Detailed information for compound 1329360

Basic information

Technical information
  • TDR Targets ID: 1329360
  • Name: N-[2-chloro-5-(dimethylsulfamoyl)phenyl]-2-py rrolidin-1-ylacetamide
  • MW: 345.845 | Formula: C14H20ClN3O3S
  • H donors: 1 H acceptors: 3 LogP: 1.43 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(S(=O)(=O)c1ccc(c(c1)NC(=O)CN1CCCC1)Cl)C
  • InChi: 1S/C14H20ClN3O3S/c1-17(2)22(20,21)11-5-6-12(15)13(9-11)16-14(19)10-18-7-3-4-8-18/h5-6,9H,3-4,7-8,10H2,1-2H3,(H,16,19)
  • InChiKey: FZXACDJFYNZVBL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2-chloro-5-(dimethylsulfamoyl)phenyl]-2-pyrrolidin-1-yl-acetamide
  • N-[2-chloro-5-(dimethylsulfamoyl)phenyl]-2-1-pyrrolidinylacetamide
  • N-[2-chloro-5-(dimethylsulfamoyl)phenyl]-2-pyrrolidin-1-yl-ethanamide
  • T0517-3655

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0042 0.0612 0.0816
Loa Loa (eye worm) hypothetical protein 0.002 0.0179 0.0153
Loa Loa (eye worm) hypothetical protein 0.002 0.0179 0.0153
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0486 0.0485
Brugia malayi Serotonin receptor 0.0034 0.0457 0.0595
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0034 0.0457 0.0457
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.0457 0.0457
Brugia malayi hypothetical protein 0.0021 0.0186 0.0211
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0234 0.0354
Mycobacterium ulcerans formate hydrogenlyase HycD 0.0041 0.0589 0.0954
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0141 0.2625 0.4652
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0292 0.567 1
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0228 0.0271
Schistosoma mansoni hypothetical protein 0.0014 0.0053 0.0053
Trichomonas vaginalis glucosylceramidase, putative 0.0289 0.5601 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0192 0.3644 0.3893
Brugia malayi Cytochrome P450 family protein 0.0023 0.0228 0.0271
Schistosoma mansoni tar DNA-binding protein 0.026 0.502 0.502
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0042 0.0612 0.0816
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0179 0.0201
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0486 0.1736
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0179 0.0201
Echinococcus granulosus lysine specific histone demethylase 1A 0.0021 0.0186 0.0186
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.1868 0.1976
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0186 0.0255
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.0457 0.0457
Echinococcus granulosus hypothetical protein 0.0034 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0453
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.3644 0.3644
Brugia malayi hypothetical protein 0.0017 0.0105 0.0096
Schistosoma mansoni opsin-like receptor 0.0034 0.0457 0.0457
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0974 0.1329
Schistosoma mansoni amine oxidase 0.0021 0.0186 0.0186
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0974 0.0974
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0457 0.0457
Echinococcus multilocularis 0.0014 0.0053 0.0053
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0042 0.0612 0.0612
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0974 0.1639
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0192 0.3644 0.3644
Loa Loa (eye worm) TAR-binding protein 0.026 0.502 0.5378
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0141 0.2625 0.4652
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0179 0.0201
Onchocerca volvulus 0.0034 0.0457 0.118
Echinococcus granulosus neuropeptides capa receptor 0.0034 0.0457 0.0457
Brugia malayi follicle stimulating hormone receptor 0.0034 0.0457 0.0595
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0179 0.0201
Schistosoma mansoni growth hormone secretagogue receptor 0.0034 0.0457 0.0457
Onchocerca volvulus 0.0034 0.0457 0.118
Schistosoma mansoni NADH dehydrogenase subunit 1 0.0041 0.0589 0.0589
Echinococcus granulosus dro:myosuppressin receptor 0.0034 0.0457 0.0457
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0179 0.0179
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0453
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0179 0.0201
Echinococcus granulosus nmda type glutamate receptor 0.0027 0.0311 0.0311
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0179 0.0179
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0453
Schistosoma mansoni hypothetical protein 0.0033 0.0434 0.0434
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0179 0.0179
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0453
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0453
Loa Loa (eye worm) hypothetical protein 0.0472 0.9302 1
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0141 0.2625 0.3671
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0486 0.0807
Onchocerca volvulus 0.0034 0.0457 0.118
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0486 0.0807
Echinococcus granulosus NADH dehydrogenase subunit 1 0.0151 0.2811 0.2811
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0453
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.3644 0.3644
