Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Equus caballus | Ferritin light chain | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 43.9 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 44.4 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 142 aa | 29.6 % |
Schistosoma japonicum | Ferritin, putative | Ferritin light chain | 175 aa | 144 aa | 24.3 % |
Echinococcus granulosus | expressed protein | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Echinococcus multilocularis | expressed protein | Ferritin light chain | 175 aa | 146 aa | 30.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0051 | 0.2703 | 0.7176 |
Echinococcus multilocularis | GPCR, family 2 | 0.0051 | 0.2703 | 0.7176 |
Schistosoma mansoni | hypothetical protein | 0.0111 | 0.6623 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3767 | 0.5688 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.2703 | 0.4082 |
Loa Loa (eye worm) | TAR-binding protein | 0.0067 | 0.3767 | 0.1458 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.2703 | 0.4082 |
Loa Loa (eye worm) | hypothetical protein | 0.0162 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3767 | 0.5688 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0136 | 0.8265 | 0.7622 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0136 | 0.8265 | 0.7622 |
Brugia malayi | TAR-binding protein | 0.0067 | 0.3767 | 0.1458 |
Mycobacterium tuberculosis | Bacterioferritin BfrB | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.6623 | 0.5371 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0051 | 0.2703 | 0.7176 |
Loa Loa (eye worm) | RNA binding protein | 0.0067 | 0.3767 | 0.1458 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3767 | 0.5688 |
Echinococcus granulosus | GPCR family 2 | 0.0051 | 0.2703 | 0.7176 |
Wolbachia endosymbiont of Brugia malayi | bacterioferritin/cytochrome b1 | 0.001 | 0 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0067 | 0.3767 | 1 |
Mycobacterium ulcerans | bacterioferritin BfrA | 0.001 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3767 | 0.5688 |
Brugia malayi | MH2 domain containing protein | 0.0136 | 0.8265 | 0.7622 |
Treponema pallidum | bacterioferrin (TpF1) | 0.001 | 0 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0051 | 0.2703 | 0.7176 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.2703 | 0.4082 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0067 | 0.3767 | 0.1458 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0051 | 0.2703 | 0.7176 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.2703 | 0.4082 |
Echinococcus multilocularis | tar DNA binding protein | 0.0067 | 0.3767 | 1 |
Mycobacterium tuberculosis | Probable bacterioferritin BfrA | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0067 | 0.3767 | 0.1458 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.3767 | 0.5688 |
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.001 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0162 | 1 | 1 |
Trichomonas vaginalis | ferritin, putative | 0.001 | 0 | 0.5 |
Brugia malayi | RNA binding protein | 0.0067 | 0.3767 | 0.1458 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0162 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0111 | 0.6623 | 0.5371 |
Mycobacterium ulcerans | bacterioferritin BfrB | 0.001 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (binding) | = 17.7828 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.