Detailed information for compound 1326396

Basic information

Technical information
  • TDR Targets ID: 1326396
  • Name: (E)-3-[5-(3,4-dichlorophenyl)furan-2-yl]-2-ph enylsulfonyl-N-(pyridin-3-ylmethyl)prop-2-ena mide
  • MW: 513.392 | Formula: C25H18Cl2N2O4S
  • H donors: 1 H acceptors: 4 LogP: 5.07 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(/C(=C\c1ccc(o1)c1ccc(c(c1)Cl)Cl)/S(=O)(=O)c1ccccc1)NCc1cccnc1
  • InChi: 1S/C25H18Cl2N2O4S/c26-21-10-8-18(13-22(21)27)23-11-9-19(33-23)14-24(34(31,32)20-6-2-1-3-7-20)25(30)29-16-17-5-4-12-28-15-17/h1-15H,16H2,(H,29,30)/b24-14+
  • InChiKey: RCFYSZPTSHODKC-ZVHZXABRSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[5-(3,4-dichlorophenyl)furan-2-yl]-2-phenylsulfonyl-N-(pyridin-3-ylmethyl)prop-2-enamide
  • (E)-3-[5-(3,4-dichlorophenyl)-2-furyl]-2-phenylsulfonyl-N-(3-pyridylmethyl)prop-2-enamide
  • 3-[5-(3,4-dichlorophenyl)-2-furyl]-2-phenylsulfonyl-N-(3-pyridylmethyl)prop-2-enamide
  • (E)-3-[5-(3,4-dichlorophenyl)-2-furyl]-2-phenylsulfonyl-N-(3-pyridylmethyl)acrylamide
  • 3-[5-(3,4-dichlorophenyl)-2-furyl]-2-phenylsulfonyl-N-(3-pyridylmethyl)acrylamide
  • STOCK2S-42857
  • (E)-2-Benzenesulfonyl-3-[5-(3,4-dichloro-phenyl)-furan-2-yl]-N-pyridin-3-ylmethyl-acrylamide
  • MLS000588403
  • SMR000212196

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens parathyroid hormone 1 receptor Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Herpes simplex virus (type 1 / strain 17) Alpha trans-inducing protein (VP16) Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens neuropeptide S receptor 1 Starlite/ChEMBL No references
Homo sapiens G protein-coupled receptor 55 Starlite/ChEMBL No references
Homo sapiens vitamin D (1,25- dihydroxyvitamin D3) receptor Starlite/ChEMBL No references
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens sphingosine-1-phosphate receptor 1 Starlite/ChEMBL No references
Homo sapiens tumor protein p53 Starlite/ChEMBL No references
Homo sapiens nuclear receptor subfamily 2, group E, member 3 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens sphingosine-1-phosphate receptor 4 Starlite/ChEMBL No references
Homo sapiens paired box 8 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Get druggable targets OG5_139945 All targets in OG5_139945
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus neuropeptide receptor A26 Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Get druggable targets OG5_136011 All targets in OG5_136011
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi photoreceptor-specific nuclear receptor Get druggable targets OG5_135311 All targets in OG5_135311
Echinococcus multilocularis neuropeptide s receptor Get druggable targets OG5_136011 All targets in OG5_136011
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) pax transcription factor protein 2 Get druggable targets OG5_139945 All targets in OG5_139945
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_135311 All targets in OG5_135311
Brugia malayi Pax transcription factor protein 2 Get druggable targets OG5_139945 All targets in OG5_139945
Schistosoma japonicum ko:K04588 secretin receptor, putative Get druggable targets OG5_139196 All targets in OG5_139196
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 518 aa 22.0 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin glutathione reductase   598 aa 537 aa 24.2 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin glutathione reductase   598 aa 513 aa 25.0 %
Onchocerca volvulus Thioredoxin glutathione reductase   598 aa 533 aa 50.8 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin glutathione reductase   598 aa 555 aa 33.5 %
Brugia malayi Nuclear hormone receptor family member nhr-49 nuclear receptor subfamily 2, group E, member 3 410 aa 384 aa 28.1 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 521 aa 21.5 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Neospora caninum hypothetical protein Thioredoxin glutathione reductase   598 aa 485 aa 30.5 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Brugia malayi steroid hormone receptor vitamin D (1,25- dihydroxyvitamin D3) receptor 427 aa 416 aa 24.5 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin glutathione reductase   598 aa 512 aa 28.3 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Neospora caninum glutathione reductase, putative Thioredoxin glutathione reductase   598 aa 532 aa 34.6 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 538 aa 25.3 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.1005 1
Schistosoma mansoni hypothetical protein 0.0038 0.0195 0.1012
Schistosoma mansoni hypothetical protein 0.0043 0.0251 0.1301
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0037 0.018 0.0932
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0037 0.018 0.0571
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.0884 0.8342
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0374 0.1187
