Detailed information for compound 1334700

Basic information

Technical information
  • TDR Targets ID: 1334700
  • Name: [1-(4-nitrophenyl)sulfonylpiperidin-3-yl]-pip eridin-1-ylmethanone
  • MW: 381.447 | Formula: C17H23N3O5S
  • H donors: 0 H acceptors: 5 LogP: 1.7 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCCCC1)C1CCCN(C1)S(=O)(=O)c1ccc(cc1)[N+](=O)[O-]
  • InChi: 1S/C17H23N3O5S/c21-17(18-10-2-1-3-11-18)14-5-4-12-19(13-14)26(24,25)16-8-6-15(7-9-16)20(22)23/h6-9,14H,1-5,10-13H2
  • InChiKey: JHGDLDUAEJSZMO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • [1-(4-nitrophenyl)sulfonyl-3-piperidyl]-(1-piperidyl)methanone
  • [1-(4-nitrophenyl)sulfonyl-3-piperidinyl]-(1-piperidyl)methanone
  • [1-(4-nitrophenyl)sulfonyl-3-piperidyl]-piperidino-methanone
  • [1-(4-nitrophenyl)sulfonylpiperidin-3-yl]-piperidin-1-yl-methanone
  • STK193867

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens ataxin 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nuclear receptor 0.0015 0.0003 0.0005
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0098 0.1872 0.8837
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0382 0.0382
Loa Loa (eye worm) fibroinase 0.0026 0.0254 0.0364
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.1218 1
Schistosoma mansoni mitochondrial import inner membrane translocase subunit tim10 0.0054 0.0886 0.1309
Echinococcus granulosus cathepsin l1 0.0026 0.0254 0.0254
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0254 0.0444
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0382 0.0554
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0382 0.0554
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0154 0.1743
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0254 0.3316
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0059
Brugia malayi hypothetical protein 0.0015 0.0003 0.0005
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0382 0.0382
Giardia lamblia Cathepsin B precursor 0.0049 0.0767 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0835 0.0835
Echinococcus multilocularis geminin 0.0173 0.3575 0.3575
Loa Loa (eye worm) transcription factor SMAD2 0.0254 0.5387 0.7798
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0157 0.3205 0.4637
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0107 0.0879
Echinococcus multilocularis calpain A 0.0069 0.1227 0.1227
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0382 0.0382
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0254 0.3316
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0254 0.0444
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0382 0.0549
Echinococcus granulosus expressed protein 0.0054 0.0886 0.0886
Echinococcus multilocularis muscleblind protein 1 0.018 0.3731 0.3731
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.009 0.0133
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0254 0.3316
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0785 0.1132
Brugia malayi Thioredoxin reductase 0.0043 0.0632 0.0915
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0351 0.1244
Entamoeba histolytica hypothetical protein 0.0024 0.0204 0.7922
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0785 0.0785
Loa Loa (eye worm) hypothetical protein 0.0121 0.2403 0.3476
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0015 0.0013 0.0019
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0835 0.0835
Brugia malayi hypothetical protein 0.002 0.0108 0.0156
Echinococcus multilocularis cathepsin L cysteine protease 0.0026 0.0254 0.0254
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0835 0.1204
Echinococcus granulosus thyroid hormone receptor alpha 0.0015 0.0003 0.0003
Onchocerca volvulus 0.0026 0.0254 0.0364
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0015 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0059
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0254 0.3316
Brugia malayi Papain family cysteine protease containing protein 0.0015 0.0013 0.0019
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.014 0.2819 1
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM23, putative 0.0046 0.0702 0.7918
Echinococcus granulosus calpain A 0.0069 0.1227 0.1227
Brugia malayi calpain 7 0.002 0.0107 0.0155
Loa Loa (eye worm) hypothetical protein 0.0046 0.0709 0.1022
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0049 0.0767 0.1133
Brugia malayi ecdysteroid receptor 0.0032 0.0382 0.0554
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0109 0.2118 1
Loa Loa (eye worm) calpain family protein 1 0.0066 0.1151 0.1663
Loa Loa (eye worm) hypothetical protein 0.0032 0.0382 0.0549
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0107 0.038
Echinococcus multilocularis thyroid hormone receptor alpha 0.0032 0.0382 0.0382
Onchocerca volvulus Cathepsin F homolog 0.0026 0.0254 0.0364
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0026 0.0254 0.0254
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0069 0.1227 0.1813
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.108 0.1564
