TDR Targets

Basic information

Technical information

TDR Targets ID: 133463
Name: 3-(1-methyl-2-sulfanylidene-3H-indol-3-yl)pro panoic acid
MW: 235.302 | Formula: C12H13NO2S
H donors: 1 H acceptors: 2 LogP: 1.44 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)CCC1c2ccccc2N(C1=S)C
InChi: 1S/C12H13NO2S/c1-13-10-5-3-2-4-8(10)9(12(13)16)6-7-11(14)15/h2-5,9H,6-7H2,1H3,(H,14,15)
InChiKey: LBALNCFWTZTSFW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-(1-methyl-2-thioxo-indolin-3-yl)propanoic acid
3-(1-methyl-2-thioxo-3-indolinyl)propanoic acid
3-(1-methyl-2-thioxo-indolin-3-yl)propionic acid
2-thioxo-1H-indole-3-alkanoic acid deriv. 10

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	epidermal growth factor receptor	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis		Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Tyrosine-protein kinase transforming protein erbB, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	IPR000494,EGF receptor, L domain,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	ko:K05085 receptor tyrosine-protein kinase erbB-4, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-4 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Brugia malayi	Furin-like cysteine rich region family protein	Get druggable targets OG5_128597	All targets in OG5_128597
Loa Loa (eye worm)	TK/EGFR protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-2 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0039	0.0636	0.1833
Loa Loa (eye worm)	TK/EGFR protein kinase	0.018	0.4799	1
Onchocerca volvulus	Alhambra homolog	0.0035	0.0515	1
Echinococcus multilocularis	lamin dm0	0.0032	0.0438	0.0541
Brugia malayi	Protein kinase domain containing protein	0.0058	0.119	0.2479
Giardia lamblia	PHD finger protein 15	0.0035	0.0515	0.7485
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0109	0.0227
Brugia malayi	jmjC domain containing protein	0.0042	0.0729	0.1519
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0028	0.0317	0.0311
Echinococcus granulosus	jumonji domain containing protein	0.0048	0.0914	0.1444
Plasmodium falciparum	thioredoxin reductase	0.0039	0.0636	0.1967
Trypanosoma brucei	trypanothione reductase	0.0112	0.2789	1
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0255	0.7009	0.8887
Echinococcus granulosus	geminin	0.0201	0.5423	1
Schistosoma mansoni	tyrosine kinase	0.0058	0.119	0.1053
Mycobacterium tuberculosis	Probable oxidoreductase	0.0284	0.7847	1
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0039	0.0636	0.1967
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0039	0.0636	1
Echinococcus multilocularis	PHD finger protein rhinoceros	0.0035	0.0515	0.0686
Echinococcus granulosus	PHD finger protein rhinoceros	0.0035	0.0515	0.0686
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0284	0.7847	1
Entamoeba histolytica	acyl-coA synthetase, putative	0.0028	0.0317	0.2632
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0039	0.0636	0.0917
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0039	0.0636	0.1833
Mycobacterium ulcerans	acyl-CoA synthetase	0.0028	0.0317	0.3118
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0039	0.0636	0.7909
Leishmania major	4-coumarate:coa ligase-like protein	0.0028	0.0317	0.0622
Loa Loa (eye worm)	transcription factor SMAD2	0.0142	0.3671	0.765
Echinococcus granulosus	peregrin	0.0035	0.0515	0.0686
Trypanosoma cruzi	trypanothione reductase, putative	0.0039	0.0636	0.1833
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0438	0.0913
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0042	0.0729	0.0585
Brugia malayi	Intermediate filament tail domain containing protein	0.0032	0.0438	0.0913
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0028	0.0317	0.3118
Loa Loa (eye worm)	MH2 domain-containing protein	0.0142	0.3671	0.765
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0109	0.0227
Plasmodium falciparum	glutathione reductase	0.0039	0.0636	0.1967
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0039	0.0636	0.0721
Echinococcus multilocularis		0.0056	0.1137	0.1866
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0284	0.7847	1
Brugia malayi	glutathione reductase	0.0112	0.2789	0.5811
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0113	0.2835	0.509
Mycobacterium ulcerans	DNA polymerase IV	0.0022	0.0153	0.0659
Schistosoma mansoni	lamin	0.0032	0.0438	0.029
Schistosoma mansoni	tyrosine kinase	0.0097	0.2345	0.2226
Schistosoma mansoni	hypothetical protein	0.0201	0.5423	0.5352
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0039	0.0636	0.1833
Brugia malayi	intermediate filament protein	0.0032	0.0438	0.0913
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0317	0.066
Schistosoma mansoni	tyrosine kinase	0.0058	0.119	0.1053
Echinococcus granulosus	epidermal growth factor receptor	0.018	0.4799	0.8817
Mycobacterium ulcerans	DNA polymerase IV	0.0022	0.0153	0.0659
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0043	0.0775	0.2362
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0255	0.7009	0.8921