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0179 0.0179
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0179 0.0179
Schistosoma mansoni neuropeptide receptor 0.0034 0.0457 0.0457
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0179 0.0179
Entamoeba histolytica hypothetical protein 0.004 0.0571 0.2063
Loa Loa (eye worm) hypothetical protein 0.0363 0.7087 0.7609
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.0457 0.0457
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0179 0.0179
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0179 0.0201
Brugia malayi Serotonin receptor 0.0034 0.0457 0.0595
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0363 0.7087 1
Schistosoma mansoni neuropeptide receptor 0.0034 0.0457 0.0457
Echinococcus multilocularis G-protein coupled receptor, putative 0.0034 0.0457 0.0457
Schistosoma mansoni thyroid hormone receptor 0.002 0.0179 0.0179
Onchocerca volvulus 0.0034 0.0457 0.118
Schistosoma mansoni amine GPCR 0.0034 0.0457 0.0457
Entamoeba histolytica hypothetical protein 0.004 0.0571 0.2063
Brugia malayi RNA, U transporter 1 0.0081 0.1396 0.1927
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0571 0.0571
Brugia malayi NADH dehydrogenase subunit 1, identical 0.0041 0.0589 0.0783
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0453
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0288 0.0356
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0434 0.0434
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0974 0.0974
Onchocerca volvulus Huntingtin homolog 0.0125 0.2291 0.6332
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0179 0.0179
Plasmodium falciparum protoporphyrinogen oxidase 0.0021 0.0186 0.0771
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.1868 0.2597
Loa Loa (eye worm) hypothetical protein 0.002 0.0179 0.0153
Schistosoma mansoni coup transcription factor 0.002 0.0179 0.0179
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0034 0.0457 0.0595
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0027 0.0311 0.0311
Onchocerca volvulus 0.0092 0.1636 0.4493
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0974 0.177
Schistosoma mansoni adenoreceptor 0.0034 0.0457 0.0457
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.3596 0.6397
Brugia malayi amine oxidase, flavin-containing family protein 0.0021 0.0186 0.0211
Brugia malayi hypothetical protein 0.0034 0.0457 0.0595
Brugia malayi Glycosyl hydrolases family 31 protein 0.016 0.2996 0.4198
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0042 0.0612 0.0621
Leishmania major C-8 sterol isomerase-like protein 0.0363 0.7087 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0302 0.5871 0.6297
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0434 0.0563
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0179 0.0201
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0192 0.3644 0.3644
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0342 0.0432
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0179 0.0153
Loa Loa (eye worm) G-protein coupled receptor 0.0034 0.0457 0.0453
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0141 0.2625 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0453
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0486 0.0807
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.0457 0.0457
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0179 0.0153
Loa Loa (eye worm) hypothetical protein 0.0472 0.9302 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0034 0.0457 0.118
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0021 0.0186 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0034 0.0457 0.0457
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0179 0.0179
Echinococcus granulosus 7tm_1 domain containing protein 0.0034 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0104 0.1868 0.1976
Brugia malayi RNA recognition motif domain containing protein 0.026 0.502 0.7068
Schistosoma mansoni myosin xvIII 0.0034 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0453
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0179 0.0398
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0486 0.0807
Loa Loa (eye worm) hypothetical protein 0.002 0.0179 0.0153
Brugia malayi Cytochrome P450 family protein 0.0052 0.0815 0.1104
Leishmania major cytochrome p450-like protein 0.0023 0.0228 0.0271
Echinococcus granulosus fmrfamide receptor 0.0034 0.0457 0.0457
Schistosoma mansoni hypothetical protein 0.0012 0.0003 0.0003
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.0457 0.0457
Echinococcus granulosus orexin receptor type 2 0.0034 0.0457 0.0457
Echinococcus granulosus snurportin 1 0.0302 0.5871 0.5871
Trypanosoma brucei C-8 sterol isomerase, putative 0.0363 0.7087 1
Onchocerca volvulus 0.0034 0.0457 0.118
Onchocerca volvulus 0.0034 0.0457 0.118
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0974 0.0974
Brugia malayi Importin beta-1 subunit 0.0028 0.0342 0.0432
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0453
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0141 0.2625 0.4652
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0486 0.4668
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0034 0.0457 0.0457
