Detailed information for compound 1329001

Basic information

Technical information
  • TDR Targets ID: 1329001
  • Name: 2-[(5-chloro-1-methyl-3-phenylpyrazole-4-carb onyl)amino]-2-phenylacetic acid
  • MW: 369.802 | Formula: C19H16ClN3O3
  • H donors: 2 H acceptors: 4 LogP: 3.42 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1c(nn(c1Cl)C)c1ccccc1)NC(c1ccccc1)C(=O)O
  • InChi: 1S/C19H16ClN3O3/c1-23-17(20)14(15(22-23)12-8-4-2-5-9-12)18(24)21-16(19(25)26)13-10-6-3-7-11-13/h2-11,16H,1H3,(H,21,24)(H,25,26)
  • InChiKey: YMJMPVARIFSETB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(5-chloro-1-methyl-3-phenyl-pyrazole-4-carbonyl)amino]-2-phenyl-acetic acid
  • 2-[[(5-chloro-1-methyl-3-phenyl-4-pyrazolyl)-oxomethyl]amino]-2-phenylacetic acid
  • 2-[(5-chloro-1-methyl-3-phenyl-pyrazol-4-yl)carbonylamino]-2-phenyl-ethanoic acid
  • 2-{[(5-chloro-1-methyl-3-phenyl-1H-pyrazol-4-yl)carbonyl]amino}-2-phenylacetic acid
  • MLS000736443
  • SMR000338393
  • 12T-0295

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.016 0.1271 1
Trypanosoma cruzi ATP-dependent protease subunit HslV, putative 0.0031 0.0103 0.0715
Schistosoma mansoni hypothetical protein 0.0345 0.2948 0.2948
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 46 0.0022 0.0013 0.0013
Giardia lamblia 20S proteasome alpha subunit 4 0.0031 0.0103 0.0715
Loa Loa (eye worm) hypothetical protein 0.0745 0.6581 0.6581
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0124 0.0947 0.7422
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0031 0.0103 0.0715
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0023 0.0023 0.0083
Echinococcus granulosus Proteasome subunit alpha type 7 0.0031 0.0103 0.009
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0031 0.0103 0.009
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0023 0.5
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0031 0.0103 0.0715
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0031 0.0103 0.0715
Toxoplasma gondii proteasome subunit alpha1, putative 0.0031 0.0103 0.0715
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.1122 1 1
Schistosoma mansoni proteasome subunit alpha 4 (T01 family) 0.0031 0.0103 0.0103
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0059 0.0354 0.2706
Trypanosoma brucei proteasome beta 6 subunit 0.0124 0.0947 0.7422
Trypanosoma cruzi 20S proteasome subunit 0.0077 0.0517 0.4007
Echinococcus granulosus geminin 0.0668 0.5885 0.588
Schistosoma mansoni ap endonuclease 0.0023 0.0023 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0354 0.2706
Plasmodium vivax proteasome subunit beta type-5, putative 0.016 0.1271 1
Brugia malayi 20S proteasome alpha5 subunit 0.0031 0.0103 0.009
Trypanosoma brucei unspecified product 0.0041 0.0187 0.1384
Schistosoma mansoni ubiquitin-specific peptidase 45 (C19 family) 0.0022 0.0013 0.0013
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0031 0.0103 0.0715
Schistosoma mansoni smad 0.0027 0.006 0.006
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0031 0.0103 0.0715
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0022 0.0013 0.0013
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0048 0.0255 0.0242
Plasmodium vivax proteasome subunit alpha type-4, putative 0.0031 0.0103 0.0715
Trypanosoma cruzi proteasome beta 2 subunit, putative 0.0031 0.0103 0.0715
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0023 0.001
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0013
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0136 0.0123
Echinococcus granulosus dna polymerase kappa 0.0059 0.0354 0.0341
Plasmodium falciparum proteasome subunit alpha type-2, putative 0.0031 0.0103 0.0715
Toxoplasma gondii proteasome subunit beta type 7 precursor, putative 0.0031 0.0103 0.0715
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0047 0.0241 0.1813
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.024 0.0227
Brugia malayi ImpB/MucB/SamB family protein 0.0059 0.0354 0.0341
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0022 0.0013 0.0013
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0031 0.0103 0.0103
Schistosoma mansoni proteasome catalytic subunit 3 (T01 family) 0.016 0.1271 0.1271
Plasmodium vivax ATP-dependent protease subunit ClpQ, putative 0.0031 0.0103 0.0715
Toxoplasma gondii proteasome subunit 0.0031 0.0103 0.0715
Loa Loa (eye worm) hypothetical protein 0.109 0.9711 0.9711
Schistosoma mansoni ubiquitin-specific peptidase 9X (C19 family) 0.0022 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0027 0.006 0.006
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0077 0.0517 0.0505
Brugia malayi Proteasome subunit alpha type 7-1 0.0031 0.0103 0.009
Echinococcus multilocularis mothers against decapentaplegic 6 0.0027 0.006 0.0047
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0124 0.0947 0.7422
Brugia malayi mbt repeat family protein 0.0047 0.024 0.0227
Schistosoma mansoni hypothetical protein 0.0288 0.2428 0.2428
Trichomonas vaginalis DNA polymerase eta, putative 0.0059 0.0354 0.2706
Giardia lamblia Proteasome subunit beta type 2 0.0077 0.0517 0.4007
Trypanosoma cruzi DNA polymerase eta, putative 0.0087 0.0611 0.4752
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0013
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0298 0.0286
Schistosoma mansoni peptidase 0.0022 0.0013 0.0013
