Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Homo sapiens | polymerase (DNA directed), beta | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | polymerase (DNA directed), beta | 335 aa | 303 aa | 32.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | carboxylesterase | 0.0336 | 0.904 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0192 | 0.4289 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0336 | 0.904 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0336 | 0.904 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0336 | 0.904 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0336 | 0.904 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0365 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0336 | 0.904 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0336 | 0.904 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0336 | 0.904 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0336 | 0.904 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0336 | 0.904 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0336 | 0.904 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0336 | 0.904 | 0.5 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0365 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0192 | 0.4289 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0173 | 0.3643 | 0.3643 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0365 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0336 | 0.904 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 0.8913 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.3564 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.