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.3596 0.6397
Plasmodium vivax importin-beta 2, putative 0.0028 0.0342 0.4149
Echinococcus multilocularis dnaJ subfamily B 0.0451 0.8871 0.8871
Loa Loa (eye worm) hypothetical protein 0.0125 0.2291 0.2432
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0019 0.0159 0.0189
Loa Loa (eye worm) hypothetical protein 0.002 0.0179 0.0153
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0034 0.0457 0.0457
Echinococcus granulosus g protein coupled receptor 0.0034 0.0457 0.0457
Echinococcus granulosus biogenic amine 5HT receptor 0.0034 0.0457 0.0457
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0457 0.0457
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0021 0.0186 0.0771
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0034 0.0457 0.0457
Schistosoma mansoni cytochrome P450 0.0014 0.0053 0.0053
Echinococcus multilocularis allatostatin A receptor 0.0034 0.0457 0.0457
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0034 0.0457 0.0453
Toxoplasma gondii exonuclease III APE 0.0019 0.015 0.1048
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0014 0.0053 0.0023
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0453
Schistosoma mansoni tar DNA-binding protein 0.026 0.502 0.502
Brugia malayi ecdysteroid receptor 0.002 0.0179 0.0201
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0003 0.0003
Loa Loa (eye worm) NADH dehydrogenase subunit 1 0.0041 0.0589 0.0596
Onchocerca volvulus Huntingtin homolog 0.0125 0.2291 0.6332
Onchocerca volvulus 0.0034 0.0457 0.118
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0021 0.0186 0.0186
Echinococcus granulosus neuropeptides capa receptor 0.0034 0.0457 0.0457
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.1204 0.1655
Brugia malayi hypothetical protein 0.0034 0.0457 0.0595
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0453
Schistosoma mansoni hypothetical protein 0.0071 0.1204 0.1204
Onchocerca volvulus 0.0034 0.0457 0.118
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0453
Loa Loa (eye worm) hypothetical protein 0.0125 0.2291 0.2432
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0272 0.5255 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0453
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0141 0.2625 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.016 0.2996 0.3194
Echinococcus granulosus neuropeptide receptor A26 0.0034 0.0457 0.0457
Schistosoma mansoni neuropeptide receptor 0.0034 0.0457 0.0457
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0034 0.0457 0.0457
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0019 0.0159 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0228 0.0206
Echinococcus multilocularis neuropeptide s receptor 0.0034 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0453
Entamoeba histolytica hypothetical protein 0.004 0.0571 0.2063
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0141 0.2625 0.4652
Brugia malayi TAR-binding protein 0.026 0.502 0.7068
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0289 0.5601 0.7892
Brugia malayi GnHR receptor homolog 0.0034 0.0457 0.0595
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0141 0.2625 1
Brugia malayi Melatonin receptor type 1A 0.0034 0.0457 0.0595
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0486 0.0486
Schistosoma mansoni cpg binding protein 0.0033 0.0446 0.0446
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0179 0.0201
Echinococcus granulosus lysine specific histone demethylase 1A 0.0021 0.0186 0.0186
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0034 0.0457 0.0457
Loa Loa (eye worm) melatonin receptor type 1A 0.0034 0.0457 0.0453
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0457 0.0457
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0019 0.0159 0.0204
Loa Loa (eye worm) hypothetical protein 0.0021 0.0186 0.0161
Brugia malayi hypothetical protein 0.0034 0.0457 0.0595
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0453
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.3596 0.6397
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0486 0.0807
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0034 0.0457 0.0453
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0179 0.0201
Brugia malayi G-protein coupled receptor 0.0034 0.0457 0.0595
Schistosoma mansoni tar DNA-binding protein 0.026 0.502 0.502
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0342 0.0342
Trichomonas vaginalis glucosylceramidase, putative 0.02 0.3802 0.6767
Schistosoma mansoni thyroid hormone receptor 0.002 0.0179 0.0179
Brugia malayi hypothetical protein 0.0034 0.0457 0.0595
Echinococcus granulosus sex peptide receptor 0.0034 0.0457 0.0457
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.3596 0.6397
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0453
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0034 0.0457 0.0457
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0034 0.0457 0.0457
Toxoplasma gondii histone lysine-specific demethylase 0.0021 0.0186 0.1432
Echinococcus granulosus tm gpcr rhodopsin 0.0034 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0021 0.0186 0.0161