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM10, putative 0.0054 0.0886 1
Plasmodium vivax mitochondrial import inner membrane translocase subunit TIM10, putative 0.0054 0.0886 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0015 0.0003 0.0005
Echinococcus multilocularis nuclear receptor nhr 48 0.0015 0.0003 0.0003
Onchocerca volvulus 0.0046 0.0709 0.1022
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0154 0.0548
Brugia malayi Cathepsin L-like precursor 0.0019 0.009 0.013
Echinococcus granulosus calpain 5 0.002 0.0107 0.0107
Giardia lamblia Cathepsin B precursor 0.0049 0.0767 1
Trypanosoma cruzi cysteine peptidase, putative 0.0015 0.0013 0.0046
Loa Loa (eye worm) hypothetical protein 0.0107 0.2085 0.3015
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0154 0.0224
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0003 0.0005
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0382 0.0565
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0154 0.0548
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0254 0.0444
Onchocerca volvulus Cathepsin L homolog 0.0026 0.0254 0.0364
Brugia malayi Papain family cysteine protease containing protein 0.0015 0.0013 0.0019
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0254 0.0903
Onchocerca volvulus Huntingtin homolog 0.0121 0.2403 0.3476
Brugia malayi Latrophilin receptor protein 2 0.005 0.0785 0.1136
Onchocerca volvulus 0.0034 0.0428 0.0616
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0315 0.6769 0.9799
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0157 0.3205 0.4639
Brugia malayi glutathione reductase 0.0043 0.0632 0.0915
Echinococcus granulosus importin subunit beta 1 0.003 0.033 0.033
Toxoplasma gondii thioredoxin reductase 0.0043 0.0632 0.5192
Schistosoma mansoni smad1 5 8 and 0.0017 0.0055 0.0081
Loa Loa (eye worm) cathepsin B 0.0049 0.0767 0.1107
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0049 0.0767 0.134
Trypanosoma cruzi trypanothione reductase, putative 0.0043 0.0632 0.2243
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0015 0.0003 0.0003
Brugia malayi RNA, U transporter 1 0.0084 0.1557 0.2254
Brugia malayi hypothetical protein 0.0017 0.0044 0.0063
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0003 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0428 0.0633
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0254 0.0903
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0382 0.0554
Schistosoma mansoni cathepsin F (C01 family) 0.0026 0.0254 0.0376
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0254 0.0444
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.009 0.0157
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0785 0.0785
Echinococcus multilocularis calpain 5 0.002 0.0107 0.0107
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0382 0.0565
Brugia malayi Muscleblind-like protein 0.018 0.3731 0.5401
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0254 0.0444
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0254 0.0903
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0003 0.0005
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0204 0.0357
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0013 0.0023
Schistosoma mansoni nuclear receptor 0.0015 0.0003 0.0005
Schistosoma mansoni Smad4 0.0017 0.0055 0.0081
Brugia malayi Cathepsin L-like precursor 0.0019 0.009 0.013
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0382 0.0549
Plasmodium falciparum glutathione reductase 0.0043 0.0632 0.7137
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0382 0.0565
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0382 0.0382
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0055 0.0074
Leishmania major cathepsin L-like protease 0.0026 0.0254 0.2089
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0015 0 0.5
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0382 0.0549
Loa Loa (eye worm) hypothetical protein 0.003 0.033 0.0474
Schistosoma mansoni smad1 5 8 and 0.0017 0.0055 0.0081
Giardia lamblia Cathepsin B precursor 0.0049 0.0767 1
Onchocerca volvulus 0.0026 0.0254 0.0364
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0098 0.1872 0.8837
Leishmania major kinesin, putative 0.002 0.0107 0.0879
Toxoplasma gondii mitochondrial inner membrane translocase subunit TIM17, putative 0.0046 0.0702 0.576
Mycobacterium tuberculosis Probable reductase 0.0098 0.1872 0.8837
Schistosoma mansoni thyroid hormone receptor 0.0032 0.0382 0.0565
Loa Loa (eye worm) hypothetical protein 0.0032 0.0382 0.0549
Brugia malayi hypothetical protein 0.0017 0.0044 0.0063
Leishmania major hypothetical protein, conserved 0.003 0.0351 0.288
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0107 0.038
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0015 0.0003 0.0005
Brugia malayi Papain family cysteine protease containing protein 0.0026 0.0254 0.0368
Loa Loa (eye worm) hypothetical protein 0.0121 0.2403 0.3476
Loa Loa (eye worm) hypothetical protein 0.0032 0.0382 0.0549
