Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0021 | 0.0073 | 0.0528 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0045 | 0.0565 | 0.0594 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0126 | 0.0133 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0045 | 0.0565 | 0.0594 |
Brugia malayi | tailless protein | 0.0021 | 0.0073 | 0.0077 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0045 | 0.0565 | 0.0594 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0045 | 0.0565 | 0.4059 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0045 | 0.0565 | 0.0594 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0045 | 0.0565 | 0.4059 |
Schistosoma mansoni | nuclear hormone receptor | 0.0045 | 0.0565 | 0.4059 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0045 | 0.0565 | 0.4059 |
Onchocerca volvulus | 0.0045 | 0.0565 | 0.0495 | |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0085 | 0.1391 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0045 | 0.0565 | 0.0594 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0021 | 0.0073 | 0.0528 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0073 | 0.0077 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0085 | 0.1391 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0045 | 0.0565 | 0.4059 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0036 | 0.0385 | 0.2767 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0073 | 0.0077 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0565 | 0.0594 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0477 | 0.9509 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0385 | 0.2767 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0045 | 0.0565 | 0.4059 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0076 | 0.1207 | 0.5 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0024 | 0.0126 | 0.0906 |
Brugia malayi | nuclear receptor RXR | 0.0024 | 0.0126 | 0.0133 |
Brugia malayi | nuclear receptor NHR-88 | 0.0021 | 0.0073 | 0.0077 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0045 | 0.0565 | 0.0594 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0085 | 0.1391 | 1 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0126 | 0.0133 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0045 | 0.0565 | 0.4059 |
Brugia malayi | nuclear hormone receptor | 0.0045 | 0.0565 | 0.0594 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0045 | 0.0565 | 0.0594 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0045 | 0.0565 | 0.0594 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0045 | 0.0565 | 0.0594 |
Schistosoma mansoni | thyroid hormone receptor | 0.0045 | 0.0565 | 0.4059 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0024 | 0.0126 | 0.0133 |
Schistosoma mansoni | nuclear hormone receptor | 0.0021 | 0.0073 | 0.0528 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0076 | 0.1207 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0073 | 0.0077 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0021 | 0.0073 | 0.0528 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0021 | 0.0073 | 0.0528 |
Brugia malayi | nuclear receptor RXR | 0.0021 | 0.0073 | 0.0077 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0385 | 0.2767 |
Schistosoma mansoni | nuclear receptor | 0.0021 | 0.0073 | 0.0528 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.2109 | 0.2218 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.004 | 0.0457 | 0.3288 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0021 | 0.0073 | 0.0528 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0045 | 0.0565 | 0.4059 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0021 | 0.0073 | 0.0528 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0045 | 0.0565 | 0.4059 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0024 | 0.0126 | 0.0906 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0085 | 0.1391 | 1 |
Loa Loa (eye worm) | DR-78 | 0.0021 | 0.0073 | 0.0077 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 0.1255 | 0.132 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0024 | 0.0126 | 0.0133 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0021 | 0.0073 | 0.0528 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0036 | 0.0385 | 0.2767 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0024 | 0.0126 | 0.0906 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0085 | 0.1391 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0045 | 0.0565 | 0.0495 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0045 | 0.0565 | 0.4059 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0078 | 0.1255 | 0.132 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0085 | 0.1391 | 1 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0021 | 0.0073 | 0.0077 |
Brugia malayi | hypothetical protein | 0.004 | 0.0457 | 0.0481 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0045 | 0.0565 | 0.0594 |
Brugia malayi | ecdysone receptor | 0.0021 | 0.0073 | 0.0077 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0114 | 0.2005 | 0.2108 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.004 | 0.0457 | 0.3288 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0126 | 0.0133 |
Schistosoma mansoni | zinc finger protein | 0.0021 | 0.0073 | 0.0528 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0045 | 0.0565 | 0.0594 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0036 | 0.0385 | 0.0405 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0021 | 0.0073 | 0.0077 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0126 | 0.0133 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0045 | 0.0565 | 0.0495 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0045 | 0.0565 | 0.4059 |
Brugia malayi | nuclear receptor NHR-67 | 0.0021 | 0.0073 | 0.0077 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0085 | 0.1391 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0565 | 0.0594 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0036 | 0.0385 | 0.2767 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0045 | 0.0565 | 0.0594 |
Echinococcus multilocularis | mitogen activated protein kinase 3 | 0.0056 | 0.08 | 0.5749 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0045 | 0.0565 | 0.0594 |
Echinococcus multilocularis | mitogen activated protein kinase | 0.0056 | 0.08 | 0.5749 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0045 | 0.0565 | 0.0594 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0045 | 0.0565 | 0.0594 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0073 | 0.0077 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0045 | 0.0565 | 0.0594 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0021 | 0.0073 | 0.0528 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0073 | 0.0077 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0073 | 0.0077 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0045 | 0.0565 | 0.0594 |
Brugia malayi | nuclear hormone receptor | 0.0477 | 0.9509 | 1 |
Brugia malayi | hypothetical protein | 0.0021 | 0.0073 | 0.0077 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0045 | 0.0565 | 0.4059 |
Brugia malayi | MAP kinase sur-1 | 0.0056 | 0.08 | 0.0841 |
Brugia malayi | ecdysteroid receptor | 0.0045 | 0.0565 | 0.0594 |