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0049 0.0267 0.0254
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0077 0.0517 0.0517
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0048 0.0255 0.0242
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0031 0.0103 0.0715
Entamoeba histolytica proteasome subunit beta type 1, putative 0.0124 0.0947 0.7422
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0048 0.0255 0.0242
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0013
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0048 0.0255 0.0242
Echinococcus multilocularis proteasome subunit beta type 7 0.0031 0.0103 0.009
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0022 0.0013 0.0013
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0023 0.0083
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0031 0.0103 0.0715
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0048 0.0255 0.0255
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0031 0.0103 0.0715
Brugia malayi Bromodomain containing protein 0.0037 0.0157 0.0144
Onchocerca volvulus 0.0048 0.0255 0.154
Toxoplasma gondii proteasome subunit beta type 1, putative 0.0124 0.0947 0.7422
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0031 0.0103 0.0103
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0022 0.0013 0.0013
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0031 0.0103 0.0715
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0345 0.2948 0.2939
Echinococcus multilocularis mothers against decapentaplegic 5 0.006 0.0361 0.0349
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0816 0.7226 0.7223
Trypanosoma brucei proteasome subunit alpha type-5, putative 0.0031 0.0103 0.0715
Brugia malayi proteasome subunit alpha type 2 0.0031 0.0103 0.009
Loa Loa (eye worm) hypothetical protein 0.0087 0.0611 0.0611
Loa Loa (eye worm) hypothetical protein 0.0048 0.0255 0.0255
Echinococcus granulosus Smad4 0.006 0.0361 0.0349
Toxoplasma gondii proteasome subunit beta type, putative 0.016 0.1271 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.109 0.9711 0.9711
Brugia malayi latrophilin 2 splice variant baaae 0.0745 0.6581 0.6576
Schistosoma mansoni ubiquitin-specific peptidase 30 (C19 family) 0.0022 0.0013 0.0013
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0059 0.0354 0.0354
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0031 0.0103 0.0715
Toxoplasma gondii heat shock protein hslv, putative 0.0031 0.0103 0.0715
Echinococcus granulosus proteasome subunit beta t family 0.0031 0.0103 0.009
Schistosoma mansoni netrin receptor unc5 0.0062 0.0378 0.0378
Schistosoma mansoni Smad4 0.0027 0.006 0.006
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0059 0.0354 0.2645
Echinococcus granulosus netrin receptor unc 5 0.0062 0.0378 0.0365
Plasmodium vivax proteasome subunit beta type-2, putative 0.0077 0.0517 0.4007
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0048 0.0255 0.0255
Plasmodium vivax proteasome subunit beta type-7, putative 0.0031 0.0103 0.0715
Entamoeba histolytica proteasome subunit alpha type 6, putative 0.0031 0.0103 0.0715
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0346 0.0334
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0013
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0017 0.0004
Echinococcus granulosus proteasome prosome macropain 0.016 0.1271 0.126
Onchocerca volvulus Notchless protein homolog 0.0031 0.0103 0.0574
Echinococcus multilocularis proteasome (prosome, macropain) subunit, beta 0.0124 0.0947 0.0935
Schistosoma mansoni Smad4 0.0027 0.006 0.006
Trypanosoma brucei proteasome subunit beta type-5, putative 0.016 0.1271 1
Echinococcus multilocularis mothers against decapentaplegic 2 0.0027 0.006 0.0047
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0187 0.1384
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0031 0.0103 0.0715
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0031 0.0103 0.0715
Schistosoma mansoni ubiquitin carboxyl-terminal hydrolase of the cysteine proteinase fold 0.0022 0.0013 0.0013
Plasmodium falciparum proteasome subunit beta type-2, putative 0.0077 0.0517 0.4007
Loa Loa (eye worm) proteasome subunit beta type 3 0.0031 0.0103 0.0103
Plasmodium vivax proteasome subunit beta type-6, putative 0.0031 0.0103 0.0715
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0136 0.0123
Trypanosoma brucei proteasome alpha 3 subunit, putative 0.0031 0.0103 0.0715
Giardia lamblia 20S proteasome alpha subunit 3 0.0031 0.0103 0.0715
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0031 0.0103 0.0715
Schistosoma mansoni tar DNA-binding protein 0.0473 0.4111 0.4111
Schistosoma mansoni ubiquitin-specific peptidase 46 (C19 family) 0.0022 0.0013 0.0013
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0048 0.0255 0.0255
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0345 0.2948 0.2939
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0354 0.2706
Echinococcus multilocularis proteasome subunit alpha type 2 0.0031 0.0103 0.009
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0031 0.0103 0.0103
Trypanosoma brucei proteasome beta 7 subunit 0.0031 0.0103 0.0715
Leishmania major proteasome alpha 1 subunit, putative 0.0031 0.0103 0.0715
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0031 0.0103 0.0715
