Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.011 | 0.2558 | 0.3478 |
Brugia malayi | Cathepsin L-like precursor | 0.0163 | 0.7355 | 0.7267 |
Brugia malayi | Cathepsin L-like precursor | 0.0163 | 0.7355 | 0.7267 |
Plasmodium vivax | vivapain-2 | 0.0163 | 0.7355 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0163 | 0.7355 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.011 | 0.2558 | 0.2312 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0163 | 0.7355 | 1 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.011 | 0.2558 | 0.2558 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0163 | 0.7355 | 1 |
Leishmania major | cathepsin L-like protease | 0.0163 | 0.7355 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0163 | 0.7355 | 1 |
Leishmania major | cathepsin L-like protease | 0.0163 | 0.7355 | 1 |
Echinococcus granulosus | cathepsin b | 0.0191 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0163 | 0.7355 | 0.7355 |
Giardia lamblia | Cathepsin B precursor | 0.0083 | 0 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0163 | 0.7355 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0163 | 0.7355 | 0.7267 |
Onchocerca volvulus | Cathepsin F homolog | 0.0163 | 0.7355 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0163 | 0.7355 | 0.7267 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.2558 | 0.2558 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0163 | 0.7355 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.011 | 0.2558 | 0.2312 |
Brugia malayi | Cathepsin L-like precursor | 0.0163 | 0.7355 | 0.7267 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0163 | 0.7355 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0163 | 0.7355 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0163 | 0.7355 | 0.7267 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0163 | 0.7355 | 0.7267 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.2558 | 0.2558 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0191 | 1 | 1 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0086 | 0.0319 | 0.0319 |
Loa Loa (eye worm) | cysteine protease | 0.0163 | 0.7355 | 0.7355 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0163 | 0.7355 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0163 | 0.7355 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0163 | 0.7355 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0086 | 0.0319 | 0.0434 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0163 | 0.7355 | 0.7267 |
Echinococcus multilocularis | cysteine protease | 0.0163 | 0.7355 | 0.7267 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0163 | 0.7355 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.7355 | 0.7355 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0086 | 0.0319 | 0.0319 |
Echinococcus granulosus | cathepsin l1 | 0.0163 | 0.7355 | 0.7267 |
Entamoeba histolytica | cysteine protease, putative | 0.0163 | 0.7355 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0163 | 0.7355 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0163 | 0.7355 | 0.7355 |
Giardia lamblia | Cathepsin B precursor | 0.0083 | 0 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0163 | 0.7355 | 0.7355 |
Schistosoma mansoni | SmCL2-like peptidase (C01 family) | 0.0086 | 0.0319 | 0.0319 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0163 | 0.7355 | 1 |
Leishmania major | cathepsin L-like protease | 0.0163 | 0.7355 | 1 |
Onchocerca volvulus | 0.0163 | 0.7355 | 1 | |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0163 | 0.7355 | 0.7355 |
Onchocerca volvulus | Cathepsin L homolog | 0.0163 | 0.7355 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0163 | 0.7355 | 0.7355 |
Onchocerca volvulus | 0.0163 | 0.7355 | 1 | |
Leishmania major | cathepsin L-like protease | 0.0163 | 0.7355 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0163 | 0.7355 | 1 |
Echinococcus granulosus | cathepsin l1 | 0.011 | 0.2558 | 0.2312 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0086 | 0.0319 | 0.0319 |
Loa Loa (eye worm) | hypothetical protein | 0.011 | 0.2558 | 0.2558 |
Onchocerca volvulus | 0.0163 | 0.7355 | 1 | |
Onchocerca volvulus | 0.0163 | 0.7355 | 1 | |
Echinococcus multilocularis | cathepsin b | 0.0191 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0163 | 0.7355 | 0.7267 |
Leishmania major | cathepsin L-like protease | 0.0163 | 0.7355 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0163 | 0.7355 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0163 | 0.7355 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0163 | 0.7355 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.011 | 0.2558 | 0.3182 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0163 | 0.7355 | 0.7267 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.011 | 0.2558 | 0.3478 |
Leishmania major | cathepsin L-like protease | 0.0163 | 0.7355 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0086 | 0.0319 | 0.0434 |
Onchocerca volvulus | 0.0163 | 0.7355 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0163 | 0.7355 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0086 | 0.0319 | 0.0434 |
