TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 388.802 | Formula: C19H17ClN2O5
H donors: 0 H acceptors: 4 LogP: 2.73 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: O=C(C1CC(=O)N(C1)Cc1ccccc1Cl)OCc1ccc(cc1)[N+](=O)[O-]
InChi: 1S/C19H17ClN2O5/c20-17-4-2-1-3-14(17)10-21-11-15(9-18(21)23)19(24)27-12-13-5-7-16(8-6-13)22(25)26/h1-8,15H,9-12H2
InChiKey: RASNFXKKZCYGDY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	nuclear receptor nhr-48	0.0105	0.041	0.0405
Schistosoma mansoni	ap endonuclease	0.0037	0.0049	0.0043
Loa Loa (eye worm)	hypothetical protein	0.0246	0.1152	0.1431
Loa Loa (eye worm)	hypothetical protein	0.0105	0.041	0.0505
Loa Loa (eye worm)	RNA binding protein	0.0062	0.018	0.0218
Brugia malayi	Steroid receptor seven-up type 2	0.0246	0.1152	0.1431
Schistosoma mansoni	hypothetical protein	0.0537	0.2693	0.2688
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0246	0.1152	0.1147
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0037	0.0049	0.5
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0142	0.0601	0.4029
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0037	0.0049	0.0181
Echinococcus granulosus	histone acetyltransferase MYST2	0.0053	0.0134	0.0496
Trypanosoma brucei	PAB1-binding protein , putative	0.0101	0.0387	0.2493
Loa Loa (eye worm)	hypothetical protein	0.0105	0.041	0.0505
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.014	0.0594	0.1438
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0246	0.1152	0.1147
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0096	0.0359	0.1333
Brugia malayi	mbt repeat family protein	0.0047	0.0099	0.0117
Brugia malayi	nuclear hormone receptor	0.0105	0.041	0.0505
Brugia malayi	TAR-binding protein	0.0062	0.018	0.0218
Entamoeba histolytica	hypothetical protein	0.0038	0.0056	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0246	0.1152	0.1431
Loa Loa (eye worm)	nuclear hormone receptor	0.0105	0.041	0.0505
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.005	0.012	0.0142
Echinococcus granulosus	ecdysone induced protein 78C	0.0246	0.1152	0.4278
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0246	0.1152	0.1431
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0037	0.0049	0.5
Plasmodium falciparum	ataxin-2 like protein, putative	0.0101	0.0387	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0246	0.1152	0.28
Leishmania major	mitochondrial DNA polymerase beta	0.0299	0.1434	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0093	0.0344	1
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0053	0.0134	0.0312
Schistosoma mansoni	coup transcription factor	0.0246	0.1152	0.1147
Brugia malayi	orphan nuclear receptor NR2E1	0.0105	0.041	0.0505
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0047	0.0099	0.0117
Onchocerca volvulus		0.0229	0.1066	0.1324
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.012	0.0783
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0157	0.0686	0.6435
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0039	0.0042
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0053	0.0134	0.0496
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0803	0.4099	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0246	0.1152	0.1431
Loa Loa (eye worm)	hypothetical protein	0.0246	0.1152	0.1431
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.014	0.0594	0.2208
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.0056	0.005
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.0075	0.0257
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0225	0.1044	1
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0042	0.0075	0.0257
Brugia malayi	beta-lactamase family protein	0.0035	0.0039	0.0042
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0246	0.1152	0.1431
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0037	0.0046	0.0073
Loa Loa (eye worm)	hypothetical protein	0.0105	0.041	0.0505
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0246	0.1152	0.1431
Plasmodium vivax	ataxin-2 like protein, putative	0.0101	0.0387	1
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0006	0.0021
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0246	0.1152	0.4278
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0045	0.0092	0.0212
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0037	0.0049	0.0054
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0105	0.041	0.0505
Brugia malayi	nuclear hormone receptor	0.0246	0.1152	0.1431
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0105	0.041	0.0505
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0096	0.0359	0.0863
Brugia malayi	RNA binding protein	0.0062	0.018	0.0218
Echinococcus granulosus	SAM and MBT domain containing protein	0.0047	0.0099	0.0369
Brugia malayi	nuclear receptor RXR	0.014	0.0594	0.0735
Brugia malayi	Pre-SET motif family protein	0.0202	0.0919	0.114
Brugia malayi	hypothetical protein	0.0105	0.041	0.0505
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0246	0.1152	0.1431
Brugia malayi	MAP kinase sur-1	0.005	0.012	0.0142
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0037	0.0049	0.0094
Loa Loa (eye worm)	hypothetical protein	0.014	0.0594	0.0735
Brugia malayi	nuclear hormone receptor family member odr-7	0.0105	0.041	0.0505
Echinococcus multilocularis	polycomb protein SCMH1	0.0047	0.0099	0.0229
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0246	0.1152	0.4278
Loa Loa (eye worm)	hypothetical protein	0.0246	0.1152	0.1431
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.018	0.0175
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.005	0.012	0.0576
