Detailed information for compound 1329444

Basic information

Technical information
  • TDR Targets ID: 1329444
  • Name: phenylmethyl (2S)-2-[[5-(3,4-dihydro-1H-isoqu inoline-2-carbonyl)1H-imidazole-4-carbonyl]am ino]propanoate
  • MW: 432.472 | Formula: C24H24N4O4
  • H donors: 2 H acceptors: 4 LogP: 2.81 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C([C@@H](NC(=O)c1[nH]cnc1C(=O)N1CCc2c(C1)cccc2)C)OCc1ccccc1
  • InChi: 1S/C24H24N4O4/c1-16(24(31)32-14-17-7-3-2-4-8-17)27-22(29)20-21(26-15-25-20)23(30)28-12-11-18-9-5-6-10-19(18)13-28/h2-10,15-16H,11-14H2,1H3,(H,25,26)(H,27,29)/t16-/m0/s1
  • InChiKey: MMCQUALYZOZDBO-INIZCTEOSA-N  

Network

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Synonyms

  • (2S)-2-[[[5-(3,4-dihydro-1H-isoquinolin-2-yl-oxomethyl)-1H-imidazol-4-yl]-oxomethyl]amino]propanoic acid phenylmethyl ester
  • (2S)-2-[[5-(3,4-dihydro-1H-isoquinoline-2-carbonyl)1H-imidazole-4-carbonyl]amino]propionic acid benzyl ester
  • phenylmethyl (2S)-2-[[5-(3,4-dihydro-1H-isoquinolin-2-ylcarbonyl)-1H-imidazol-4-yl]carbonylamino]propanoate
  • MLS000834664
  • SMR000463898

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Giardia lamblia U5 small nuclear ribonucleoprotein 200 kDa helicase, putative RecQ helicase-like 649 aa 521 aa 19.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Mycobacterium leprae Conserved hypothetical protein 0.0068 0.4312 0.5
Loa Loa (eye worm) RecQ helicase 0.0024 0.105 0.105
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0068 0.4312 1
Brugia malayi follicle stimulating hormone receptor 0.0055 0.3392 0.3392
Echinococcus granulosus fmrfamide receptor 0.0055 0.3392 0.7866
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0068 0.4312 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.105 0.2178
Brugia malayi Cytochrome P450 family protein 0.0068 0.4312 0.4312
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0068 0.4312 1
Echinococcus multilocularis orexin receptor type 2 0.0055 0.3392 0.7866
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0055 0.3392 0.7866
Echinococcus granulosus biogenic amine 5HT receptor 0.0055 0.3392 0.7866
Echinococcus granulosus biogenic amine 5HT receptor 0.0055 0.3392 0.7866
Echinococcus granulosus allatostatin A receptor 0.0055 0.3392 0.7866
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0068 0.4312 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.3392 0.7866
Brugia malayi hypothetical protein 0.0055 0.3392 0.3392
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.105 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0068 0.4312 0.4312
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0023 0.0959 0.8998
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0055 0.3392 0.7866
Brugia malayi Dopamine receptor protein 1 0.0055 0.3392 0.3392
Echinococcus granulosus neuropeptide Y receptor 0.0055 0.3392 0.7866
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.3392 0.7866
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0068 0.4312 1
Schistosoma mansoni neuropeptide receptor 0.0055 0.3392 0.7866
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.105 0.105
Echinococcus granulosus neuropeptides capa receptor 0.0055 0.3392 0.7866
Echinococcus multilocularis G-protein coupled receptor, putative 0.0055 0.3392 0.7866
Schistosoma mansoni hypothetical protein 0.0068 0.4312 1
Brugia malayi cytochrome P450 0.0068 0.4312 0.4312
Brugia malayi Serotonin receptor 0.0055 0.3392 0.3392
Echinococcus granulosus neuropeptide FF receptor 2 0.0055 0.3392 0.7866
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0068 0.4312 1
Echinococcus granulosus g protein coupled receptor 0.0055 0.3392 0.7866
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0068 0.4312 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0012 0.0142 0.033
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Brugia malayi RE15519p 0.0055 0.3392 0.3392
Brugia malayi Dopamine receptor protein 2 0.0055 0.3392 0.3392
Entamoeba histolytica recQ family DNA helicase 0.0012 0.0177 0.0381
Brugia malayi Cytochrome P450 family protein 0.0068 0.4312 0.4312
Schistosoma mansoni amine GPCR 0.0055 0.3392 0.7866
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0068 0.4312 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.3392 0.7866
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0068 0.4312 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.105 0.105
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Loa Loa (eye worm) TYRA-2 protein 0.0055 0.3392 0.3392
Brugia malayi Dopamine receptor 0.0055 0.3392 0.3392
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.3392 0.7866
Echinococcus granulosus neuropeptide receptor 0.0055 0.3392 0.7866
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0055 0.3392 0.7866
Echinococcus multilocularis dro:myosuppressin receptor 0.0055 0.3392 0.7866