Echinococcus multilocularis | GPCR, family 2 | 0.0036 | 0.0385 | 0.2767 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0021 | 0.0073 | 0.0077 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0565 | 0.0594 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0085 | 0.1391 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0085 | 0.1391 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0126 | 0.0133 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0021 | 0.0073 | 0.0528 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0073 | 0.0077 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0565 | 0.0594 |
Schistosoma mansoni | thyroid hormone receptor | 0.0045 | 0.0565 | 0.4059 |
Schistosoma mansoni | nuclear hormone receptor | 0.0021 | 0.0073 | 0.0528 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0085 | 0.1391 | 1 |
Brugia malayi | hypothetical protein | 0.0024 | 0.0126 | 0.0133 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0021 | 0.0073 | 0.0528 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0045 | 0.0565 | 0.4059 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0045 | 0.0565 | 0.4059 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0385 | 0.2767 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0385 | 0.0405 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0056 | 0.08 | 0.5 |
Loa Loa (eye worm) | inositol-1 | 0.0085 | 0.1391 | 0.1463 |
Brugia malayi | nuclear receptor NHR-88 | 0.0045 | 0.0565 | 0.0594 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0021 | 0.0073 | 0.0528 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0045 | 0.0565 | 0.0594 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0021 | 0.0073 | 0.0077 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0045 | 0.0565 | 0.0594 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0045 | 0.0565 | 0.4059 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0045 | 0.0565 | 0.0594 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.2109 | 0.2218 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0073 | 0.0077 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0045 | 0.0565 | 0.4059 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0126 | 0.0133 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0045 | 0.0565 | 0.0594 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0045 | 0.0565 | 0.4059 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0565 | 0.0594 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0036 | 0.0385 | 0.2767 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0021 | 0.0073 | 0.0077 |
Echinococcus granulosus | GPCR family 2 | 0.0036 | 0.0385 | 0.2767 |
Brugia malayi | Inositol-1 | 0.0085 | 0.1391 | 0.1463 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0045 | 0.0565 | 0.4059 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0073 | 0.0077 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0259 | 0.4993 | 0.525 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0259 | 0.4993 | 0.525 |
Onchocerca volvulus | Huntingtin homolog | 0.0119 | 0.2109 | 0.2051 |
Onchocerca volvulus | Huntingtin homolog | 0.0119 | 0.2109 | 0.2051 |
Brugia malayi | hypothetical protein | 0.0021 | 0.0073 | 0.0077 |
Brugia malayi | conserved hypotetical protein | 0.0021 | 0.0073 | 0.0077 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0565 | 0.0594 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0385 | 0.2767 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0024 | 0.0126 | 0.0133 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0056 | 0.08 | 0.0841 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0021 | 0.0073 | 0.0528 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0021 | 0.0073 | 0.0077 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0045 | 0.0565 | 0.4059 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0021 | 0.0073 | 0.0528 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0114 | 0.2005 | 0.2108 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0021 | 0.0073 | 0.0528 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0073 | 0.0077 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0045 | 0.0565 | 0.4059 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0085 | 0.1391 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0045 | 0.0565 | 0.4059 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0021 | 0.0073 | 0.0077 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0045 | 0.0565 | 0.4059 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0085 | 0.1391 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0045 | 0.0565 | 0.4059 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0045 | 0.0565 | 0.0594 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0045 | 0.0565 | 0.4059 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0565 | 0.0594 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0073 | 0.0077 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0045 | 0.0565 | 0.0594 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0073 | 0.0077 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0045 | 0.0565 | 0.4059 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0073 | 0.0077 |
Schistosoma mansoni | nuclear receptor | 0.0021 | 0.0073 | 0.0528 |
Schistosoma mansoni | inositol monophosphatase | 0.0085 | 0.1391 | 1 |
Echinococcus granulosus | mitogen activated protein kinase | 0.0056 | 0.08 | 0.5749 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0036 | 0.0385 | 0.0405 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0045 | 0.0565 | 0.0594 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0024 | 0.0126 | 0.0906 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0085 | 0.1391 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.2005 | 0.2108 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0114 | 0.2005 | 0.2108 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0036 | 0.0385 | 0.0405 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.004 | 0.0457 | 0.3288 |
Brugia malayi | hypothetical protein | 0.0119 | 0.2109 | 0.2218 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0021 | 0.0073 | 0.0077 |
Loa Loa (eye worm) | hypothetical protein | 0.0455 | 0.907 | 0.9539 |
Schistosoma mansoni | inositol monophosphatase | 0.0085 | 0.1391 | 1 |
Brugia malayi | steroid hormone receptor | 0.0045 | 0.0565 | 0.0594 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0565 | 0.0594 |
Schistosoma mansoni | hypothetical protein | 0.0078 | 0.1255 | 0.9023 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0045 | 0.0565 | 0.4059 |
Brugia malayi | MH2 domain containing protein | 0.0259 | 0.4993 | 0.525 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0457 | 0.3288 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0045 | 0.0565 | 0.4059 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0056 | 0.08 | 0.5749 |
Echinococcus granulosus | mitogen activated protein kinase 3 | 0.0056 | 0.08 | 0.5749 |
Echinococcus granulosus | FTZ F1 alpha | 0.0045 | 0.0565 | 0.4059 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0045 | 0.0565 | 0.4059 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0021 | 0.0073 | 0.0528 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 0 % | Inhibition of Monoamine oxidase B (MAO B) in rat brain at 0.1 uM | ChEMBL. | 9258353 |
Inhibition (binding) | = 0 % | Inhibition of Monoamine oxidase B (MAO B) in rat brain at 0.1 uM | ChEMBL. | 9258353 |
Inhibition (binding) | = 15 % | Inhibition of Monoamine oxidase A (MAO A) in rat brain at 1 uM | ChEMBL. | 9258353 |
Inhibition (binding) | = 15 % | Inhibition of Monoamine oxidase A (MAO A) in rat brain at 1 uM | ChEMBL. | 9258353 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.