Detailed information for compound 1328584

Basic information

Technical information
  • TDR Targets ID: 1328584
  • Name: N-[2-(4-chlorophenyl)sulfonyl-2-furan-2-yleth yl]-N'-(phenylmethyl)oxamide
  • MW: 446.904 | Formula: C21H19ClN2O5S
  • H donors: 2 H acceptors: 4 LogP: 2.94 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)S(=O)(=O)C(c1ccco1)CNC(=O)C(=O)NCc1ccccc1
  • InChi: 1S/C21H19ClN2O5S/c22-16-8-10-17(11-9-16)30(27,28)19(18-7-4-12-29-18)14-24-21(26)20(25)23-13-15-5-2-1-3-6-15/h1-12,19H,13-14H2,(H,23,25)(H,24,26)
  • InChiKey: UAPCAFPPBONTHK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-(4-chlorophenyl)sulfonyl-2-(2-furyl)ethyl]-N'-(phenylmethyl)oxamide
  • N'-(benzyl)-N-[2-(4-chlorophenyl)sulfonyl-2-(2-furyl)ethyl]oxamide
  • N-[2-(4-chlorophenyl)sulfonyl-2-furan-2-yl-ethyl]-N'-(phenylmethyl)ethanediamide
  • G856-5316
  • NCGC00136144-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mechanistic target of rapamycin (serine/threonine kinase) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3-kinase (tor2)-like protein Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related Get druggable targets OG5_127212 All targets in OG5_127212
Giardia lamblia GTOR Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Neospora caninum Phosphatidylinositol 3-kinase tor2, related Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upsteam TOR2 CDS (CaP19.9461) Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania braziliensis target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans frameshifted from upstream TOR2 CDS (CaP19.1905) Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K07203 FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Toxoplasma gondii target of rapamycin (TOR), putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei phosphatidylinositol 4-kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0043 0.0416 0.0741
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.008 0.1034 0.1975
Echinococcus granulosus mothers against decapentaplegic 5 0.0042 0.0389 0.0632
Trichomonas vaginalis CAMK family protein kinase 0.0302 0.478 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0226 0.3505 0.8837
Brugia malayi Latrophilin receptor protein 2 0.018 0.2733 0.2733
Giardia lamblia DNA repair protein RAD52 0.0342 0.5457 1
Toxoplasma gondii NADPH-glutathione reductase 0.0034 0.0266 0.1055
Schistosoma mansoni smad 0.0042 0.0389 0.062
Schistosoma mansoni hypothetical protein 0.018 0.2733 0.4359
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0301 0.0262
Loa Loa (eye worm) transcription factor SMAD2 0.0611 1 1
Brugia malayi Pre-SET motif family protein 0.0242 0.378 0.378
Brugia malayi MH2 domain containing protein 0.0042 0.0389 0.0389
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0386 0.62 0.7322
Brugia malayi isocitrate dehydrogenase 0.008 0.1034 0.1034
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0165 0.2468 1
Loa Loa (eye worm) TAR-binding protein 0.0329 0.5236 0.5236
Echinococcus multilocularis segment polarity protein dishevelled 0.0019 0.0007 0.0012
Brugia malayi Thioredoxin reductase 0.0099 0.136 0.136
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0185 0.2804 0.5356
Trichomonas vaginalis CAMK family protein kinase 0.0302 0.478 1
Schistosoma mansoni tar DNA-binding protein 0.0329 0.5236 0.8352
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0273 0.0436
Brugia malayi MH2 domain containing protein 0.0042 0.0389 0.0389
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0019 0.0007 0.0007
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0057 0.0644 0.1718
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0181 0.0002
Brugia malayi hypothetical protein 0.0035 0.0282 0.0282
Schistosoma mansoni smad1 5 8 and 0.0042 0.0389 0.062
Toxoplasma gondii hypothetical protein 0.0057 0.0644 0.2591
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0057 0.0644 0.1718
Schistosoma mansoni peptidase Clp (S14 family) 0.0165 0.2468 0.3937
Onchocerca volvulus 0.052 0.8468 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.008 0.1034 0.1975
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0415 0.0511
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0007 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0007 0.0007
Trypanosoma cruzi target of rapamycin kinase 3 0.0043 0.0416 0.0331
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0273 0.0436
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0034 0.0266 0.0423
Brugia malayi Pre-SET motif family protein 0.0035 0.0273 0.0273
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0226 0.3505 0.8837
Trichomonas vaginalis CAMK family protein kinase 0.0302 0.478 1
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0165 0.2468 1
Loa Loa (eye worm) pip kinase 2 0.0185 0.2804 0.2804
Brugia malayi latrophilin 2 splice variant baaae 0.039 0.6269 0.6269
Trichomonas vaginalis CAMK family protein kinase 0.0302 0.478 1
Brugia malayi hypothetical protein 0.0019 0.0007 0.0007
Brugia malayi MH1 domain containing protein 0.0023 0.0075 0.0075
Echinococcus granulosus GPCR family 2 0.018 0.2733 0.4445
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0007 0.0011
Trypanosoma cruzi trypanothione reductase, putative 0.0099 0.136 0.2424
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0242 0.378 0.378
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0054 0.0602 0.0602