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0068 0.4312 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0055 0.3392 0.7866
Echinococcus multilocularis serotonin receptor 0.0055 0.3392 0.7866
Onchocerca volvulus 0.0055 0.3392 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0055 0.3392 0.7866
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0055 0.3392 0.7866
Treponema pallidum exodeoxyribonuclease (exoA) 0.0023 0.0959 1
Loa Loa (eye worm) G-protein coupled receptor 0.0055 0.3392 0.3392
Schistosoma mansoni hypothetical protein 0.0055 0.3392 0.7866
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.3392 0.7866
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0055 0.3392 0.7866
Loa Loa (eye worm) cytochrome P450 family protein 0.0068 0.4312 0.4312
Schistosoma mansoni histamine h1 receptor 0.0055 0.3392 0.7866
Brugia malayi hypothetical protein 0.0055 0.3392 0.3392
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0055 0.3392 0.7866
Echinococcus multilocularis bloom syndrome protein 0.0024 0.105 0.2436
Schistosoma mansoni blooms syndrome DNA helicase 0.0012 0.0177 0.041
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0023 0.0959 0.2225
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0055 0.3392 0.3392
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0177 0.0083
Echinococcus granulosus G protein coupled receptor 139 0.0055 0.3392 0.7866
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0055 0.3392 0.7866
Onchocerca volvulus 0.0055 0.3392 0.5
Schistosoma mansoni biogenic amine receptor 0.0055 0.3392 0.7866
Onchocerca volvulus 0.0055 0.3392 0.5
Brugia malayi hypothetical protein 0.0055 0.3392 0.3392
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.3392 0.7866
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0055 0.3392 0.3392
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.3392 0.7866
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 1 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0055 0.3392 0.3392
Brugia malayi G protein-coupled receptor F59B2.13 0.0055 0.3392 0.3392
Onchocerca volvulus 0.0055 0.3392 0.5
Brugia malayi G protein-coupled receptor 0.0055 0.3392 0.3392
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Brugia malayi GnHR receptor homolog 0.0055 0.3392 0.3392
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0024 0.105 0.105
Schistosoma mansoni adenoreceptor 0.0055 0.3392 0.7866
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.105 0.2112
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Loa Loa (eye worm) neuropeptide F receptor 0.0055 0.3392 0.3392
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Brugia malayi G-protein coupled receptor 0.0055 0.3392 0.3392
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0055 0.3392 0.3392
Onchocerca volvulus 0.0055 0.3392 0.5
Echinococcus granulosus bloom syndrome protein 0.0024 0.105 0.2436
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0068 0.4312 1
Echinococcus granulosus g protein coupled receptor 0.0055 0.3392 0.7866
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Echinococcus multilocularis neuropeptide receptor A26 0.0055 0.3392 0.7866
Schistosoma mansoni neuropeptide F-like receptor 0.0055 0.3392 0.7866
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0024 0.105 0.2436
Echinococcus granulosus peptide allatostatin:somatostatin 0.0055 0.3392 0.7866
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0068 0.4312 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0055 0.3392 0.5
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0068 0.4312 1
Brugia malayi putative neuropeptide receptor NPR1 0.0055 0.3392 0.3392
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.3392 0.7866
Schistosoma mansoni alpha-1 adrenergic receptor 0.0055 0.3392 0.7866
Schistosoma mansoni cytochrome P450 0.0068 0.4312 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0023 0.0959 0.2225
Schistosoma mansoni hypothetical protein 0.0055 0.3392 0.7866
Entamoeba histolytica recQ family helicase, putative 0.0024 0.105 1
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0068 0.4312 1
Echinococcus granulosus hypothetical protein 0.0055 0.3392 0.7866
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0055 0.3392 0.7866
Schistosoma mansoni hypothetical protein 0.0055 0.3392 0.7866
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Onchocerca volvulus 0.0055 0.3392 0.5
Onchocerca volvulus 0.0055 0.3392 0.5
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Echinococcus granulosus g-protein coupled receptor 0.0055 0.3392 0.7866
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0055 0.3392 0.7866
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Brugia malayi hypothetical protein 0.0055 0.3392 0.3392
Brugia malayi hypothetical protein 0.0055 0.3392 0.3392
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.3392 0.7866
Brugia malayi hypothetical protein 0.0055 0.3392 0.3392
Echinococcus granulosus tm gpcr rhodopsin 0.0055 0.3392 0.7866