Schistosoma mansoni intermediate filament proteins 0.0033 0.0138 0.0714
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0374 0.1937
Loa Loa (eye worm) hypothetical protein 0.0037 0.018 0.0571
Loa Loa (eye worm) latrophilin receptor protein 2 0.0038 0.0195 0.062
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0037 0.018 0.0571
Entamoeba histolytica hypothetical protein 0.0043 0.0251 0.5
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0037 0.018 0.0571
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0037 0.018 0.0932
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0037 0.018 0.0315
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0037 0.018 0.0571
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.018 0.018
Echinococcus granulosus lamin 0.0033 0.0138 0.0241
Schistosoma mansoni hypothetical protein 0.0038 0.0195 0.1012
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0138 0.0437
Plasmodium falciparum glutathione reductase 0.0046 0.0274 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.018 0.0571
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.018 0.0315
Schistosoma mansoni survival motor neuron protein 0.0058 0.0405 0.21
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0037 0.018 0.0571
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.018 0.0571
Loa Loa (eye worm) hypothetical protein 0.0037 0.018 0.0571
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.012 0.1053 0.3343
Brugia malayi Latrophilin receptor protein 2 0.0038 0.0195 0.062
Brugia malayi photoreceptor-specific nuclear receptor 0.0322 0.315 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0037 0.018 0.0932
Brugia malayi latrophilin 2 splice variant baaae 0.0082 0.0656 0.2082
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0274 0.0871
Schistosoma mansoni hypothetical protein 0.0038 0.0195 0.1012
Brugia malayi Thioredoxin reductase 0.0046 0.0274 0.0871
Schistosoma mansoni hypothetical protein 0.0082 0.0656 0.3398
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0037 0.018 0.0571
Loa Loa (eye worm) hypothetical protein 0.0038 0.0195 0.062
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0251 0.044
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0038 0.0195 0.0342
Onchocerca volvulus 0.0291 0.2826 1
Echinococcus multilocularis neuropeptide receptor A26 0.0567 0.5706 0.5706
Onchocerca volvulus 0.006 0.0421 0.1052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0037 0.018 0.0571
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.2773 0.4861
Echinococcus granulosus ecdysone induced protein 78C 0.0037 0.018 0.0315
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.018 0.0571
Loa Loa (eye worm) hypothetical protein 0.0148 0.134 0.4254
Brugia malayi nuclear receptor NHR-88 0.0037 0.018 0.0571
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0251 0.1301
Plasmodium falciparum thioredoxin reductase 0.0046 0.0274 0.5
Loa Loa (eye worm) pax transcription factor protein 2 0.0291 0.2826 0.8973
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0274 0.5
Mycobacterium tuberculosis Probable reductase 0.0104 0.0884 0.8342
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0374 0.0655
Onchocerca volvulus Huntingtin homolog 0.0148 0.134 0.4471
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.13 0.4129
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0037 0.018 0.0571
Schistosoma mansoni cellular tumor antigen P53 0.006 0.0421 0.2179
Onchocerca volvulus Protein ultraspiracle homolog 0.0037 0.018 0.0157
Loa Loa (eye worm) hypothetical protein 0.0037 0.018 0.0571
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0374 0.1937
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0037 0.018 0.0315
Brugia malayi hypothetical protein 0.0286 0.2773 0.8805
Loa Loa (eye worm) hypothetical protein 0.0032 0.0132 0.0418
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0037 0.018 0.0571
Schistosoma mansoni RAR-like nuclear receptor 0.0037 0.018 0.0932
Loa Loa (eye worm) hypothetical protein 0.006 0.0421 0.1336
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0037 0.018 0.0932
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0274 0.5
Entamoeba histolytica hypothetical protein 0.0043 0.0251 0.5
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0038 0.0195 0.0195
Schistosoma mansoni hypothetical protein 0.0205 0.193 1
Loa Loa (eye worm) steroid hormone receptor 0.0037 0.018 0.0571
Brugia malayi hypothetical protein 0.0148 0.134 0.4254
Loa Loa (eye worm) hypothetical protein 0.0322 0.315 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0374 0.0374
Loa Loa (eye worm) hypothetical protein 0.0037 0.018 0.0571
Schistosoma mansoni hypothetical protein 0.0058 0.0405 0.21
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0038 0.0195 0.0195
Schistosoma mansoni thyroid hormone receptor 0.0037 0.018 0.0932
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0374 0.1937
Echinococcus multilocularis neuropeptide s receptor 0.0567 0.5706 0.5706
