Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Latrophilin receptor protein 2 | 0.0038 | 0.2006 | 0.2006 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.2006 | 0.1112 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.1469 | 0.1469 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0038 | 0.2006 | 0.1259 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.5736 | 1 |
Onchocerca volvulus | 0.0033 | 0.1469 | 0.5 | |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0038 | 0.2006 | 0.2006 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5736 | 0.8832 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.2006 | 0.1112 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.2006 | 0.2006 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1411 | 0.1411 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5736 | 0.8832 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.63 | 0.63 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.2006 | 0.1112 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.5736 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.5736 | 0.5736 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0038 | 0.2006 | 0.1259 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.5736 | 0.5736 |
Onchocerca volvulus | 0.0033 | 0.1469 | 0.5 | |
Echinococcus granulosus | GPCR family 2 | 0.0038 | 0.2006 | 0.1259 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0038 | 0.2006 | 0.1259 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.5736 | 0.5736 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5736 | 0.8832 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.2006 | 0.1112 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.1469 | 0.1469 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.1469 | 0.1469 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5736 | 0.8832 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.5736 | 0.5736 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.1469 | 0.1469 |
Echinococcus multilocularis | GPCR, family 2 | 0.0038 | 0.2006 | 0.1259 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.5736 | 0.8832 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.63 | 1 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.5736 | 0.5736 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0082 | 0.63 | 0.63 |
Brugia malayi | RNA binding protein | 0.0076 | 0.5736 | 0.5736 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.012 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1469 | 0.1469 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0038 | 0.2006 | 0.1259 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.012 | 1 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0038 | 0.2006 | 0.2006 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 5.6234 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 6.3096 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.1254 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | = 25.1189 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] | ChEMBL. | No reference |
Potency (functional) | 29.081 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 70.7946 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.