Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | polymerase (DNA directed), beta | Starlite/ChEMBL | No references |
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | polymerase (DNA directed), beta | 335 aa | 303 aa | 32.3 % |
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0365 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0134 | 0.2627 | 0.6122 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0062 | 0.0358 | 0.0358 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0192 | 0.4493 | 0.5 |
Brugia malayi | Muscleblind-like protein | 0.018 | 0.4119 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.4893 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.4893 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 0.4893 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0365 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0192 | 0.4493 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0134 | 0.2627 | 0.6122 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.013 | 0.2504 | 0.5801 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0173 | 0.3871 | 0.3871 |
Echinococcus granulosus | geminin | 0.0205 | 0.4893 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0134 | 0.2627 | 0.6122 |
Brugia malayi | TAR-binding protein | 0.0134 | 0.2627 | 0.6122 |
Brugia malayi | RNA binding protein | 0.0134 | 0.2627 | 0.6122 |
Echinococcus multilocularis | muscleblind protein | 0.018 | 0.4119 | 0.6586 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0134 | 0.2627 | 0.6122 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 0.4119 | 0.6586 |
Toxoplasma gondii | hypothetical protein | 0.0059 | 0.0241 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0365 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.4119 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.4119 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.013 | 0.2504 | 0.5801 |
Echinococcus granulosus | muscleblind protein | 0.018 | 0.4119 | 0.6586 |
Brugia malayi | MH2 domain containing protein | 0.013 | 0.2504 | 0.5801 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0173 | 0.3871 | 0.3871 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.3162 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 2.3323 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 4.1095 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.6234 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (binding) | 14.1254 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the Phosphatase Activity of Eya2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488939] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | ||
Homo sapiens | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.