Detailed information for compound 1333456

Basic information

Technical information
  • TDR Targets ID: 1333456
  • Name: N-(5-methyl-1,2-oxazol-3-yl)-2-[[8-oxo-7-(2-p henylethyl)-[1,3]dioxolo[4,5-g]quinazolin-6-y l]sulfanyl]acetamide
  • MW: 464.494 | Formula: C23H20N4O5S
  • H donors: 1 H acceptors: 3 LogP: 3.67 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1noc(c1)C)CSc1nc2cc3OCOc3cc2c(=O)n1CCc1ccccc1
  • InChi: 1S/C23H20N4O5S/c1-14-9-20(26-32-14)25-21(28)12-33-23-24-17-11-19-18(30-13-31-19)10-16(17)22(29)27(23)8-7-15-5-3-2-4-6-15/h2-6,9-11H,7-8,12-13H2,1H3,(H,25,26,28)
  • InChiKey: PWQFMVXKVXAKNS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(5-methylisoxazol-3-yl)-2-[[8-oxo-7-(2-phenylethyl)-[1,3]dioxolo[4,5-g]quinazolin-6-yl]sulfanyl]acetamide
  • N-(5-methyl-3-isoxazolyl)-2-[[8-oxo-7-(2-phenylethyl)-[1,3]dioxolo[4,5-g]quinazolin-6-yl]thio]acetamide
  • 2-[[8-keto-7-(2-phenylethyl)-[1,3]dioxolo[4,5-g]quinazolin-6-yl]thio]-N-(5-methylisoxazol-3-yl)acetamide
  • N-(5-methyl-1,2-oxazol-3-yl)-2-[[8-oxo-7-(2-phenylethyl)-[1,3]dioxolo[4,5-g]quinazolin-6-yl]sulfanyl]ethanamide
  • MLS000095412
  • N-(5-methylisoxazol-3-yl)-2-{[8-oxo-7-(2-phenylethyl)-7,8-dihydro[1,3]dioxolo[4,5-g]quinazolin-6-yl]thio}acetamide
  • SMR000030966

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mus musculus DNA-damage inducible transcript 3 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens X-box binding protein 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni hypothetical protein Get druggable targets OG5_134980 All targets in OG5_134980
Schistosoma japonicum IPR011700,Basic leucine zipper;IPR004827,Basic-leucine zipper (bZIP) transcription factor;IPR008917,Eukaryotic transcription fac Get druggable targets OG5_134980 All targets in OG5_134980
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis X box binding protein 1 Get druggable targets OG5_134980 All targets in OG5_134980
Schistosoma japonicum IPR011700,Basic leucine zipper;IPR004827,Basic-leucine zipper (bZIP) transcription factor;IPR008917,Eukaryotic transcription fac Get druggable targets OG5_134980 All targets in OG5_134980
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus X box binding protein 1 Get druggable targets OG5_134980 All targets in OG5_134980
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus FK506 binding protein 8 38 kDa 0.0066 0.1221 0.122
Toxoplasma gondii histone deacetylase HDAC3 0.0041 0.0694 0.5426
Brugia malayi Histone deacetylase family protein 0.0012 0.0069 0.0069
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.048 1 1
Echinococcus granulosus dna polymerase kappa 0.002 0.0251 0.0249
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.349 0.344
Brugia malayi Smad1 0.0009 0.0001 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0117 0.0048
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.048 1 1
Schistosoma mansoni transcriptional factor nfil3/e4bp4 0.0011 0.0054 0.0052
Schistosoma mansoni hypothetical protein 0.0205 0.4162 0.4161
Giardia lamblia Histone deacetylase 0.0041 0.0694 0.0644
Echinococcus granulosus neuropeptide s receptor 0.0448 0.9323 0.9323
Echinococcus granulosus geminin 0.0205 0.4162 0.4161
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0012 0.0076 0.0006
Leishmania major histone deacetylase, putative 0.0041 0.0694 0.0629
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0251 0.0251
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0052
Mycobacterium tuberculosis Possible L-asparagine permease AnsP2 (L-asparagine transport protein) 0.0036 0.0582 0.3492
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.5127 0.509
Trichomonas vaginalis ap endonuclease, putative 0.002 0.024 0.0165
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.1781 0.178
Brugia malayi TAR-binding protein 0.0065 0.1189 0.1189
Schistosoma mansoni histone deacetylase hda2 0.0012 0.0069 0.0068
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0022 0.0292 0.029
Loa Loa (eye worm) amino acid permease 0.0253 0.5179 0.5178
Loa Loa (eye worm) hypothetical protein 0.0012 0.0076 0.0074
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0034 0.0547 0.0475
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0251 0.0249
Echinococcus granulosus histone deacetylase 6 0.0012 0.0069 0.0068
Schistosoma mansoni immunophilin 0.048 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.3302 0.3251
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.0547 0.0546
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-30 0.0066 0.1221 0.122
Loa Loa (eye worm) hypothetical protein 0.0217 0.4416 0.4416
Echinococcus multilocularis dna polymerase eta 0.002 0.0251 0.0249
