TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 540.918 | Formula: C28H20ClF3N2O4
H donors: 2 H acceptors: 3 LogP: 6.48 Rotable bonds: 11
Rule of 5 violations (Lipinski): 2
SMILES: O=C(OC(C(=O)Nc1cc(ccc1Cl)C(F)(F)F)c1ccccc1)CNC(=O)c1cccc2c1cccc2
InChi: 1S/C28H20ClF3N2O4/c29-22-14-13-19(28(30,31)32)15-23(22)34-27(37)25(18-8-2-1-3-9-18)38-24(35)16-33-26(36)21-12-6-10-17-7-4-5-11-20(17)21/h1-15,25H,16H2,(H,33,36)(H,34,37)
InChiKey: OZUPDFUCQAJLEY-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Trypanosoma cruzi	cysteine peptidase, putative	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0412	0.2952
Schistosoma mansoni	hypothetical protein	0.0166	0.939	1
Echinococcus granulosus	cathepsin l cysteine peptidase	0.002	0.0412	0.0412
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0412	0.2952
Leishmania major	cathepsin L-like protease	0.002	0.0412	0.0844
Loa Loa (eye worm)	fibroinase	0.002	0.0412	0.0412
Entamoeba histolytica	cysteine proteinase, putative	0.002	0.0412	0.2952
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0412	0.2952
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.3912	1
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.002	0.0412	0.0412
Echinococcus multilocularis	cysteine protease	0.002	0.0412	0.0221
Brugia malayi	Bromodomain containing protein	0.0073	0.3691	0.3691
Leishmania major	cathepsin L-like protease	0.0077	0.3912	1
Plasmodium vivax	vivapain-2	0.002	0.0412	0.5
Schistosoma mansoni	zinc finger protein	0.0019	0.0347	0.037
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0412	0.2952
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0195	0.0208
Onchocerca volvulus	Cathepsin F homolog	0.002	0.0412	1
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0022	0.0526	0.0338
Echinococcus granulosus	histone lysine methyltransferase setb	0.0017	0.0195	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0038	0.1481	0.1481
Loa Loa (eye worm)	TAR-binding protein	0.0138	0.7669	0.7669
Echinococcus multilocularis	cathepsin L cysteine protease	0.002	0.0412	0.0221
Brugia malayi	Cathepsin L-like precursor	0.002	0.0412	0.0412
Schistosoma mansoni	tar DNA-binding protein	0.0138	0.7669	0.8168
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0412	0.2952
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.3912	1
Trypanosoma brucei	cytochrome P450, putative	0.0019	0.0362	0.0713
Echinococcus multilocularis	cysteine protease	0.002	0.0412	0.0221
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.3912	1
Leishmania major	cathepsin L-like protease	0.002	0.0412	0.0844
Echinococcus multilocularis	geminin	0.0166	0.939	0.9378
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1739	0.1739
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.3912	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0077	0.3912	1
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.1395	1
Brugia malayi	Cytochrome P450 family protein	0.0019	0.0362	0.0362
Schistosoma mansoni	hypothetical protein	0.002	0.0411	0.0438
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.002	0.0412	0.0412
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.1395	0.3415
Trypanosoma cruzi	cysteine peptidase, putative	0.0077	0.3912	1
Echinococcus granulosus	geminin	0.0166	0.939	0.939
Leishmania major	cathepsin L-like protease	0.002	0.0412	0.0844
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0412	0.2952
Echinococcus multilocularis	muscleblind protein	0.0176	1	1
Trypanosoma cruzi	cytochrome P450, putative	0.0019	0.0362	0.0713
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0032	0.1161	0.5
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0032	0.1161	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.3912	1
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0017	0.0195	0.0195
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0035	0.1334	0.1334
Plasmodium vivax	vivapain-2	0.002	0.0412	0.5
Brugia malayi	RNA binding protein	0.0138	0.7669	0.7669
Leishmania major	cathepsin L-like protease	0.0077	0.3912	1
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0035	0.1334	0.1162
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0412	0.2952
