Detailed information for compound 1327128

Basic information

Technical information
  • TDR Targets ID: 1327128
  • Name: N'-[2-[(5-ethyl-4-methyl-6-oxo-3H-pyrimidin-2 -yl)sulfanyl]acetyl]-2-(4-methoxyphenyl)aceto hydrazide
  • MW: 390.457 | Formula: C18H22N4O4S
  • H donors: 3 H acceptors: 5 LogP: 2.64 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)CC(=O)NNC(=O)CSc1nc(C)c(c(n1)O)CC
  • InChi: 1S/C18H22N4O4S/c1-4-14-11(2)19-18(20-17(14)25)27-10-16(24)22-21-15(23)9-12-5-7-13(26-3)8-6-12/h5-8H,4,9-10H2,1-3H3,(H,21,23)(H,22,24)(H,19,20,25)
  • InChiKey: OOHLFFSMFCEQEC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N'-[2-[(5-ethyl-4-methyl-6-oxo-3H-pyrimidin-2-yl)thio]-1-oxoethyl]-2-(4-methoxyphenyl)acetohydrazide
  • N'-[2-[(5-ethyl-4-keto-6-methyl-1H-pyrimidin-2-yl)thio]acetyl]-2-(4-methoxyphenyl)acetohydrazide
  • N'-[2-[(5-ethyl-4-methyl-6-oxo-3H-pyrimidin-2-yl)sulfanyl]ethanoyl]-2-(4-methoxyphenyl)ethanehydrazide
  • SMR000415068
  • ZINC05026940
  • STK328927
  • (4-Methoxy-phenyl)-acetic acid N'-[2-(5-ethyl-4-hydroxy-6-methyl-pyrimidin-2-ylsulfanyl)-acetyl]-hydrazide
  • MLS001043269

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tar DNA binding protein 0.0205 0.4399 0.4399
Echinococcus granulosus guanine nucleotide binding protein G protein 0.001 0.0035 0.0035
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0131 0.0175
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0286 0.0286
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0063
Trichomonas vaginalis replication factor C large subunit, putative 0.0011 0.0036 0.0003
Onchocerca volvulus 0.0022 0.0286 0.0708
Brugia malayi RNA binding protein 0.0205 0.4399 0.7916
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0691 0.1188
Echinococcus multilocularis Polycystic kidney disease protein 0.0022 0.0286 0.0286
Echinococcus multilocularis expressed protein 0.001 0.0035 0.0035
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0691 0.797
Onchocerca volvulus 0.0104 0.2123 0.5894
Schistosoma mansoni alpha-glucosidase 0.0154 0.3257 0.3257
Schistosoma mansoni cpg binding protein 0.0034 0.0556 0.0556
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0244 0.5279 0.5279
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0131 0.0175
Echinococcus granulosus cpg binding protein 0.0034 0.0556 0.0556
Brugia malayi RNA recognition motif domain containing protein 0.0205 0.4399 0.7916
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0691 0.1188
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.004 0.0691 0.5382
Brugia malayi hypothetical protein 0.001 0.0035 0.0063
Onchocerca volvulus 0.0011 0.0036 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0036 0.0003
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0063
Echinococcus multilocularis lamin 0.0027 0.0401 0.0401
Schistosoma mansoni cpg binding protein 0.0034 0.0556 0.0556
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.001 0.0035 0.0063
Loa Loa (eye worm) hypothetical protein 0.0015 0.0131 0.0237
Brugia malayi Glycosyl hydrolases family 31 protein 0.004 0.0691 0.1243
Echinococcus granulosus guanine nucleotide binding protein G protein 0.001 0.0035 0.0035
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0244 0.5279 0.5279
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0691 1
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.001 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0012 0.0079 0.0141
Schistosoma mansoni hypothetical protein 0.0455 1 1
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.001 0.0035 0.0035
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.5558 1
Loa Loa (eye worm) TAR-binding protein 0.0205 0.4399 0.7916
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0061 0.1161 0.1161
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0131 0.0175
Loa Loa (eye worm) hypothetical protein 0.0022 0.0286 0.0514
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0036 0.0003
Schistosoma mansoni lipoxygenase 0.0022 0.0286 0.0286
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0244 0.5279 0.5279
Loa Loa (eye worm) hypothetical protein 0.0012 0.0079 0.0141
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.3616 0.3616
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0131 0.0175
Schistosoma mansoni intermediate filament proteins 0.0027 0.0401 0.0401
Echinococcus multilocularis geminin 0.0355 0.7756 0.7756
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0036 0.0003
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.1319 0.1319
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0131 0.1455
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0257 0.5558 1
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.001 0.0035 0.0035
Schistosoma mansoni alpha glucosidase 0.004 0.0691 0.0691
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0954 0.1665
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0954 0.7548
Schistosoma mansoni trimeric G-protein alpha o subunit 0.001 0.0035 0.0035
Echinococcus granulosus intermediate filament protein 0.0027 0.0401 0.0401