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0251 0.3932 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0165 0.2468 0.4714
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0368 0.0408
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.008 0.1034 0.1702
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0368 0.0408
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0165 0.2468 1
Toxoplasma gondii thioredoxin reductase 0.0099 0.136 0.55
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.018 0.2733 0.522
Loa Loa (eye worm) hypothetical protein 0.0019 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0234 0.0116
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0108 0.1509 0.3392
Loa Loa (eye worm) hypothetical protein 0.0023 0.0075 0.0075
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0025 0.01 0.0162
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0054 0.0602 0.1137
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0181 0.0002
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0302 0.478 0.7775
Loa Loa (eye worm) MH2 domain-containing protein 0.0042 0.0389 0.0389
Loa Loa (eye worm) MH1 domain-containing protein 0.0042 0.0389 0.0389
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.0266 0.0423
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0165 0.2468 1
Brugia malayi RNA binding protein 0.0329 0.5236 0.5236
Loa Loa (eye worm) Smad1 0.0042 0.0389 0.0389
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0368 0.0408
Mycobacterium tuberculosis Probable oxidoreductase 0.0251 0.3932 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0234 0.0116
Schistosoma mansoni hypothetical protein 0.018 0.2733 0.4359
Brugia malayi Isocitrate dehydrogenase 0.008 0.1034 0.1034
Echinococcus granulosus FTZ F1 alpha 0.0383 0.6148 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0602 0.0918
Schistosoma mansoni dishevelled 0.0019 0.0007 0.001
Echinococcus granulosus segment polarity protein dishevelled 0.0019 0.0007 0.0011
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0302 0.478 0.9129
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0185 0.2804 0.4561
Plasmodium vivax ataxin-2 like protein, putative 0.0055 0.0609 0.1555
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0034 0.0266 0.0423
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0007 0.0011
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0165 0.2468 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0251 0.3932 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.004 0.0368 0.1467
Schistosoma mansoni smad1 5 8 and 0.0042 0.0389 0.062
Loa Loa (eye worm) pigment dispersing factor receptor c 0.057 0.9316 0.9316
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0342 0.5457 1
Schistosoma mansoni hypothetical protein 0.039 0.6269 1
Leishmania major hypothetical protein, conserved 0.0055 0.0609 0.0759
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0302 0.478 0.478
Echinococcus granulosus smad 0.0042 0.0389 0.0632
Loa Loa (eye worm) isocitrate dehydrogenase 0.008 0.1034 0.1034
Plasmodium falciparum glutathione reductase 0.0099 0.136 0.4969
Brugia malayi MH1 domain containing protein 0.0023 0.0075 0.0075
Onchocerca volvulus 0.0237 0.3681 0.4348
Echinococcus multilocularis thioredoxin glutathione reductase 0.01 0.137 0.2617
Toxoplasma gondii isocitrate dehydrogenase 0.008 0.1034 0.4175
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0042 0.0389 0.0742
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0273 0.0522
Loa Loa (eye worm) pax transcription factor protein 2 0.0237 0.3681 0.3681
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0042 0.0389 0.062
Trypanosoma brucei isocitrate dehydrogenase, putative 0.008 0.1034 0.2053
Trichomonas vaginalis glutathione reductase, putative 0.0034 0.0266 0.0187
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.008 0.1034 0.1975
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0007 0.0007
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0165 0.2468 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0273 0.0436
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0185 0.2804 0.4473
Echinococcus multilocularis GPCR, family 2 0.018 0.2733 0.522
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0108 0.1509 0.3392
Loa Loa (eye worm) thioredoxin reductase 0.0099 0.136 0.136
Onchocerca volvulus Serine\/threonine kinase homolog 0.0302 0.478 0.5644
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0273 0.1083
Trypanosoma cruzi polo-like protein kinase, putative 0.0302 0.478 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0273 0.0522
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0099 0.136 0.2985
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0609 0.1555
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0054 0.0602 0.0745
Schistosoma mansoni serine/threonine protein kinase 0.0302 0.478 0.7625
Onchocerca volvulus 0.0035 0.0273 0.0323
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0019 0.0007 0.0008
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.008 0.1034 0.3489
Loa Loa (eye worm) hypothetical protein 0.0165 0.2468 0.2468
Loa Loa (eye worm) hypothetical protein 0.0386 0.62 0.62
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0468 0.0627
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0034 0.0266 0.1055
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.008 0.1034 0.3489