Plasmodium falciparum proteasome subunit alpha type-6, putative 0.0031 0.0103 0.0715
Brugia malayi MH2 domain containing protein 0.0879 0.7801 0.7798
Leishmania major hypothetical protein, conserved 0.011 0.0819 0.6406
Echinococcus granulosus death domain containing protein 0.0062 0.0378 0.0365
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0346 0.0334
Entamoeba histolytica proteasome subunit beta type 3, putative 0.0031 0.0103 0.0715
Brugia malayi G-protein alpha subunit 0.0048 0.0255 0.0242
Trypanosoma cruzi proteasome alpha 3 subunit, putative 0.0031 0.0103 0.0715
Schistosoma mansoni proteasome subunit beta 1 (T01 family) 0.0124 0.0947 0.0947
Loa Loa (eye worm) hypothetical protein 0.0048 0.0255 0.0255
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.1122 1 1
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0031 0.0103 0.0715
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0354 0.2706
Echinococcus multilocularis netrin receptor unc 5 0.0062 0.0378 0.0365
Schistosoma mansoni hypothetical protein 0.0345 0.2948 0.2948
Leishmania major DNA polymerase eta, putative 0.0047 0.0241 0.1813
Schistosoma mansoni TGF-beta signal transducer Smad2 0.006 0.0361 0.0361
Trypanosoma cruzi proteasome beta 6 subunit, putative 0.0124 0.0947 0.7422
Giardia lamblia 20S proteasome alpha subunit 1 0.0031 0.0103 0.0715
Schistosoma mansoni Smad4 0.006 0.0361 0.0361
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0022 0.0013 0.0013
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0031 0.0103 0.0715
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0298 0.0286
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0059 0.0354 0.2706
Schistosoma mansoni ubiquitin-specific peptidase 42 (C19 family) 0.0022 0.0013 0.0013
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0023 0.001
Mycobacterium leprae proteasome (beta subunit) PrcB 0.016 0.1271 1
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0031 0.0103 0.0715
Brugia malayi RNA recognition motif domain containing protein 0.0473 0.4111 0.4104
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0298 0.0286
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0013
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0345 0.2948 0.2939
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0077 0.0517 0.4007
Entamoeba histolytica G protein alpha subunit, putative 0.0048 0.0255 0.192
Entamoeba histolytica proteasome subunit alpha type 4, putative 0.0031 0.0103 0.0715
Mycobacterium tuberculosis Conserved hypothetical protein 0.0059 0.0354 0.2645
Entamoeba histolytica proteasome subunit alpha type 7, putative 0.0031 0.0103 0.0715
Echinococcus multilocularis proteasome subunit beta type 6 0.0031 0.0103 0.009
Entamoeba histolytica probable proteasome subunit beta type 2, putative 0.0077 0.0517 0.4007
Plasmodium vivax proteasome subunit alpha type-6, putative 0.0031 0.0103 0.0715
Giardia lamblia Proteasome subunit beta type 4 precursor 0.0031 0.0103 0.0715
Echinococcus granulosus mothers against decapentaplegic 2 0.0027 0.006 0.0047
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0048 0.0255 0.0255
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0022 0.0013 0.0013
Toxoplasma gondii 20S proteasome subunit beta 7, putative 0.0031 0.0103 0.0715
Leishmania major proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative 0.0124 0.0947 0.7422
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0048 0.0255 0.0242
Loa Loa (eye worm) hypothetical protein 0.0048 0.0255 0.0255
Trypanosoma brucei PAB1-binding protein , putative 0.011 0.0819 0.6406
Giardia lamblia Proteasome subunit beta type 5 precursor 0.016 0.1271 1
Plasmodium vivax proteasome subunit alpha type-3, putative 0.0031 0.0103 0.0715
Loa Loa (eye worm) hypothetical protein 0.0345 0.2948 0.2948
Brugia malayi Proteasome A-type and B-type family protein 0.0031 0.0103 0.009
Brugia malayi Proteasome A-type and B-type family protein 0.0031 0.0103 0.009
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0298 0.0286
Plasmodium falciparum proteasome subunit beta type-1, putative 0.0124 0.0947 0.7422
Brugia malayi MH1 domain containing protein 0.0033 0.0118 0.0105
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0048 0.0255 0.0255
Trypanosoma brucei proteasome beta 3 subunit, putative 0.0031 0.0103 0.0715
Toxoplasma gondii LsmAD domain-containing protein 0.011 0.0819 0.6406
Onchocerca volvulus 0.0047 0.024 0.1446
Schistosoma mansoni GTP-binding protein alpha subunit 0.0048 0.0255 0.0255
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0031 0.0103 0.0715
Leishmania major hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B 0.0031 0.0103 0.0715
Schistosoma mansoni smad1 5 8 and 0.006 0.0361 0.0361
Giardia lamblia Proteasome subunit beta type 1 0.0124 0.0947 0.7422
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0354 0.2706
Trypanosoma cruzi proteasome alpha 1 subunit, putative 0.0031 0.0103 0.0715
Schistosoma mansoni hypothetical protein 0.0022 0.0013 0.0013
Loa Loa (eye worm) proteasome subunit beta type 1 0.0124 0.0947 0.0947
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.024 0.0227
Brugia malayi Proteasome A-type and B-type family protein 0.016 0.1271 0.126
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0031 0.0103 0.009
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0031 0.0103 0.0103