Brugia malayi hypothetical protein 0.0022 0.0286 0.0514
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.001 0.0035 0.0063
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0052 0.0971 0.0971
Chlamydia trachomatis DNA ligase 0.0011 0.0036 0.5
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.004 0.0691 0.797
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0011 0.0036 0.0065
Entamoeba histolytica hypothetical protein 0.0039 0.0665 0.7651
Echinococcus granulosus tar DNA binding protein 0.0205 0.4399 0.4399
Schistosoma mansoni tar DNA-binding protein 0.0205 0.4399 0.4399
Echinococcus granulosus neutral alpha glucosidase AB 0.004 0.0691 0.0691
Schistosoma mansoni hypothetical protein 0.0039 0.0665 0.0665
Schistosoma mansoni tar DNA-binding protein 0.0205 0.4399 0.4399
Brugia malayi Latrophilin receptor protein 2 0.0052 0.0971 0.1747
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0165 0.3501 0.63
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0063
Schistosoma mansoni hypothetical protein 0.0052 0.0971 0.0971
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.001 0.0035 0.0063
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0665 0.0665
Echinococcus multilocularis lipoxygenase domain containing protein 0.0022 0.0286 0.0286
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0286 0.0286
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.001 0.0035 0.0063
Onchocerca volvulus 0.0022 0.0286 0.0708
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0015 0.0131 0.0175
Schistosoma mansoni hypothetical protein 0.0355 0.7756 0.7756
Echinococcus granulosus lipoxygenase domain containing protein 0.0022 0.0286 0.0286
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0665 0.0665
Plasmodium falciparum LCCL domain-containing protein 0.0022 0.0286 0.3035
Brugia malayi MH2 domain containing protein 0.0131 0.2743 0.4936
Echinococcus multilocularis RUN 0.0022 0.0286 0.0286
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0954 0.7548
Schistosoma mansoni alpha-glucosidase 0.0154 0.3257 0.3257
Echinococcus multilocularis lysosomal alpha glucosidase 0.0179 0.3817 0.3817
Echinococcus granulosus expressed protein 0.001 0.0035 0.0035
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0954 0.0954
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0052 0.0971 0.0971
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.001 0.0035 0.0035
Echinococcus granulosus GPCR family 2 0.0052 0.0971 0.0971
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0065
Schistosoma mansoni hypothetical protein 0.0355 0.7756 0.7756
Treponema pallidum DNA ligase (lig) 0.0011 0.0036 0.5
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.3726 0.6705
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.001 0.0035 0.0035
Loa Loa (eye worm) RNA binding protein 0.0205 0.4399 0.7916
Entamoeba histolytica hypothetical protein 0.0039 0.0665 0.7651
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.001 0.0035 0.0035
Schistosoma mansoni lipoxygenase 0.0061 0.1161 0.1161
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0401 0.0721
Loa Loa (eye worm) hypothetical protein 0.0022 0.0286 0.0514
Echinococcus granulosus Polycystic kidney disease protein 0.0022 0.0286 0.0286
Brugia malayi Calcitonin receptor-like protein seb-1 0.0165 0.3501 0.63
Schistosoma mansoni GTP-binding protein alpha subunit 0.001 0.0035 0.0035
Schistosoma mansoni GTP-binding protein alpha subunit 0.001 0.0035 0.0035
Brugia malayi Doublecortin family protein 0.0022 0.0286 0.0514
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0011 0.0036 0.0003
Schistosoma mansoni tar DNA-binding protein 0.0205 0.4399 0.4399
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0954 0.1665
Loa Loa (eye worm) hypothetical protein 0.0027 0.0401 0.0721
Echinococcus multilocularis lysosomal alpha glucosidase 0.0179 0.3817 0.3817
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.001 0.0035 0.0035
Echinococcus granulosus guanine nucleotide binding protein subunit 0.001 0.0035 0.0035
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.009 0.009
Trichomonas vaginalis sucrase-isomaltase, putative 0.004 0.0691 0.1188
Schistosoma mansoni hypothetical protein 0.0052 0.0971 0.0971
Brugia malayi intermediate filament protein 0.0027 0.0401 0.0721
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0257 0.5558 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0244 0.5279 0.5279
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.3577 0.6415
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0018 0.0033
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.001 0.0035 0.0063
Brugia malayi hypothetical protein 0.0022 0.0286 0.0514
Echinococcus granulosus lamin dm0 0.0027 0.0401 0.0401
Loa Loa (eye worm) acetyltransferase 0.0175 0.3726 0.6705
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0065
Brugia malayi CXXC zinc finger family protein 0.0032 0.0516 0.0928
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0858 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0244 0.5279 0.5279