Onchocerca volvulus 0.0116 0.2292 0.6889
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase, putative 0.0066 0.1221 0.116
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0012 0.0076 0.0006
Loa Loa (eye worm) hypothetical protein 0.0036 0.0582 0.0581
Brugia malayi hypothetical protein 0.0012 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0217 0.4416 0.4416
Echinococcus multilocularis protocadherin 11 0.0011 0.0054 0.0052
Trichomonas vaginalis histone deacetylase, putative 0.0041 0.0694 0.0623
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1781 0.178
Echinococcus multilocularis histone deacetylase 1 0.0041 0.0694 0.0693
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0022 0.0292 0.0224
Onchocerca volvulus 0.0034 0.0547 0.152
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.1781 0.178
Echinococcus multilocularis protocadherin 11 0.0011 0.0054 0.0052
Trichomonas vaginalis lysine-specific permease, putative 0.0036 0.0582 0.0511
Echinococcus multilocularis cpg binding protein 0.0029 0.0444 0.0442
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.024 0.0172
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30 0.0066 0.1221 0.1221
Echinococcus granulosus leukotriene A 4 hydrolase 0.0012 0.0076 0.0074
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0034 0.0547 0.0546
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0066 0.1221 0.1173
Echinococcus granulosus protocadherin 11 0.0011 0.0054 0.0052
Loa Loa (eye worm) hypothetical protein 0.0253 0.5179 0.5178
Echinococcus multilocularis ccaat enhancer binding protein delta ccaat enhancer binding protein beta 0.0011 0.0054 0.0052
Brugia malayi Histone deacetylase family protein 0.0012 0.0069 0.0069
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.048 1 1
Brugia malayi Peptidase family M1 containing protein 0.0034 0.0547 0.0547
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.0066 0.1221 1
Brugia malayi Amino acid permease family protein 0.0036 0.0582 0.0582
Trypanosoma brucei unspecified product 0.0014 0.0117 0.0048
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0034 0.0547 0.0546
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.048 1 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1189 0.1188
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0117 0.0048
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0547 0.0546
Trypanosoma cruzi aminopeptidase, putative 0.0034 0.0547 0.0482
Schistosoma mansoni hypothetical protein 0.0011 0.0054 0.0052
Brugia malayi hypothetical protein 0.0034 0.0547 0.0547
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.024 0.0165
Brugia malayi Hypothetical 112.3 kDa protein K02A2.3 in chromosome II 0.0253 0.5179 0.5179
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0076 0.0074
Loa Loa (eye worm) hypothetical protein 0.002 0.0251 0.0249
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0066 0.1221 0.1173
Loa Loa (eye worm) peptidase family M1 containing protein 0.0094 0.182 0.1819
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0582 0.0511
Trypanosoma brucei hypothetical protein, conserved 0.0066 0.1221 0.116
Echinococcus multilocularis X box binding protein 1 0.0348 0.7203 0.7202
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.024 0.0238
Echinococcus granulosus solute carrier family 12 0.0253 0.5179 0.5178
Brugia malayi CXXC zinc finger family protein 0.0028 0.041 0.041
Trichomonas vaginalis histone deacetylase, putative 0.0041 0.0694 0.0623
Echinococcus multilocularis histone deacetylase 6 0.0012 0.0069 0.0068
Leishmania major DNA polymerase kappa, putative 0.002 0.0251 0.0183
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0034 0.0547 0.0482
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0251 0.0249
Echinococcus granulosus histone deacetylase 1 0.0041 0.0694 0.0693
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0251 0.0183
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.3302 0.3251
Echinococcus granulosus histone deacetylase 6 0.0012 0.0069 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0582 0.0511
Echinococcus multilocularis neuropeptide receptor A26 0.0448 0.9323 0.9323
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.048 1 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0547 0.0546
Brugia malayi bZIP transcription factor family protein 0.0011 0.0054 0.0054
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.048 1 1
Echinococcus granulosus aminopeptidase N 0.0116 0.2292 0.2291
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0582 0.0511
Toxoplasma gondii aminopeptidase N, putative 0.0012 0.0076 0.0056