Plasmodium vivax vivapain-2 0.0026 0.0254 0.2872
Loa Loa (eye worm) hypothetical protein 0.0032 0.0382 0.0549
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0382 0.0549
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0254 0.0444
Plasmodium vivax importin-beta 2, putative 0.003 0.033 0.3726
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0351 0.3959
Trypanosoma cruzi kinesin, putative 0.002 0.0107 0.038
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0059
Trypanosoma brucei kinesin, putative 0.002 0.0107 0.1395
Brugia malayi Nuclear hormone receptor E75 0.0015 0.0003 0.0005
Brugia malayi nuclear hormone receptor 0.0032 0.0382 0.0554
Schistosoma mansoni ran 0.0022 0.0154 0.0228
Plasmodium vivax vivapain-3 0.0015 0.0013 0.0147
Schistosoma mansoni ran 0.0022 0.0154 0.0228
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0254 0.0444
Echinococcus granulosus GPCR family 2 0.005 0.0785 0.0785
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0003 0.0003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0015 0.0013 0.017
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0109 0.2118 1
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0046 0.0702 0.1016
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0382 0.0554
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0254 0.0444
Loa Loa (eye worm) cysteine protease 0.0026 0.0254 0.0364
Echinococcus granulosus thioredoxin glutathione reductase 0.0044 0.0645 0.0645
Loa Loa (eye worm) hypothetical protein 0.0019 0.009 0.0125
Brugia malayi Smad1 0.0017 0.0055 0.0079
Echinococcus granulosus cathepsin L cysteine proteinase 0.0026 0.0254 0.0254
Echinococcus multilocularis calpain family protein 1, d 0.0046 0.0709 0.0709
Schistosoma mansoni Mername-AA248 (C02 family) 0.002 0.0107 0.0158
Schistosoma mansoni hypothetical protein 0.005 0.0785 0.1159
Schistosoma mansoni smad 0.0017 0.0055 0.0081
Loa Loa (eye worm) glutathione reductase 0.0043 0.0632 0.0911
Echinococcus granulosus smad 0.0017 0.0055 0.0055
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.014 0.2819 0.4165
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0785 0.0785
Brugia malayi Mitochondrial import inner membrane translocase subunit TIM10 0.0054 0.0886 0.1283
Echinococcus granulosus cathepsin l1 0.0019 0.009 0.009
Echinococcus granulosus tar DNA binding protein 0.0063 0.108 0.108
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0107 0.0879
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.108 0.156
Toxoplasma gondii aldehyde dehydrogenase 0.0069 0.1218 1
Brugia malayi ecdysone receptor 0.0015 0.0003 0.0005
Toxoplasma gondii cathepsin B 0.0049 0.0767 0.6299
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0382 0.0382
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0254 0.0444
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0428 0.0428
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0026 0.0254 0.2872
Trichomonas vaginalis set domain proteins, putative 0.0269 0.5724 1
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0351 0.4572
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0428 0.0633
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0254 0.3316
Plasmodium falciparum importin beta, putative 0.003 0.033 0.3726
Trypanosoma brucei calpain-like protein, putative 0.002 0.0107 0.1395
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0254 0.0444
Brugia malayi nuclear hormone receptor family member nhr-6 0.0015 0.0003 0.0005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0254 0.0444
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0069 0.1227 0.1227
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0059
Brugia malayi orphan nuclear receptor NR2E1 0.0015 0.0003 0.0005
Schistosoma mansoni hypothetical protein 0.0315 0.6769 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0382 0.0554
Loa Loa (eye worm) transport to inner mitochondrial membrane family member 0.0054 0.0886 0.1279
Loa Loa (eye worm) hypothetical protein 0.0066 0.1151 0.1663
Plasmodium vivax calpain, putative 0.002 0.0107 0.1208
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0254 0.0444
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0835 0.1233
Echinococcus multilocularis expressed protein 0.0054 0.0886 0.0886
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0254 0.0444
Schistosoma mansoni cathepsin F (C01 family) 0.0026 0.0254 0.0376
Schistosoma mansoni smad1 5 8 and 0.0017 0.0055 0.0081
Entamoeba histolytica Ran family GTPase 0.0022 0.0154 0.5858
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.1218 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0382 0.0554
Trypanosoma brucei calpain-like protein, putative 0.002 0.0107 0.1395
Brugia malayi calpain family protein 1 0.0066 0.1151 0.1667
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.002 0.0107 0.1395
Brugia malayi nuclear receptor NHR-88 0.0032 0.0382 0.0554
Leishmania major cathepsin L-like protease 0.0026 0.0254 0.2089
Echinococcus multilocularis cysteine protease 0.0026 0.0254 0.0254
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0154 0.1268
