Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0011 | 0.1036 | 0.1036 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0011 | 0.1036 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0011 | 0.1036 | 0.1036 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0011 | 0.1036 | 0.1036 |
Brugia malayi | nuclear receptor NHR-88 | 0.0011 | 0.1036 | 0.1036 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.1036 | 0.1036 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0011 | 0.1036 | 0.1036 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0011 | 0.1036 | 0.1036 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0011 | 0.1036 | 0.1036 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0011 | 0.1036 | 0.1036 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.1036 | 0.1036 |
Echinococcus granulosus | dna polymerase eta | 0.0021 | 0.3348 | 0.258 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0021 | 0.3348 | 0.3348 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0011 | 0.1036 | 0.1036 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0011 | 0.1036 | 0.1036 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 1 | 1 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0021 | 0.3348 | 1 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0007 | 0 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0021 | 0.3348 | 0.3348 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.3348 | 1 |
Plasmodium vivax | DNA repair protein REV1, putative | 0.0007 | 0 | 0.5 |
Leishmania major | DNA polymerase eta, putative | 0.0021 | 0.3348 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0015 | 0.1841 | 0.55 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.3348 | 1 |
Echinococcus multilocularis | dna polymerase kappa | 0.0021 | 0.3348 | 0.258 |
Onchocerca volvulus | 0.0011 | 0.1036 | 0.5 | |
Brugia malayi | hypothetical protein | 0.004 | 0.7544 | 0.7544 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0011 | 0.1036 | 0.1036 |
Trypanosoma brucei | unspecified product | 0.0015 | 0.1841 | 0.55 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.1036 | 0.1036 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0011 | 0.1036 | 0.1036 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.1036 | 0.1036 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0011 | 0.1036 | 0.1036 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0011 | 0.1036 | 0.1036 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.3348 | 1 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.7544 | 1 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.3348 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0015 | 0.1841 | 0.55 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0011 | 0.1036 | 0.1036 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0011 | 0.1036 | 0.1036 |
Brugia malayi | steroid hormone receptor | 0.0011 | 0.1036 | 0.1036 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.3348 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0011 | 0.1036 | 0.1036 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0011 | 0.1036 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.005 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0011 | 0.1036 | 0.1036 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.005 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.7544 | 0.7544 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0021 | 0.3348 | 0.258 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0011 | 0.1036 | 0.1036 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.1036 | 0.1036 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0011 | 0.1036 | 0.1036 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.1036 | 0.1036 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0021 | 0.3348 | 0.3348 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.3348 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.3348 | 1 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0021 | 0.3348 | 0.3348 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.1036 | 0.1036 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.1036 | 0.1036 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0021 | 0.3348 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.3348 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.0021 | 0.3348 | 0.258 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0.7544 | 0.726 |
Schistosoma mansoni | DNA polymerase eta | 0.0021 | 0.3348 | 0.3348 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.7544 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0015 | 0.1841 | 0.55 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0011 | 0.1036 | 0.1036 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0011 | 0.1036 | 0.1036 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.3348 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.0021 | 0.3348 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0021 | 0.3348 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0021 | 0.3348 | 0.5 |
Trypanosoma brucei | unspecified product | 0.0021 | 0.3348 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.3348 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.0021 | 0.3348 | 0.258 |
Schistosoma mansoni | nuclear hormone receptor | 0.0011 | 0.1036 | 0.1036 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0.3348 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0011 | 0.1036 | 0.1036 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.3348 | 0.3348 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.3348 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.1036 | 0.1036 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.1036 | 0.1036 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0007 | 0 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0011 | 0.1036 | 0.1036 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0021 | 0.3348 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.1036 | 0.1036 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0011 | 0.1036 | 0.1036 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0.7544 | 0.726 |
Brugia malayi | ecdysteroid receptor | 0.0011 | 0.1036 | 0.1036 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0021 | 0.3348 | 0.258 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0011 | 0.1036 | 0.1036 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.3348 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.3348 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.3348 | 1 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0021 | 0.3348 | 0.3348 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0011 | 0.1036 | 0.1036 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0011 | 0.1036 | 0.1036 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0011 | 0.1036 | 0.1036 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.7544 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.7544 | 0.7544 |
Schistosoma mansoni | coup transcription factor | 0.0011 | 0.1036 | 0.1036 |
Toxoplasma gondii | BRCA1 C Terminus (BRCT) domain-containing protein | 0.0007 | 0 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0011 | 0.1036 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.004 | 0.7544 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0021 | 0.3348 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0021 | 0.3348 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0021 | 0.3348 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.005 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0011 | 0.1036 | 0.1036 |
Schistosoma mansoni | thyroid hormone receptor | 0.0011 | 0.1036 | 0.1036 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0021 | 0.3348 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0021 | 0.3348 | 1 |
Trypanosoma brucei | unspecified product | 0.0015 | 0.1841 | 0.55 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.005 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0011 | 0.1036 | 0.1036 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.1036 | 0.1036 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0021 | 0.3348 | 0.5 |
Plasmodium falciparum | DNA repair protein REV1, putative | 0.0007 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0021 | 0.3348 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0011 | 0.1036 | 0.1036 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.