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.048 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0251 0.0183
Loa Loa (eye worm) hypothetical protein 0.0217 0.4416 0.4416
Plasmodium vivax peptidyl-prolyl cis-trans isomerase, putative 0.0066 0.1221 0.116
Schistosoma mansoni histone deacetylase 0.0041 0.0694 0.0693
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0251 0.0176
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0076 0.0074
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0251 0.0183
Giardia lamblia Hypothetical protein 0.0066 0.1221 0.1173
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.3302 0.3251
Echinococcus granulosus histone deacetylase 3 0.0041 0.0694 0.0693
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.048 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.3302 0.3251
Schistosoma mansoni par domain protein 0.0011 0.0054 0.0052
Echinococcus multilocularis histone deacetylase 7 0.0012 0.0069 0.0068
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.3302 0.3251
Schistosoma mansoni cpg binding protein 0.0029 0.0444 0.0442
Loa Loa (eye worm) hypothetical protein 0.0217 0.4416 0.4416
Brugia malayi Amino acid permease family protein 0.0253 0.5179 0.5179
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0002 0.0001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.1781 0.178
Brugia malayi TATA binding protein associated factor 0.0012 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0217 0.4416 0.4416
Echinococcus granulosus neuropeptide receptor A26 0.0448 0.9323 0.9323
Echinococcus multilocularis histone deacetylase 6 0.0012 0.0069 0.0068
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0251 0.0183
Trypanosoma brucei Aminopeptidase M1, putative 0.0034 0.0547 0.0482
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0251 0.0249
Echinococcus granulosus cpg binding protein 0.0029 0.0444 0.0442
Schistosoma mansoni histone deacetylase 1 2 3 0.0012 0.0069 0.0068
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.0547 0.0546
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0582 0.0511
Brugia malayi MH2 domain containing protein 0.0009 0.0001 0.0001
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.024 0.0172
Echinococcus granulosus dna polymerase eta 0.002 0.0251 0.0249
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0034 0.0547 0.0482
Echinococcus multilocularis histone deacetylase 6 0.0012 0.0069 0.0068
Trichomonas vaginalis fk506-binding protein, putative 0.0066 0.1221 0.1154
Onchocerca volvulus Solute carrier family 12 member 8 homolog 0.0036 0.0582 0.1627
Onchocerca volvulus Histone deacetylase 10 homolog 0.0012 0.0069 0.0048
Leishmania major peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative 0.0066 0.1221 0.116
Echinococcus multilocularis fk506 binding protein 0.048 1 1
Loa Loa (eye worm) hypothetical protein 0.0253 0.5179 0.5178
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0117 0.0048
Loa Loa (eye worm) histone deacetylase 11 0.0012 0.0069 0.0068
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13 0.0066 0.1221 0.1221
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.1072 0.107
Onchocerca volvulus Glucosylceramidase homolog 0.0164 0.3302 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0251 0.0112
Loa Loa (eye worm) hypothetical protein 0.0414 0.8599 0.8599
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.5127 0.509
Leishmania major DNA polymerase eta, putative 0.002 0.0251 0.0183
Brugia malayi Peptidase family M1 containing protein 0.0012 0.0076 0.0076
Echinococcus multilocularis cation chloride cotransporter 0.0036 0.0582 0.0581
Toxoplasma gondii exonuclease III APE 0.002 0.024 0.1481
Entamoeba histolytica histone deacetylase, putative 0.0041 0.0694 0.0644
Schistosoma mansoni histone deacetylase 4 5 0.0012 0.0069 0.0068
Trypanosoma brucei unspecified product 0.002 0.0251 0.0183
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0012 0.0076 0.0006
Brugia malayi Cell death specification protein 2 0.0011 0.0054 0.0054
Schistosoma mansoni cpg binding protein 0.0028 0.041 0.0409
Leishmania major peptidylprolyl isomerase-like protein 0.048 1 1
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0251 0.0183
Brugia malayi MH1 domain containing protein 0.0009 0.0001 0.0001
Entamoeba histolytica aminopeptidase, putative 0.0034 0.0547 0.0496
Schistosoma mansoni fk506 binding protein 0.0066 0.1221 0.122
Brugia malayi hypothetical protein 0.0036 0.0582 0.0582
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.024 0.0187
Brugia malayi Cell death specification protein 2 0.0011 0.0054 0.0054
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.025 0.5127 0.5127