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0021 0.0186 0.0236
Brugia malayi hypothetical protein 0.0026 0.0288 0.0356
Schistosoma mansoni amine GPCR 0.0034 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0033 0.0434 0.0428
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0974 0.1639
Echinococcus multilocularis 0.0021 0.0186 0.0186
Echinococcus multilocularis GPCR, family 2 0.0033 0.0434 0.0434
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0034 0.0457 0.0457
Brugia malayi RE15519p 0.0034 0.0457 0.0595
Echinococcus granulosus g-protein coupled receptor 0.0034 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0185 0.351 0.3748
Onchocerca volvulus 0.0034 0.0457 0.118
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.3596 0.6397
Mycobacterium tuberculosis Possible formate hydrogenlyase HycD (FHL) 0.0041 0.0589 0.103
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0453
Onchocerca volvulus 0.0034 0.0457 0.118
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0179 0.0179
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0021 0.0186 0.0186
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0179 0.0179
Loa Loa (eye worm) TYRA-2 protein 0.0034 0.0457 0.0453
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0453
Echinococcus multilocularis neuropeptide FF receptor 2 0.0034 0.0457 0.0457
Schistosoma mansoni hypothetical protein 0.0033 0.0434 0.0434
Brugia malayi hypothetical protein 0.0034 0.0457 0.0595
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0434 0.0563
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0034 0.0457 0.0595
Echinococcus multilocularis nmda type glutamate receptor 0.0027 0.0311 0.0311
Leishmania major cytochrome p450-like protein 0.0014 0.0053 0.0023
Echinococcus granulosus cpg binding protein 0.0033 0.0446 0.0446
Echinococcus multilocularis neuropeptide receptor 0.0034 0.0457 0.0457
Echinococcus multilocularis fmrfamide receptor 0.0034 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0453
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0021 0.0186 0.0186
Echinococcus multilocularis g protein coupled receptor 0.0034 0.0457 0.0457
Echinococcus granulosus tar DNA binding protein 0.026 0.502 0.502
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0003 0.0003
Echinococcus multilocularis g protein coupled receptor 0.0034 0.0457 0.0457
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0042 0.0612 0.0816
Schistosoma mansoni hypothetical protein 0.0034 0.0457 0.0457
Brugia malayi hypothetical protein 0.0034 0.0457 0.0595
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0021 0.0186 0.0771
Brugia malayi Cytochrome P450 family protein 0.0023 0.0228 0.0271
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0192 0.3644 0.3644
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0179 0.0179
Brugia malayi Dopamine receptor protein 1 0.0034 0.0457 0.0595
Echinococcus multilocularis neuropeptides capa receptor 0.0034 0.0457 0.0457
Echinococcus multilocularis somatostatin receptor 0.0034 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0453
Brugia malayi G protein-coupled receptor 0.0034 0.0457 0.0595
Leishmania major cytochrome p450-like protein 0.0014 0.0053 0.0023
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0034 0.0457 0.0457
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0179 0.0179
Brugia malayi putative neuropeptide receptor NPR1 0.0034 0.0457 0.0595
Echinococcus granulosus tm gpcr rhodopsin 0.0034 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0453
Echinococcus multilocularis tar DNA binding protein 0.026 0.502 0.502
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.3596 0.6397
Brugia malayi hypothetical protein 0.0041 0.0589 0.0783
Loa Loa (eye worm) hypothetical protein 0.002 0.0179 0.0153
Schistosoma mansoni neuropeptide F-like receptor 0.0034 0.0457 0.0457
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0141 0.2625 0.4652
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0486 0.0486
Brugia malayi G protein-coupled receptor F59B2.13 0.0034 0.0457 0.0595
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0141 0.2625 0.4652
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0457 0.0457
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.015 0.0204
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0179 0.0201
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0457 0.0457
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0141 0.2625 0.4945
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0292 0.567 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0342 0.0432
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0034 0.0457 0.0457
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0434 0.0428
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0034 0.0457 0.0457
Wolbachia endosymbiont of Brugia malayi NADH dehydrogenase subunit H 0.0151 0.2811 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0571 0.0571
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.002 0.0179 0.0153
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0228 0.0206
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0179 0.0179
