Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | RAB9A, member RAS oncogene family | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | Get druggable targets OG5_139225 | All targets in OG5_139225 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Plasmodium falciparum | ras-related protein Rab-5B | RAB9A, member RAS oncogene family | 201 aa | 165 aa | 30.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0024 | 0.5 |
Echinococcus multilocularis | neuroligin | 0.0153 | 0.1192 | 0.117 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1192 | 0.1294 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.0024 | 0.0027 |
Loa Loa (eye worm) | carboxylesterase | 0.0153 | 0.1192 | 0.1294 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0153 | 0.1192 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0024 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1192 | 0.1294 |
Plasmodium falciparum | choline kinase | 0.0044 | 0.003 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0905 | 0.9209 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0153 | 0.1192 | 0.1294 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0153 | 0.1192 | 0.1294 |
Onchocerca volvulus | 0.0153 | 0.1192 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0153 | 0.1192 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1192 | 0.1294 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0153 | 0.1192 | 0.1271 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0905 | 0.9209 | 0.9207 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0203 | 0.022 |
Loa Loa (eye worm) | choline/ethanolamine kinase | 0.0044 | 0.003 | 0.0032 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0153 | 0.1192 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0153 | 0.1192 | 0.1294 |
Loa Loa (eye worm) | hypothetical protein | 0.0905 | 0.9209 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0905 | 0.9209 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0905 | 0.9209 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0905 | 0.9209 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0905 | 0.9209 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0203 | 0.022 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0153 | 0.1192 | 0.1271 |
Schistosoma mansoni | gliotactin | 0.0153 | 0.1192 | 0.1294 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1192 | 0.1294 |
Echinococcus multilocularis | acetylcholinesterase | 0.0905 | 0.9209 | 0.9207 |
Loa Loa (eye worm) | carboxylesterase | 0.0153 | 0.1192 | 0.1294 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0153 | 0.1192 | 0.1271 |
Onchocerca volvulus | 0.0153 | 0.1192 | 0.5 | |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0153 | 0.1192 | 0.117 |
Brugia malayi | Choline/ethanolamine kinase family protein | 0.0044 | 0.003 | 0.0032 |
Echinococcus granulosus | neuroligin | 0.0153 | 0.1192 | 0.1271 |
Onchocerca volvulus | 0.0153 | 0.1192 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1192 | 0.1294 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0203 | 0.022 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0153 | 0.1192 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0024 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.0024 | 0.5 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0153 | 0.1192 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1192 | 0.1294 |
Plasmodium vivax | choline kinase, putative | 0.0044 | 0.003 | 0.5 |
Echinococcus multilocularis | choline:ethanolamine kinase | 0.0044 | 0.003 | 0.0005 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0153 | 0.1192 | 0.1294 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0153 | 0.1192 | 0.117 |
Brugia malayi | hypothetical protein | 0.0043 | 0.0024 | 0.0027 |
Onchocerca volvulus | 0.0153 | 0.1192 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.0905 | 0.9209 | 1 |
Onchocerca volvulus | 0.0153 | 0.1192 | 0.5 | |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0153 | 0.1192 | 0.117 |
Echinococcus granulosus | acetylcholinesterase | 0.0905 | 0.9209 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0153 | 0.1192 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0905 | 0.9209 | 1 |
Brugia malayi | hypothetical protein | 0.0153 | 0.1192 | 0.1294 |
Toxoplasma gondii | phosphotransferase enzyme family protein | 0.0044 | 0.003 | 0.5 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0153 | 0.1192 | 0.1294 |
Loa Loa (eye worm) | hypothetical protein | 0.0153 | 0.1192 | 0.1294 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0905 | 0.9209 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.0024 | 0.0027 |
Brugia malayi | Carboxylesterase family protein | 0.0153 | 0.1192 | 0.1294 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0153 | 0.1192 | 0.1294 |
Schistosoma mansoni | acetylcholinesterase | 0.0153 | 0.1192 | 0.1294 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0203 | 0.022 |
Echinococcus multilocularis | acetylcholinesterase | 0.0905 | 0.9209 | 0.9207 |
Brugia malayi | Carboxylesterase family protein | 0.0153 | 0.1192 | 0.1294 |
Echinococcus granulosus | choline:ethanolamine kinase | 0.0044 | 0.003 | 0.0006 |
Brugia malayi | Carboxylesterase family protein | 0.0153 | 0.1192 | 0.1294 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1299 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] | ChEMBL. | No reference |
Potency (functional) | 0.2592 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 0.7308 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 0.8913 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 1.7783 um | PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 20.7865 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 26.8545 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | = 28.1838 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.