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0251 0.0183
Loa Loa (eye worm) cell death specification protein 2 0.0011 0.0054 0.0052
Mycobacterium tuberculosis Probable D-serine/alanine/glycine transporter protein CycA 0.0036 0.0582 0.3492
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.024 0.0187
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0066 0.1221 0.1173
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0251 0.0183
Loa Loa (eye worm) histone deacetylase 7A 0.0012 0.0069 0.0068
Echinococcus multilocularis histone deacetylase 3 0.0041 0.0694 0.0693
Trichomonas vaginalis amino acid permease, putative 0.0036 0.0582 0.0511
Loa Loa (eye worm) TAR-binding protein 0.0065 0.1189 0.1188
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.2485 0.2484
Schistosoma mansoni immunophilin 0.0414 0.8599 0.8599
Echinococcus multilocularis dna polymerase kappa 0.002 0.0251 0.0249
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0251 0.0249
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.048 1 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.024 0.0172
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0011 0.0054 0.0052
Trypanosoma brucei unspecified product 0.0014 0.0117 0.0048
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0052
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0066 0.1221 0.116
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0251 0.0183
Schistosoma mansoni histone deacetylase 0.0041 0.0694 0.0693
Echinococcus granulosus cation chloride cotransporter 0.0036 0.0582 0.0581
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0002 0.0001
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0034 0.0547 0.0475
Chlamydia trachomatis peptidyl-prolyl cis-trans isomerase 0.0066 0.1221 0.5
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0251 0.0176
Schistosoma mansoni hypothetical protein 0.0011 0.0054 0.0052
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.024 0.0172
Loa Loa (eye worm) hypothetical protein 0.0036 0.0582 0.0581
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0012 0.0076 0.0006
Trichomonas vaginalis cation chloride cotransporter, putative 0.0036 0.0582 0.0511
Trichomonas vaginalis histone deacetylase, putative 0.0041 0.0694 0.0623
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.5127 0.509
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.024 0.0172
Trichomonas vaginalis fk506-binding protein, putative 0.048 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0251 0.0183
Toxoplasma gondii aminopeptidase N protein 0.0012 0.0076 0.0056
Loa Loa (eye worm) hypothetical protein 0.0253 0.5179 0.5178
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0066 0.1221 1
Brugia malayi histone deacetylase 3 (HD3) 0.0041 0.0694 0.0694
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0582 0.0511
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0066 0.1221 0.116
Schistosoma mansoni DNA polymerase eta 0.002 0.0251 0.0249
Brugia malayi MH2 domain containing protein 0.0126 0.2485 0.2485
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33 0.0066 0.1221 0.1221
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0011 0.0054 0.0052
Loa Loa (eye worm) hypothetical protein 0.0022 0.0292 0.029
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.5127 0.509
Brugia malayi hypothetical protein 0.0011 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0052
Loa Loa (eye worm) hypothetical protein 0.0041 0.0694 0.0693
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0034 0.0547 0.0482
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0041 0.0694 0.0623
Brugia malayi hypothetical protein 0.0036 0.0582 0.0582
Echinococcus multilocularis tar DNA binding protein 0.0065 0.1189 0.1188
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.048 1 1
Schistosoma mansoni ap endonuclease 0.002 0.024 0.0238
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-33 0.0066 0.1221 0.122
Brugia malayi Cell death specification protein 2 0.0011 0.0054 0.0054
Brugia malayi MH2 domain containing protein 0.0009 0.0001 0.0001
Loa Loa (eye worm) solute carrier family 12 member 1 0.0036 0.0582 0.0581
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1189 0.1188
Loa Loa (eye worm) histone deacetylase 1 0.0041 0.0694 0.0693
Trypanosoma brucei histone deacetylase 1 0.0041 0.0694 0.0629
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.349 0.344
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.1189 0.1189
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.048 1 1
Echinococcus granulosus histone deacetylase 6 0.0012 0.0069 0.0068
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.024 0.0238