Echinococcus granulosus	geminin	0.0537	0.2693	1
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0246	0.1152	0.1431
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0084	0.0295	0.2543
Schistosoma mansoni	nuclear hormone receptor	0.0105	0.041	0.0405
Mycobacterium tuberculosis	Probable dehydrogenase	0.0084	0.0295	0.2543
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0039	0.0034
Schistosoma mansoni	nuclear hormone receptor	0.0246	0.1152	0.1147
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0039	0.088
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0246	0.1152	0.1431
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0299	0.1434	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0105	0.041	0.0988
Brugia malayi	hypothetical protein	0.0065	0.0198	0.024
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0246	0.1152	0.1431
Echinococcus multilocularis	ecdysone induced protein 78C	0.0246	0.1152	0.28
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.012	0.0114
Brugia malayi	ecdysone receptor	0.0105	0.041	0.0505
Brugia malayi	Nuclear hormone receptor E75	0.0105	0.041	0.0505
Brugia malayi	Nuclear hormone receptor E75	0.0105	0.041	0.0505
Brugia malayi	hypothetical protein	0.0038	0.0056	0.0063
Brugia malayi	Thioredoxin reductase	0.0037	0.0046	0.0051
Brugia malayi	beta-lactamase	0.0035	0.0039	0.0042
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.014	0.0594	0.0735
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0105	0.041	0.0988
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0142	0.0601	0.4029
Loa Loa (eye worm)	hypothetical protein	0.0105	0.041	0.0505
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0105	0.041	0.1523
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0037	0.0049	0.0106
Schistosoma mansoni	RAR-like nuclear receptor	0.0246	0.1152	0.1147
Brugia malayi	glutathione reductase	0.0037	0.0046	0.0051
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0246	0.1152	0.4278
Brugia malayi	photoreceptor-specific nuclear receptor	0.0246	0.1152	0.1431
Trichomonas vaginalis	set domain proteins, putative	0.0229	0.1066	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0105	0.041	0.1523
Trichomonas vaginalis	ap endonuclease, putative	0.0037	0.0049	0.0092
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0037	0.0049	0.0064
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0246	0.1152	0.28
Echinococcus multilocularis	mitogen activated protein kinase	0.005	0.012	0.0278
Echinococcus granulosus	nuclear receptor nhr 48	0.0105	0.041	0.1523
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.005	0.012	0.0576
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0246	0.1152	0.1431
Brugia malayi	Nuclear hormone receptor-like 1	0.0246	0.1152	0.1431
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0105	0.041	0.0505
Brugia malayi	ecdysteroid receptor	0.1544	0.8018	1
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0105	0.041	0.0505
Trypanosoma cruzi	PAB1-binding protein , putative	0.0101	0.0387	0.2493
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0096	0.0359	0.0354
Onchocerca volvulus	Protein ultraspiracle homolog	0.0246	0.1152	0.1431
Leishmania major	hypothetical protein, conserved	0.0101	0.0387	0.2493
Loa Loa (eye worm)	hypothetical protein	0.014	0.0594	0.0735
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0096	0.0359	0.0863
Toxoplasma gondii	LsmAD domain-containing protein	0.0101	0.0387	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0096	0.0359	0.0441
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0037	0.0049	0.1129
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0084	0.0295	0.8382
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0246	0.1152	0.1431
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0096	0.0359	0.0354
Schistosoma mansoni	nuclear hormone receptor	0.0105	0.041	0.0405
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0042	0.0075	0.0257
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0246	0.1152	0.1431
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0093	0.0344	0.3034
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0096	0.0359	0.1333
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.005	0.012	0.0576
Entamoeba histolytica	hypothetical protein	0.0038	0.0056	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0039	0.0042
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0246	0.1152	0.1431
Trypanosoma brucei	trypanothione reductase	0.0037	0.0046	0.0052
Echinococcus granulosus	FTZ F1 alpha	0.0246	0.1152	0.4278
Loa Loa (eye worm)	hypothetical protein	0.0105	0.041	0.0505
Plasmodium falciparum	ataxin-2 like protein, putative	0.0101	0.0387	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0039	0.0042
Schistosoma mansoni	hypothetical protein	0.0045	0.0092	0.0087
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0105	0.041	0.0505
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0037	0.0049	0.0105
Toxoplasma gondii	hypothetical protein	0.0048	0.0108	0.268
Loa Loa (eye worm)	MBCTL1	0.0053	0.0134	0.016
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0084	0.0295	0.2543
Loa Loa (eye worm)	hypothetical protein	0.0246	0.1152	0.1431
Loa Loa (eye worm)	glutathione reductase	0.0037	0.0046	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0105	0.041	0.0505
Brugia malayi	steroid hormone receptor	0.0246	0.1152	0.1431
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0105	0.041	0.1523
Brugia malayi	Nuclear hormone receptor-like 1	0.014	0.0594	0.0735