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0254 0.0444
Schistosoma mansoni hypothetical protein 0.005 0.0785 0.1159
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0382 0.0554
Brugia malayi tailless protein 0.0015 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0046 0.0702 0.1011
Loa Loa (eye worm) hypothetical protein 0.005 0.0785 0.1132
Brugia malayi calpain 5 0.002 0.0107 0.0155
Schistosoma mansoni tar DNA-binding protein 0.0063 0.108 0.1596
Schistosoma mansoni coup transcription factor 0.0032 0.0382 0.0565
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.0013 0.0023
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0382 0.0549
Onchocerca volvulus 0.0321 0.6908 1
Loa Loa (eye worm) calpain 5 0.002 0.0107 0.015
Echinococcus granulosus snurportin 1 0.0315 0.6769 0.6769
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0204 0.0357
Loa Loa (eye worm) hypothetical protein 0.018 0.3731 0.5399
Plasmodium falciparum thioredoxin reductase 0.0043 0.0632 0.7137
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0382 0.0549
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0015 0.0003 0.0003
Echinococcus granulosus cathepsin L 0.0015 0.0013 0.0013
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0835 0.1209
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0254 0.0903
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0204 0.0357
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0254 0.3316
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0046 0.0702 0.1016
Echinococcus granulosus cysteine protease 0.0015 0.0013 0.0013
Leishmania major cathepsin L-like protease 0.0026 0.0254 0.2089
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0428 0.3517
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0069 0.1218 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0254 0.3316
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0382 0.0565
Echinococcus granulosus cathepsin b 0.014 0.2819 0.2819
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0382 0.0382
Onchocerca volvulus 0.0026 0.0254 0.0364
Onchocerca volvulus Huntingtin homolog 0.0121 0.2403 0.3476
Toxoplasma gondii TIM10 family protein, putative 0.0054 0.0886 0.7275
Schistosoma mansoni tar DNA-binding protein 0.0063 0.108 0.1596
Leishmania major cathepsin L-like protease 0.0026 0.0254 0.2089
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0382 0.0565
Echinococcus multilocularis smad 0.0017 0.0055 0.0055
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0043 0.0632 0.2985
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0382 0.0565
Loa Loa (eye worm) hypothetical protein 0.0321 0.6908 1
Onchocerca volvulus 0.0026 0.0254 0.0364
Schistosoma mansoni calpain C (C02 family) 0.002 0.0107 0.0158
Trypanosoma cruzi calpain cysteine peptidase, putative 0.002 0.0107 0.038
Brugia malayi hypothetical protein 0.0042 0.0601 0.087
Schistosoma mansoni zinc finger protein 0.0015 0.0003 0.0005
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0204 0.0725
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0254 0.3316
Loa Loa (eye worm) hypothetical protein 0.0046 0.0709 0.1022
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0055 0.0081
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0044 0.0063
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0154 0.2013
Loa Loa (eye worm) MH2 domain-containing protein 0.0254 0.5387 0.7798
Schistosoma mansoni hypothetical protein 0.0173 0.3575 0.5282
Treponema pallidum NADH oxidase 0.0015 0 0.5
Schistosoma mansoni hypothetical protein 0.0046 0.0702 0.1036
Onchocerca volvulus 0.0026 0.0254 0.0364
Brugia malayi MH1 domain containing protein 0.0017 0.0055 0.0079
Schistosoma mansoni nuclear receptor nhr-48 0.0015 0.0003 0.0005
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0254 0.3316
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0069 0.1218 0.1218
Leishmania major cathepsin L-like protease 0.0026 0.0254 0.2089
Trypanosoma cruzi cysteine proteinase, putative 0.0015 0.0013 0.0046
Loa Loa (eye worm) hypothetical protein 0.0157 0.3205 0.4637
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0254 0.3316
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0015 0.0013 0.017
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0107 0.038
Brugia malayi Cathepsin L-like precursor 0.0026 0.0254 0.0368
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0026 0.0254 0.0254
Brugia malayi calpain family protein 1 0.0066 0.1151 0.1667
Loa Loa (eye worm) TAR-binding protein 0.0063 0.108 0.156
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0428 0.0428
Brugia malayi Cathepsin L-like precursor 0.0026 0.0254 0.0368
Brugia malayi cathepsin B-like cysteine proteinase 0.014 0.2819 0.4081
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0107 0.038
Leishmania major trypanothione reductase 0.0043 0.0632 0.5192
Brugia malayi Cathepsin L-like precursor 0.0026 0.0254 0.0368
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0382 0.0554
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0026 0.0254 0.0444