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0015 0.0131 0.1174
Echinococcus granulosus replication factor c subunit 1 0.0011 0.0036 0.0036
Echinococcus multilocularis musashi 0.0027 0.0401 0.0401
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.001 0.0035 0.0063
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0052 0.0971 0.0971
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0065
Schistosoma mansoni loxhd1 0.0022 0.0286 0.0286
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0205 0.4399 0.7916
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.001 0.0035 0.0063
Loa Loa (eye worm) doublecortin family protein 0.0022 0.0286 0.0514
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0065
Trichomonas vaginalis maltase-glucoamylase, putative 0.004 0.0691 0.1188
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.3781 0.6783
Echinococcus granulosus guanine nucleotide binding protein subunit 0.001 0.0035 0.0035
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.3577 0.6415
Schistosoma mansoni topbp1 0.0011 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0026 0.039 0.0701
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.001 0.0035 0.0035
Echinococcus multilocularis GPCR, family 2 0.0052 0.0971 0.0971
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.5558 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0065 0.1253 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0015 0.0131 0.0237
Brugia malayi hypothetical protein 0.0011 0.0036 0.0065
Loa Loa (eye worm) hypothetical protein 0.0165 0.3501 0.63
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0063
Brugia malayi DKFZp564C0469 protein 0.0011 0.0036 0.0065
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0858 1
Schistosoma mansoni hypothetical protein 0.0052 0.0971 0.0971
Brugia malayi latrophilin 2 splice variant baaae 0.0113 0.233 0.4192
Schistosoma mansoni lamin 0.0027 0.0401 0.0401
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0691 0.1188
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0122 0.0219
Schistosoma mansoni chromosome transmission fidelity factor 0.0011 0.0036 0.0036
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0165 0.3501 0.63
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0011 0.0036 0.5
Echinococcus multilocularis cpg binding protein 0.0034 0.0556 0.0556
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.001 0.0035 0.0035
Onchocerca volvulus 0.0032 0.0516 0.1357
Trichomonas vaginalis conserved hypothetical protein 0.019 0.4054 0.7277
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0015 0.0131 0.0273
Schistosoma mansoni hypothetical protein 0.0022 0.0286 0.0286
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0036 0.0003
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.001 0.0035 0.0063
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0691 0.1188
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0691 1
Entamoeba histolytica hypothetical protein 0.0011 0.0036 0.0017
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.3726 0.3726
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0195 0.4173 0.7509
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0011 0.0036 0.0017
Entamoeba histolytica hypothetical protein 0.0039 0.0665 0.7651
Echinococcus multilocularis neutral alpha glucosidase AB 0.004 0.0691 0.0691
Schistosoma mansoni topbp1 0.0011 0.0036 0.0036
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0122 0.0219
Brugia malayi TAR-binding protein 0.0205 0.4399 0.7916
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.3577 0.6415
Echinococcus granulosus nibrin 0.0011 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.0052 0.0971 0.0971
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.001 0.0035 0.0035
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0401 0.0721
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.001 0.0035 0.0063
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.001 0.0035 0.0035
Schistosoma mansoni rab6-interacting 0.0022 0.0286 0.0286
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.001 0.0035 0.0035
Schistosoma mansoni tar DNA-binding protein 0.0205 0.4399 0.4399
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0015 0.0131 0.1455
Trypanosoma brucei glycosyl hydrolase-like protein 0.0015 0.0131 0.1455
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0036 0.0003
Echinococcus multilocularis replication factor c subunit 1 0.0011 0.0036 0.0036
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.5558 1
Schistosoma mansoni polycystin 1-related 0.0022 0.0286 0.0286
Echinococcus granulosus lysosomal alpha glucosidase 0.0179 0.3817 0.3817
Loa Loa (eye worm) hypothetical protein 0.0013 0.009 0.0161
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0244 0.5279 0.9499
Echinococcus granulosus geminin 0.0355 0.7756 0.7756
Onchocerca volvulus 0.0027 0.0401 0.1033
Brugia malayi hypothetical protein 0.0039 0.0665 0.1196
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0021 0.0021
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.3577 0.6415