Brugia malayi	Inositol-1	0.0036	0.1395	0.1395
Echinococcus granulosus	inositol monophosphatase 1	0.0036	0.1395	0.1395
Loa Loa (eye worm)	CYP4Cod1	0.0019	0.0362	0.0362
Leishmania major	cysteine peptidase A (CPA)	0.002	0.0412	0.0844
Loa Loa (eye worm)	hypothetical protein	0.002	0.0412	0.0412
Loa Loa (eye worm)	MH2 domain-containing protein	0.0141	0.7825	0.7825
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0412	0.2952
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.3912	1
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0036	0.1395	1
Leishmania major	cytochrome p450-like protein	0.0019	0.0362	0.0713
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.007	0.35	0.8923
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0058	0.2768	0.2768
Onchocerca volvulus		0.002	0.0412	1
Echinococcus granulosus	fetal alzheimer antigen falz	0.0022	0.0526	0.0526
Entamoeba histolytica	cysteine proteinase, putative	0.002	0.0412	0.2952
Echinococcus multilocularis	inositol monophosphatase 1	0.0036	0.1395	0.1223
Onchocerca volvulus	Cathepsin L homolog	0.002	0.0412	1
Trypanosoma cruzi	cruzipain precursor, putative	0.0077	0.3912	1
Schistosoma mansoni	cathepsin F (C01 family)	0.002	0.0412	0.0439
Trypanosoma cruzi	cysteine peptidase, putative	0.0077	0.3912	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0061	0.2896	0.7343
Schistosoma mansoni	cathepsin F (C01 family)	0.002	0.0412	0.0439
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.002	0.0412	0.0221
Leishmania major	cathepsin L-like protease	0.002	0.0412	0.0844
Onchocerca volvulus		0.002	0.0412	1
Brugia malayi	Bromodomain containing protein	0.0038	0.1477	0.1477
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0195	0.0195
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.1395	0.3415
Loa Loa (eye worm)	PHD-finger family protein	0.002	0.0411	0.0411
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0138	0.7669	0.7669
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0412	0.2952
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0058	0.2768	0.2624
Onchocerca volvulus		0.002	0.0412	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0412	0.2952
Brugia malayi	RNA recognition motif domain containing protein	0.0138	0.7669	0.7669
Loa Loa (eye worm)	bromodomain containing protein	0.0017	0.0232	0.0232
Echinococcus multilocularis	muscleblind protein 1	0.0176	1	1
Brugia malayi	Cathepsin L-like precursor	0.002	0.0412	0.0412
Echinococcus multilocularis	cathepsin L cysteine protease	0.002	0.0412	0.0221
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0412	0.2952
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0036	0.1395	1
Brugia malayi	Papain family cysteine protease containing protein	0.002	0.0412	0.0412
Loa Loa (eye worm)	hypothetical protein	0.0176	1	1
Echinococcus granulosus	cathepsin l1	0.002	0.0412	0.0412
Brugia malayi	Cathepsin L-like precursor	0.002	0.0412	0.0412
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0412	0.2952
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.1395	0.3415
Echinococcus granulosus	zinc finger protein	0.0019	0.0347	0.0347
Leishmania major	cathepsin L-like protease	0.002	0.0412	0.0844
Schistosoma mansoni	hypothetical protein	0.0166	0.939	1
Brugia malayi	TAR-binding protein	0.0138	0.7669	0.7669
Leishmania major	cathepsin L-like protease	0.0077	0.3912	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0412	0.2952
Schistosoma mansoni	tar DNA-binding protein	0.0138	0.7669	0.8168
Onchocerca volvulus		0.002	0.0412	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0412	0.2952
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0036	0.1395	0.5
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.002	0.0412	0.5
Loa Loa (eye worm)	inositol-1	0.0036	0.1395	0.1395
Brugia malayi	Cytochrome P450 family protein	0.0019	0.0362	0.0362
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0412	0.2952
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.3912	1
Schistosoma mansoni	tar DNA-binding protein	0.0138	0.7669	0.8168
Loa Loa (eye worm)	cysteine protease	0.002	0.0412	0.0412
Brugia malayi	MH2 domain containing protein	0.0141	0.7825	0.7825