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0165 0.2468 1
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0019 0.0007 0.0012
Brugia malayi MH1 domain containing protein 0.0042 0.0389 0.0389
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0602 0.0918
Echinococcus granulosus tar DNA binding protein 0.0329 0.5236 0.8516
Loa Loa (eye worm) hypothetical protein 0.052 0.8468 0.8468
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0251 0.3932 1
Onchocerca volvulus 0.0019 0.0007 0.0008
Brugia malayi hypothetical protein 0.0055 0.0609 0.0609
Loa Loa (eye worm) hypothetical protein 0.0019 0.0007 0.0007
Giardia lamblia Kinase, PLK 0.0302 0.478 0.8695
Toxoplasma gondii isocitrate dehydrogenase 0.008 0.1034 0.4175
Echinococcus granulosus Smad4 0.0042 0.0389 0.0632
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0057 0.0644 0.1718
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0034 0.0266 0.0266
Loa Loa (eye worm) hypothetical protein 0.018 0.2733 0.2733
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0185 0.2804 0.4473
Brugia malayi hypothetical protein 0.052 0.8468 0.8468
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0415 0.0511
Brugia malayi Smad1 0.0042 0.0389 0.0389
Brugia malayi Pax transcription factor protein 2 0.0237 0.3681 0.3681
Brugia malayi hypothetical protein 0.0019 0.0007 0.0007
Brugia malayi RNA recognition motif domain containing protein 0.0329 0.5236 0.5236
Loa Loa (eye worm) hypothetical protein 0.0055 0.0609 0.0609
Echinococcus granulosus TGF beta signal transducer SmadC 0.0042 0.0389 0.0632
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0025 0.01 0.0191
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0302 0.478 1
Loa Loa (eye worm) glutathione reductase 0.0099 0.136 0.136
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0368 0.0408
Onchocerca volvulus 0.0276 0.4346 0.5132
Entamoeba histolytica serine/threonine protein kinase, putative 0.0302 0.478 0.8604
Schistosoma mansoni dep domain containing protein 0.0019 0.0007 0.001
Trypanosoma brucei trypanothione reductase 0.0099 0.136 0.2745
Schistosoma mansoni tar DNA-binding protein 0.0329 0.5236 0.8352
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0026 0.0119 0.0112
Trichomonas vaginalis CAMK family protein kinase 0.0302 0.478 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0226 0.3505 0.8837
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0165 0.2468 1
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0025 0.0112 0.0112
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0025 0.0112 0.0112
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.018 0.2733 0.2733
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0281 0.0219
Schistosoma mansoni hypothetical protein 0.018 0.2733 0.4359
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0368 0.0408
Loa Loa (eye worm) hypothetical protein 0.057 0.9316 0.9316
Brugia malayi serine/threonine-protein kinase plk-2 0.0302 0.478 0.478
Plasmodium vivax SET domain protein, putative 0.0035 0.0273 0.0032
Schistosoma mansoni dishevelled 0.0019 0.0007 0.001
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0165 0.2468 1
Echinococcus multilocularis isocitrate dehydrogenase 0.008 0.1034 0.1975
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0252 0.0409
Trichomonas vaginalis CAMK family protein kinase 0.0302 0.478 1
Brugia malayi MH1 domain containing protein 0.0042 0.0389 0.0389
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0234 0.0116
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0165 0.2468 0.5547
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.018 0.2733 0.4445
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.008 0.1034 0.2096
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.018 0.2733 0.4445
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.008 0.1034 0.1975
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0054 0.0602 0.098
Giardia lamblia GTOR 0.0054 0.0602 0.0648
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0226 0.3505 0.8837
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0181 0.0002
Toxoplasma gondii LsmAD domain-containing protein 0.0055 0.0609 0.2446
Echinococcus granulosus segment polarity protein dishevelled 0.0019 0.0007 0.0011
Loa Loa (eye worm) DIX domain-containing protein 0.0019 0.0007 0.0007
Brugia malayi Probable ClpP-like protease 0.0165 0.2468 0.2468
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0165 0.2468 0.4015
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0108 0.1509 0.2632
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.008 0.1034 0.165
Trypanosoma brucei PAB1-binding protein , putative 0.0055 0.0609 0.115
Schistosoma mansoni hypothetical protein 0.0025 0.01 0.0159
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0329 0.5236 0.5236
Loa Loa (eye worm) hypothetical protein 0.039 0.6269 0.6269
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0609 0.0759
Echinococcus multilocularis mothers against decapentaplegic 5 0.0042 0.0389 0.0742
Onchocerca volvulus 0.0185 0.2804 0.3311
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0273 0.0444
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.0609 0.1555
Schistosoma mansoni tar DNA-binding protein 0.0329 0.5236 0.8352
Trichomonas vaginalis set domain proteins, putative 0.0276 0.4346 0.9057
Schistosoma mansoni smad1 5 8 and 0.0042 0.0389 0.062
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.057 0.9316 0.9316