Plasmodium falciparum ataxin-2 like protein, putative 0.011 0.0819 0.6406
Trypanosoma cruzi proteasome subunit alpha type-5, putative 0.0031 0.0103 0.0715
Echinococcus granulosus proteasome subunit alpha type 6 0.0031 0.0103 0.009
Echinococcus granulosus TGF beta signal transducer SmadC 0.006 0.0361 0.0349
Echinococcus granulosus mothers against decapentaplegic 5 0.006 0.0361 0.0349
Schistosoma mansoni hypothetical protein 0.0668 0.5885 0.5885
Trypanosoma brucei proteasome alpha 7 subunit 0.0031 0.0103 0.0715
Schistosoma mansoni proteasome subunit beta 4 (T01 family) 0.0031 0.0103 0.0103
Mycobacterium tuberculosis Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. 0.016 0.1271 1
Loa Loa (eye worm) Smad1 0.006 0.0361 0.0361
Trypanosoma brucei proteasome beta-1 subunit, putative 0.0031 0.0103 0.0715
Loa Loa (eye worm) pigment dispersing factor receptor c 0.109 0.9711 0.9711
Loa Loa (eye worm) MH2 domain-containing protein 0.0879 0.7801 0.7801
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0354 0.2706
Entamoeba histolytica deoxycytidyl transferase, putative 0.0059 0.0354 0.2706
Echinococcus multilocularis proteasome (prosome, macropain) 0.016 0.1271 0.126
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.1122 1 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0345 0.2948 0.2948
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0023 0.0023
Schistosoma mansoni terminal deoxycytidyl transferase 0.0059 0.0354 0.0354
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.024 0.0227
Leishmania major proteasome alpha 3 subunit, putative 0.0031 0.0103 0.0715
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0031 0.0103 0.0715
Plasmodium vivax ataxin-2 like protein, putative 0.011 0.0819 0.6406
Leishmania major proteasome beta 7 subunit, putative 0.0031 0.0103 0.0715
Brugia malayi Smad1 0.006 0.0361 0.0349
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0031 0.0103 0.0103
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.1122 1 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0059 0.0354 0.0341
Echinococcus multilocularis proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta 0.0031 0.0103 0.009
Schistosoma mansoni proteasome catalytic subunit 1 (T01 family) 0.0031 0.0103 0.0103
Schistosoma mansoni ubiquitin-specific peptidase 4 (C19 family) 0.0022 0.0013 0.0013
Wolbachia endosymbiont of Brugia malayi ATP-dependent protease peptidase subunit 0.0031 0.0103 1
Schistosoma mansoni hypothetical protein 0.0049 0.0267 0.0267
Brugia malayi Bromodomain containing protein 0.0073 0.0482 0.0469
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0124 0.0947 0.0935
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0048 0.0255 0.0242
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.016 0.1271 1
Brugia malayi proteasome subunit beta type 1 0.0124 0.0947 0.0935
Brugia malayi proteasome subunit beta type 2 0.0077 0.0517 0.0505
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0022 0.0013 0.0013
Echinococcus granulosus proteasome prosome macropain subunit beta type 0.0031 0.0103 0.009
Echinococcus multilocularis Ankyrin 0.0062 0.038 0.0367
Loa Loa (eye worm) proteasome subunit alpha type 1 0.0031 0.0103 0.0103
Leishmania major proteasome beta 5 subunit, putative 0.016 0.1271 1
Trypanosoma cruzi hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B 0.0031 0.0103 0.0715
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0048 0.0255 0.0255
Brugia malayi hypothetical protein 0.0048 0.0255 0.0242
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0354 0.2706
Plasmodium vivax proteasome subunit alpha type-1, putative 0.0031 0.0103 0.0715
Loa Loa (eye worm) RNA binding protein 0.0473 0.4111 0.4111
Onchocerca volvulus 0.0048 0.0255 0.154
Schistosoma mansoni proteasome subunit alpha 7 (T01 family) 0.0031 0.0103 0.0103
Leishmania major proteasome beta-1 subunit, putative 0.0031 0.0103 0.0715
Schistosoma mansoni ubiquitin-specific peptidase 22 (C19 family) 0.0022 0.0013 0.0013
Trypanosoma brucei proteasome subunit beta type-2, putative 0.0077 0.0517 0.4007
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0354 0.2706
Plasmodium falciparum proteasome subunit alpha type-5, putative 0.0031 0.0103 0.0715
Brugia malayi RNA binding protein 0.0473 0.4111 0.4104
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0059 0.0354 0.0354
Loa Loa (eye worm) proteasome subunit alpha type 7-1 0.0031 0.0103 0.0103
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.024 0.0227
Loa Loa (eye worm) hypothetical protein 0.0062 0.0378 0.0378
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0048 0.0255 0.192
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.024 0.024
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.1122 1 1
Trypanosoma brucei unspecified product 0.0059 0.0354 0.2706
Leishmania major proteasome beta 2 subunit, putative 0.0077 0.0517 0.4007
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0048 0.0255 0.0255
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0031 0.0103 0.0715
Schistosoma mansoni ubiquitin-specific peptidase 16 (C19 family) 0.0022 0.0013 0.0013
Brugia malayi Proteasome A-type and B-type family protein 0.0031 0.0103 0.009
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0013
Loa Loa (eye worm) 20S proteasome alpha5 subunit 0.0031 0.0103 0.0103
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0048 0.0255 0.192
