Detailed information for compound 132722

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 346.917 | Formula: C19H23ClN2S
  • H donors: 1 H acceptors: 0 LogP: 5.49 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(c(c1)NCCN1CCCCC1)Sc1ccccc1
  • InChi: 1S/C19H23ClN2S/c20-16-9-10-19(23-17-7-3-1-4-8-17)18(15-16)21-11-14-22-12-5-2-6-13-22/h1,3-4,7-10,15,21H,2,5-6,11-14H2
  • InChiKey: FNKDGELORZKSNJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus acetylcholinesterase 0.0704 0.4159 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.0742 0.4253
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0072 0.0172
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0364 0.1928
Brugia malayi TAR-binding protein 0.0076 0.0361 0.0867
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0035 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0035 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0035 0.0085
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0035 0.0061
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0044 0.017 0.1152
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0035 0.0085
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0051 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0024 0.0057
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0035 0.0085
Echinococcus granulosus mitogen activated protein kinase 3 0.0061 0.0271 0.0652
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0044 0.017 0.0409
Schistosoma mansoni BC026374 protein (S09 family) 0.0119 0.0622 0.1496
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0035 0.0085
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0293 0.1675 1
Brugia malayi Carboxylesterase family protein 0.0119 0.0622 0.1496
Schistosoma mansoni acetylcholinesterase 0.0119 0.0622 0.1496
Loa Loa (eye worm) hypothetical protein 0.0022 0.0035 0.0085
Echinococcus granulosus BC026374 protein S09 family 0.0119 0.0622 0.1496
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0271 0.1948
Onchocerca volvulus 0.0119 0.0622 0.4715
Echinococcus granulosus microtubule associated protein 2 0.0693 0.4091 0.9835
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.017 0.1152
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0114 0.0198
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0035 0.0085
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0035 0.0085
Echinococcus multilocularis cysteine protease 0.002 0.0024 0.0041
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0035 0.0085
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0035 0.0085
Echinococcus granulosus tar DNA binding protein 0.0076 0.0361 0.0867
Onchocerca volvulus 0.0119 0.0622 0.4715
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.1675 1
Echinococcus granulosus para nitrobenzyl esterase 0.0119 0.0622 0.1496
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.1124 0.2702
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.129 0.2239
Trypanosoma cruzi major cysteine proteinase, putative 0.006 0.0265 0.1462
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0152 0.0624
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0101 0.0243
Brugia malayi Cathepsin L-like precursor 0.002 0.0024 0.0057
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0361 0.0626
Echinococcus granulosus geminin 0.037 0.2141 0.5148
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0035 0.0085
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0051 0.0163
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0044 0.017 0.0735
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0078 0.2191
Loa Loa (eye worm) hypothetical protein 0.0119 0.0622 0.1496
Loa Loa (eye worm) cysteine protease 0.002 0.0024 0.0057
Echinococcus granulosus neuropeptide receptor A26 0.0553 0.3244 0.78
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0024 0.0041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0364 0.1928
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0044 0.017 0.0409
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0035 0.0089
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.018 0.0434
Echinococcus multilocularis para nitrobenzyl esterase 0.0119 0.0622 0.108
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0114 0.0274
Loa Loa (eye worm) hypothetical protein 0.0022 0.0035 0.0085
Loa Loa (eye worm) hypothetical protein 0.0119 0.0622 0.1496
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0271 0.0652
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0035 0.0085
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0051 0.1088
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0271 0.1948
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0035 0.0085
Brugia malayi Carboxylesterase family protein 0.0119 0.0622 0.1496
Echinococcus granulosus cathepsin l cysteine peptidase 0.002 0.0024 0.0057
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0035 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0035 0.0085
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0364 0.1928
Brugia malayi ecdysteroid receptor 0.0022 0.0035 0.0085
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0035 0.0085
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.1295 0.7733 0.7582
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.007 0.0324 0.1817
Brugia malayi Cathepsin L-like precursor 0.002 0.0024 0.0057
Brugia malayi hypothetical protein 0.0035 0.0114 0.0274
Schistosoma mansoni hypothetical protein 0.0033 0.0101 0.0243