Leishmania major	4-coumarate:coa ligase-like protein	0.0028	0.0317	0.0622
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0153	0.0319
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0039	0.0636	0.1967
Schistosoma mansoni	tyrosine kinase	0.0096	0.2315	0.2195
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0043	0.0775	0.2362
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0039	0.0636	0.1967
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0043	0.0775	1
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0039	0.0636	0.0917
Plasmodium vivax	glutathione reductase, putative	0.0112	0.2789	1
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0039	0.0636	0.1833
Echinococcus multilocularis	inositol monophosphatase 1	0.0043	0.0775	0.1181
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0039	0.0636	0.1833
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0043	0.0775	0.2362
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0109	0.0227
Schistosoma mansoni	bromodomain-containing nuclear protein 1 brd1	0.0035	0.0515	0.0367
Schistosoma mansoni	lamin	0.0032	0.0438	0.029
Mycobacterium ulcerans	acyl-CoA synthetase	0.0028	0.0317	0.3118
Leishmania major	4-coumarate:coa ligase-like protein	0.0028	0.0317	0.0622
Echinococcus multilocularis	epidermal growth factor receptor	0.018	0.4799	0.8817
Loa Loa (eye worm)	TK/INSR protein kinase	0.0058	0.119	0.2479
Brugia malayi	Inositol-1	0.0043	0.0775	0.1616
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0028	0.0317	0.3118
Onchocerca volvulus		0.0032	0.0438	0.6132
Plasmodium vivax	thioredoxin reductase, putative	0.0112	0.2789	1
Trichomonas vaginalis	mercuric reductase, putative	0.0039	0.0636	0.7761
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0043	0.0775	0.1147
Brugia malayi	AMP-binding enzyme family protein	0.0028	0.0317	0.066
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0515	0.1514
Echinococcus multilocularis	insulin receptor	0.0058	0.119	0.1967
Brugia malayi	Thioredoxin reductase	0.0112	0.2789	0.5811
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0028	0.0317	0.3118
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0032	0.0438	0.0913
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0039	0.0636	0.1833
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0039	0.0636	0.0491
Schistosoma mansoni	tyrosine kinase	0.0097	0.2345	0.2226
Echinococcus granulosus	lysine specific demethylase 5A	0.0042	0.0729	0.1094
Loa Loa (eye worm)	hypothetical protein	0.0059	0.1243	0.259
Schistosoma mansoni	hypothetical protein	0.0201	0.5423	0.5352
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0028	0.0333	0.0694
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0039	0.0636	0.1833
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0028	0.0317	0.2632
Mycobacterium tuberculosis	Probable reductase	0.0255	0.7009	0.8921
Treponema pallidum	NADH oxidase	0.0039	0.0636	0.5
Echinococcus multilocularis	epidermal growth factor receptor	0.0097	0.2345	0.4159
Brugia malayi	AMP-binding enzyme family protein	0.0028	0.0317	0.066
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0039	0.0636	0.1833
Leishmania major	trypanothione reductase	0.0112	0.2789	1
Brugia malayi	ImpB/MucB/SamB family protein	0.0022	0.0153	0.0319
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0039	0.0636	0.1833
Brugia malayi	PHD-finger family protein	0.0035	0.0515	0.1072
Echinococcus granulosus	epidermal growth factor receptor	0.0097	0.2345	0.4159
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0039	0.0636	0.1833
Brugia malayi	Bromodomain containing protein	0.0035	0.0515	0.1072
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0039	0.0636	1
Trichomonas vaginalis	glutathione reductase, putative	0.0039	0.0636	0.7761
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0421	0.0877
Loa Loa (eye worm)	intermediate filament protein	0.0032	0.0438	0.0913
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0255	0.7009	0.8921
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0039	0.0636	0.1833
Echinococcus granulosus	inositol monophosphatase 1	0.0043	0.0775	0.1181
Brugia malayi	jmjC domain containing protein	0.0113	0.2835	0.5908
Schistosoma mansoni	hypothetical protein	0.0035	0.0515	0.0367
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0039	0.0641	0.0728
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0255	0.7009	0.8921
Echinococcus granulosus	thioredoxin glutathione reductase	0.0112	0.2789	0.5001
Loa Loa (eye worm)	jmjC domain-containing protein	0.0072	0.1601	0.3335
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0112	0.2789	0.5001
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0028	0.0333	0.0694
Schistosoma mansoni	inositol monophosphatase	0.0043	0.0775	0.0632
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0039	0.0636	0.1833
Loa Loa (eye worm)	thioredoxin reductase	0.0112	0.2789	0.5811
Schistosoma mansoni	intermediate filament proteins	0.0032	0.0438	0.029
Toxoplasma gondii	thioredoxin reductase	0.0112	0.2789	1
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0028	0.0317	0.3118