Echinococcus multilocularis dna polymerase eta 0.0087 0.0611 0.0599
Trypanosoma cruzi proteasome subunit beta type-2, putative 0.0077 0.0517 0.4007
Echinococcus granulosus proteasome subunit alpha type 2 0.0031 0.0103 0.009
Toxoplasma gondii proteasome subunit alpha type 1, putative 0.0031 0.0103 0.0715
Brugia malayi TAR-binding protein 0.0473 0.4111 0.4104
Brugia malayi mbt repeat family protein 0.0047 0.024 0.0227
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0048 0.0255 0.192
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0031 0.0103 0.0715
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0031 0.0103 0.0715
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0354 0.2706
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0062 0.038 0.038
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0031 0.0103 0.0103
Giardia lamblia DINP protein human, muc B family 0.0059 0.0354 0.2706
Schistosoma mansoni family C19 unassigned peptidase (C19 family) 0.0022 0.0013 0.0013
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0048 0.0255 0.0255
Loa Loa (eye worm) hypothetical protein 0.0037 0.0157 0.0157
Plasmodium falciparum proteasome subunit beta type-4 0.0031 0.0103 0.0715
Giardia lamblia 20S proteasome alpha subunit 7 0.0031 0.0103 0.0715
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0049 0.0267 0.0254
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0188 0.1524 0.1513
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0047 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0013
Schistosoma mansoni proteasome subunit alpha 2 (T01 family) 0.0031 0.0103 0.0103
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0031 0.0103 0.0715
Echinococcus granulosus dna polymerase eta 0.0087 0.0611 0.0599
Onchocerca volvulus Netrin receptor homolog 0.0062 0.0378 0.2324
Brugia malayi proteasome subunit alpha type 3 0.0031 0.0103 0.009
Loa Loa (eye worm) transcription factor SMAD2 0.0879 0.7801 0.7801
Entamoeba histolytica proteasome subunit alpha type 2-A, putative 0.0031 0.0103 0.0715
Echinococcus multilocularis tar DNA binding protein 0.0473 0.4111 0.4104
Entamoeba histolytica proteasome subunit alpha type 3, putative 0.0031 0.0103 0.0715
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0187 0.1384
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0013
Plasmodium vivax proteasome subunit alpha type-7, putative 0.0031 0.0103 0.0715
Echinococcus multilocularis Proteasome subunit alpha type 7 0.0031 0.0103 0.009
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0048 0.0255 0.192
Trypanosoma brucei ATP-dependent protease subunit HslV 0.0031 0.0103 0.0715
Echinococcus granulosus nuclear factor of activated T cells 5 0.0604 0.5297 0.5291
Giardia lamblia 20S proteasome alpha subunit 6 0.0031 0.0103 0.0715
Schistosoma mansoni smad 0.006 0.0361 0.0361
Loa Loa (eye worm) G protein alpha subunit 3 0.0048 0.0255 0.0255
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0048 0.0255 0.0255
Loa Loa (eye worm) MBCTL1 0.0053 0.0298 0.0298
Toxoplasma gondii exonuclease III APE 0.0023 0.0023 0.0083
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.1122 1 1
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0031 0.0103 0.0715
Plasmodium falciparum ataxin-2 like protein, putative 0.011 0.0819 0.6406
Entamoeba histolytica proteasome subunit beta type 6 precursor, putative 0.0031 0.0103 0.0715
Schistosoma mansoni smad1 5 8 and 0.006 0.0361 0.0361
Echinococcus multilocularis TGF beta signal transducer SmadC 0.006 0.0361 0.0349
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0027 0.006 0.0302
Plasmodium falciparum proteasome subunit beta type-7, putative 0.0031 0.0103 0.0715
Loa Loa (eye worm) proteasome subunit alpha type 3 0.0031 0.0103 0.0103
Brugia malayi proteasome subunit alpha type 1 0.0031 0.0103 0.009
Leishmania major DNA polymerase kappa, putative 0.0059 0.0354 0.2706
Loa Loa (eye worm) hypothetical protein 0.0033 0.0118 0.0118
Schistosoma mansoni hypothetical protein 0.0062 0.0378 0.0378
Plasmodium falciparum proteasome subunit beta type-5 0.016 0.1271 1
Trypanosoma cruzi PAB1-binding protein , putative 0.011 0.0819 0.6406
Giardia lamblia 20S proteasome alpha subunit 5 0.0031 0.0103 0.0715
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0048 0.0255 0.192
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0345 0.2948 0.2939
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0048 0.0255 0.0255
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0048 0.0255 0.0242
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0048 0.0255 0.0242
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0048 0.0255 0.0255
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0345 0.2948 0.2939
Toxoplasma gondii proteasome beta subunit 0.0031 0.0103 0.0715
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0023 0.0023 0.0083
Trypanosoma brucei Proteasome subunit A N-terminal signature/Proteasome subunit, putative 0.0031 0.0103 0.0715
Brugia malayi mothers against decapentaplegic homolog 3 0.0027 0.006 0.0047
Plasmodium vivax proteasome subunit alpha type-5, putative 0.0031 0.0103 0.0715
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0188 0.1524 0.1513
Trypanosoma cruzi proteasome beta 7 subunit, putative 0.0031 0.0103 0.0715
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0022 0.0013 0.0013