Mycobacterium tuberculosis Probable trigger factor (TF) protein Tig 0.0066 0.1221 1
Echinococcus granulosus transcriptional factor nfil3:e4bp4 0.0011 0.0054 0.0052
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0002 0.0001
Loa Loa (eye worm) histone deacetylase 0.0012 0.0069 0.0068
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0251 0.0183
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0414 0.8599 0.8599
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.024 0.024
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0012 0.0076 0.0074
Loa Loa (eye worm) hypothetical protein 0.0217 0.4416 0.4416
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-13 0.0066 0.1221 0.122
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0251 0.0249
Trypanosoma brucei aminopeptidase, putative 0.0012 0.0076 0.0006
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0414 0.8599 0.8599
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.048 1 1
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0066 0.1221 0.116
Brugia malayi Histone deacetylase 1 0.0041 0.0694 0.0694
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type (slyD) 0.0066 0.1221 0.1005
Trypanosoma cruzi histone deacetylase 1, putative 0.0041 0.0694 0.0629
Loa Loa (eye worm) hypothetical protein 0.0217 0.4416 0.4416
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0022 0.0292 0.029
Echinococcus granulosus tar DNA binding protein 0.0065 0.1189 0.1188
Loa Loa (eye worm) TATA binding protein associated factor 0.0012 0.0076 0.0074
Echinococcus multilocularis solute carrier family 12 0.0253 0.5179 0.5178
Schistosoma mansoni hypothetical protein 0.0066 0.1221 0.122
Echinococcus granulosus FK506 binding protein 2 0.0066 0.1221 0.122
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0052
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0251 0.0183
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.3302 0.3251
Loa Loa (eye worm) hypothetical protein 0.0253 0.5179 0.5178
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0066 0.1221 1
Schistosoma mansoni hypothetical protein 0.0348 0.7203 0.7202
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0251 0.0183
Schistosoma mansoni solute carrier family 12 electroneutral k-cl cotransporter 0.0253 0.5179 0.5178
Schistosoma mansoni immunophilin 0.048 1 1
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0012 0.0076 0.0006
Plasmodium falciparum histone deacetylase 1 0.0041 0.0694 0.0629
Loa Loa (eye worm) hypothetical protein 0.0066 0.1221 0.122
Loa Loa (eye worm) hypothetical protein 0.0012 0.0076 0.0074
Loa Loa (eye worm) hypothetical protein 0.0022 0.0292 0.029
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0251 0.0183
Echinococcus granulosus histone deacetylase 0.0012 0.0069 0.0068
Onchocerca volvulus 0.0028 0.041 0.1097
Loa Loa (eye worm) aminopeptidase N 0.0034 0.0547 0.0546
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0251 0.0198
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0011 0.0054 0.0052
Onchocerca volvulus 0.0012 0.0076 0.0068
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0034 0.0547 0.0482
Echinococcus multilocularis transcriptional factor nfil3:e4bp4 0.0011 0.0054 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0582 0.0511
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0012 0.0076 0.0006
Trichomonas vaginalis ap endonuclease, putative 0.002 0.024 0.0165
Schistosoma mansoni cation chloride cotransporter 0.0036 0.0582 0.0581
Echinococcus multilocularis aminopeptidase N 0.0116 0.2292 0.2291
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0251 0.0183
Loa Loa (eye worm) hypothetical protein 0.0012 0.0076 0.0074
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0066 0.1221 0.116
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.1221 0.1154
Trypanosoma cruzi macrophage infectivity potentiator, precursor, putative 0.0066 0.1221 0.116
Mycobacterium ulcerans D-serine/D-alanine/glycine transporter, CycA 0.0036 0.0582 0.0511
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0582 0.0511
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.1781 0.178
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0547 0.0546
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1189 0.1188
Loa Loa (eye worm) hypothetical protein 0.0253 0.5179 0.5178
Loa Loa (eye worm) bZIP transcription factor family protein 0.0011 0.0054 0.0052
Leishmania major histone deacetylase, putative 0.0041 0.0694 0.0629
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.3302 0.3251
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0066 0.1221 0.116
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.048 1 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.1564 0.1563
