Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0726 | 0.1002 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0208 | 0.7244 | 1 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0208 | 0.7244 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0726 | 0.1002 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.1503 | 0.2076 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0726 | 0.1002 |
Onchocerca volvulus | 0.0043 | 0.0726 | 0.5 | |
Mycobacterium ulcerans | proteasome PrcB | 0.0208 | 0.7244 | 1 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0208 | 0.7244 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0043 | 0.0726 | 0.1002 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.1503 | 0.1193 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0208 | 0.7244 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0043 | 0.0726 | 0.1002 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.1503 | 0.1193 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.1503 | 0.1193 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.1503 | 0.1193 |
Onchocerca volvulus | 0.0043 | 0.0726 | 0.5 | |
Brugia malayi | TAR-binding protein | 0.0063 | 0.1503 | 0.2076 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0208 | 0.7244 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0726 | 0.1002 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0726 | 0.1002 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0208 | 0.7244 | 1 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0208 | 0.7244 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0043 | 0.0726 | 0.1002 |
Brugia malayi | RNA binding protein | 0.0063 | 0.1503 | 0.2076 |
Plasmodium vivax | hypothetical protein, conserved | 0.0043 | 0.0726 | 0.1002 |
Onchocerca volvulus | 0.0043 | 0.0726 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0726 | 0.1002 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0208 | 0.7244 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.1503 | 0.2076 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0208 | 0.7244 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.0043 | 0.0726 | 0.1002 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0043 | 0.0726 | 0.1002 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0208 | 0.7244 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.1503 | 0.1193 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0208 | 0.7244 | 0.7028 |
Toxoplasma gondii | ABC1 family protein | 0.0043 | 0.0726 | 0.1002 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.1503 | 0.2076 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0208 | 0.7244 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.1503 | 0.2076 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.1503 | 0.1193 |
Brugia malayi | beta-lactamase family protein | 0.0043 | 0.0726 | 0.1002 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.1503 | 0.1193 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0726 | 0.1002 |
Brugia malayi | beta-lactamase | 0.0043 | 0.0726 | 0.1002 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0208 | 0.7244 | 0.5 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0043 | 0.0726 | 0.1002 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0208 | 0.7244 | 1 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0208 | 0.7244 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.0726 | 0.1002 |
Echinococcus granulosus | proteasome prosome macropain | 0.0208 | 0.7244 | 1 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0208 | 0.7244 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 10 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.