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.1126 0.1126
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0179 0.0153
Echinococcus multilocularis fmrfamide receptor 0.0034 0.0457 0.0457
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0457 0.0457
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0021 0.0186 0.0771
Mycobacterium ulcerans NADH dehydrogenase subunit H 0.0151 0.2811 0.491
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0042 0.0612 0.1034
Trichomonas vaginalis glucosylceramidase, putative 0.0289 0.5601 1
Schistosoma mansoni alpha-glucosidase 0.0138 0.2547 0.2547
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0234 0.0279
Schistosoma mansoni nuclear hormone receptor 0.002 0.0179 0.0179
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.015 0.0161
Mycobacterium ulcerans oxidoreductase 0.0021 0.0186 0.0236
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0034 0.0457 0.0457
Brugia malayi Dopamine receptor protein 2 0.0034 0.0457 0.0595
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0034 0.0457 0.0457
Echinococcus granulosus tm gpcr rhodopsin 0.0034 0.0457 0.0457
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0186 0.0771
Brugia malayi sulfakinin receptor protein 0.0034 0.0457 0.0595
Onchocerca volvulus 0.0021 0.0186 0.0418
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0457 0.0457
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0486 0.0807
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0042 0.0612 0.1034
Echinococcus granulosus g protein coupled receptor 0.0034 0.0457 0.0457
Echinococcus granulosus cytochrome P450 2K1 0.0014 0.0053 0.0053
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0288 0.2984
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0179 0.0201
Onchocerca volvulus Glucosylceramidase homolog 0.019 0.3596 1
Entamoeba histolytica hypothetical protein 0.0023 0.0234 0.076
Brugia malayi nuclear hormone receptor 0.002 0.0179 0.0201
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0179 0.0179
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0179 0.0153
Trichomonas vaginalis glucosylceramidase, putative 0.0289 0.5601 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0234 0.0354
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0034 0.0457 0.0595
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0042 0.0612 0.0612
Schistosoma mansoni biogenic amine (5HT) receptor 0.0034 0.0457 0.0457
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.015 0.0173
Schistosoma mansoni amine GPCR 0.0034 0.0457 0.0457
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0228 0.0271
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0034 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0453
Brugia malayi G-protein coupled receptor 0.0034 0.0457 0.0595
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0342 0.3113
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0453
Echinococcus granulosus serotonin receptor 0.0034 0.0457 0.0457
Loa Loa (eye worm) G-protein coupled receptor 0.0034 0.0457 0.0453
Chlamydia trachomatis protoporphyrinogen oxidase 0.0021 0.0186 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0034 0.0457 0.0457
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0042 0.0612 0.6024
Loa Loa (eye worm) RNA binding protein 0.026 0.502 0.5378
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0034 0.0457 0.0457
Onchocerca volvulus 0.0034 0.0457 0.118
Brugia malayi CXXC zinc finger family protein 0.0032 0.0409 0.0528
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0019 0.0159 1
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0486 0.0637
Brugia malayi ORL1-like opioid receptor 0.0034 0.0457 0.0595
Schistosoma mansoni amine oxidase 0.0021 0.0186 0.0186
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.0457 0.0457
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0457 0.0457
Brugia malayi hypothetical protein 0.004 0.0571 0.0757
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0034 0.0457 0.0457
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0457 0.0457
Echinococcus granulosus lysosomal alpha glucosidase 0.016 0.2996 0.2996
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0042 0.0612 0.0816
Schistosoma mansoni tar DNA-binding protein 0.026 0.502 0.502
Brugia malayi cytochrome P450 0.0014 0.0053 0.0023
Trichomonas vaginalis glucosylceramidase, putative 0.0289 0.5601 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0186 0.0161
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.0053 0.0023
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0457 0.0457
Echinococcus granulosus alpha 1A adrenergic receptor 0.0034 0.0457 0.0457
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0179 0.0398
Loa Loa (eye worm) hypothetical protein 0.0021 0.0186 0.0161
Onchocerca volvulus Neuropeptide F receptor homolog 0.0034 0.0457 0.118
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0453
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0179 0.0179
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0034 0.0457 0.0457
Trichomonas vaginalis glucosylceramidase, putative 0.0289 0.5601 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0179 0.0153