Brugia malayi | Cathepsin L-like precursor | 0.0163 | 0.7355 | 0.7267 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0163 | 0.7355 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0163 | 0.7355 | 0.7355 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0163 | 0.7355 | 1 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0163 | 0.7355 | 0.7267 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0163 | 0.7355 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0163 | 0.7355 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0163 | 0.7355 | 0.7355 |
Brugia malayi | cathepsin L-like precursor | 0.011 | 0.2558 | 0.2312 |
Plasmodium vivax | vivapain-2 | 0.0163 | 0.7355 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0163 | 0.7355 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.011 | 0.2558 | 0.2558 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.0086 | 0.0319 | 0.0319 |
Echinococcus granulosus | cathepsin b | 0.0191 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0191 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0191 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0191 | 1 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0163 | 0.7355 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0163 | 0.7355 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0083 | 0 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.0163 | 0.7355 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0163 | 0.7355 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0163 | 0.7355 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.011 | 0.2558 | 0.2312 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0163 | 0.7355 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0163 | 0.7355 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0163 | 0.7355 | 0.7355 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0163 | 0.7355 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0163 | 0.7355 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0163 | 0.7355 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0163 | 0.7355 | 0.7267 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0163 | 0.7355 | 0.7355 |
Leishmania major | cysteine peptidase A (CPA) | 0.0163 | 0.7355 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0163 | 0.7355 | 1 |
Onchocerca volvulus | 0.0163 | 0.7355 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0163 | 0.7355 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0086 | 0.0319 | 0.0434 |
Leishmania major | cathepsin L-like protease | 0.0163 | 0.7355 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0086 | 0.0319 | 0.0319 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.0086 | 0.0319 | 0.0319 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0163 | 0.7355 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0163 | 0.7355 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0163 | 0.7355 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0163 | 0.7355 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0191 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0191 | 1 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0163 | 0.7355 | 0.7355 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0163 | 0.7355 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0163 | 0.7355 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0191 | 1 | 1 |
Onchocerca volvulus | 0.0163 | 0.7355 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0163 | 0.7355 | 1 |
Trypanosoma cruzi | cysteine protease, putative | 0.0086 | 0.0319 | 0.0319 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0163 | 0.7355 | 0.7355 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0163 | 0.7355 | 0.7267 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0163 | 0.7355 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 19 % | Activity of the compound against LTB4 biosynthesis in the rat RPAR plurisy model po (25 mg/kg) | ChEMBL. | 8568813 |
Inhibition (functional) | = 34 % | Oral dose of 25 mg/Kg was tested for the inhibition of antigen induced bronchoconstriction in guinea pig | ChEMBL. | 8568813 |
Inhibition (functional) | = 34 % | Oral dose of 25 mg/Kg was tested for the inhibition of antigen induced bronchoconstriction in guinea pig | ChEMBL. | 8568813 |
Inhibition (functional) | = 59 % | Ex vivo inhibitory activity of the compound at an peroral dose of 5 mg/Kg against LTB4 biosynthesis in rat blood, after pretreatment period of 6 hr | ChEMBL. | 8568813 |
Inhibition (functional) | = 70 % | Inhibition of LTB4 biosynthesis at 1 microM, in calcium ionophore-stimulated human whole blood leukocyte (HBL) assay. | ChEMBL. | 8568813 |
Inhibition (functional) | = 70 % | Inhibition of LTB4 biosynthesis at 1 microM, in calcium ionophore-stimulated human whole blood leukocyte (HBL) assay. | ChEMBL. | 8568813 |
Inhibition (functional) | = 85 % | Intravenous dose of 10 mg/Kg was tested for the inhibition of antigen induced bronchoconstriction in guinea pig | ChEMBL. | 8568813 |
Inhibition (functional) | = 85 % | Intravenous dose of 10 mg/Kg was tested for the inhibition of antigen induced bronchoconstriction in guinea pig | ChEMBL. | 8568813 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.