Echinococcus granulosus Ankyrin 0.0062 0.038 0.0367
Loa Loa (eye worm) hypothetical protein 0.011 0.0819 0.0819
Entamoeba histolytica proteasome subunit beta Type 4 precursor, putative 0.0031 0.0103 0.0715
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0031 0.0103 0.0715
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0048 0.0255 0.0242
Echinococcus multilocularis 20S proteasome subunit alpha 6 0.0031 0.0103 0.009
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0031 0.0103 0.0715
Echinococcus multilocularis Smad4 0.006 0.0361 0.0349
Entamoeba histolytica proteasome subunit beta type 7-B precursor, putative 0.0031 0.0103 0.0715
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0048 0.0255 0.0242
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0354 0.2706
Mycobacterium ulcerans DNA polymerase IV 0.0059 0.0354 0.2645
Echinococcus granulosus tar DNA binding protein 0.0473 0.4111 0.4104
Toxoplasma gondii proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative 0.0031 0.0103 0.0715
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0604 0.5297 0.5291
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0354 0.2706
Schistosoma mansoni DNA polymerase eta 0.0087 0.0611 0.0611
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0022 0.0013 0.0013
Plasmodium falciparum proteasome subunit alpha type-7, putative 0.0031 0.0103 0.0715
Schistosoma mansoni smad1 5 8 and 0.006 0.0361 0.0361
Plasmodium falciparum proteasome subunit beta type-3, putative 0.0031 0.0103 0.0715
Brugia malayi N-terminal motif family protein 0.0194 0.1582 0.1571
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0298 0.0286
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0023 0.0083
Schistosoma mansoni ubiquitin-specific peptidase 9X (C19 family) 0.0022 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0013
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0023 0.0083
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0048 0.0255 0.0242
Schistosoma mansoni calpain-7 (C02 family) 0.0022 0.0013 0.0013
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0048 0.0255 0.0242
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0017 0.0004
Giardia lamblia 20S proteasome alpha subunit 2 0.0031 0.0103 0.0715
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0194 0.1582 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0195 0.0195
Loa Loa (eye worm) MH2 domain-containing protein 0.006 0.0361 0.0361
Brugia malayi Latrophilin receptor protein 2 0.0345 0.2948 0.2939
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0354 0.2706
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.1122 1 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0027 0.006 0.006
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0022 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.004 0.0178 0.0178
Loa Loa (eye worm) hypothetical protein 0.0053 0.0298 0.0298
Trypanosoma cruzi proteasome alpha 7 subunit, putative 0.0031 0.0103 0.0715
Mycobacterium ulcerans proteasome PrcB 0.016 0.1271 1
Onchocerca volvulus 0.0048 0.0255 0.154
Leishmania major proteasome beta 2 subunit, putative 0.0031 0.0103 0.0715
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0017 0.0017
Brugia malayi hypothetical protein 0.0071 0.0464 0.0452
Echinococcus multilocularis Proteasome, subunit alpha beta 0.0031 0.0103 0.009
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0013
Plasmodium vivax proteasome subunit alpha type-2, putative 0.0031 0.0103 0.0715
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0048 0.0255 0.192
Echinococcus multilocularis proteasome (prosome macropain) subunit alpha 0.0031 0.0103 0.009
Toxoplasma gondii peptidase, T1 family protein 0.0031 0.0103 0.0715
Brugia malayi Uncoordinated protein 44 0.0062 0.0378 0.0365
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0062 0.0378 0.0365
Brugia malayi MH1 domain containing protein 0.0033 0.0118 0.0105
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0048 0.0255 0.0255
Trypanosoma cruzi PAB1-binding protein , putative 0.011 0.0819 0.6406
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.024 0.024
Giardia lamblia Proteasome subunit beta type 7 precursor 0.0031 0.0103 0.0715
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0048 0.0255 0.0242
Schistosoma mansoni hypothetical protein 0.0345 0.2948 0.2948
Brugia malayi Proteasome subunit alpha type 1 0.0031 0.0103 0.009
Loa Loa (eye worm) proteasome subunit beta type 2 0.0077 0.0517 0.0517
Echinococcus granulosus proteasome prosome macropain subunit beta 0.0077 0.0517 0.0505
Schistosoma mansoni GTP-binding protein alpha subunit 0.0048 0.0255 0.0255
Loa Loa (eye worm) proteasome subunit alpha type 6 0.0031 0.0103 0.0103
Echinococcus granulosus smad 0.006 0.0361 0.0349
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0022 0.0013 0.0013
Schistosoma mansoni ubiquitin-specific peptidase 24 (C19 family) 0.0022 0.0013 0.0013
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0023 0.0083
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0048 0.0255 0.0255
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0062 0.0378 0.0378
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0048 0.0255 0.0255
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0031 0.0103 0.0715