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0061 0.0271 0.1497
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0035 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0035 0.0085
Echinococcus multilocularis neuropeptide s receptor 0.0553 0.3244 0.563
Loa Loa (eye worm) MH2 domain-containing protein 0.0236 0.1328 0.3192
Loa Loa (eye worm) hypothetical protein 0.0022 0.0035 0.0085
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0035 0.0085
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0114 0.0274
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.0122
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.018 0.0434
Loa Loa (eye worm) carboxylesterase 0.0119 0.0622 0.1496
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0152 0.0776
Loa Loa (eye worm) hypothetical protein 0.0022 0.0035 0.0085
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0035 0.0061
Loa Loa (eye worm) RNA binding protein 0.0076 0.0361 0.0867
Brugia malayi hypothetical protein 0.0119 0.0622 0.1496
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0044 0.017 0.0886
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0361 0.0867
Giardia lamblia Kinase, CMGC MAPK 0.0061 0.0271 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0078 0.0188
Chlamydia trachomatis replicative DNA helicase 0.0375 0.217 0.5
Schistosoma mansoni hypothetical protein 0.0047 0.0186 0.0447
Loa Loa (eye worm) carboxylesterase 0.0119 0.0622 0.1496
Schistosoma mansoni gliotactin 0.0119 0.0622 0.1496
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0035 0.0061
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.0529 0.1272
Loa Loa (eye worm) hypothetical protein 0.0022 0.0035 0.0085
Loa Loa (eye worm) acetylcholinesterase 1 0.0704 0.4159 1
Echinococcus multilocularis mitogen activated protein kinase 0.0061 0.0271 0.047
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0035 0.0061
Leishmania major cathepsin L-like protease 0.0076 0.0364 0.2059
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0742 0.4347
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0078 0.0188
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0035 0.0061
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.002 0.0024 0.0057
Loa Loa (eye worm) hypothetical protein 0.0119 0.0622 0.1496
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0152 0.0776
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0024 0.0057
Mycobacterium leprae Conserved hypothetical protein 0.0491 0.2874 1
Loa Loa (eye worm) hypothetical protein 0.0119 0.0622 0.1496
Schistosoma mansoni hypothetical protein 0.037 0.2141 0.5148
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0044 0.017 0.0409
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0119 0.0622 0.1496
Onchocerca volvulus 0.0047 0.0186 0.1277
Schistosoma mansoni hypothetical protein 0.0035 0.0114 0.0274
Echinococcus multilocularis acetylcholinesterase 0.0704 0.4159 0.7218
Echinococcus multilocularis cysteine protease 0.002 0.0024 0.0041
Loa Loa (eye worm) hypothetical protein 0.0229 0.129 0.3102
Schistosoma mansoni coup transcription factor 0.0022 0.0035 0.0085
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0035 0.0085
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0035 0.0085
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0035 0.0085
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0361 0.0867
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.018 0.0434
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0051 0.4968
Loa Loa (eye worm) hypothetical protein 0.0119 0.0622 0.1496
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.1675 1
Schistosoma mansoni microtubule-associated protein tau 0.0693 0.4091 0.9835
Onchocerca volvulus 0.0022 0.0035 0.0089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0035 0.0085
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0044 0.017 0.0886
Echinococcus multilocularis neuroligin 0.0119 0.0622 0.108
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0035 0.0085
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0035 0.0085
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0035 0.0085
Echinococcus granulosus neuroligin 0.0119 0.0622 0.1496
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0024 0.0057
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0044 0.017 0.0295
Schistosoma mansoni neuroligin 3 (S09 family) 0.0119 0.0622 0.1496
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0364 0.1928
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0078 0.0188
Schistosoma mansoni hypothetical protein 0.037 0.2141 0.5148
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0024 0.0041
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0035 0.0089
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0704 0.4159 1
Loa Loa (eye worm) twinkle helicase 0.0107 0.0551 0.1324
Loa Loa (eye worm) hypothetical protein 0.0022 0.0035 0.0085
Brugia malayi nuclear hormone receptor 0.0022 0.0035 0.0085
Brugia malayi steroid hormone receptor 0.0022 0.0035 0.0085
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0035 0.0085
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.018 0.0434
Brugia malayi Carboxylesterase family protein 0.0704 0.4159 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0061 0.0271 0.1497
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0035 0.0061
Echinococcus granulosus GPCR family 2 0.0033 0.0101 0.0243
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0035 0.0085
