Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thyroid stimulating hormone receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | Get druggable targets OG5_130089 | All targets in OG5_130089 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | Get druggable targets OG5_130089 | All targets in OG5_130089 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0072 | 0.1468 | 0.1897 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.0255 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0033 | 0.0401 | 0.0401 |
Onchocerca volvulus | 0.0147 | 0.3534 | 0.3534 | |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0401 | 0.0519 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0447 | 0.0578 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.3173 | 0.4102 |
Plasmodium falciparum | importin beta, putative | 0.0028 | 0.0255 | 0.5 |
Brugia malayi | hypothetical protein | 0.0147 | 0.3534 | 0.3534 |
Echinococcus granulosus | snurportin 1 | 0.03 | 0.7736 | 1 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.028 | 0.7183 | 0.7183 |
Echinococcus multilocularis | snurportin 1 | 0.03 | 0.7736 | 1 |
Brugia malayi | follicle stimulating hormone receptor | 0.028 | 0.7183 | 0.7183 |
Brugia malayi | TAR-binding protein | 0.0134 | 0.3173 | 0.3173 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0072 | 0.1468 | 0.1468 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0023 | 0.0109 | 0.5 |
Schistosoma mansoni | importin beta-1 | 0.0028 | 0.0255 | 0.033 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.3173 | 0.4102 |
Leishmania major | importin beta-1 subunit, putative | 0.0023 | 0.0109 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.3173 | 0.4102 |
Brugia malayi | RNA binding protein | 0.0134 | 0.3173 | 0.3173 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0028 | 0.0255 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0447 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0134 | 0.3173 | 0.4102 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0401 | 0.0519 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0447 | 0.0578 |
Loa Loa (eye worm) | hypothetical protein | 0.0382 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.2387 | 0.2387 |
Echinococcus granulosus | tar DNA binding protein | 0.0134 | 0.3173 | 0.4102 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.3173 | 0.4102 |
Schistosoma mansoni | tar DNA-binding protein | 0.0134 | 0.3173 | 0.4102 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0109 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0447 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0033 | 0.0401 | 0.0519 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0028 | 0.0255 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.0401 | 0.0519 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.03 | 0.7736 | 0.7736 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0105 | 0.2387 | 0.2387 |
Loa Loa (eye worm) | hypothetical protein | 0.0147 | 0.3534 | 0.3534 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0447 | 0.0578 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.0401 | 0.0519 |
Schistosoma mansoni | hypothetical protein | 0.03 | 0.7736 | 1 |
Trichomonas vaginalis | importin beta-1, putative | 0.0023 | 0.0109 | 0.5 |
Plasmodium vivax | importin-beta 2, putative | 0.0028 | 0.0255 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0401 | 0.0401 |
Echinococcus granulosus | GPCR family 2 | 0.0033 | 0.0401 | 0.0519 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0382 | 1 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0033 | 0.0401 | 0.0401 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0447 | 0.0447 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0447 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0134 | 0.3173 | 0.3173 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1468 | 0.1468 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0033 | 0.0401 | 0.0401 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0033 | 0.0401 | 0.0519 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0134 | 0.3173 | 0.3173 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0401 | 0.0519 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0105 | 0.2387 | 0.2387 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0023 | 0.0109 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.0401 | 0.0519 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0033 | 0.0401 | 0.0519 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0028 | 0.0255 | 0.033 |
Loa Loa (eye worm) | RNA binding protein | 0.0134 | 0.3173 | 0.3173 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0447 | 1 |
Echinococcus granulosus | importin subunit beta 1 | 0.0028 | 0.0255 | 0.033 |
Brugia malayi | RNA, U transporter 1 | 0.008 | 0.1681 | 0.1681 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0447 | 0.0578 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0105 | 0.2387 | 0.2387 |
Brugia malayi | Importin beta-1 subunit | 0.0028 | 0.0255 | 0.0255 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0255 | 0.0255 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0134 | 0.3173 | 0.3173 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.1585 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 0.1585 um | PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 14.7157 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.