Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | penicillin-binding protein | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Possible penicillin-binding protein | Get druggable targets OG5_149948 | All targets in OG5_149948 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thyroid hormone receptor | 0.0103 | 0 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0103 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0103 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0103 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0402 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0103 | 0 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0103 | 0 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0103 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0245 | 0.4753 | 0.7454 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0103 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0103 | 0 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0294 | 0.6377 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0103 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0278 | 0.5841 | 0.5 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0245 | 0.4753 | 0.7454 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0103 | 0 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0103 | 0 | 0.5 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0294 | 0.6377 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0402 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0103 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.631 um | PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.