Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | RecQ helicase-like | Starlite/ChEMBL | No references |
Homo sapiens | glycoprotein hormones, alpha polypeptide | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Giardia lamblia | U5 small nuclear ribonucleoprotein 200 kDa helicase, putative | RecQ helicase-like | 649 aa | 521 aa | 19.8 % |
Toxoplasma gondii | intraflagellar transport protein 172, putative | glycoprotein hormones, alpha polypeptide | 116 aa | 94 aa | 26.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0012 | 0.0381 | 0.0381 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 1 | 1 |
Echinococcus granulosus | bloom syndrome protein | 0.0024 | 1 | 0.5 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0012 | 0.0381 | 0.0381 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0024 | 1 | 0.5 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0024 | 1 | 0.5 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0024 | 1 | 0.5 |
Schistosoma mansoni | DNA helicase recq5 | 0.0024 | 1 | 1 |
Loa Loa (eye worm) | RecQ helicase | 0.0024 | 1 | 1 |
Treponema pallidum | ATP-dependent DNA helicase | 0.0012 | 0.0381 | 0.5 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0024 | 1 | 0.5 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0024 | 1 | 1 |
Entamoeba histolytica | recQ family DNA helicase | 0.0012 | 0.0381 | 0.0381 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0024 | 1 | 1 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0024 | 1 | 0.5 |
Echinococcus multilocularis | bloom syndrome protein | 0.0024 | 1 | 0.5 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0024 | 1 | 0.5 |
Schistosoma mansoni | DNA helicase recq1 | 0.0024 | 1 | 1 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.0024 | 1 | 0.5 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0024 | 1 | 0.5 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0024 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0381 | 0.00000000841 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0024 | 1 | 0.5 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0024 | 1 | 1 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0024 | 1 | 0.5 |
Entamoeba histolytica | recQ family helicase, putative | 0.0024 | 1 | 1 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0024 | 1 | 0.5 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0024 | 1 | 0.5 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0024 | 1 | 0.5 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0012 | 0.0381 | 1 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0024 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1.4125 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1). (Class of assay: confirmatory) [Related pubchem assays: 594 (Rhodamine region spectral profiling screen), 593 (Fluorescein region spectral profiling screen), 2367 (Probe Development Summary for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1)), 2353 (qHTS Validation Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1))] | ChEMBL. | No reference |
Potency (functional) | 5.0119 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 14.7157 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.