Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | bromodomain adjacent to zinc finger domain, 2B | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | lamin | 0.0033 | 0.2068 | 0.2432 |
Echinococcus multilocularis | musashi | 0.0033 | 0.2068 | 0.2325 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.5168 | 0.6727 |
Echinococcus granulosus | lamin | 0.0033 | 0.2068 | 0.2325 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.2068 | 0.2068 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0025 | 0.1022 | 0.1099 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0021 | 0.043 | 0.0366 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.2068 | 0.2325 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.043 | 0.0463 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.3951 | 0.4251 |
Echinococcus multilocularis | lamin | 0.0033 | 0.2068 | 0.2325 |
Loa Loa (eye worm) | bromodomain containing protein | 0.0021 | 0.0532 | 0.0572 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.2068 | 0.2325 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0021 | 0.043 | 0.0366 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.2068 | 0.2068 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0043 | 0.3548 | 0.4427 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0043 | 0.3548 | 0.4427 |
Onchocerca volvulus | 0.0033 | 0.2068 | 0.5 | |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.2068 | 0.2225 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.1986 | 0.2137 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0027 | 0.1337 | 0.151 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0021 | 0.043 | 0.0366 |
Onchocerca volvulus | 0.0033 | 0.2068 | 0.5 | |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0027 | 0.1337 | 0.1287 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.9294 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.4342 | 0.4672 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.4657 | 0.5011 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.2068 | 0.2225 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.5168 | 0.5168 |
Brugia malayi | Bromodomain containing protein | 0.0046 | 0.3939 | 0.3939 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.2068 | 0.2432 |
Schistosoma mansoni | lamin | 0.0033 | 0.2068 | 0.2432 |
Trypanosoma brucei | ISWI complex protein | 0.0018 | 0.0141 | 0.5 |
Echinococcus multilocularis | zinc finger protein | 0.0024 | 0.0847 | 0.0592 |
Echinococcus granulosus | zinc finger protein | 0.0024 | 0.0847 | 0.0592 |
Schistosoma mansoni | methyl-cpg binding protein mbd | 0.0021 | 0.043 | 0.0366 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.5168 | 0.6727 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0072 | 0.7474 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.2068 | 0.2225 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.5168 | 0.6345 |
Schistosoma mansoni | hypothetical protein | 0.0025 | 0.1022 | 0.1112 |
Brugia malayi | PHD-finger family protein | 0.003 | 0.1728 | 0.1728 |
Trypanosoma cruzi | ISWI complex protein | 0.0018 | 0.0141 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.2068 | 0.2325 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.5168 | 0.6345 |
Schistosoma mansoni | zinc finger protein | 0.0024 | 0.0847 | 0.0891 |
Trypanosoma cruzi | ISWI complex protein | 0.0018 | 0.0141 | 0.5 |
Schistosoma mansoni | bromodomain containing protein | 0.0076 | 0.8065 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.5168 | 0.6727 |
Leishmania major | hypothetical protein, conserved | 0.0018 | 0.0141 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0072 | 0.7474 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0027 | 0.1337 | 0.1287 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.5168 | 0.5561 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.5168 | 0.6727 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.5168 | 0.6345 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 2.5119 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 5.2213 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 14.1254 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Potency (functional) | 32.6427 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.