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0037 0.018 0.018
Schistosoma mansoni coup transcription factor 0.0037 0.018 0.0932
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0037 0.018 0.0571
Echinococcus granulosus FTZ F1 alpha 0.0037 0.018 0.0315
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0405 0.1287
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.018 0.0571
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.0884 0.8342
Echinococcus multilocularis geminin 0.0205 0.193 0.193
Echinococcus granulosus neuropeptide receptor A26 0.0567 0.5706 1
Onchocerca volvulus 0.0037 0.018 0.0157
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0037 0.018 0.018
Onchocerca volvulus Huntingtin homolog 0.0148 0.134 0.4471
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0037 0.018 0.0571
Loa Loa (eye worm) hypothetical protein 0.012 0.1053 0.3343
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.018 0.0315
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.0884 0.8342
Echinococcus multilocularis lamin 0.0033 0.0138 0.0138
Echinococcus multilocularis thyroid hormone receptor alpha 0.0037 0.018 0.018
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0037 0.018 0.018
Brugia malayi ecdysteroid receptor 0.0037 0.018 0.0571
Echinococcus multilocularis lamin dm0 0.0033 0.0138 0.0138
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0037 0.018 0.0932
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0037 0.018 0.018
Loa Loa (eye worm) glutathione reductase 0.0046 0.0274 0.0871
Brugia malayi glutathione reductase 0.0046 0.0274 0.0871
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0281 0.0281
Schistosoma mansoni nuclear hormone receptor 0.0037 0.018 0.0932
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0037 0.018 0.0315
Schistosoma mansoni steroid hormone receptor ad4bp 0.0037 0.018 0.0932
Brugia malayi MH2 domain containing protein 0.0144 0.13 0.4129
Brugia malayi steroid hormone receptor 0.0037 0.018 0.0571
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0138 0.0437
Toxoplasma gondii thioredoxin reductase 0.0046 0.0274 0.5
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0038 0.0195 0.0342
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.1005 1
Echinococcus multilocularis musashi 0.0033 0.0138 0.0138
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0037 0.018 0.0571
Echinococcus granulosus geminin 0.0205 0.193 0.3383
Loa Loa (eye worm) hypothetical protein 0.0033 0.0138 0.0437
Brugia malayi intermediate filament protein 0.0033 0.0138 0.0437
Echinococcus granulosus intermediate filament protein 0.0033 0.0138 0.0241
Brugia malayi Steroid receptor seven-up type 2 0.0037 0.018 0.0571
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.0884 0.8342
Leishmania major trypanothione reductase 0.0046 0.0274 0.5
Echinococcus granulosus neuropeptide s receptor 0.0567 0.5706 1
Echinococcus granulosus lamin dm0 0.0033 0.0138 0.0241
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0037 0.018 0.0315
Schistosoma mansoni lamin 0.0033 0.0138 0.0714
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0037 0.018 0.0571
Plasmodium vivax glutathione reductase, putative 0.0046 0.0274 0.5
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0138 0.0437
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0037 0.018 0.0571
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0038 0.0195 0.062
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0374 0.1187
Entamoeba histolytica hypothetical protein 0.0043 0.0251 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0037 0.018 0.0571
Schistosoma mansoni hypothetical protein 0.0205 0.193 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.0884 0.8342
Echinococcus multilocularis tumor protein p63 0.0408 0.4049 0.4049
Loa Loa (eye worm) hypothetical protein 0.0037 0.018 0.0571
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.2773 0.2773
Loa Loa (eye worm) hypothetical protein 0.0082 0.0656 0.2082
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0037 0.018 0.0157
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.1005 1
Schistosoma mansoni thyroid hormone receptor 0.0037 0.018 0.0932
Onchocerca volvulus Bile acid receptor homolog 0.0037 0.018 0.0157
Schistosoma mansoni retinoic acid receptor RXR 0.0037 0.018 0.0932
Echinococcus multilocularis ecdysone induced protein 78C 0.0037 0.018 0.018
Loa Loa (eye worm) pigment dispersing factor receptor c 0.012 0.1053 0.3343
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0281 0.0492
Entamoeba histolytica hypothetical protein 0.0043 0.0251 0.5
Brugia malayi hypothetical protein 0.0043 0.0251 0.0797
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0374 0.0374
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.018 0.018
Schistosoma mansoni lamin 0.0033 0.0138 0.0714
Schistosoma mansoni hypothetical protein 0.0038 0.0195 0.1012
