Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0675 | 0.0871 |
Echinococcus multilocularis | musashi | 0.0033 | 0.2997 | 0.2925 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0675 | 0.0578 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.7745 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.2997 | 0.2925 |
Schistosoma mansoni | lamin | 0.0033 | 0.2997 | 0.2491 |
Echinococcus multilocularis | lamin | 0.0033 | 0.2997 | 0.2925 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0675 | 0.0375 |
Onchocerca volvulus | 0.0033 | 0.2997 | 0.5 | |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.2997 | 0.387 |
Onchocerca volvulus | 0.0033 | 0.2997 | 0.5 | |
Echinococcus granulosus | lamin | 0.0033 | 0.2997 | 0.2925 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.2997 | 0.387 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.2997 | 0.387 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 1 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.4472 | 0.4073 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.2997 | 0.3537 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0675 | 0.0871 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0675 | 0.0578 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0675 | 0.0578 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.2997 | 0.2491 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.4472 | 0.5545 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.2997 | 0.2925 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.4472 | 0.5775 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.2997 | 0.3537 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.7745 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 1 | 0.5 |
Schistosoma mansoni | lamin | 0.0033 | 0.2997 | 0.2491 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.7745 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.2895 | 0.3738 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.0399 | 0.0516 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0675 | 0.0375 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.7745 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0675 | 0.0578 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0675 | 0.0578 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.2997 | 0.2925 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 1 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0675 | 0.0578 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 1 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 1 | 0.5 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 1 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0102 | 0.0132 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.0224 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 3.9811 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 5.8584 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 10 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 32.6427 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.