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0109 0.2118 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0382 0.0549
Trypanosoma brucei antigen, putative 0.002 0.0107 0.1395
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0254 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0017 0.0044 0.0044
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.04 0.04
Echinococcus granulosus cathepsin L cysteine protease 0.0015 0.0013 0.0013
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0055 0.0055
Trypanosoma brucei cysteine peptidase C (CPC) 0.0049 0.0767 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0382 0.0549
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0382 0.0382
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0015 0.0013 0.0019
Entamoeba histolytica calpain large subunit domain III containing protein 0.002 0.0107 0.3895
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0351 0.288
Schistosoma mansoni hypothetical protein 0.005 0.0785 0.1159
Loa Loa (eye worm) hypothetical protein 0.0019 0.009 0.0125
Loa Loa (eye worm) calpain 0.002 0.0107 0.015
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.033 0.4303
Echinococcus multilocularis neuropeptide s receptor 0.0458 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0835 0.0835
Echinococcus multilocularis cathepsin b 0.014 0.2819 0.2819
Schistosoma mansoni tar DNA-binding protein 0.0063 0.108 0.1596
Brugia malayi hypothetical protein 0.0321 0.6908 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0254 0.3316
Echinococcus multilocularis GPCR, family 2 0.005 0.0785 0.0785
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0015 0 0.5
Echinococcus multilocularis tar DNA binding protein 0.0063 0.108 0.108
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.033 0.4303
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0785 0.1136
Plasmodium vivax thioredoxin reductase, putative 0.0043 0.0632 0.7137
Onchocerca volvulus 0.0032 0.0382 0.0549
Brugia malayi hypothetical protein 0.0042 0.0601 0.087
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0017 0.0044 0.0059
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0015 0.0013 0.0019
Leishmania major cysteine peptidase A (CPA) 0.0026 0.0254 0.2089
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0382 0.0382
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0098 0.1872 0.8837
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0015 0.0003 0.0005
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0107 0.038
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0107 0.038
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0044 0.0065
Loa Loa (eye worm) calpain family protein 1 0.0046 0.0709 0.1022
Echinococcus multilocularis snurportin 1 0.0315 0.6769 0.6769
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0835 0.1233
Loa Loa (eye worm) hypothetical protein 0.018 0.3731 0.5399
Echinococcus granulosus calpain A 0.002 0.0107 0.0107
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.014 0.2819 0.4165
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0351 0.3959
Brugia malayi Importin beta-1 subunit 0.003 0.033 0.0478
Echinococcus granulosus neuropeptide receptor A26 0.0458 1 1
Entamoeba histolytica cysteine protease, putative 0.0026 0.0254 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0382 0.0382
Brugia malayi nuclear receptor NHR-88 0.0015 0.0003 0.0005
Schistosoma mansoni hypothetical protein 0.005 0.0785 0.1159
Trypanosoma brucei calpain-like protein, putative 0.002 0.0107 0.1395
Echinococcus granulosus Smad4 0.0017 0.0055 0.0055
Echinococcus granulosus nuclear receptor nhr 48 0.0015 0.0003 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0382 0.0549
Leishmania major GTP-binding protein, putative 0.0022 0.0154 0.1268
Brugia malayi Mitochondrial import inner membrane translocase subunit Tim17 family protein 0.0046 0.0702 0.1016
Brugia malayi nuclear hormone receptor 0.0015 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0034 0.0428 0.0616
Echinococcus granulosus cathepsin b 0.014 0.2819 0.2819
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0382 0.0382
Brugia malayi nuclear receptor RXR 0.0015 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0026 0.0254 0.0364
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0154 0.0154
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0382 0.0554
Brugia malayi steroid hormone receptor 0.0032 0.0382 0.0554
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0254 0.0444
Echinococcus multilocularis calpain 7 (C02 family) 0.002 0.0107 0.0107
Brugia malayi Cathepsin L-like cysteine proteinase 0.0019 0.009 0.013
Onchocerca volvulus 0.0269 0.5724 0.8286
Plasmodium vivax unspecified product 0.0015 0.0013 0.0147
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0785 0.0785
Schistosoma mansoni calpain (C02 family) 0.002 0.0107 0.0158
Echinococcus granulosus Nuclear hormone receptor HR96 0.0015 0.0003 0.0003
Leishmania major importin beta-1 subunit, putative 0.0024 0.0204 0.1677