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.3392 0.7866
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.3392 0.7866
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.3392 0.7866
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0068 0.4312 1
Echinococcus multilocularis serotonin receptor 0.0055 0.3392 0.7866
Leishmania major cytochrome p450-like protein 0.0068 0.4312 1
Brugia malayi Serotonin receptor 0.0055 0.3392 0.3392
Echinococcus multilocularis g-protein coupled receptor 0.0055 0.3392 0.7866
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0068 0.4312 1
Echinococcus multilocularis G protein coupled receptor 139 0.0055 0.3392 0.7866
Echinococcus granulosus neuropeptide Y receptor 0.0055 0.3392 0.7866
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0068 0.4312 1
Brugia malayi larval opioid receptor 0.0055 0.3392 0.3392
Mycobacterium leprae putative cytochrome p450 0.0068 0.4312 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.3392 0.7866
Loa Loa (eye worm) cytochrome P450 0.0068 0.4312 0.4312
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0055 0.3392 0.3392
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Echinococcus granulosus orexin receptor type 2 0.0055 0.3392 0.7866
Schistosoma mansoni amine GPCR 0.0055 0.3392 0.7866
Schistosoma mansoni biogenic amine (5HT) receptor 0.0055 0.3392 0.7866
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Loa Loa (eye worm) transcription factor SMAD2 0.0144 1 1
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0068 0.4312 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.3392 0.7866
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0068 0.4312 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.3392 0.7866
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0055 0.3392 0.3392
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0068 0.4312 1
Echinococcus multilocularis neuropeptides capa receptor 0.0055 0.3392 0.7866
Schistosoma mansoni neuropeptide f receptor 76f 0.0055 0.3392 0.7866
Onchocerca volvulus 0.0055 0.3392 0.5
Brugia malayi hypothetical protein 0.0055 0.3392 0.3392
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0068 0.4312 1
Onchocerca volvulus 0.0055 0.3392 0.5
Schistosoma mansoni neuropeptide receptor 0.0055 0.3392 0.7866
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Loa Loa (eye worm) melatonin receptor type 1A 0.0055 0.3392 0.3392
Brugia malayi Cytochrome P450 family protein 0.0068 0.4312 0.4312
Echinococcus multilocularis neuropeptide Y receptor 0.0055 0.3392 0.7866
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0055 0.3392 0.7866
Echinococcus granulosus neuropeptides capa receptor 0.0055 0.3392 0.7866
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Schistosoma mansoni biogenic amine receptor 0.0055 0.3392 0.7866
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0068 0.4312 1
Brugia malayi ORL1-like opioid receptor 0.0055 0.3392 0.3392
Brugia malayi Melatonin receptor type 1A 0.0055 0.3392 0.3392
Brugia malayi exodeoxyribonuclease III family protein 0.0023 0.0959 0.0959
Toxoplasma gondii exonuclease III APE 0.0023 0.0959 0.1959
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0055 0.3392 0.7866
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0068 0.4312 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Schistosoma mansoni neuropeptide receptor 0.0055 0.3392 0.7866
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.3392 0.7866
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0055 0.3392 0.3392
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.3392 0.7866
Echinococcus multilocularis g protein coupled receptor 0.0055 0.3392 0.7866
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0068 0.4312 1
Onchocerca volvulus 0.0055 0.3392 0.5
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.105 0.0271
Echinococcus granulosus alpha 1A adrenergic receptor 0.0055 0.3392 0.7866
Echinococcus granulosus neuropeptide receptor A26 0.0055 0.3392 0.7866
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.3392 0.7866
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Echinococcus granulosus tachykinin peptides receptor 99D 0.0055 0.3392 0.7866
Echinococcus granulosus sex peptide receptor 0.0055 0.3392 0.7866
Echinococcus granulosus serotonin receptor 0.0055 0.3392 0.7866
Echinococcus multilocularis neuropeptide FF receptor 2 0.0055 0.3392 0.7866
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0024 0.105 1
Trypanosoma cruzi cytochrome P450, putative 0.0068 0.4312 1
Brugia malayi neuropeptide F receptor 0.0055 0.3392 0.3392
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0024 0.105 0.2436
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Echinococcus multilocularis neuropeptides capa receptor 0.0055 0.3392 0.7866
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0055 0.3392 0.7866
Schistosoma mansoni biogenic amine (5HT) receptor 0.0055 0.3392 0.7866