Echinococcus multilocularis GPCR, family 2 0.0038 0.0195 0.0195
Echinococcus multilocularis FTZ F1 alpha 0.0037 0.018 0.018
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.1005 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0037 0.018 0.0315
Brugia malayi nuclear hormone receptor 0.0037 0.018 0.0571
Brugia malayi Calcitonin receptor-like protein seb-1 0.012 0.1053 0.3343
Brugia malayi Pax transcription factor protein 2 0.0291 0.2826 0.8973
Loa Loa (eye worm) hypothetical protein 0.0037 0.018 0.0571
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0037 0.018 0.0571
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0251 0.0251
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.13 0.4129
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0037 0.018 0.0571
Loa Loa (eye worm) hypothetical protein 0.0148 0.134 0.4254
Onchocerca volvulus 0.0058 0.0405 0.0995
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0374 0.0655
Trypanosoma brucei trypanothione reductase 0.0046 0.0274 0.5
Echinococcus granulosus GPCR family 2 0.0038 0.0195 0.0342
Echinococcus granulosus tumor protein p63 0.0408 0.4049 0.7097
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0037 0.018 0.0932
Loa Loa (eye worm) hypothetical protein 0.0286 0.2773 0.8805
Loa Loa (eye worm) hypothetical protein 0.0037 0.018 0.0571

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 4.66 uM PubChem BioAssay. HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
EC50 (functional) = 1.608518 uM PUBCHEM_BIOASSAY: Image-based HTS for Selective Agonists of GPR55. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1965, AID2338, AID2339, AID2340, AID2341, AID2347, AID2843, AID2844, AID434922, AID434924, AID434925, AID434928, AID434929, AID463192, AID485279] ChEMBL. No reference
EC50 (functional) > 120 um PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Activators of 5'UTR Stem-Loop Driven Prion Protein mRNA Translation in H4 Neuroglioblastoma Cells. (Class of assay: confirmatory) [Related pubchem assays: 1829 (Project Summary), 1814 (Primary HTS)] ChEMBL. No reference
IC50 (functional) = 0.965 um PUBCHEM_BIOASSAY: Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation in triplicates.), 1510 (Primary screen.)] ChEMBL. No reference
IC50 (functional) 4.079 uM PubChem BioAssay. Luminescence-based cell-based high throughput dose response assay for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3). (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) 7.958 uM PubChem BioAssay. Counterscreen for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3):Luminescence-based cell-based high throughput dose response assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16). (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = 8.814 um PUBCHEM_BIOASSAY: Fluorescence-based counterscreen assay for S1P4 antagonists: Cell-based dose response high throughput screening assay to identify antagonists of the Sphingosine 1-Phosphate Receptor 1 (S1P1). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen.), 1510 (Primary screen.)] ChEMBL. No reference
IC50 (functional) 26.682 uM PubChem BioAssay. Counterscreen for inhibitors of the interaction of nucleotide-binding oligomerization domain containing 2 (NOD2) and receptor-interacting serine-threonine kinase 2 (RIPK2): Fluorescence-based cell-based high throughput dose response assay to identify non-selective inhibitors of the beta-lactamase enzyme (BLA). (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) > 50 um PUBCHEM_BIOASSAY: Late stage fluorescence dose response cell-based screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4). (Class of assay: confirmatory) [Related pubchem assays: 1524 (Confirmation screen (S1P4 antagonists).), 1510 (Primary screen (S1P4 antagonists).), 1853 (Summary AID (S1P4 antagonists).), 1692 (Dose response screen (S1P4 antagonists).)] ChEMBL. No reference
Potency (functional) 2.2387 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation using a Texas Red Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.9811 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation using a Fluorescein Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.4668 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 4.4668 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 6.5131 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.3078 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Agonists. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.5821 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation using a Beta-Lactamase Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 15.003 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation in Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference
Potency (functional) 58.4789 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 84.9214 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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