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.3912	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0412	0.2952
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0017	0.0195	0.0208
Schistosoma mansoni	tar DNA-binding protein	0.0138	0.7669	0.8168
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0412	0.2952
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0412	0.2952
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0412	0.2952
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.002	0.0412	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0176	1	1
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0036	0.1395	0.3415
Loa Loa (eye worm)	cytochrome P450 family protein	0.0019	0.0362	0.0362
Schistosoma mansoni	zinc finger protein	0.0015	0.0089	0.0095
Onchocerca volvulus		0.002	0.0412	1
Onchocerca volvulus		0.002	0.0412	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0412	0.2952
Echinococcus multilocularis	tar DNA binding protein	0.0138	0.7669	0.7623
Brugia malayi	Cathepsin L-like precursor	0.002	0.0412	0.0412
Echinococcus granulosus	tar DNA binding protein	0.0138	0.7669	0.7669
Trypanosoma cruzi	cytochrome P450, putative	0.0019	0.0362	0.0713
Schistosoma mansoni	inositol monophosphatase	0.0036	0.1395	0.1485
Brugia malayi	Cytochrome P450 family protein	0.003	0.0999	0.0999
Trypanosoma cruzi	cysteine peptidase, putative	0.002	0.0412	0.0844
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.002	0.0412	0.2952
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0022	0.0526	0.0561
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0412	0.2952
Loa Loa (eye worm)	cytochrome P450 family protein	0.003	0.0999	0.0999
Onchocerca volvulus	Cathepsin L homolog	0.002	0.0412	1
Schistosoma mansoni	bromodomain containing protein	0.0062	0.2984	0.3178
Trichomonas vaginalis	inositol monophosphatase, putative	0.0036	0.1395	1
Echinococcus multilocularis	zinc finger protein	0.0019	0.0347	0.0155
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.002	0.0412	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.3912	1
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0036	0.1395	1
Loa Loa (eye worm)	ctsf protein	0.002	0.0412	0.0412
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.002	0.0412	0.2952
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0036	0.1395	1
Loa Loa (eye worm)	RNA binding protein	0.0138	0.7669	0.7669
Loa Loa (eye worm)	transcription factor SMAD2	0.0141	0.7825	0.7825
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0017	0.0195	0.0208
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.002	0.0412	0.2952
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0195	0.0208
Echinococcus granulosus	muscleblind protein	0.0176	1	1
Plasmodium falciparum	cysteine proteinase falcipain 3	0.002	0.0412	0.5
Brugia malayi	Cathepsin L-like precursor	0.002	0.0412	0.0412
Loa Loa (eye worm)	hypothetical protein	0.0069	0.3433	0.3433
Onchocerca volvulus		0.002	0.0412	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.1624	0.1624
Schistosoma mansoni	tar DNA-binding protein	0.0138	0.7669	0.8168
Schistosoma mansoni	inositol monophosphatase	0.0036	0.1395	0.1485
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.3912	1
Loa Loa (eye worm)	cytochrome P450 family protein	0.0019	0.0362	0.0362
Brugia malayi	PHD-finger family protein	0.0024	0.0669	0.0669
Brugia malayi	Cathepsin L-like precursor	0.002	0.0412	0.0412
Entamoeba histolytica	cysteine protease, putative	0.002	0.0412	0.2952
Echinococcus granulosus	cathepsin L cysteine proteinase	0.002	0.0412	0.0412
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0077	0.3912	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.002	0.0412	0.2952
Schistosoma mansoni	hypothetical protein	0.0015	0.0089	0.0095

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	= 12.5893 um	PUBCHEM_BIOASSAY: Confirmation qHTS Assay for Inhibitors of Cruzain. (Class of assay: confirmatory) [Related pubchem assays: 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1476 (cruzain qHTS without detergent), 1478 (cruzain qHTS with detergent)]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1436606

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1332832