Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polymerase (DNA directed) iota | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | unspecified product | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0067 | 0.5148 | 0.5148 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0023 | 0 | 0.5 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0067 | 0.5148 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0067 | 0.5148 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Onchocerca volvulus | Phospholipase A2 homolog | 0.0108 | 1 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 1 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0023 | 0 | 0.5 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0067 | 0.5148 | 0.5148 |
Echinococcus granulosus | acetylcholinesterase | 0.0067 | 0.5148 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0067 | 0.5148 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0067 | 0.5148 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.5148 | 0.5148 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0023 | 0 | 0.5 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.5148 | 0.5148 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0023 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0067 | 0.5148 | 0.5148 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0023 | 0 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0023 | 0 | 0.5 |
Onchocerca volvulus | Phospholipase A2 homolog | 0.0108 | 1 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0067 | 0.5148 | 0.5148 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0023 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0067 | 0.5148 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0023 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0023 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0067 | 0.5148 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.631 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.