Echinococcus granulosus neuropeptide receptor 0.0034 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0021 0.0186 0.0161
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0288 0.2984
Schistosoma mansoni alpha-1 adrenergic receptor 0.0034 0.0457 0.0457
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0228 0.0206
Loa Loa (eye worm) hypothetical protein 0.002 0.0179 0.0153
Loa Loa (eye worm) hypothetical protein 0.0028 0.0342 0.0329
Schistosoma mansoni hypothetical protein 0.0507 1 1
Leishmania major hypothetical protein, conserved 0.0026 0.0288 0.0356
Echinococcus granulosus neuropeptide Y receptor 0.0034 0.0457 0.0457
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0042 0.0612 0.0621
Schistosoma mansoni hypothetical protein 0.0507 1 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0034 0.0457 0.0457
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0042 0.0612 0.0612
Echinococcus granulosus neuropeptide FF receptor 2 0.0034 0.0457 0.0457
Echinococcus granulosus g protein coupled receptor 0.0034 0.0457 0.0457
Echinococcus multilocularis neuropeptide receptor 0.0034 0.0457 0.0457
Schistosoma mansoni cpg binding protein 0.0032 0.0409 0.0409
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0179 0.0201
Brugia malayi hypothetical protein 0.0034 0.0457 0.0595
Brugia malayi neuropeptide F receptor 0.0034 0.0457 0.0595
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0034 0.0457 0.0453
Brugia malayi hypothetical protein 0.0125 0.2291 0.3197
Echinococcus multilocularis neuropeptides capa receptor 0.0034 0.0457 0.0457
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0179 0.0201
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0434 0.0434
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0179 0.0179
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0034 0.0457 0.0457
Brugia malayi Tachykinin-like peptides receptor 99D 0.0034 0.0457 0.0595
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0453
Loa Loa (eye worm) cytochrome P450 family protein 0.0052 0.0815 0.084
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0023 0.0225 0.1851
Leishmania major importin beta-1 subunit, putative 0.0023 0.0234 0.0279
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0453
Brugia malayi hypothetical protein 0.0034 0.0457 0.0595
Echinococcus multilocularis serotonin receptor 0.0034 0.0457 0.0457
Brugia malayi neuropeptide F receptor 0.0034 0.0457 0.0595
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0486 0.0807
Mycobacterium ulcerans monoamine oxidase 0.0021 0.0186 0.0236
Echinococcus granulosus neuropeptide receptor 0.0034 0.0457 0.0457
Schistosoma mansoni amine GPCR 0.0034 0.0457 0.0457
Echinococcus multilocularis G protein coupled receptor 139 0.0034 0.0457 0.0457
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0034 0.0457 0.0457
Loa Loa (eye worm) neuropeptide F receptor 0.0034 0.0457 0.0453
Echinococcus granulosus tachykinin peptides receptor 99D 0.0034 0.0457 0.0457
Schistosoma mansoni amine GPCR 0.0034 0.0457 0.0457
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0434 0.0434
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0974 0.9923
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0179 0.0179
Schistosoma mansoni opsin-like receptor 0.0034 0.0457 0.0457
Leishmania major UDP-galactopyranose mutase 0.0021 0.0186 0.0211
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0453
Echinococcus granulosus peptide allatostatin:somatostatin 0.0034 0.0457 0.0457
Trichomonas vaginalis glucosylceramidase, putative 0.019 0.3596 0.6397
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0486 0.0637
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0453
Echinococcus granulosus neuropeptide Y receptor 0.0034 0.0457 0.0457
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0486 0.0637
Mycobacterium tuberculosis Probable NADH dehydrogenase I (chain H) NuoH (NADH-ubiquinone oxidoreductase chain H) 0.0151 0.2811 0.5302
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0034 0.0457 0.0453
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0034 0.0457 0.0457
Schistosoma mansoni biogenic amine receptor 0.0034 0.0457 0.0457
Brugia malayi Dopamine receptor 0.0034 0.0457 0.0595
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.0053 0.0023
Schistosoma mansoni hypothetical protein 0.0034 0.0457 0.0457
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0034 0.0457 0.0457
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.015 0.0161
Brugia malayi hypothetical protein 0.0034 0.0457 0.0595
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0453
Echinococcus granulosus allatostatin A receptor 0.0034 0.0457 0.0457
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0042 0.0612 0.0816
Trypanosoma brucei glucosidase, putative 0.0035 0.0486 0.0637
Brugia malayi SWIRM domain containing protein 0.0021 0.0186 0.0211
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0288 0.0356
Echinococcus multilocularis snurportin 1 0.0302 0.5871 0.5871
Brugia malayi RNA binding protein 0.026 0.502 0.7068
Schistosoma mansoni hypothetical protein 0.0034 0.0457 0.0457
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.015 0.0161
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0179 0.0153