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.0099	0.0094
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0039	0.0034
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0246	0.1152	0.1147
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0099	0.0117
Onchocerca volvulus	Bile acid receptor homolog	0.1544	0.8018	1
Schistosoma mansoni	nuclear receptor	0.0105	0.041	0.0405
Brugia malayi	mbt repeat family protein	0.0047	0.0099	0.0117
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.018	0.0175
Loa Loa (eye worm)	thioredoxin reductase	0.0037	0.0046	0.0051
Schistosoma mansoni	sex comb on midleg homolog	0.0047	0.0099	0.0094
Brugia malayi	nuclear receptor RXR	0.0105	0.041	0.0505
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0037	0.0049	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0105	0.041	0.0505
Brugia malayi	hypothetical protein	0.014	0.0594	0.0735
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0039	0.0042
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0093	0.0344	0.3034
Mycobacterium ulcerans	hypothetical protein	0.0157	0.0686	1
Echinococcus granulosus	tar DNA binding protein	0.0062	0.018	0.067
Trypanosoma brucei	protein kinase, putative	0.005	0.012	0.0576
Schistosoma mansoni	thyroid hormone receptor	0.0246	0.1152	0.1147
Loa Loa (eye worm)	hypothetical protein	0.1544	0.8018	1
Echinococcus multilocularis	FTZ F1 alpha	0.0246	0.1152	0.28
Onchocerca volvulus		0.0035	0.0039	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0246	0.1152	0.1431
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.012	0.0783
Mycobacterium tuberculosis	Probable oxidoreductase	0.0093	0.0344	0.3034
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.018	0.0175
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0105	0.041	0.0505
Loa Loa (eye worm)	steroid hormone receptor	0.0246	0.1152	0.1431
Brugia malayi	nuclear receptor NHR-88	0.0246	0.1152	0.1431
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0039	0.0082
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0053	0.0134	0.0128
Echinococcus granulosus	thioredoxin glutathione reductase	0.0037	0.0049	0.0182
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0042	0.0075	0.0257
Schistosoma mansoni	nuclear receptor	0.0105	0.041	0.0405
Echinococcus granulosus	mitogen activated protein kinase	0.005	0.012	0.0444
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0246	0.1152	0.1431
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.005	0.012	0.0576
Toxoplasma gondii	thioredoxin reductase	0.0037	0.0046	0.1071
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0037	0.0049	0.0068
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0246	0.1152	0.1431
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0246	0.1152	0.1147
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.018	0.0427
Schistosoma mansoni	hypothetical protein	0.0291	0.1392	0.1387
Loa Loa (eye worm)	hypothetical protein	0.0105	0.041	0.0505
Brugia malayi	hypothetical protein	0.014	0.0594	0.0735
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0246	0.1152	0.28
Loa Loa (eye worm)	hypothetical protein	0.0105	0.041	0.0505
Toxoplasma gondii	exonuclease III APE	0.0037	0.0049	0.1129
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0299	0.1434	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0246	0.1152	0.1431
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0037	0.0049	0.0068
Schistosoma mansoni	hypothetical protein	0.0038	0.0056	0.005
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.005	0.012	0.2988
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0047	0.0099	0.0094
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.005	0.012	0.0576
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0246	0.1152	0.4278
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0246	0.1152	0.1431
Loa Loa (eye worm)	hypothetical protein	0.014	0.0594	0.0735
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0246	0.1152	0.28
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0105	0.041	0.0988
Mycobacterium tuberculosis	Probable reductase	0.0084	0.0295	0.2543
Leishmania major	trypanothione reductase	0.0037	0.0046	0.0052
Plasmodium vivax	glutathione reductase, putative	0.0037	0.0046	0.1071
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0096	0.0359	0.0441
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0039	0.0042
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0039	0.0042
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.018	0.0175
Brugia malayi	nuclear receptor NHR-67	0.0105	0.041	0.0505
Brugia malayi	tailless protein	0.0105	0.041	0.0505
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0142	0.0601	0.4029
Echinococcus multilocularis	geminin	0.0537	0.2693	0.6564
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0191	0.0864	0.321
Trichomonas vaginalis	ap endonuclease, putative	0.0037	0.0049	0.0092
Onchocerca volvulus		0.0047	0.0099	0.0117
Echinococcus granulosus	thyroid hormone receptor alpha	0.0105	0.041	0.1523
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0039	0.0042
Loa Loa (eye worm)	hypothetical protein	0.014	0.0594	0.0735
Echinococcus multilocularis	mitogen activated protein kinase 3	0.005	0.012	0.0278
Brugia malayi	conserved hypotetical protein	0.0105	0.041	0.0505
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0053	0.0134	0.016
Brugia malayi	Nuclear hormone receptor-like 1	0.014	0.0594	0.0735
Onchocerca volvulus		0.0105	0.041	0.0505
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0246	0.1152	0.1147
Trypanosoma cruzi	PAB1-binding protein , putative	0.0101	0.0387	0.2493
