	0.1497	1	1
Brugia malayi	GnHR receptor homolog	0.005	0.001	0.0036
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0248	0.1375	0.5
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0371	0.2224	0.8336
Brugia malayi	Serotonin receptor	0.005	0.001	0.0036
Echinococcus granulosus	BC026374 protein S09 family	0.0074	0.0171	0.0161
Brugia malayi	larval opioid receptor	0.005	0.001	0.0036
Brugia malayi	hypothetical protein	0.0248	0.1375	0.5154
Echinococcus granulosus	neuroligin	0.0074	0.0171	0.0161
Brugia malayi	Carboxylesterase family protein	0.0435	0.2668	1
Echinococcus multilocularis	serotonin transporter	0.0371	0.2224	0.2217
Brugia malayi	ShTK domain containing protein	0.0094	0.0314	0.1178
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.005	0.001	0.001
Onchocerca volvulus		0.0248	0.1375	0.6166
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.1497	1	1
Onchocerca volvulus		0.0074	0.0171	0.0727
Loa Loa (eye worm)	neuropeptide F receptor	0.005	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Schistosoma mansoni	survival motor neuron protein	0.0058	0.0065	0.0055
Loa Loa (eye worm)	G-protein coupled receptor	0.005	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0171	0.0171
Echinococcus multilocularis	muscleblind protein	0.018	0.0909	0.09
Loa Loa (eye worm)	hypothetical protein	0.018	0.0909	0.0909
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0248	0.1375	0.1367
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0371	0.2224	0.2224
Echinococcus multilocularis	tar DNA binding protein	0.0076	0.0191	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0171	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0371	0.2224	0.2224
Brugia malayi	Carboxylesterase family protein	0.0074	0.0171	0.0639
Loa Loa (eye worm)	hypothetical protein	0.0286	0.1635	0.1635
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.005	0.001	0.001
Brugia malayi	putative neuropeptide receptor	0.005	0.001	0.0036
Schistosoma mansoni	tyrosinase precursor	0.0094	0.0314	0.0305
Loa Loa (eye worm)	hypothetical protein	0.018	0.0909	0.0909
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0371	0.2224	0.2224
Onchocerca volvulus		0.0074	0.0171	0.0727
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0248	0.1375	0.1367
Loa Loa (eye worm)	hypothetical protein	0.1497	1	1
Brugia malayi	hypothetical protein	0.005	0.001	0.0036
Echinococcus granulosus	geminin	0.0166	0.0809	0.08
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Echinococcus multilocularis	muscleblind protein 1	0.018	0.0909	0.09
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Schistosoma mansoni	tyrosinase precursor	0.0094	0.0314	0.0305
Plasmodium vivax	amine transporter, putative	0.0248	0.1375	0.5
Loa Loa (eye worm)	hypothetical protein	0.0248	0.1375	0.1375
Loa Loa (eye worm)	carboxylesterase	0.0074	0.0171	0.0171
Echinococcus granulosus	muscleblind protein	0.018	0.0909	0.09
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0314	0.0314
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Brugia malayi	Tachykinin-like peptides receptor 99D	0.005	0.001	0.0036
Schistosoma mansoni	gliotactin	0.0074	0.0171	0.0161
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0248	0.1375	0.5
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Loa Loa (eye worm)	ShTK domain-containing protein	0.0094	0.0314	0.0314
Brugia malayi	hypothetical protein	0.005	0.001	0.0036
Echinococcus granulosus	survival motor neuron protein 1	0.0286	0.1635	0.1627
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0058	0.0065	0.0243
Loa Loa (eye worm)	melatonin receptor type 1A	0.005	0.001	0.001
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0248	0.1375	0.1367
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Brugia malayi	G protein-coupled receptor F59B2.13	0.005	0.001	0.0036
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0074	0.0171	0.0161
Onchocerca volvulus		0.0248	0.1375	0.6166
Onchocerca volvulus		0.0058	0.0065	0.025
Brugia malayi	G-protein coupled receptor	0.005	0.001	0.0036
Loa Loa (eye worm)	transcription factor SMAD2	0.0144	0.0658	0.0658
Echinococcus multilocularis	para nitrobenzyl esterase	0.0074	0.0171	0.0161
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Loa Loa (eye worm)	carboxylesterase	0.0435	0.2668	0.2668
Onchocerca volvulus		0.0094	0.0314	0.1376
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0074	0.0171	0.0161
Brugia malayi	hypothetical protein	0.005	0.001	0.0036