Brugia malayi G-protein alpha subunit 0.001 0.0035 0.0063
Schistosoma mansoni rab6-interacting 0.0022 0.0286 0.0286
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0244 0.5279 0.9499
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.001 0.0035 0.0035
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0179 0.3817 0.6868
Loa Loa (eye worm) hypothetical protein 0.0113 0.233 0.4192
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.001 0.0035 0.0035
Plasmodium vivax multidomain scavenger receptor, putative 0.0022 0.0286 0.2717
Onchocerca volvulus Glucosylceramidase homolog 0.0168 0.3577 1
Trypanosoma brucei glucosidase, putative 0.004 0.0691 1
Brugia malayi Pax transcription activation domain interacting protein 0.0011 0.0036 0.0065
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0021 0.0021
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0011 0.0036 0.0003
Brugia malayi Glycosyl hydrolases family 31 protein 0.0179 0.3817 0.6868
Loa Loa (eye worm) transcription factor SMAD2 0.0131 0.2743 0.4936
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0061 0.1161 0.1161
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0858 1
Trichomonas vaginalis glucosylceramidase, putative 0.0177 0.3781 0.6783
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.5558 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0063
Loa Loa (eye worm) G protein alpha subunit 3 0.001 0.0035 0.0063
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0065
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0401 0.0721
Echinococcus granulosus lamin 0.0027 0.0401 0.0401
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.5558 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0954 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0015 0.0131 0.0175
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.001 0.0035 0.0063
Schistosoma mansoni lamin 0.0027 0.0401 0.0401
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.001 0.0035 0.0063
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0131 0.0175
Leishmania major alpha glucosidase II subunit, putative 0.004 0.0691 1
Brugia malayi hypothetical protein 0.0011 0.0036 0.0065
Schistosoma mansoni cpg binding protein 0.0032 0.0516 0.0516
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0691 0.1188
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0065
Entamoeba histolytica hypothetical protein 0.0039 0.0665 0.7651
Loa Loa (eye worm) hypothetical protein 0.0052 0.0971 0.1747
Loa Loa (eye worm) histone methyltransferase 0.001 0.0021 0.0038
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.001 0.0035 0.0035
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.004 0.0691 0.1243
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.001 0.0035 0.0063
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0052 0.0971 0.1747
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0665 0.0665
Echinococcus granulosus RUN 0.0022 0.0286 0.0286
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.3577 0.6415
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.3577 0.6415
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0052 0.0971 0.0971
Brugia malayi topoisomerase 0.0011 0.0036 0.0065
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0011 0.0036 0.0003
Echinococcus multilocularis dnaJ subfamily B 0.0455 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0168 0.3577 0.6415
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0011 0.0036 0.5
Onchocerca volvulus 0.0027 0.0401 0.1033
Trichomonas vaginalis alpha-glucosidase, putative 0.0015 0.0131 0.0175
Loa Loa (eye worm) MH2 domain-containing protein 0.0131 0.2743 0.4936
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.3726 0.3726
Loa Loa (eye worm) latrophilin receptor protein 2 0.0052 0.0971 0.1747
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0244 0.5279 0.5279
Schistosoma mansoni DNA ligase IV 0.0011 0.0036 0.0036
Schistosoma mansoni tar DNA-binding protein 0.0205 0.4399 0.4399
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0011 0.0036 0.5
Echinococcus multilocularis nibrin 0.0011 0.0036 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0036 0.0003
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.001 0.0035 0.0063
Echinococcus multilocularis lamin dm0 0.0027 0.0401 0.0401
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.001 0.0035 0.0035
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0516 0.0928
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.009 0.009
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.5558 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.004 0.0691 0.1188
Trichomonas vaginalis alpha-glucosidase, putative 0.004 0.0691 0.1188
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0244 0.5279 0.5279
Schistosoma mansoni hypothetical protein 0.0113 0.233 0.233
Loa Loa (eye worm) hypothetical protein 0.0195 0.4173 0.7509

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (binding) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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