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0034 0.0457 0.0457
Onchocerca volvulus 0.0034 0.0457 0.118
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0179 0.0179
Onchocerca volvulus 0.0034 0.0457 0.118
Onchocerca volvulus 0.0034 0.0457 0.118
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0457 0.0457
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0034 0.0457 0.0457
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.015 0.0122
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.2996 0.2996
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0974 0.1639
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0179 0.0179
Echinococcus multilocularis cpg binding protein 0.0033 0.0446 0.0446
Echinococcus multilocularis neuropeptide Y receptor 0.0034 0.0457 0.0457
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.026 0.502 0.5378
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0179 0.0179
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0486 0.0807
Schistosoma mansoni histamine h1 receptor 0.0034 0.0457 0.0457
Echinococcus multilocularis neuropeptide Y receptor 0.0034 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0453
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0453
Schistosoma mansoni neuropeptide receptor 0.0034 0.0457 0.0457
Onchocerca volvulus 0.0041 0.0589 0.1551
Echinococcus multilocularis g-protein coupled receptor 0.0034 0.0457 0.0457
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0288 0.2984
Schistosoma mansoni hypothetical protein 0.0451 0.8871 0.8871
Echinococcus multilocularis serotonin receptor 0.0034 0.0457 0.0457
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.015 0.0161
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0042 0.0612 0.2222
Schistosoma mansoni ap endonuclease 0.0019 0.015 0.015
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0179 0.0179
Brugia malayi hypothetical protein 0.0034 0.0457 0.0595
Trichomonas vaginalis glucosylceramidase, putative 0.02 0.3802 0.6767
Brugia malayi Cytochrome P450 family protein 0.0014 0.0053 0.0023
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.2996 0.2996
Schistosoma mansoni ap endonuclease 0.0019 0.015 0.015
Brugia malayi putative neuropeptide receptor 0.0034 0.0457 0.0595
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0453
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.015 0.0187
Schistosoma mansoni importin beta-1 0.0028 0.0342 0.0342
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0486 0.0637
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0179 0.0179
Onchocerca volvulus 0.0041 0.0589 0.1551
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0179 0.0153
Schistosoma mansoni opsin-like receptor 0.0034 0.0457 0.0457
Schistosoma mansoni hypothetical protein 0.0302 0.5871 0.5871
Schistosoma mansoni hypothetical protein 0.0033 0.0434 0.0434
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.015 0.0204
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0453
Brugia malayi nuclear receptor NHR-88 0.002 0.0179 0.0201
Echinococcus multilocularis orexin receptor type 2 0.0034 0.0457 0.0457
Trypanosoma cruzi UDP-galactopyranose mutase 0.0021 0.0186 0.0211
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0981 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0434 0.0434
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0034 0.0457 0.0595
Echinococcus multilocularis protoporphyrinogen oxidase 0.0021 0.0186 0.0186
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0192 0.3644 0.3644
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0457 0.0457
Schistosoma mansoni biogenic amine receptor 0.0034 0.0457 0.0457
Schistosoma mansoni hypothetical protein 0.0034 0.0457 0.0457
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0288 0.0356
Schistosoma mansoni neuropeptide f receptor 76f 0.0034 0.0457 0.0457
Echinococcus multilocularis rhodopsin orphan GPCR 0.0034 0.0457 0.0457
Echinococcus granulosus biogenic amine 5HT receptor 0.0034 0.0457 0.0457
Schistosoma mansoni biogenic amine receptor 0.0034 0.0457 0.0457
Echinococcus granulosus dnaJ subfamily B 0.0451 0.8871 0.8871
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0288 0.2533
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0141 0.2625 0.4579
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0179 0.0179
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0453
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0179 0.0201
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0192 0.3644 0.5116
Echinococcus multilocularis sex peptide receptor 0.0034 0.0457 0.0457
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.015 0.0161
Echinococcus granulosus importin subunit beta 1 0.0028 0.0342 0.0342
Echinococcus granulosus FTZ F1 alpha 0.002 0.0179 0.0179
Loa Loa (eye worm) cytochrome P450 0.0014 0.0053 0.0017
Loa Loa (eye worm) hypothetical protein 0.0071 0.1204 0.126
Echinococcus granulosus neuropeptide s receptor 0.0034 0.0457 0.0457
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0034 0.0457 0.0453
Brugia malayi larval opioid receptor 0.0034 0.0457 0.0595
Echinococcus granulosus rhodopsin orphan GPCR 0.0034 0.0457 0.0457
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0974 0.0974
