Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Influenza A virus | Nonstructural protein 1 | Starlite/ChEMBL | No references |
Homo sapiens | hydroxyprostaglandin dehydrogenase 15-(NAD) | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Hypothetical protein | Nonstructural protein 1 | 230 aa | 202 aa | 23.8 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Plasmodium falciparum | steroid dehydrogenase, putative | hydroxyprostaglandin dehydrogenase 15-(NAD) | 266 aa | 216 aa | 22.2 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1494 | 0.2464 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.2345 | 0.2243 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.037 | 0.0739 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0038 | 0.1494 | 0.138 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.3266 | 0.6521 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.2337 | 0.179 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.2047 | 0.4088 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.2041 | 0.4076 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.2047 | 0.3376 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.012 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.3266 | 0.5386 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0038 | 0.1494 | 0.2983 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2047 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0038 | 0.1494 | 0.0887 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0038 | 0.1494 | 0.2983 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.1494 | 0.138 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.2879 | 0.2784 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.3266 | 0.5386 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.2047 | 0.3376 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.2641 | 0.2543 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.037 | 0.0739 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.3266 | 0.2785 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.2047 | 0.4088 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.3266 | 0.3176 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2047 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1494 | 0.2464 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2047 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 1 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.5008 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0038 | 0.1494 | 0.2983 |
Brugia malayi | hypothetical protein | 0.0043 | 0.2047 | 0.148 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1494 | 0.2464 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.5008 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0038 | 0.1494 | 0.2983 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.2041 | 0.4076 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.3266 | 0.6521 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.3266 | 0.6521 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.2047 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.3266 | 0.6521 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.5454 | 0.8996 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0082 | 0.6063 | 0.5782 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.6063 | 0.601 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.6063 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0038 | 0.1494 | 0.2983 |
Brugia malayi | Bromodomain containing protein | 0.0091 | 0.6917 | 0.6697 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.0132 | 0.0218 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1494 | 0.2464 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.012 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.6383 | 0.6335 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0038 | 0.1494 | 0.2983 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.3266 | 0.5386 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.037 | 0.0611 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0038 | 0.1494 | 0.0887 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 41.7 uM | PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463190, AID463194, AID504542, AID504544] | ChEMBL. | No reference |
Potency (functional) | 0.0657 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 0.7079 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 1 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 3.5481 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 10 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.6891 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 12.9953 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | = 22.3872 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.081 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.