Brugia malayi	hypothetical protein	0.0074	0.0171	0.0639
Schistosoma mansoni	sodium/chloride dependent transporter	0.0248	0.1375	0.1367
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0074	0.0171	0.5
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0248	0.1375	0.1367
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0979	0.6426	0.6422
Echinococcus granulosus	serotonin transporter	0.0371	0.2224	0.2217
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0248	0.1375	0.1367
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.005	0.001	0.0036
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0435	0.2668	0.2668
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0248	0.1375	0.5154
Brugia malayi	Muscleblind-like protein	0.018	0.0909	0.3405
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0074	0.0171	0.5
Brugia malayi	hypothetical protein	0.005	0.001	0.0036
Echinococcus granulosus	sodium and chloride dependent glycine	0.0248	0.1375	0.1367
Toxoplasma gondii	hypothetical protein	0.0248	0.1375	0.5
Brugia malayi	RNA recognition motif domain containing protein	0.0076	0.0191	0.0716
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.005	0.001	0.0036
Schistosoma mansoni	hypothetical protein	0.0058	0.0065	0.0055
Treponema pallidum	sodium- and chloride- dependent transporter	0.0371	0.2224	0.5
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0171	0.0171
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0074	0.0171	0.0161
Brugia malayi	sulfakinin receptor protein	0.005	0.001	0.0036
Plasmodium vivax	hypothetical protein, conserved	0.0248	0.1375	0.5
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Brugia malayi	neuropeptide F receptor	0.005	0.001	0.0036
Loa Loa (eye worm)	carboxylesterase	0.0074	0.0171	0.0171
Echinococcus granulosus	tar DNA binding protein	0.0076	0.0191	0.0182
Schistosoma mansoni	hypothetical protein	0.0166	0.0809	0.08
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0248	0.1375	0.1367
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Onchocerca volvulus		0.0094	0.0314	0.1376
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0171	0.0171
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Echinococcus multilocularis	survival motor neuron protein 1	0.0286	0.1635	0.1627
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0248	0.1375	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0191	0.0182
Loa Loa (eye worm)	TAR-binding protein	0.0076	0.0191	0.0191
Brugia malayi	Serotonin receptor	0.005	0.001	0.0036
Loa Loa (eye worm)	TYRA-2 protein	0.005	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0248	0.1375	0.1375
Brugia malayi	Carboxylesterase family protein	0.0074	0.0171	0.0639
Brugia malayi	hypothetical protein	0.005	0.001	0.0036
Loa Loa (eye worm)	neuropeptide F receptor	0.005	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0371	0.2224	0.2224
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Onchocerca volvulus		0.0074	0.0171	0.0727
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Schistosoma mansoni	hypothetical protein	0.0166	0.0809	0.08
Loa Loa (eye worm)	hypothetical protein	0.0248	0.1375	0.1375
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.005	0.001	0.0036
Onchocerca volvulus		0.0371	0.2224	1
Brugia malayi	Dopamine receptor protein 2	0.005	0.001	0.0036
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Loa Loa (eye worm)	tyrosinase 1	0.0094	0.0314	0.0314
Loa Loa (eye worm)	hypothetical protein	0.0248	0.1375	0.1375
Brugia malayi	Hypothetical tyrosinase-like protein F21C3.2 in chromosome I	0.0094	0.0314	0.1178
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Echinococcus granulosus	para nitrobenzyl esterase	0.0074	0.0171	0.0161
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0248	0.1375	0.1367
Loa Loa (eye worm)	hypothetical protein	0.0248	0.1375	0.1375
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Brugia malayi	Carboxylesterase family protein	0.0435	0.2668	1
Schistosoma mansoni	sodium/chloride dependent transporter	0.0248	0.1375	0.1367
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0171	0.0171
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0074	0.0171	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0435	0.2668	0.2668
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0248	0.1375	0.1375
Schistosoma mansoni	acetylcholinesterase	0.0074	0.0171	0.0161
Brugia malayi	hypothetical protein	0.005	0.001	0.0036
