Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.414 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.414 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0076 | 0.414 | 0.414 |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.414 | 0.414 |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.414 | 0.414 |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.414 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.414 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.414 | 0.414 |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0029 | 0 | 0.5 |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0029 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.414 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.414 | 1 |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.414 | 0.414 |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.414 | 1 |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.414 | 0.414 |
Onchocerca volvulus | 0.0029 | 0 | 0.5 | |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 1 | 1 |
Onchocerca volvulus | 0.0029 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.1475 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 32.6427 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 32.6427 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization. This assay monitors tau fibrillation by fluorescence polarization (FP) of Alexa 594-labeled K18 P301L, which does not fibrillize readily but incorporates into growing filaments of unlabeled tau. (Class of assay: confirmatory) [Related pubchem assays: 596 ] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 89.1251 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Saccharomyces cerevisiae | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.