Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | aldehyde dehydrogenase 1 family, member A1 | Starlite/ChEMBL | No references |
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 | aldehyde dehydrogenase 1 family, member A1 | 501 aa | 456 aa | 33.3 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.437 | 0.5625 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0503 | 0.0503 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.7703 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0503 | 0.0653 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0503 | 0.0653 |
Echinococcus granulosus | transient receptor potential cation channel | 0.0017 | 0.0085 | 0.0085 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.437 | 0.5673 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 0.4772 | 0.4772 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.437 | 0.437 |
Brugia malayi | hypothetical protein | 0.0043 | 0.4772 | 0.6152 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.4772 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 0.4772 | 0.4772 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0503 | 0.0503 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0503 | 0.0548 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0017 | 0.0085 | 0.0085 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0503 | 0.0503 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0503 | 0.0503 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.4772 | 0.4772 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0503 | 0.0503 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0017 | 0.0085 | 0.0085 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0073 | 1 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.4772 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0503 | 0.0548 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.4772 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.7703 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0503 | 0.0503 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.4772 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0503 | 0.0503 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0085 | 0.0111 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.7703 | 1 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0017 | 0.0085 | 0.0085 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0503 | 0.0503 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.7703 | 1 |
Echinococcus multilocularis | transient receptor potential cation channel | 0.0017 | 0.0085 | 0.0085 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0503 | 0.0503 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.4772 | 0.4772 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0073 | 1 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.0017 | 0.0085 | 0.0085 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 1 | 0.5 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0073 | 1 | 0.5 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0503 | 0.0503 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0073 | 1 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0073 | 1 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 1 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0073 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0657 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 0.2311 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 11.2202 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | = 35.4813 um | PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.