Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | TAR DNA binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3804 | 0.3804 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.1716 | 0.1716 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.1716 | 0.1716 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.2775 | 0.3151 |
Echinococcus granulosus | tar DNA binding protein | 0.0076 | 0.3804 | 0.3804 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0612 | 0.0695 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0175 | 0.0199 |
Echinococcus multilocularis | tar DNA binding protein | 0.0076 | 0.3804 | 0.3804 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0175 | 0.0175 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0016 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.2775 | 0.3151 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0076 | 0.3804 | 0.432 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3804 | 0.3804 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0175 | 0.0199 |
Brugia malayi | MH2 domain containing protein | 0.0123 | 0.6742 | 0.7656 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0612 | 1 |
Brugia malayi | hypothetical protein | 0.0043 | 0.1716 | 0.1949 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0175 | 0.0199 |
Echinococcus multilocularis | geminin | 0.0175 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1716 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 1 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0175 | 0.0175 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.8806 | 1 |
Brugia malayi | RNA binding protein | 0.0076 | 0.3804 | 0.432 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0175 | 0.0175 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.0612 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0612 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0175 | 0.0199 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3804 | 0.3804 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0123 | 0.6742 | 0.7656 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1572 | 0.1572 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0612 | 0.0695 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0175 | 0.0175 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0612 | 1 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0031 | 0.0035 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.2775 | 0.3151 |
Loa Loa (eye worm) | TAR-binding protein | 0.0076 | 0.3804 | 0.432 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0175 | 0.0175 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1716 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0612 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.0612 | 1 |
Onchocerca volvulus | 0.0156 | 0.8806 | 0.5 | |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.1716 | 0.1716 |
Brugia malayi | TAR-binding protein | 0.0076 | 0.3804 | 0.432 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.1716 | 0.1716 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0175 | 0.0175 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0175 | 0.0175 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1716 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.2775 | 0.3151 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1572 | 0.1785 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0123 | 0.6742 | 0.7656 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0175 | 0.0175 |
Brugia malayi | hypothetical protein | 0.0156 | 0.8806 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0076 | 0.3804 | 0.432 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.0612 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3804 | 0.3804 |
Loa Loa (eye worm) | RNA binding protein | 0.0076 | 0.3804 | 0.432 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0175 | 0.0175 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0612 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0175 | 0.0175 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.1716 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1572 | 0.1785 |
Schistosoma mansoni | tar DNA-binding protein | 0.0076 | 0.3804 | 0.3804 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.