Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0266 | 0.947 | 0.947 |
Schistosoma mansoni | tar DNA-binding protein | 0.0266 | 0.947 | 0.947 |
Brugia malayi | RNA binding protein | 0.0266 | 0.947 | 0.947 |
Brugia malayi | TAR-binding protein | 0.0266 | 0.947 | 0.947 |
Brugia malayi | hypothetical protein | 0.0017 | 0.007 | 0.007 |
Trichomonas vaginalis | glutaminase, putative | 0.028 | 1 | 1 |
Trypanosoma brucei | proteasome regulatory non-ATPase subunit 11 | 0.0016 | 0.0034 | 0.078 |
Loa Loa (eye worm) | glutaminase | 0.028 | 1 | 1 |
Schistosoma mansoni | glutaminase | 0.028 | 1 | 1 |
Giardia lamblia | Non ATPase subunit MPR1 of 26S proteasome | 0.0016 | 0.0034 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0027 | 0.0432 | 1 |
Toxoplasma gondii | proteasome regulatory subunit | 0.0022 | 0.0229 | 0.531 |
Brugia malayi | hypothetical protein | 0.0027 | 0.0432 | 0.0432 |
Mycobacterium ulcerans | glutaminase | 0.028 | 1 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0266 | 0.947 | 0.947 |
Echinococcus granulosus | 26S proteasome regulatory subunit N11 | 0.0016 | 0.0034 | 0.0036 |
Plasmodium falciparum | 26S proteasome regulatory subunit RPN11, putative | 0.0022 | 0.0229 | 0.531 |
Leishmania major | proteasome regulatory non-ATP-ase subunit 11, putative,19S proteasome regulatory subunit, Metallo- peptidase, Clan MP, Family M6 | 0.0016 | 0.0034 | 0.078 |
Echinococcus multilocularis | 26S proteasome regulatory subunit N11 | 0.0016 | 0.0034 | 0.0036 |
Schistosoma mansoni | tar DNA-binding protein | 0.0266 | 0.947 | 0.947 |
Echinococcus granulosus | 26S proteasome regulatory subunit N11 | 0.0022 | 0.0229 | 0.0242 |
Echinococcus multilocularis | tar DNA binding protein | 0.0266 | 0.947 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0432 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0266 | 0.947 | 0.947 |
Loa Loa (eye worm) | TAR-binding protein | 0.0266 | 0.947 | 0.947 |
Loa Loa (eye worm) | glutaminase 2 | 0.028 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0266 | 0.947 | 0.947 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0432 | 0.0432 |
Plasmodium vivax | 26S proteasome regulatory subunit RPN11, putative | 0.0022 | 0.0229 | 0.531 |
Trypanosoma brucei | proteasome regulatory non-ATPase subunit 11 | 0.0016 | 0.0034 | 0.078 |
Loa Loa (eye worm) | proteasome 26S subunit | 0.0016 | 0.0034 | 0.0034 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0027 | 0.0432 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0016 | 0 | 0.5 |
Brugia malayi | Hypothetical 35.8 kDa protein F37A4.5 in chromosome III | 0.0022 | 0.0229 | 0.0229 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0266 | 0.947 | 0.947 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0432 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.0432 | 1 |
Loa Loa (eye worm) | 26S proteasome regulatory subunit rpn11 | 0.0022 | 0.0229 | 0.0229 |
Echinococcus granulosus | tar DNA binding protein | 0.0266 | 0.947 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.0432 | 1 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0027 | 0.0432 | 1 |
Trypanosoma cruzi | proteasome regulatory non-ATPase subunit 11, putative | 0.0016 | 0.0034 | 0.078 |
Schistosoma mansoni | tar DNA-binding protein | 0.0266 | 0.947 | 0.947 |
Brugia malayi | 26S proteasome regulatory subunit rpn11 | 0.0022 | 0.0229 | 0.0229 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0.0432 | 1 |
Entamoeba histolytica | 26S proteasome non-ATPase regulatory subunit 14, putative | 0.0022 | 0.0229 | 0.5 |
Echinococcus multilocularis | 26S proteasome regulatory subunit N11 | 0.0022 | 0.0229 | 0.0242 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (binding) | = 31.6228 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.