Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.1479 | 0.4395 |
Echinococcus multilocularis | geminin | 0.0177 | 1 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.1031 | 0.0914 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1031 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1031 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0038 | 0.1028 | 0.0911 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1031 | 0.5 |
Brugia malayi | hypothetical protein | 0.0038 | 0.1031 | 0.2209 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0062 | 0.2625 | 0.2529 |
Schistosoma mansoni | bromodomain containing protein | 0.0066 | 0.2866 | 0.2866 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1351 | 0.4014 |
Brugia malayi | Bromodomain containing protein | 0.0078 | 0.3653 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.1031 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0177 | 1 | 1 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0024 | 0.0128 | 0.0128 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.1031 | 0.1031 |
Brugia malayi | Bromodomain containing protein | 0.004 | 0.1187 | 0.2673 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.1031 | 0.1031 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0062 | 0.2625 | 0.2529 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.1031 | 0.0914 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.3366 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0038 | 0.1028 | 0.0911 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1192 | 0.3541 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 14.7157 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 16.5113 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 112.2018 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.