Detailed information for compound 1332934

Basic information

Technical information
  • TDR Targets ID: 1332934
  • Name: N-[5-[(6-methyl-4-oxo-1H-quinolin-2-yl)methyl sulfanyl]-1,3,4-thiadiazol-2-yl]acetamide
  • MW: 346.427 | Formula: C15H14N4O2S2
  • H donors: 2 H acceptors: 4 LogP: 2.22 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)Nc1nnc(s1)SCc1cc(=O)c2c([nH]1)ccc(c2)C
  • InChi: 1S/C15H14N4O2S2/c1-8-3-4-12-11(5-8)13(21)6-10(17-12)7-22-15-19-18-14(23-15)16-9(2)20/h3-6H,7H2,1-2H3,(H,17,21)(H,16,18,20)
  • InChiKey: DRQGOJHMRJBOEX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-[5-[(6-methyl-4-oxo-1H-quinolin-2-yl)methylthio]-1,3,4-thiadiazol-2-yl]acetamide
  • N-[5-[(4-keto-6-methyl-1H-quinolin-2-yl)methylthio]-1,3,4-thiadiazol-2-yl]acetamide
  • N-[5-[(6-methyl-4-oxo-1H-quinolin-2-yl)methylsulfanyl]-1,3,4-thiadiazol-2-yl]ethanamide
  • G751-3119
  • NCGC00133916-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed) kappa Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi polk-prov protein Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania braziliensis DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Giardia lamblia DINP protein human, muc B family Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus multilocularis dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis DNA polymerase IV / kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania infantum DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium tuberculosis Probable DNA polymerase IV DinX (pol IV 1) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Schistosoma japonicum ko:K03511 DNA polymerase kappa subunit, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania infantum DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania braziliensis DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium ulcerans DNA polymerase IV Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma congolense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei gambiense DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania mexicana DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania major DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trichomonas vaginalis DNA polymerase eta, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania donovani DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Echinococcus granulosus dna polymerase kappa Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma cruzi DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase kappa, putative Get druggable targets OG5_127393 All targets in OG5_127393
Trypanosoma brucei DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
Leishmania mexicana DNA polymerase kappa, putative,DNA polymerase IV, putative Get druggable targets OG5_127393 All targets in OG5_127393
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) steroid hormone receptor 0.0049 0.9924 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.9924 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.1806 0.182
Loa Loa (eye worm) hypothetical protein 0.0023 0.1806 0.182
Mycobacterium ulcerans DNA polymerase IV 0.005 1 0.5
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0049 0.9924 1
Brugia malayi Nuclear hormone receptor E75 0.0023 0.1806 0.182
Loa Loa (eye worm) hypothetical protein 0.0023 0.1806 0.182
Brugia malayi nuclear receptor RXR 0.0026 0.2675 0.2696
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0049 0.9924 0.9924
Echinococcus granulosus Nuclear hormone receptor HR96 0.0023 0.1806 0.1806
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0049 0.9924 1
Echinococcus multilocularis FTZ F1 alpha 0.0049 0.9924 0.9924
Brugia malayi nuclear receptor RXR 0.0023 0.1806 0.182
Loa Loa (eye worm) hypothetical protein 0.0023 0.1806 0.182
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.005 1 0.5
Brugia malayi nuclear receptor NHR-67 0.0023 0.1806 0.182
Brugia malayi photoreceptor-specific nuclear receptor 0.0049 0.9924 1
Brugia malayi nuclear hormone receptor 0.0049 0.9924 1
Trypanosoma brucei DNA polymerase kappa, putative 0.005 1 1
Echinococcus granulosus nuclear receptor nhr 48 0.0023 0.1806 0.1806
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0049 0.9924 0.9924
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0792 0.0792
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0049 0.9924 1
Brugia malayi steroid hormone receptor 0.0049 0.9924 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0049 0.9924 1
Schistosoma mansoni coup transcription factor 0.0049 0.9924 1
Schistosoma mansoni nuclear hormone receptor 0.0023 0.1806 0.182
Loa Loa (eye worm) hypothetical protein 0.0023 0.1806 0.182
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0049 0.9924 0.9924
Leishmania major DNA polymerase kappa, putative 0.0025 0.2481 1