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0246	0.1152	0.4278
Schistosoma mansoni	ap endonuclease	0.0037	0.0049	0.0043
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0246	0.1152	0.28
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0105	0.041	0.1523
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0134	0.016
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0246	0.1152	0.1431
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0202	0.0919	0.114
Echinococcus granulosus	polycomb protein SCMH1	0.0047	0.0099	0.0369
Onchocerca volvulus		0.0035	0.0039	0.0042
Loa Loa (eye worm)	DR-78	0.0105	0.041	0.0505
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.005	0.012	0.0576
Loa Loa (eye worm)	hypothetical protein	0.014	0.0594	0.0735
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0246	0.1152	0.1431
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.018	0.0218
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0246	0.1152	0.28
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0084	0.0295	0.2543
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0084	0.0295	0.2543
Entamoeba histolytica	hypothetical protein	0.0038	0.0056	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.0056	0.0122
Brugia malayi	hypothetical protein	0.0101	0.0387	0.0476
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0045	0.0092	0.0343
Onchocerca volvulus		0.0105	0.041	0.0505
Echinococcus multilocularis	nuclear receptor nhr 48	0.0105	0.041	0.0988
Entamoeba histolytica	hypothetical protein	0.0038	0.0056	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0246	0.1152	0.1147
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0051	0.0124	0.0606
Onchocerca volvulus		0.0035	0.0039	0.0042
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.018	0.0175
Schistosoma mansoni	hypothetical protein	0.0537	0.2693	0.2688
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0246	0.1152	0.28
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0299	0.1434	1
Loa Loa (eye worm)	hypothetical protein	0.0246	0.1152	0.1431
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.018	0.0218
Brugia malayi	hypothetical protein	0.0105	0.041	0.0505
Onchocerca volvulus		0.0246	0.1152	0.1431
Brugia malayi	nuclear receptor NHR-88	0.0105	0.041	0.0505
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0047	0.0099	0.0229
Brugia malayi	exodeoxyribonuclease III family protein	0.0037	0.0049	0.0054
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.014	0.0594	0.0589
Schistosoma mansoni	retinoic acid receptor RXR	0.0246	0.1152	0.1147
Loa Loa (eye worm)	hypothetical protein	0.0246	0.1152	0.1431
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0387	0.0476
Trypanosoma cruzi	trypanothione reductase, putative	0.0037	0.0046	0.0052
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0037	0.0049	0.0068
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0246	0.1152	0.4278
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0037	0.0049	0.0068
Plasmodium vivax	thioredoxin reductase, putative	0.0037	0.0046	0.1071
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.014	0.0594	0.0589
Giardia lamblia	Kinase, CMGC MAPK	0.005	0.012	1
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0246	0.1152	0.1431
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0039	0.0146
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0191	0.0864	0.2098
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0246	0.1152	0.4278
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0053	0.0134	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0105	0.041	0.0505
Loa Loa (eye worm)	mbt repeat family protein	0.0047	0.0099	0.0117
Loa Loa (eye worm)	hypothetical protein	0.0105	0.041	0.0505
Loa Loa (eye worm)	hypothetical protein	0.0105	0.041	0.0505
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0105	0.041	0.0988
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.018	0.0218
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.012	0.0783
Brugia malayi	beta-lactamase family protein	0.0035	0.0039	0.0042
Toxoplasma gondii	ABC1 family protein	0.0035	0.0039	0.088
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.0056	0.0207
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0105	0.041	0.0988
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0096	0.0359	0.0354
Schistosoma mansoni	thyroid hormone receptor	0.0246	0.1152	0.1147
Echinococcus granulosus	mitogen activated protein kinase 3	0.005	0.012	0.0444
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0039	0.0042
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0246	0.1152	0.1147
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.005	0.012	0.0576
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0039	0.0042
Schistosoma mansoni	zinc finger protein	0.0105	0.041	0.0405
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0105	0.041	0.0405
Loa Loa (eye worm)	hypothetical protein	0.0105	0.041	0.0505
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0246	0.1152	0.1431
Trichomonas vaginalis	CMGC family protein kinase	0.005	0.012	0.0783

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	10.4179 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (binding)	28.1838 uM	PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	29.9349 uM	PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	39.8107 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	75.6863 uM	PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1471966

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1329086