Loa Loa (eye worm) transcription factor SMAD2 0.0236 0.1328 0.3192
Echinococcus granulosus cathepsin l1 0.002 0.0024 0.0057
Trypanosoma cruzi cysteine peptidase, putative 0.0076 0.0364 0.2059
Schistosoma mansoni hypothetical protein 0.0033 0.0101 0.0243
Brugia malayi hypothetical protein 0.0229 0.129 0.3102
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0035 0.0085
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.0529 0.1272
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0271 0.1948
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0051 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0035 0.0085
Brugia malayi Carboxylesterase family protein 0.0119 0.0622 0.1496
Leishmania major hypothetical protein, conserved 0.0024 0.0051 0.0163
Brugia malayi Cathepsin L-like precursor 0.002 0.0024 0.0057
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0024 0.0057
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0035 0.0085
Brugia malayi Pre-SET motif family protein 0.0202 0.1124 0.2702
Loa Loa (eye worm) hypothetical protein 0.0704 0.4159 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.017 0.0409
Schistosoma mansoni hypothetical protein 0.0033 0.0101 0.0243
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0364 0.1928
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0044 0.017 0.1152
Toxoplasma gondii hypothetical protein 0.0047 0.0189 0.6667
Echinococcus multilocularis geminin 0.037 0.2141 0.3716
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0361 0.0867
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0035 0.0085
Loa Loa (eye worm) hypothetical protein 0.0033 0.0101 0.0243
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0035 0.0085
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0044 0.017 0.0409
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0035 0.0061
Brugia malayi Cathepsin L-like precursor 0.002 0.0024 0.0057
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0186 0.0447
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0035 0.0061
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0364 0.1928
Trypanosoma cruzi cysteine peptidase, putative 0.0076 0.0364 0.2059
Brugia malayi Cathepsin L-like precursor 0.002 0.0024 0.0057
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0207 0.1106
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0035 0.0085
Loa Loa (eye worm) hypothetical protein 0.0119 0.0622 0.1496
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.018 0.0434
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0035 0.0085
Loa Loa (eye worm) fibroinase 0.002 0.0024 0.0057
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0035 0.0085
Onchocerca volvulus 0.0029 0.0078 0.0427
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0078 0.0188
Echinococcus granulosus acetylcholinesterase 0.0704 0.4159 1
Loa Loa (eye worm) ctsf protein 0.002 0.0024 0.0057
Echinococcus multilocularis microtubule associated protein 2 0.0693 0.4091 0.7099
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0152 0.0776
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0101 0.0243
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0119 0.0622 0.1496
Leishmania major cathepsin L-like protease 0.0076 0.0364 0.2059
Entamoeba histolytica hypothetical protein 0.0035 0.0114 0.6162
Loa Loa (eye worm) hypothetical protein 0.0071 0.0331 0.0795
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.018 0.0313
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0101 0.0175
Echinococcus multilocularis acetylcholinesterase 0.0704 0.4159 0.7218
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0375 0.217 1
Brugia malayi MAP kinase sur-1 0.0061 0.0271 0.0652
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0078 0.0135
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0101 0.0243
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0101 0.0243
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.0271 0.1948
Schistosoma mansoni hypothetical protein 0.0033 0.0101 0.0243
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0061 0.0271 0.1497
Brugia malayi Pre-SET motif family protein 0.0029 0.0078 0.0188
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0051 0.0163
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0361 0.0867
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0969 0.5762 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.0529 0.1272
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0364 0.1928
Echinococcus multilocularis neuropeptide receptor A26 0.0553 0.3244 0.563
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0035 0.0085
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0044 0.017 0.0409
Schistosoma mansoni hypothetical protein 0.0071 0.0331 0.0795
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0364 0.1928
Echinococcus granulosus carboxylesterase 5A 0.0704 0.4159 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0101 0.0243
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0361 0.0867
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0361 0.0867
Echinococcus multilocularis ubiquitin specific protease 41 0.0044 0.017 0.0295
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0119 0.0622 0.1496
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0035 0.0085
Trypanosoma cruzi cysteine peptidase, putative 0.0076 0.0364 0.2059
Onchocerca volvulus 0.0119 0.0622 0.4715
Echinococcus multilocularis carboxylesterase 5A 0.0704 0.4159 0.7218