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1189 0.1188
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0012 0.0076 0.0074
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0066 0.1221 0.1173
Mycobacterium ulcerans aminopeptidase N PepN 0.0034 0.0547 0.0475
Trichomonas vaginalis conserved hypothetical protein 0.0066 0.1221 0.1154
Brugia malayi histone deacetylase 1 (HD1) 0.0041 0.0694 0.0694
Schistosoma mansoni histone deacetylase 4 5 0.0012 0.0069 0.0068
Loa Loa (eye worm) hypothetical protein 0.0253 0.5179 0.5178
Echinococcus multilocularis 0.0066 0.1221 0.122
Echinococcus granulosus X box binding protein 1 0.0348 0.7203 0.7202
Schistosoma mansoni hypothetical protein 0.0205 0.4162 0.4161
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0066 0.1221 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0938 0.7544
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.048 1 1
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0034 0.0547 0.0546
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.048 1 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.0547 0.0546
Trichomonas vaginalis gaba permease, putative 0.0036 0.0582 0.0511
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0012 0.0076 0.0006
Schistosoma mansoni histone deacetylase hda2 0.0012 0.0069 0.0068
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0251 0.0176
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0012 0.0076 0.0006
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.024 0.0238
Toxoplasma gondii peptidyl-prolyl isomerase FKBP12, putative 0.0066 0.1221 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0251 0.0183
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.5127 0.509
Loa Loa (eye worm) RNA binding protein 0.0065 0.1189 0.1188
Echinococcus multilocularis FK506 binding protein 8, 38 kDa 0.0066 0.1221 0.122
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0012 0.0076 0.0006
Trypanosoma cruzi aminopeptidase, putative 0.0012 0.0076 0.0006
Trichomonas vaginalis fk506-binding protein, putative 0.0066 0.1221 0.1154
Brugia malayi Hepatic leukemia factor 0.0011 0.0054 0.0054
Trypanosoma brucei FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0066 0.1221 0.116
Toxoplasma gondii histone deacetylase HDAC2 0.0041 0.0694 0.5426
Schistosoma mansoni tar DNA-binding protein 0.0065 0.1189 0.1188
Trichomonas vaginalis fk506 binding protein, putative 0.0066 0.1221 0.1154
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.024 0.0172
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.048 1 1
Plasmodium vivax histone deacetylase 1, putative 0.0041 0.0694 0.0629
Trichomonas vaginalis cation chloride cotransporter, putative 0.0036 0.0582 0.0511
Echinococcus multilocularis geminin 0.0205 0.4162 0.4161
Toxoplasma gondii aminopeptidase n, putative 0.0012 0.0076 0.0056
Brugia malayi solute carrier family 12 member 1 0.0036 0.0582 0.0582
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.0547 0.0546
Brugia malayi hypothetical protein 0.0011 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0052
Loa Loa (eye worm) hypothetical protein 0.0036 0.0582 0.0581
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0251 0.0183
Leishmania major fk506-binding protein 1-like protein 0.048 1 1
Brugia malayi histone deacetylase 11 0.0012 0.0069 0.0069
Mycobacterium ulcerans L-asparagine permease AnsP1 0.0036 0.0582 0.0511
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0066 0.1221 0.1173
Trichomonas vaginalis histone deacetylase, putative 0.0041 0.0694 0.0623
Loa Loa (eye worm) FKBP5 protein 0.048 1 1
Trichomonas vaginalis histone deacetylase, putative 0.0041 0.0694 0.0623
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.041 0.0409
Brugia malayi MH1 domain containing protein 0.0009 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0253 0.5179 0.5178
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.2485 0.2484
Schistosoma mansoni solute carrier family 12 k-cl cotransporter 0.0036 0.0582 0.0581
Schistosoma mansoni ap endonuclease 0.002 0.024 0.0238
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0251 0.0183
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0251 0.0251
Onchocerca volvulus Solute carrier family 12 member 9 homolog 0.0036 0.0582 0.1627
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0547 0.0546
Echinococcus multilocularis histone deacetylase 0.0012 0.0069 0.0068
Loa Loa (eye worm) hypothetical protein 0.0012 0.0069 0.0068
Schistosoma mansoni thyrotroph embryonic factor related 0.0011 0.0054 0.0052
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0547 0.0546