Trypanosoma brucei DNA polymerase kappa, putative 0.005 1 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0023 0.1806 0.182
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0049 0.9924 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0049 0.9924 1
Brugia malayi hypothetical protein 0.0026 0.2675 0.2696
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0049 0.9924 1
Brugia malayi hypothetical protein 0.0023 0.1806 0.182
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0049 0.9924 1
Schistosoma mansoni nuclear receptor nhr-48 0.0023 0.1806 0.182
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0049 0.9924 0.9924
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0023 0.1806 0.1806
Schistosoma mansoni nuclear hormone receptor 0.0049 0.9924 1
Schistosoma mansoni RAR-like nuclear receptor 0.0049 0.9924 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0049 0.9924 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.2675 0.2696
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0049 0.9924 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0049 0.9924 0.9924
Loa Loa (eye worm) hypothetical protein 0.0026 0.2675 0.2696
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.2675 0.2696
Schistosoma mansoni nuclear receptor 0.0023 0.1806 0.182
Loa Loa (eye worm) hypothetical protein 0.0049 0.9924 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.2675 0.2696
Trypanosoma brucei DNA polymerase IV, putative 0.0042 0.7519 0.7519
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0023 0.1806 0.1806
Trypanosoma brucei unspecified product 0.0042 0.7519 0.7519
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0049 0.9924 0.9924
Echinococcus multilocularis nuclear receptor nhr 48 0.0023 0.1806 0.1806
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0049 0.9924 0.9924
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0023 0.1806 0.182
Schistosoma mansoni zinc finger protein 0.0023 0.1806 0.182
Trichomonas vaginalis DNA polymerase eta, putative 0.005 1 0.5
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0049 0.9924 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0023 0.1806 0.182
Mycobacterium ulcerans DNA polymerase IV 0.005 1 0.5
Brugia malayi Steroid receptor seven-up type 2 0.0049 0.9924 1
Brugia malayi tailless protein 0.0023 0.1806 0.182
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0049 0.9924 0.9924
Onchocerca volvulus Bile acid receptor homolog 0.0049 0.9924 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.9924 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0023 0.1806 0.1806
Loa Loa (eye worm) hypothetical protein 0.0023 0.1806 0.182
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0049 0.9924 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0049 0.9924 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0026 0.2675 0.2675
Loa Loa (eye worm) hypothetical protein 0.0049 0.9924 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0049 0.9924 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0049 0.9924 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0049 0.9924 0.9924
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0049 0.9924 1
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0023 0.1806 0.182
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0792 0.0792
Loa Loa (eye worm) hypothetical protein 0.0026 0.2675 0.2696
Trypanosoma brucei DNA polymerase kappa, putative 0.005 1 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0023 0.1806 0.182
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0049 0.9924 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.1806 0.182
Trypanosoma brucei DNA polymerase kappa, putative 0.005 1 1
Giardia lamblia DINP protein human, muc B family 0.0025 0.2481 0.5
Loa Loa (eye worm) nuclear hormone receptor 0.0023 0.1806 0.182
Loa Loa (eye worm) DR-78 0.0023 0.1806 0.182
Echinococcus multilocularis thyroid hormone receptor alpha 0.0049 0.9924 0.9924
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0049 0.9924 1
Brugia malayi Nuclear hormone receptor-like 1 0.0026 0.2675 0.2696
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0049 0.9924 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.6246 0.6246
Schistosoma mansoni retinoic acid receptor RXR 0.0049 0.9924 1
Trypanosoma brucei DNA polymerase kappa, putative 0.005 1 1
Brugia malayi Nuclear hormone receptor-like 1 0.0049 0.9924 1
Trypanosoma brucei DNA polymerase kappa, putative 0.005 1 1
Schistosoma mansoni nuclear receptor 0.0023 0.1806 0.182
Brugia malayi nuclear hormone receptor 0.0023 0.1806 0.182
Trypanosoma brucei DNA polymerase kappa, putative 0.005 1 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0023 0.1806 0.1806