Loa Loa (eye worm) carboxylesterase 0.0704 0.4159 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0035 0.0085
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0061 0.0271 0.1497
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0119 0.0622 0.108
Schistosoma mansoni Replicative DNA helicase 0.0375 0.217 0.5218
Brugia malayi Carboxylesterase family protein 0.0119 0.0622 0.1496
Brugia malayi Cathepsin L-like precursor 0.002 0.0024 0.0057
Loa Loa (eye worm) papain family cysteine protease containing protein 0.002 0.0024 0.0057
Mycobacterium tuberculosis Conserved hypothetical protein 0.0154 0.0836 0.0228
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0119 0.0622 0.4715
Trichomonas vaginalis set domain proteins, putative 0.023 0.1293 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0364 0.1928
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0364 0.1928
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0076 0.0364 0.1928
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0035 0.0061
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0035 0.0089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0035 0.0085
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0035 0.0085
Trypanosoma brucei protein kinase, putative 0.0061 0.0271 0.1356
Echinococcus multilocularis GPCR, family 2 0.0033 0.0101 0.0175
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0035 0.0085
Echinococcus granulosus cathepsin L cysteine proteinase 0.002 0.0024 0.0057
Brugia malayi MH2 domain containing protein 0.0236 0.1328 0.3192
Loa Loa (eye worm) hypothetical protein 0.0022 0.0035 0.0085
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0331 0.0795
Loa Loa (eye worm) hypothetical protein 0.0119 0.0622 0.1496
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.018 0.0434
Loa Loa (eye worm) hypothetical protein 0.0704 0.4159 1
Brugia malayi hypothetical protein 0.0024 0.0051 0.0122
Schistosoma mansoni survival motor neuron protein 0.0047 0.0186 0.0447
Entamoeba histolytica hypothetical protein 0.0035 0.0114 0.6162
Echinococcus granulosus ubiquitin specific protease 41 0.0044 0.017 0.0409
Mycobacterium ulcerans hypothetical protein 0.0154 0.0836 0.1383
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0101 0.0175
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.018 0.0313
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0119 0.0622 0.1496
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0035 0.0085
Leishmania major mitochondrial DNA polymerase beta 0.0293 0.1675 1
Brugia malayi Carboxylesterase family protein 0.0704 0.4159 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0061 0.0271 1
Entamoeba histolytica hypothetical protein 0.0035 0.0114 0.6162
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0061 0.0271 0.0652
Echinococcus multilocularis cathepsin L cysteine protease 0.002 0.0024 0.0041
Echinococcus multilocularis BC026374 protein (S09 family) 0.0119 0.0622 0.108
Echinococcus multilocularis mitogen activated protein kinase 3 0.0061 0.0271 0.047
Entamoeba histolytica hypothetical protein 0.0035 0.0114 0.6162
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.018 0.0434
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0061 0.0271 0.1497
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0035 0.0085
Trypanosoma cruzi cruzipain precursor, putative 0.0076 0.0364 0.2059
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0361 0.0867
Echinococcus granulosus neuropeptide s receptor 0.0553 0.3244 0.78
Onchocerca volvulus 0.0119 0.0622 0.4715
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0061 0.0271 0.1356
Brugia malayi nuclear receptor NHR-88 0.0022 0.0035 0.0085
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0375 0.217 0.5
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0035 0.0085
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0044 0.017 0.0295
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0361 0.0867
Trichomonas vaginalis spcc417.12 protein, putative 0.0119 0.0622 0.4715
Treponema pallidum replicative DNA helicase (dnaB) 0.0375 0.217 0.5
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0742 0.4347
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0061 0.0271 0.1497
Onchocerca volvulus 0.023 0.1293 1
Onchocerca volvulus 0.0119 0.0622 0.4715
Loa Loa (eye worm) hypothetical protein 0.0029 0.0078 0.0188
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0078 0.0135
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0044 0.017 1
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0035 0.0085
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.129 0.3102
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0044 0.017 0.0886
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0078 0.0188
Plasmodium vivax SET domain protein, putative 0.0029 0.0078 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0529 0.1272
Leishmania major cathepsin L-like protease 0.0076 0.0364 0.2059
Echinococcus multilocularis cathepsin l cysteine peptidase 0.002 0.0024 0.0041
Brugia malayi RNA binding protein 0.0076 0.0361 0.0867
Echinococcus granulosus mitogen activated protein kinase 0.0061 0.0271 0.0652

Activities

Activity type Activity value Assay description Source Reference
Inhibition constant (binding) = 6.55 Natural log of the value in (microM) of inhibition constant was tested against Trypanothione Reductase ChEMBL. 9240356

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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