Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin D2 receptor (DP) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | rhodopsin orphan GPCR | prostaglandin D2 receptor (DP) | 359 aa | 312 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.0072 | 1 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0072 | 1 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.0072 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0072 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.0072 | 1 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.0072 | 1 | 1 |
Leishmania major | p450 reductase, putative | 0.0072 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.0072 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.0072 | 1 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0036 | 0 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0064 | 0.7743 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.0072 | 1 | 0.5 |
Brugia malayi | FAD binding domain containing protein | 0.0072 | 1 | 1 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0036 | 0.0151 | 0.0151 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0045 | 0.2407 | 0.2407 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.0072 | 1 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0072 | 1 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0045 | 0.2407 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.0064 | 0.7743 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.0072 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.0072 | 1 | 1 |
Trypanosoma cruzi | p450 reductase, putative | 0.0072 | 1 | 0.5 |
Trichomonas vaginalis | sulfite reductase, putative | 0.0072 | 1 | 1 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.0072 | 1 | 1 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.0072 | 1 | 1 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0036 | 0 | 0.5 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.0072 | 1 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.0072 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.1 uM | In vitro inhibition of [3H]- PGD-2 radioligand binding to prostaglandin D2 receptor on human platelet membrane | ChEMBL. | 12773047 |
IC50 (binding) | = 0.1 uM | In vitro inhibition of [3H]- PGD-2 radioligand binding to prostaglandin D2 receptor on human platelet membrane | ChEMBL. | 12773047 |
IC50 (functional) | = 0.18 uM | In vitro inhibition of cAMP formation evoked by prostaglandin D2 receptor in human platelets | ChEMBL. | 12773047 |
IC50 (functional) | = 0.18 uM | In vitro inhibition of cAMP formation evoked by prostaglandin D2 receptor in human platelets | ChEMBL. | 12773047 |
IC50 (binding) | = 0.2 uM | In vitro inhibition of [3H]- PGD-2 radioligand binding to prostaglandin D2 receptor on human platelet membrane | ChEMBL. | 12773047 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.