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0039	0.0636	0.1325
Schistosoma mansoni	tyrosine kinase	0.018	0.4799	0.4719
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0021	0.0109	0.0043
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0043	0.0775	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0028	0.0317	0.3118
Echinococcus granulosus	insulin receptor	0.0058	0.119	0.1967
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0042	0.0729	0.0585
Loa Loa (eye worm)	PHD-finger family protein	0.0035	0.0515	0.1072
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0317	0.066
Brugia malayi	Furin-like cysteine rich region family protein	0.018	0.4799	1
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0039	0.0636	0.0534
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0097	0.2345	0.4159
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0043	0.0775	0.2362
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0028	0.0317	0.0311
Schistosoma mansoni	tyrosine kinase	0.0096	0.2315	0.2195
Wolbachia endosymbiont of Brugia malayi	fructose-1,6-bisphosphatase	0.0043	0.0775	1
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0058	0.119	0.1967
Echinococcus granulosus	intermediate filament protein	0.0032	0.0438	0.0541
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0109	0.0227
Mycobacterium tuberculosis	Probable dehydrogenase	0.0255	0.7009	0.8921
Echinococcus granulosus	lamin dm0	0.0032	0.0438	0.0541
Plasmodium falciparum	thioredoxin reductase	0.0112	0.2789	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0028	0.0317	0.2632
Plasmodium falciparum	phd finger protein, putative	0.0035	0.0515	0.1514
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0039	0.0636	0.7909
Toxoplasma gondii	NADPH-glutathione reductase	0.0039	0.0636	0.0534
Brugia malayi	MH2 domain containing protein	0.0142	0.3671	0.765
Brugia malayi	AMP-binding enzyme family protein	0.0028	0.0317	0.066
Loa Loa (eye worm)	glutathione reductase	0.0112	0.2789	0.5811
Schistosoma mansoni	inositol monophosphatase	0.0043	0.0775	0.0632
Brugia malayi	ImpB/MucB/SamB family protein	0.0022	0.0153	0.0319
Loa Loa (eye worm)	inositol-1	0.0043	0.0775	0.1616
Plasmodium falciparum	glutathione reductase	0.0112	0.2789	1
Echinococcus granulosus	lamin	0.0032	0.0438	0.0541
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0109	0.0227
Echinococcus multilocularis	musashi	0.0032	0.0438	0.0541
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0255	0.7009	0.8921
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0022	0.0153	0.01
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0022	0.0153	0.0319
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0317	0.066
Trichomonas vaginalis	inositol monophosphatase, putative	0.0043	0.0775	1
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0043	0.0775	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0284	0.7847	1
Echinococcus multilocularis	geminin	0.0201	0.5423	1
Echinococcus multilocularis	peregrin	0.0035	0.0515	0.0686
Onchocerca volvulus		0.0032	0.0438	0.6132
Schistosoma mansoni	jumonji domain containing protein	0.009	0.2149	0.2027
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0039	0.0636	0.1833
Echinococcus multilocularis	jumonji domain containing protein	0.0048	0.0914	0.1444
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0039	0.0636	0.7909
Mycobacterium ulcerans	hypothetical protein	0.0028	0.0317	0.3118
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0058	0.119	0.1967
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0113	0.2835	0.509
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0022	0.0153	0.01
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0039	0.0636	0.1833
Loa Loa (eye worm)	jmjC domain-containing protein	0.0042	0.0729	0.1519
Echinococcus multilocularis	lamin	0.0032	0.0438	0.0541
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0043	0.0775	1
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0039	0.0636	0.1967
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0112	0.2789	0.3491
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0039	0.0636	0.1833
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0039	0.0641	0.0431
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0515	0.1072
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0039	0.0636	0.1833
Schistosoma mansoni	tyrosine kinase	0.0096	0.2315	0.2195
Echinococcus multilocularis	lysine specific demethylase 5A	0.0042	0.0729	0.1094
Trypanosoma cruzi	trypanothione reductase, putative	0.0112	0.2789	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 6.7 uM	Inhibition of EGF-stimulated EGFR tyrosine kinase activity using plasma membrane vesicles shed from cultured human A431 carcinoma cells	ChEMBL.	8355247
IC50 (functional)	= 6.7 uM	Inhibition of EGF-stimulated EGFR tyrosine kinase activity using plasma membrane vesicles shed from cultured human A431 carcinoma cells	ChEMBL.	8355247

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 5328540

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 133463