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.1497	1	1
Echinococcus multilocularis	carboxylesterase 5A	0.0435	0.2668	0.2661
Brugia malayi	AKH receptor	0.005	0.001	0.0036
Brugia malayi	hypothetical protein	0.005	0.001	0.0036
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0074	0.0171	0.0161
Echinococcus granulosus	acetylcholinesterase	0.0435	0.2668	0.2661
Brugia malayi	Common central domain of tyrosinase family protein	0.0094	0.0314	0.1178
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0074	0.0171	0.5
Trichomonas vaginalis	spcc417.12 protein, putative	0.0074	0.0171	0.5
Brugia malayi	G protein-coupled receptor	0.005	0.001	0.0036
Toxoplasma gondii	hypothetical protein	0.0248	0.1375	0.5
Echinococcus granulosus	carboxylesterase 5A	0.0435	0.2668	0.2661
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0248	0.1375	0.1367
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0094	0.0314	0.1178
Brugia malayi	putative neuropeptide receptor NPR1	0.005	0.001	0.0036
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0248	0.1375	0.1367
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0248	0.1375	0.5154
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Echinococcus granulosus	sodium and chloride dependent glycine	0.0248	0.1375	0.1367
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0248	0.1375	0.1375
Loa Loa (eye worm)	hypothetical protein	0.0074	0.0171	0.0171
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0248	0.1375	0.1367
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0191	0.0182
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.005	0.001	0.001
Echinococcus multilocularis	geminin	0.0166	0.0809	0.08
Schistosoma mansoni	tar DNA-binding protein	0.0076	0.0191	0.0182
Onchocerca volvulus		0.0094	0.0314	0.1376
Brugia malayi	G-protein coupled receptor	0.005	0.001	0.0036
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0074	0.0171	0.5
Brugia malayi	neuropeptide F receptor	0.005	0.001	0.0036
Loa Loa (eye worm)	ShTK domain-containing protein	0.0094	0.0314	0.0314
Loa Loa (eye worm)	G-protein coupled receptor	0.005	0.001	0.001
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0435	0.2668	0.2661
Onchocerca volvulus		0.0248	0.1375	0.6166
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0248	0.1375	0.5154
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.0248	0.1375	0.5
Brugia malayi	hypothetical protein	0.005	0.001	0.0036
Brugia malayi	Carboxylesterase family protein	0.0074	0.0171	0.0639
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Brugia malayi	RE15519p	0.005	0.001	0.0036
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.1497	1	1
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0248	0.1375	0.1367
Brugia malayi	MH2 domain containing protein	0.0144	0.0658	0.2467
Brugia malayi	Melatonin receptor type 1A	0.005	0.001	0.0036
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0248	0.1375	0.1367
Plasmodium falciparum	transporter, putative	0.0248	0.1375	0.5
Loa Loa (eye worm)	RNA binding protein	0.0076	0.0191	0.0191
Schistosoma mansoni	sodium/chloride dependent transporter	0.0371	0.2224	0.2217
Brugia malayi	Hypothetical tyrosinase-like protein C02C2.1 in chromosome III	0.0094	0.0314	0.1178
Echinococcus multilocularis	neuroligin	0.0074	0.0171	0.0161
Brugia malayi	Dopamine receptor	0.005	0.001	0.0036
Echinococcus multilocularis	acetylcholinesterase	0.0435	0.2668	0.2661
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Onchocerca volvulus		0.0074	0.0171	0.0727
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Brugia malayi	ORL1-like opioid receptor	0.005	0.001	0.0036
Loa Loa (eye worm)	hypothetical protein	0.005	0.001	0.001
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0371	0.2224	0.2217

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.0146 uM	PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]	ChEMBL.	No reference
Potency (functional)	0.6573 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (binding)	7.0795 uM	PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	15.8489 uM	PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (binding)	= 22.3872 um	PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)]	ChEMBL.	No reference
Potency (functional)	28.1838 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Saccharomyces cerevisiae	ChEMBL23
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1467446

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1326202