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0041 0.0694 0.0623
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0251 0.0183
Brugia malayi RNA binding protein 0.0065 0.1189 0.1189
Trypanosoma brucei Aminopeptidase M1, putative 0.0034 0.0547 0.0482
Echinococcus granulosus protocadherin 11 0.0011 0.0054 0.0052
Trypanosoma cruzi histone deacetylase 1, putative 0.0041 0.0694 0.0629
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0251 0.0176
Echinococcus granulosus histone deacetylase 7 0.0012 0.0069 0.0068
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1781 0.178
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.1189 0.1188
Echinococcus multilocularis neuropeptide s receptor 0.0448 0.9323 0.9323
Echinococcus multilocularis cyclic AMP responsive element binding protein 0.0011 0.0054 0.0052
Echinococcus granulosus histone deacetylase 8 0.0012 0.0069 0.0068
Trichomonas vaginalis histone deacetylase, putative 0.0041 0.0694 0.0623
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.1781 0.178
Onchocerca volvulus 0.0066 0.1221 0.3593
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.048 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.1781 0.178
Loa Loa (eye worm) histone deacetylase 3 0.0041 0.0694 0.0693
Trypanosoma brucei macrophage infectivity potentiator, precursor, putative 0.0066 0.1221 0.116
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0012 0.0076 0.0074
Onchocerca volvulus 0.0066 0.1221 0.3593
Giardia lamblia DINP protein human, muc B family 0.002 0.0251 0.0198
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.025 0.5127 0.5127
Brugia malayi Peptidase family M1 containing protein 0.0116 0.2292 0.2292
Brugia malayi hypothetical protein 0.0011 0.0054 0.0054
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0012 0.0076 0.0074
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.048 1 1
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.048 1 1
Trypanosoma cruzi Aminopeptidase M1, putative 0.0034 0.0547 0.0482
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0251 0.0112
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0066 0.1221 0.116
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0251 0.0183
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0011 0.0054 0.0052
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0251 0.0183
Trichomonas vaginalis glucosylceramidase, putative 0.025 0.5127 0.509
Trichomonas vaginalis aromatic amino acid transporter, putative 0.0036 0.0582 0.0511
Mycobacterium ulcerans GabA permease GabP 0.0036 0.0582 0.0511
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0582 0.0511
Mycobacterium ulcerans hypothetical protein 0.0066 0.1221 0.1154
Schistosoma mansoni aminopeptidase A (M01 family) 0.0012 0.0076 0.0074
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.048 1 1
Echinococcus multilocularis histone deacetylase 8 0.0012 0.0069 0.0068
Trichomonas vaginalis immunophilin, putative 0.048 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0582 0.0511
Echinococcus granulosus ccaat enhancer binding protein delta 0.0011 0.0054 0.0052
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.048 1 1
Schistosoma mansoni cpg binding protein 0.0029 0.0444 0.0442
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0041 0.0694 0.0623
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.048 1 1
Leishmania major FKBP-type peptidyl-prolyl cis-trans isomerase, putative 0.0066 0.1221 0.116
Loa Loa (eye worm) hypothetical protein 0.0104 0.2036 0.2035
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0012 0.0076 0.0006
Loa Loa (eye worm) hypothetical protein 0.0011 0.0054 0.0052
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.1781 0.1781
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0582 0.0511
Mycobacterium leprae PROBABLE TRIGGER FACTOR (TF) PROTEIN TIG 0.0066 0.1221 1
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.0066 0.1221 1
Mycobacterium tuberculosis Probable GABA permease GabP (4-amino butyrate transport carrier) (GAMA-aminobutyrate permease) 0.0036 0.0582 0.3492
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0582 0.0511

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 10 uM PUBCHEM_BIOASSAY: XBP1 DR counterscreen for CHOP. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2732, AID493217] ChEMBL. No reference
IC50 (functional) = 10 uM PUBCHEM_BIOASSAY: CHOP dose-response primary assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2732, AID493217] ChEMBL. No reference
Potency (functional) 3.6964 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 4.1095 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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