Brugia malayi nuclear receptor NHR-88 0.0049 0.9924 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0049 0.9924 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0025 0.2481 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0049 0.9924 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.2675 0.2696
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0049 0.9924 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.1806 0.182
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0049 0.9924 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0023 0.1806 0.182
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0049 0.9924 1
Schistosoma mansoni thyroid hormone receptor 0.0049 0.9924 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.1806 0.182
Loa Loa (eye worm) hypothetical protein 0.0023 0.1806 0.182
Loa Loa (eye worm) hypothetical protein 0.0038 0.6246 0.6294
Schistosoma mansoni thyroid hormone receptor 0.0049 0.9924 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0792 0.0792
Trypanosoma brucei DNA polymerase kappa, putative 0.0025 0.2481 0.2481
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 1 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0025 0.2481 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0023 0.1806 0.1806
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0049 0.9924 0.9924
Schistosoma mansoni steroid hormone receptor ad4bp 0.0049 0.9924 1
Onchocerca volvulus 0.0049 0.9924 1
Trypanosoma brucei DNA polymerase IV, putative 0.005 1 1
Brugia malayi orphan nuclear receptor NR2E1 0.0023 0.1806 0.182
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0049 0.9924 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.1806 0.182
Loa Loa (eye worm) hypothetical protein 0.0049 0.9924 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0049 0.9924 0.9924
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0049 0.9924 1
Echinococcus multilocularis dna polymerase kappa 0.005 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.005 1 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0026 0.2675 0.2696
Trypanosoma brucei DNA polymerase kappa, putative 0.005 1 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.1806 0.182
Brugia malayi nuclear hormone receptor family member odr-7 0.0023 0.1806 0.182
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0049 0.9924 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 1 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0017 0 0.5
Brugia malayi polk-prov protein 0.0038 0.6246 0.6294
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.1806 0.1806
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0049 0.9924 0.9924
Brugia malayi nuclear receptor NHR-88 0.0023 0.1806 0.182
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.6246 0.6246
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.1806 0.1806
Schistosoma mansoni nuclear hormone receptor 0.0023 0.1806 0.182
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0023 0.1806 0.1806
Brugia malayi ecdysteroid receptor 0.0049 0.9924 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0049 0.9924 0.9924
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0026 0.2675 0.2696
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0049 0.9924 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.005 1 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.9924 1
Brugia malayi hypothetical protein 0.0026 0.2675 0.2696
Loa Loa (eye worm) hypothetical protein 0.0023 0.1806 0.182
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0023 0.1806 0.1806
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0049 0.9924 0.9924
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0026 0.2675 0.2696
Brugia malayi hypothetical protein 0.0023 0.1806 0.182
Brugia malayi Nuclear hormone receptor E75 0.0023 0.1806 0.182
Loa Loa (eye worm) hypothetical protein 0.0049 0.9924 1
Brugia malayi conserved hypotetical protein 0.0023 0.1806 0.182
Echinococcus granulosus FTZ F1 alpha 0.0049 0.9924 0.9924
Echinococcus granulosus ecdysone induced protein 78C 0.0049 0.9924 0.9924
Loa Loa (eye worm) hypothetical protein 0.0049 0.9924 1
Brugia malayi ecdysone receptor 0.0023 0.1806 0.182
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0026 0.2675 0.2675
Trypanosoma brucei DNA polymerase IV, putative 0.005 1 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 16.8336 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Kappa: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. A Novel Cell-Based Assay to Identify Small Molecules for B -Galactocerebrosidase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 67.0158 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 95.2834 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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