Loa Loa (eye worm) hypothetical protein 0.0185 0.2804 0.2804
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0273 0.0436
Echinococcus multilocularis smad 0.0042 0.0389 0.0742
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.008 0.1034 0.2053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0415 0.0511
Brugia malayi N-terminal motif family protein 0.0386 0.62 0.62
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0054 0.0602 0.0745
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.0609 0.0759
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0054 0.0602 0.0961
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0007 0.0007
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0043 0.0416 0.0331
Brugia malayi Calcitonin receptor-like protein seb-1 0.057 0.9316 0.9316
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0054 0.0602 0.0745
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0097 0.1328 0.1495
Loa Loa (eye worm) phosphatidylinositol 3 0.0054 0.0602 0.0602
Mycobacterium tuberculosis Probable dehydrogenase 0.0226 0.3505 0.8837
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0054 0.0602 0.1137
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0165 0.2468 1
Echinococcus multilocularis segment polarity protein dishevelled 0.0019 0.0007 0.0012
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.018 0.2733 0.522
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0368 0.0408
Trichomonas vaginalis CAMK family protein kinase 0.0149 0.2207 0.4408
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0034 0.0266 0.0508
Trypanosoma brucei polo-like protein kinase 0.0302 0.478 1
Plasmodium falciparum thioredoxin reductase 0.0099 0.136 0.4969
Trypanosoma cruzi polo-like protein kinase, putative 0.0302 0.478 1
Leishmania major trypanothione reductase 0.0099 0.136 0.2424
Brugia malayi glutathione reductase 0.0099 0.136 0.136
Schistosoma mansoni tar DNA-binding protein 0.0329 0.5236 0.8352
Schistosoma mansoni hypothetical protein 0.018 0.2733 0.4359
Brugia malayi DIX domain containing protein 0.0019 0.0007 0.0007
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0226 0.3505 0.8703
Loa Loa (eye worm) latrophilin receptor protein 2 0.018 0.2733 0.2733
Plasmodium vivax thioredoxin reductase, putative 0.0099 0.136 0.4969
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0019 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0602 0.0918
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0228 0.0105
Echinococcus multilocularis peptidase Clp (S14 family) 0.0108 0.1509 0.2883
Brugia malayi Pip kinase protein 2 0.0185 0.2804 0.2804
Echinococcus granulosus Pleckstrin G protein interacting region 0.0019 0.0007 0.0011
Mycobacterium tuberculosis Probable reductase 0.0226 0.3505 0.8837
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.008 0.1034 0.1702
Echinococcus multilocularis tar DNA binding protein 0.0329 0.5236 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0181 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0415 0.0511
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0054 0.0602 0.0745
Loa Loa (eye worm) hypothetical protein 0.0035 0.0273 0.0273
Loa Loa (eye worm) nuclear factor I 0.0023 0.0075 0.0075
Trichomonas vaginalis CAMK family protein kinase 0.0302 0.478 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0054 0.0602 0.115
Echinococcus granulosus peptidase Clp S14 family 0.0108 0.1509 0.2455
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0007 0.0012
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.0266 0.0423
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.008 0.1034 0.1702
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0007 0.0012
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.008 0.1034 0.1682
Schistosoma mansoni kinase 0.0153 0.2275 0.3629
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0415 0.0511
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0034 0.0266 0.0425
Loa Loa (eye worm) RNA binding protein 0.0329 0.5236 0.5236
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0034 0.0266 0.0433
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0228 0.0105
Loa Loa (eye worm) MH2 domain-containing protein 0.0611 1 1
Schistosoma mansoni Smad4 0.0042 0.0389 0.062
Echinococcus granulosus thioredoxin glutathione reductase 0.01 0.137 0.2229
Echinococcus multilocularis Smad4 0.0042 0.0389 0.0742
Brugia malayi TAR-binding protein 0.0329 0.5236 0.5236
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0019 0.0007 0.001
Schistosoma mansoni tar DNA-binding protein 0.0329 0.5236 0.8352
Entamoeba histolytica hypothetical protein 0.0097 0.1328 0.1495
Plasmodium vivax glutathione reductase, putative 0.0099 0.136 0.4969
Trichomonas vaginalis CAMK family protein kinase 0.0149 0.2207 0.4408
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0007 0.001
Trichomonas vaginalis mercuric reductase, putative 0.0034 0.0266 0.0187
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0368 0.0408

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.0795 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 18.4927 uM PUBCHEM_BIOASSAY: Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Sytravon. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2660, AID2666, AID2667, AID2668, AID2681, AID504465] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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