Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Streptococcus pyogenes serotype M1 | Streptokinase A | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | beta-NAC-like protein | 0.0042 | 0.2841 | 0.7823 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0051 | 0.3514 | 1 |
Toxoplasma gondii | NAC domain-containing protein | 0.0042 | 0.2841 | 1 |
Echinococcus multilocularis | bloom syndrome protein | 0.0027 | 0.1637 | 0.3934 |
Entamoeba histolytica | transcription factor BTF3, putative | 0.0042 | 0.2841 | 1 |
Schistosoma mansoni | transcription factor btf3 | 0.0042 | 0.2841 | 0.8083 |
Entamoeba histolytica | hypothetical protein | 0.0042 | 0.2841 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.3514 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0051 | 0.3514 | 1 |
Schistosoma mansoni | DNA helicase recq5 | 0.0011 | 0.042 | 0.1194 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0027 | 0.1637 | 0.4451 |
Loa Loa (eye worm) | ICD-1 protein | 0.0042 | 0.2841 | 0.2841 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.042 | 0.042 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.3514 | 1 |
Treponema pallidum | ATP-dependent DNA helicase | 0.0006 | 0.0000000003529 | 0.5 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0018 | 0.0949 | 0.3341 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.042 | 0.1477 |
Echinococcus multilocularis | transcription factor btf3 | 0.0042 | 0.2841 | 0.7823 |
Plasmodium falciparum | basic transcription factor 3b, putative | 0.0042 | 0.2841 | 1 |
Trypanosoma brucei | transcription factor BTF3, putative | 0.0042 | 0.2841 | 1 |
Leishmania major | basic transcription factor 3a, putative | 0.0042 | 0.2841 | 1 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0023 | 0.1385 | 0.3988 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.3514 | 1 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0011 | 0.042 | 0.042 |
Plasmodium vivax | basic transcription factor 3b, putative | 0.0042 | 0.2841 | 1 |
Entamoeba histolytica | recQ family helicase, putative | 0.0014 | 0.0671 | 0.2363 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0051 | 0.3514 | 1 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0042 | 0.2841 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.3514 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0051 | 0.3514 | 0.3514 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0027 | 0.1637 | 0.3934 |
Schistosoma mansoni | DNA helicase recq1 | 0.0011 | 0.042 | 0.1194 |
Trypanosoma cruzi | transcription factor btf3, putative | 0.0042 | 0.2841 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0042 | 0.2841 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0042 | 0.2841 | 1 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0027 | 0.1637 | 0.4451 |
Echinococcus granulosus | transcription factor btf3 | 0.0042 | 0.2841 | 0.7823 |
Loa Loa (eye worm) | RecQ helicase | 0.0027 | 0.1637 | 0.1637 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0042 | 0.2841 | 1 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0011 | 0.042 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0051 | 0.3514 | 1 |
Echinococcus granulosus | bloom syndrome protein | 0.0027 | 0.1637 | 0.3934 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.042 | 0.1477 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0021 | 0.1201 | 0.3417 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0014 | 0.0671 | 0.2363 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 4.576 um | PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1662 (Primary HTS)] | ChEMBL. | No reference |
EC50 (functional) | > 150 um | PUBCHEM_BIOASSAY: Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1902 (Retest at Dose), 1900 (Counter Screen), 1662 (Primary HTS)] | ChEMBL. | No reference |
Potency (functional) | 0.2332 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 25.929 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.