Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | lamin A/C | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 1 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 1 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 1 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 1 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0287 | 0.0375 |
Loa Loa (eye worm) | intermediate filament protein | 0.0033 | 0.2706 | 0.3537 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.7651 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 1 | 0.5 |
Schistosoma mansoni | lamin | 0.0033 | 0.2706 | 0.2491 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.7651 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.2599 | 0.3397 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.4242 | 0.5545 |
Echinococcus granulosus | intermediate filament protein | 0.0033 | 0.2706 | 0.2491 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.7651 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0033 | 0.2706 | 0.3537 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.4242 | 0.4073 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.4242 | 0.5545 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 1 | 0.5 |
Echinococcus multilocularis | lamin | 0.0033 | 0.2706 | 0.2491 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0287 | 0.0375 |
Schistosoma mansoni | intermediate filament proteins | 0.0033 | 0.2706 | 0.2491 |
Schistosoma mansoni | lamin | 0.0033 | 0.2706 | 0.2491 |
Echinococcus multilocularis | lamin dm0 | 0.0033 | 0.2706 | 0.2491 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.2706 | 0.3537 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0287 | 0.0375 |
Echinococcus multilocularis | musashi | 0.0033 | 0.2706 | 0.2491 |
Brugia malayi | intermediate filament protein | 0.0033 | 0.2706 | 0.3537 |
Onchocerca volvulus | 0.0033 | 0.2706 | 0.5 | |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0033 | 0.2706 | 0.3537 |
Echinococcus granulosus | lamin | 0.0033 | 0.2706 | 0.2491 |
Echinococcus granulosus | lamin dm0 | 0.0033 | 0.2706 | 0.2491 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0287 | 0.0375 |
Onchocerca volvulus | 0.0033 | 0.2706 | 0.5 | |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.7651 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.1995 um | PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 23.0999 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.