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0068 0.4312 1
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0068 0.4312 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.3392 0.7866
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0023 0.0959 0.0959
Loa Loa (eye worm) hypothetical protein 0.0012 0.0177 0.0177
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0068 0.4312 1
Echinococcus multilocularis g protein coupled receptor 0.0055 0.3392 0.7866
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.3392 0.7866
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0068 0.4312 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.3392 0.7866
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0024 0.105 0.2436
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0023 0.0959 0.1892
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0055 0.3392 0.7866
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0068 0.4312 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0055 0.3392 0.7866
Brugia malayi sulfakinin receptor protein 0.0055 0.3392 0.3392
Schistosoma mansoni amine GPCR 0.0055 0.3392 0.7866
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.105 1
Leishmania major cytochrome p450-like protein 0.0068 0.4312 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0055 0.3392 0.7866
Onchocerca volvulus 0.0055 0.3392 0.5
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0068 0.4312 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0068 0.4312 1
Schistosoma mansoni opsin-like receptor 0.0055 0.3392 0.7866
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0068 0.4312 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0055 0.3392 0.7866
Schistosoma mansoni hypothetical protein 0.0055 0.3392 0.7866
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0055 0.3392 0.7866
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0068 0.4312 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.3392 0.7866
Schistosoma mansoni growth hormone secretagogue receptor 0.0055 0.3392 0.7866
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Echinococcus multilocularis neuropeptide receptor 0.0055 0.3392 0.7866
Onchocerca volvulus 0.0055 0.3392 0.5
Schistosoma mansoni myosin xvIII 0.0055 0.3392 0.7866
Schistosoma mansoni amine GPCR 0.0055 0.3392 0.7866
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Loa Loa (eye worm) cytochrome P450 family protein 0.0068 0.4312 0.4312
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.105 1
Trypanosoma cruzi cytochrome P450, putative 0.0068 0.4312 1
Schistosoma mansoni neuropeptide receptor 0.0055 0.3392 0.7866
Onchocerca volvulus 0.0055 0.3392 0.5
Schistosoma mansoni DNA helicase recq5 0.0024 0.105 0.2436
Echinococcus multilocularis neuropeptide receptor 0.0055 0.3392 0.7866
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.3392 0.7866
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.105 0.0271
Echinococcus granulosus 7tm_1 domain containing protein 0.0055 0.3392 0.7866
Loa Loa (eye worm) hypothetical protein 0.0012 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0068 0.4312 1
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0068 0.4312 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0024 0.105 0.105
Echinococcus multilocularis fmrfamide receptor 0.0055 0.3392 0.7866
Brugia malayi hypothetical protein 0.0055 0.3392 0.3392
Loa Loa (eye worm) CYP4Cod1 0.0068 0.4312 0.4312
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0068 0.4312 1
Schistosoma mansoni ap endonuclease 0.0023 0.0959 0.2225
Echinococcus multilocularis somatostatin receptor 0.0055 0.3392 0.7866
Onchocerca volvulus 0.0055 0.3392 0.5
Loa Loa (eye worm) G-protein coupled receptor 0.0055 0.3392 0.3392
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0023 0.0959 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Echinococcus granulosus neuropeptide receptor 0.0055 0.3392 0.7866
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0068 0.4312 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0055 0.3392 0.5
Brugia malayi G-protein coupled receptor 0.0055 0.3392 0.3392
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0055 0.3392 0.7866
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0068 0.4312 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0068 0.4312 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Echinococcus granulosus cytochrome P450 2K1 0.0068 0.4312 1
Onchocerca volvulus 0.0055 0.3392 0.5
Echinococcus multilocularis neuropeptide s receptor 0.0055 0.3392 0.7866
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Echinococcus granulosus g protein coupled receptor 0.0055 0.3392 0.7866
Giardia lamblia Sgs1 DNA helicase, putative 0.0024 0.105 1
Leishmania major cytochrome p450-like protein 0.0068 0.4312 1
Brugia malayi hypothetical protein 0.0055 0.3392 0.3392