Echinococcus multilocularis dna polymerase kappa 0.0059 0.0354 0.0341
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0022 0.0013 0.0013
Brugia malayi MH1 domain containing protein 0.006 0.0361 0.0349
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0031 0.0103 0.0715
Loa Loa (eye worm) MH1 domain-containing protein 0.0027 0.006 0.006
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0023 0.0083
Plasmodium falciparum proteasome subunit alpha type-4, putative 0.0031 0.0103 0.0715
Leishmania major proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) 0.0031 0.0103 0.0715
Loa Loa (eye worm) hypothetical protein 0.0194 0.1582 0.1582
Leishmania major proteasome alpha 2 subunit, putative 0.0031 0.0103 0.0715
Schistosoma mansoni ubiquitin-specific peptidase 14 (C19 family) 0.0022 0.0013 0.0013
Leishmania major 20s proteasome beta 7 subunit, (putative) 0.0031 0.0103 0.0715
Schistosoma mansoni hypothetical protein 0.0668 0.5885 0.5885
Plasmodium vivax proteasome subunit beta type-4, putative 0.0031 0.0103 0.0715
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0023 0.0023 0.0083
Loa Loa (eye worm) PAS-3 protein 0.0031 0.0103 0.0103
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0048 0.0255 0.0242
Trypanosoma cruzi proteasome beta-1 subunit, putative 0.0031 0.0103 0.0715
Schistosoma mansoni proteasome subunit alpha 3 (T01 family) 0.0031 0.0103 0.0103
Trypanosoma cruzi proteasome subunit beta type-5, putative 0.016 0.1271 1
Brugia malayi proteasome subunit beta type 3 0.0031 0.0103 0.009
Brugia malayi Calcitonin receptor-like protein seb-1 0.109 0.9711 0.9711
Brugia malayi MH2 domain containing protein 0.006 0.0361 0.0349
Brugia malayi PHD-finger family protein 0.0024 0.0038 0.0025
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0023 0.0083
Trichomonas vaginalis Family T1, proteasome alpha subunit, threonine peptidase 0.0031 0.0103 0.0715
Loa Loa (eye worm) hypothetical protein 0.0048 0.0255 0.0255
Echinococcus granulosus GPCR family 2 0.0345 0.2948 0.2939
Giardia lamblia Proteasome subunit beta type 9 precursor 0.0031 0.0103 0.0715
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0013
Mycobacterium ulcerans proteasome PrcA 0.0031 0.0103 0.0637
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0022 0.0013 0.0013
Loa Loa (eye worm) TAR-binding protein 0.0473 0.4111 0.4111
Trypanosoma cruzi proteasome subunit alpha type-1, putative 0.0031 0.0103 0.0715
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.024 0.1446
Schistosoma mansoni hypothetical protein 0.0345 0.2948 0.2948
Entamoeba histolytica calcium-dependent protein kinase 2, putative 0.0031 0.0103 0.0715
Schistosoma mansoni ap endonuclease 0.0023 0.0023 0.0023
Brugia malayi MH2 domain containing protein 0.0027 0.006 0.0047
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.1122 1 1
Trypanosoma cruzi proteasome alpha 2 subunit, putative 0.0031 0.0103 0.0715
Trichomonas vaginalis ap endonuclease, putative 0.0023 0.0023 0.0083
Echinococcus multilocularis GPCR, family 2 0.0345 0.2948 0.2939
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0048 0.0255 0.0242
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0062 0.0378 0.0365
Echinococcus multilocularis proteasome subunit alpha type 6 0.0031 0.0103 0.009
Schistosoma mansoni tar DNA-binding protein 0.0473 0.4111 0.4111
Brugia malayi proteasome subunit alpha type 6 0.0031 0.0103 0.009
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0031 0.0103 0.0103
Brugia malayi ImpB/MucB/SamB family protein 0.0087 0.0611 0.0599
Giardia lamblia Proteasome subunit beta type 3 0.0031 0.0103 0.0715
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0048 0.0255 0.0242
Toxoplasma gondii proteasome subunit alpha type, putative 0.0031 0.0103 0.0715
Leishmania major proteasome beta 3 subunit, putative 0.0031 0.0103 0.0715
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0059 0.0354 0.0341
Schistosoma mansoni bromodomain containing protein 0.0062 0.0378 0.0378
Trypanosoma brucei proteasome alpha 7 subunit, putative 0.0031 0.0103 0.0715
Plasmodium vivax proteasome subunit beta type-3, putative 0.0031 0.0103 0.0715
Loa Loa (eye worm) MH1 domain-containing protein 0.006 0.0361 0.0361
Trypanosoma brucei proteasome beta 2 subunit, putative 0.0031 0.0103 0.0715
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0048 0.0255 0.0255
Echinococcus multilocularis smad 0.006 0.0361 0.0349
Plasmodium falciparum ATP-dependent protease subunit ClpQ 0.0031 0.0103 0.0715
Echinococcus granulosus Proteasome subunit alpha beta 0.0031 0.0103 0.009
Brugia malayi hypothetical protein 0.011 0.0819 0.0807
Toxoplasma gondii proteasome subunit beta type 2, putative 0.0077 0.0517 0.4007
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0031 0.0103 0.0103
Entamoeba histolytica proteasome subunit alpha type 1, putative 0.0031 0.0103 0.0715
Trypanosoma cruzi proteasome beta 3 subunit, putative 0.0031 0.0103 0.0715
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.024 0.024
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0048 0.0255 0.0242
Schistosoma mansoni ankyrin 23/unc44 0.0062 0.0378 0.0378
Toxoplasma gondii proteasome subunit alpha type 5-2, putative 0.0031 0.0103 0.0715
Echinococcus multilocularis expressed protein 0.0048 0.0255 0.0242
Leishmania major proteasome alpha 7 subunit, putative 0.0031 0.0103 0.0715