Loa Loa (eye worm) neuropeptide F receptor 0.0034 0.0457 0.0453
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0571 0.0571
Echinococcus granulosus G protein coupled receptor 139 0.0034 0.0457 0.0457
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0486 0.1736
Onchocerca volvulus 0.0034 0.0457 0.118
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0021 0.0186 0.0771
Schistosoma mansoni alpha glucosidase 0.0035 0.0486 0.0486
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.015 0.0438
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0289 0.5601 0.6005
Trypanosoma cruzi UDP-galactopyranose mutase 0.0021 0.0186 0.0211
Entamoeba histolytica hypothetical protein 0.004 0.0571 0.2063
Onchocerca volvulus 0.0141 0.2625 0.7273
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0453
Echinococcus granulosus somatostatin receptor 0.0034 0.0457 0.0457
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0034 0.0457 0.0457
Schistosoma mansoni hypothetical protein 0.0033 0.0434 0.0434
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0034 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0026 0.0288 0.0271
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0014 0.0053 0.0023
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0453
Echinococcus granulosus GPCR family 2 0.0033 0.0434 0.0434
Echinococcus multilocularis geminin 0.0507 1 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0409 0.0402
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0042 0.0612 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0179 0.0179
Trichomonas vaginalis glucosylceramidase, putative 0.0289 0.5601 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0457 0.0457
Onchocerca volvulus 0.002 0.0179 0.0398
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0453
Schistosoma mansoni hypothetical protein 0.004 0.0571 0.0571
Echinococcus multilocularis g protein coupled receptor 0.0034 0.0457 0.0457
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0042 0.0612 0.0816
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0457 0.0457
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0486 0.0807
Schistosoma mansoni alpha-glucosidase 0.0138 0.2547 0.2547
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0179 0.0201
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0034 0.0457 0.0457
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0034 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0453
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0228 0.0271
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0228 0.0311
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0042 0.0612 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0034 0.0457 0.0457
Mycobacterium ulcerans dehydrogenase 0.0021 0.0186 0.0236
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0363 0.7087 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0453
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0034 0.0457 0.0457
Onchocerca volvulus 0.0032 0.0409 0.1046
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0179 0.0179
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0014 0.0053 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0179 0.0153
Echinococcus multilocularis neuropeptide receptor A26 0.0034 0.0457 0.0457
Schistosoma mansoni cpg binding protein 0.0033 0.0446 0.0446
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0034 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0453
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0453
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0141 0.2625 0.2793
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.015 0.015
Plasmodium falciparum importin beta, putative 0.0028 0.0342 0.4149
Brugia malayi steroid hormone receptor 0.002 0.0179 0.0201
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0034 0.0457 0.0457
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0179 0.0398
Loa Loa (eye worm) hypothetical protein 0.0034 0.0457 0.0453
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0186 0.0771
Mycobacterium tuberculosis Possible oxidoreductase 0.0021 0.0186 0.0255
Onchocerca volvulus 0.0034 0.0457 0.118
Schistosoma mansoni biogenic amine (5HT) receptor 0.0034 0.0457 0.0457
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0034 0.0457 0.0595
Brugia malayi NADH dehydrogenase subunit 1 0.0041 0.0589 0.0783
Echinococcus multilocularis dro:myosuppressin receptor 0.0034 0.0457 0.0457
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0179 0.0201
Brugia malayi AKH receptor 0.0034 0.0457 0.0595
Onchocerca volvulus 0.0034 0.0457 0.118
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0234 0.0354
Schistosoma mansoni hypothetical protein 0.0151 0.2811 0.2811
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0192 0.3644 0.3644
Schistosoma mansoni tar DNA-binding protein 0.026 0.502 0.502
Schistosoma mansoni neuropeptide F-like receptor 0.0034 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0021 0.0186 0.0161
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.1868 0.2597

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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