Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Homo sapiens | l(3)mbt-like 1 (Drosophila) | Starlite/ChEMBL | No references |
Homo sapiens | euchromatic histone-lysine N-methyltransferase 2 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0058 | 0.0661 | 0.1089 |
Schistosoma mansoni | tar DNA-binding protein | 0.0139 | 0.3262 | 0.3262 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.021 | 0.021 |
Brugia malayi | beta-lactamase | 0.0043 | 0.021 | 0.0307 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0 | 0.5 |
Loa Loa (eye worm) | MBCTL1 | 0.0066 | 0.0915 | 0.1063 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.021 | 0.5 |
Brugia malayi | hypothetical protein | 0.0177 | 0.4465 | 0.6523 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0227 | 0.6068 | 1 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0227 | 0.6068 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.6845 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.4465 | 0.6413 |
Brugia malayi | TAR-binding protein | 0.0139 | 0.3262 | 0.4765 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0058 | 0.0661 | 0.1089 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0066 | 0.0915 | 0.0915 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0122 | 0.2731 | 0.3799 |
Mycobacterium ulcerans | lipase LipD | 0.0043 | 0.021 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0139 | 0.3262 | 0.3262 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0058 | 0.0661 | 0.1089 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0058 | 0.0661 | 0.068 |
Onchocerca volvulus | 0.0058 | 0.0661 | 0.0582 | |
Onchocerca volvulus | 0.0286 | 0.7953 | 1 | |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0139 | 0.3262 | 0.5375 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0043 | 0.021 | 0.021 |
Toxoplasma gondii | ABC1 family protein | 0.0043 | 0.021 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0139 | 0.3262 | 0.5375 |
Brugia malayi | RNA binding protein | 0.0139 | 0.3262 | 0.4765 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0058 | 0.0661 | 0.0661 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0058 | 0.0661 | 0.1089 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0043 | 0.021 | 0.5 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0066 | 0.0915 | 0.1508 |
Onchocerca volvulus | 0.0177 | 0.4465 | 0.5495 | |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0066 | 0.0915 | 0.1508 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.7689 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0139 | 0.3262 | 0.3262 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0122 | 0.2731 | 0.3799 |
Loa Loa (eye worm) | RNA binding protein | 0.0139 | 0.3262 | 0.4599 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0043 | 0.021 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0139 | 0.3262 | 0.4599 |
Trichomonas vaginalis | set domain proteins, putative | 0.0286 | 0.7953 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0043 | 0.021 | 0.0346 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0058 | 0.0661 | 0.0661 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0043 | 0.021 | 0.0346 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0661 | 0.068 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.021 | 0.5 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.021 | 0.0307 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0058 | 0.0661 | 0.0661 |
Mycobacterium leprae | Probable lipase LipE | 0.0043 | 0.021 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.6845 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.021 | 0.0307 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0139 | 0.3262 | 0.4765 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0066 | 0.0915 | 0.1508 |
Schistosoma mansoni | tar DNA-binding protein | 0.0139 | 0.3262 | 0.3262 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0066 | 0.0915 | 0.1337 |
Mycobacterium leprae | conserved hypothetical protein | 0.0043 | 0.021 | 0.5 |
Brugia malayi | mbt repeat family protein | 0.0058 | 0.0661 | 0.0965 |
Mycobacterium ulcerans | beta-lactamase | 0.0043 | 0.021 | 0.5 |
Brugia malayi | mbt repeat family protein | 0.0058 | 0.0661 | 0.0965 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0915 | 0.1063 |
Schistosoma mansoni | tar DNA-binding protein | 0.0139 | 0.3262 | 0.3262 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0.021 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0043 | 0.021 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0122 | 0.2731 | 0.399 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0066 | 0.0915 | 0.1508 |
Mycobacterium ulcerans | hypothetical protein | 0.0043 | 0.021 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0139 | 0.3262 | 0.4599 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.021 | 0.0307 |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0.021 | 0.5 |
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0058 | 0.0661 | 0.0582 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.631 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | 4.4668 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | = 5.6234 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 70.7946 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.