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0354 0.2706
Schistosoma mansoni ubiquitin-specific peptidase 10 (C19 family) 0.0022 0.0013 0.0013
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0473 0.4111 0.4111
Schistosoma mansoni ubiquitin-specific peptidase 7 (C19 family) 0.0022 0.0013 0.0013
Loa Loa (eye worm) proteasome subunit alpha type 2 0.0031 0.0103 0.0103
Leishmania major proteasome alpha 7 subunit, putative 0.0031 0.0103 0.0715
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.0031 0.0103 0.0103
Brugia malayi Death domain containing protein 0.0062 0.0378 0.0365
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0048 0.0255 0.192
Mycobacterium ulcerans DNA polymerase IV 0.0059 0.0354 0.2645
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0354 0.2706
Brugia malayi MH2 domain containing protein 0.006 0.0361 0.0349
Trypanosoma brucei DNA polymerase IV, putative 0.0059 0.0354 0.2706
Echinococcus granulosus subfamily T1A non peptidase ue 0.0031 0.0103 0.009
Echinococcus granulosus proteasome subunit beta type 6 0.0031 0.0103 0.009
Echinococcus multilocularis subfamily T1A non peptidase ue 0.0031 0.0103 0.009
Trypanosoma brucei DNA polymerase kappa, putative 0.0059 0.0354 0.2706
Entamoeba histolytica proteasome subunit beta type 5 precursor, putative 0.016 0.1271 1
Brugia malayi Protein kinase domain containing protein 0.0062 0.0378 0.0365
Schistosoma mansoni tar DNA-binding protein 0.0473 0.4111 0.4111
Schistosoma mansoni proteasome subunit beta 2 (T01 family) 0.0077 0.0517 0.0517
Schistosoma mansoni tar DNA-binding protein 0.0473 0.4111 0.4111
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0048 0.0255 0.192
Trypanosoma brucei DNA polymerase eta, putative 0.0087 0.0611 0.4752
Entamoeba histolytica proteasome subunit alpha type 5, putative 0.0031 0.0103 0.0715
Plasmodium vivax proteasome subunit beta type-1, putative 0.0124 0.0947 0.7422
Echinococcus multilocularis proteasome (prosome macropain) subunit beta type 0.0031 0.0103 0.009
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0048 0.0255 0.0242
Loa Loa (eye worm) hypothetical protein 0.0048 0.0255 0.0255
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0187 0.1384
Schistosoma mansoni tar DNA-binding protein 0.0473 0.4111 0.4111
Mycobacterium tuberculosis Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. 0.0031 0.0103 0.0637
Loa Loa (eye worm) hypothetical protein 0.0022 0.0013 0.0013
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0077 0.0517 0.4007
Loa Loa (eye worm) hypothetical protein 0.0069 0.0444 0.0444
Echinococcus granulosus expressed protein 0.0048 0.0255 0.0242
Echinococcus granulosus proteasome subunit beta type 7 0.0031 0.0103 0.009
Plasmodium falciparum proteasome subunit alpha type-1, putative 0.0031 0.0103 0.0715
Trypanosoma brucei unspecified product 0.0041 0.0187 0.1384
Brugia malayi MH1 domain containing protein 0.006 0.0361 0.0349
Echinococcus granulosus mothers against decapentaplegic 6 0.0027 0.006 0.0047
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0023 0.001
Trypanosoma brucei proteasome alpha 1 subunit, putative 0.0031 0.0103 0.0715
Loa Loa (eye worm) proteasome A-type and B-type family protein 0.016 0.1271 0.1271
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.024 0.024
Schistosoma mansoni proteasome subunit beta 3 (T01 family) 0.0031 0.0103 0.0103
Loa Loa (eye worm) nuclear factor I 0.0033 0.0118 0.0118
Schistosoma mansoni proteasome catalytic subunit 2 (T01 family) 0.0031 0.0103 0.0103
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0354 0.2706
Leishmania major DNA polymerase eta, putative 0.0087 0.0611 0.4752
Loa Loa (eye worm) hypothetical protein 0.0062 0.038 0.038
Echinococcus granulosus 20S proteasome subunit alpha 6 0.0031 0.0103 0.009
Schistosoma mansoni subfamily T1A non-peptidase homologue (T01 family) 0.0031 0.0103 0.0103
Plasmodium falciparum proteasome subunit beta type-6, putative 0.0031 0.0103 0.0715
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0048 0.0255 0.0242
Schistosoma mansoni ubiquitin-specific peptidase 48 (C19 family) 0.0022 0.0013 0.0013
Trichomonas vaginalis Family T1, proteasome beta subunit, threonine peptidase 0.0031 0.0103 0.0715
Schistosoma mansoni hypothetical protein 0.0745 0.6581 0.6581
Trypanosoma brucei proteasome alpha 2 subunit, putative 0.0031 0.0103 0.0715
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0022 0.0013 0.0013
Schistosoma mansoni calpain-7 (C02 family) 0.0022 0.0013 0.0013
Brugia malayi Immunoglobulin I-set domain containing protein 0.0062 0.0378 0.0365
Brugia malayi proteasome subunit alpha type 4 0.0031 0.0103 0.009
Echinococcus granulosus proteasome prosome macropain subunit alpha 0.0031 0.0103 0.009
Plasmodium falciparum proteasome subunit alpha type-3, putative 0.0031 0.0103 0.0715
Leishmania major proteasome alpha 1 subunit, putative 0.0031 0.0103 0.0715
Echinococcus multilocularis geminin 0.0668 0.5885 0.588
Trypanosoma cruzi DNA polymerase kappa, putative 0.0059 0.0354 0.2706
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0298 0.0298
Trypanosoma cruzi DNA polymerase eta, putative 0.0047 0.0241 0.1813

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0008 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 100 um PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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