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Brugia malayi AKH receptor 0.0055 0.3392 0.3392
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.3392 0.7866
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0068 0.4312 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Schistosoma mansoni opsin-like receptor 0.0055 0.3392 0.7866
Brugia malayi Cytochrome P450 family protein 0.0068 0.4312 0.4312
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0055 0.3392 0.7866
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0055 0.3392 0.7866
Loa Loa (eye worm) neuropeptide F receptor 0.0055 0.3392 0.3392
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0068 0.4312 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0055 0.3392 0.7866
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.105 0.105
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0055 0.3392 0.7866
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Onchocerca volvulus 0.0055 0.3392 0.5
Schistosoma mansoni amine GPCR 0.0055 0.3392 0.7866
Echinococcus granulosus neuropeptide s receptor 0.0055 0.3392 0.7866
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.3392 0.7866
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0055 0.3392 0.7866
Trypanosoma brucei cytochrome P450, putative 0.0068 0.4312 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Echinococcus multilocularis g protein coupled receptor 0.0055 0.3392 0.7866
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0068 0.4312 1
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0024 0.105 0.2436
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0068 0.4312 1
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0068 0.4312 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0055 0.3392 0.7866
Echinococcus multilocularis allatostatin A receptor 0.0055 0.3392 0.7866
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0068 0.4312 1
Echinococcus multilocularis neuropeptide Y receptor 0.0055 0.3392 0.7866
Echinococcus granulosus 7TM GPCR rhodopsin 0.0055 0.3392 0.7866
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.3392 0.7866
Echinococcus multilocularis rhodopsin orphan GPCR 0.0055 0.3392 0.7866
Schistosoma mansoni biogenic amine receptor 0.0055 0.3392 0.7866
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0055 0.3392 0.7866
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0068 0.4312 1
Schistosoma mansoni opsin-like receptor 0.0055 0.3392 0.7866
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0055 0.3392 0.3392
Toxoplasma gondii cytochrome p450 superfamily protein 0.0068 0.4312 1
Brugia malayi hypothetical protein 0.0055 0.3392 0.3392
Echinococcus multilocularis sex peptide receptor 0.0055 0.3392 0.7866
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.3392 0.7866
Schistosoma mansoni ap endonuclease 0.0023 0.0959 0.2225
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0055 0.3392 0.7866
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0023 0.0959 0.5
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.105 0.2178
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0055 0.3392 0.7866
Brugia malayi putative neuropeptide receptor 0.0055 0.3392 0.3392
Echinococcus multilocularis 0.0068 0.4312 1
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0012 0.0177 0.0423
Echinococcus multilocularis fmrfamide receptor 0.0055 0.3392 0.7866
Brugia malayi neuropeptide F receptor 0.0055 0.3392 0.3392
Schistosoma mansoni DNA helicase recq1 0.0024 0.105 0.2436
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0055 0.3392 0.3392
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0055 0.3392 0.3392
Onchocerca volvulus 0.0055 0.3392 0.5
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0024 0.105 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0023 0.0959 0.1892
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Echinococcus granulosus dro:myosuppressin receptor 0.0055 0.3392 0.7866
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0055 0.3392 0.7866
Schistosoma mansoni neuropeptide F-like receptor 0.0055 0.3392 0.7866
Loa Loa (eye worm) hypothetical protein 0.0055 0.3392 0.3392
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0055 0.3392 0.3392
Echinococcus granulosus somatostatin receptor 0.0055 0.3392 0.7866
Echinococcus granulosus rhodopsin orphan GPCR 0.0055 0.3392 0.7866

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0794 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 594 (Rhodamine region spectral profiling screen), 593 (Fluorescein region spectral profiling screen), 2367 (Probe Development Summary for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2353 (qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1))] ChEMBL. No reference
Potency (functional) 4.1475 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Saccharomyces cerevisiae ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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