Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | RAR-related orphan receptor gamma | Starlite/ChEMBL | No references |
Homo sapiens | mitogen-activated protein kinase 1 | Starlite/ChEMBL | No references |
Bacillus anthracis | Anthrax lethal factor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase 1 | 360 aa | 361 aa | 33.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.015 | 1 | 0.5 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2501 | 1 |
Trypanosoma cruzi | mitogen activated protein kinase 4, putative | 0.0062 | 0.2379 | 0.5 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.0062 | 0.2379 | 0.5 |
Brugia malayi | RNA binding protein | 0.0063 | 0.2501 | 0.2501 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0062 | 0.2379 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 11, putative | 0.0062 | 0.2379 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.2501 | 0.2501 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.2501 | 0.2501 |
Brugia malayi | MAP kinase sur-1 | 0.0062 | 0.2379 | 0.2379 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2501 | 1 |
Toxoplasma gondii | CMGC kinase, MAPK family (ERK) MAPK-1 | 0.0062 | 0.2379 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.1348 | 0.1348 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.1348 | 0.1348 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0062 | 0.2379 | 0.9513 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.2379 | 0.5 |
Trypanosoma brucei | protein kinase, putative | 0.0062 | 0.2379 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2501 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.2501 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 1 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/ERK1 protein kinase | 0.0062 | 0.2379 | 0.2379 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.2501 | 0.2501 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2501 | 1 |
Giardia lamblia | Kinase, CMGC MAPK | 0.0062 | 0.2379 | 0.5 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.2379 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.2501 | 0.2501 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.1348 | 0.1348 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.2379 | 0.5 |
Trypanosoma cruzi | mitogen activated protein kinase 2, putative | 0.0062 | 0.2379 | 0.5 |
Trypanosoma brucei | mitogen activated protein kinase 4, putative | 0.0062 | 0.2379 | 0.5 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.0062 | 0.2379 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1348 | 0.1348 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0062 | 0.2379 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.2501 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2501 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.2501 | 0.2501 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | = 1.9953 um | PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 17.7828 um | PUBCHEM_BIOASSAY: VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | 31.6228 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.