Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.2925 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 1 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.2925 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 1 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 1 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.2925 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.2925 | 0.2925 |
Echinococcus granulosus | lamin | 0.0033 | 0.2925 | 0.2925 |
Onchocerca volvulus | 0.0033 | 0.2925 | 0.5 | |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.2925 | 0.2925 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.2821 | 0.9646 |
Echinococcus multilocularis | lamin | 0.0033 | 0.2925 | 0.2925 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 1 | 0.5 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.2925 | 0.2925 |
Onchocerca volvulus | 0.0033 | 0.2925 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.2925 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.03 | 0.1026 |
Echinococcus multilocularis | musashi | 0.0033 | 0.2925 | 0.2925 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.2925 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.0355 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 10 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (binding) | 31.6228 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.