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.002 0.0107 0.1395
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0015 0.0003 0.0003
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0015 0.0003 0.0003
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0026 0.0254 0.2872
Plasmodium vivax vivapain-1 0.0015 0.0013 0.0147
Loa Loa (eye worm) hypothetical protein 0.0032 0.0382 0.0549
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0055 0.0055
Brugia malayi nuclear receptor RXR 0.0017 0.0044 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0382 0.0554
Brugia malayi hypothetical protein 0.003 0.0351 0.0508
Trypanosoma cruzi cysteine protease, putative 0.0015 0.0013 0.0046
Loa Loa (eye worm) hypothetical protein 0.014 0.2819 0.4079
Loa Loa (eye worm) Smad1 0.0017 0.0055 0.0074
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0026 0.0254 0.0364
Schistosoma mansoni calpain-7 (C02 family) 0.002 0.0107 0.0158
Brugia malayi Pre-SET motif family protein 0.0034 0.0428 0.062
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0055 0.0074
Loa Loa (eye worm) ctsf protein 0.0026 0.0254 0.0364
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0044 0.0063
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0154 0.1743
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0254 0.0444
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0382 0.0382
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0236 0.4989 0.7221
Schistosoma mansoni calpain-7 (C02 family) 0.002 0.0107 0.0158
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0049 0.0767 0.6299
Brugia malayi MH2 domain containing protein 0.0017 0.0055 0.0079
Echinococcus multilocularis cathepsin L cysteine protease 0.0026 0.0254 0.0254
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0154 0.0219
Echinococcus granulosus calpain 0.002 0.0107 0.0107
Echinococcus multilocularis muscleblind protein 0.018 0.3731 0.3731
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0428 0.0428
Loa Loa (eye worm) hypothetical protein 0.0017 0.0044 0.0059
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0254 0.0444
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0382 0.0549
Echinococcus multilocularis cathepsin b 0.014 0.2819 0.2819
Plasmodium falciparum cysteine proteinase falcipain 1 0.0015 0.0013 0.0147
Echinococcus multilocularis neuropeptide receptor A26 0.0458 1 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0069 0.1227 0.1813
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.1218 0.1799
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0835 0.0835
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0017 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0019 0.009 0.0125
Brugia malayi Cathepsin L-like precursor 0.0026 0.0254 0.0368
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0382 0.0549
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0382 0.0565
Trypanosoma cruzi kinesin, putative 0.002 0.0107 0.038
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0055 0.0055
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.002 0.0107 0.0879
Echinococcus multilocularis mitochondrial import inner membrane translocase subunit TIM23, putative 0.0046 0.0702 0.0702
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0428 0.0633
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.014 0.2819 0.4165
Loa Loa (eye worm) hypothetical protein 0.0066 0.1151 0.1663
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0382 0.0565
Onchocerca volvulus 0.0026 0.0254 0.0364
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0069 0.1218 0.1218
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0382 0.0382
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0154 0.2013
Mycobacterium tuberculosis Probable oxidoreductase 0.0109 0.2118 1
Trypanosoma brucei calpain-like protein, putative 0.002 0.0107 0.1395
Trichomonas vaginalis ran, putative 0.0022 0.0154 0.027
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0254 0.0444
Echinococcus multilocularis importin subunit beta 1 0.003 0.033 0.033
Echinococcus granulosus geminin 0.0173 0.3575 0.3575
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0066 0.1151 0.1701
Loa Loa (eye worm) hypothetical protein 0.0032 0.0382 0.0549
Brugia malayi nuclear receptor NHR-67 0.0015 0.0003 0.0005
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0382 0.0554
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0254 0.0444
Plasmodium falciparum cysteine proteinase falcipain 3 0.0026 0.0254 0.2872
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0382 0.0382
Trypanosoma brucei trypanothione reductase 0.0043 0.0632 0.8242
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0254 0.0444
Loa Loa (eye worm) thioredoxin reductase 0.0043 0.0632 0.0911
Brugia malayi conserved hypotetical protein 0.0015 0.0003 0.0005
Loa Loa (eye worm) hypothetical protein 0.0032 0.0382 0.0549
Schistosoma mansoni hypothetical protein 0.0107 0.2085 0.308
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0351 0.1244
Loa Loa (eye worm) hypothetical protein 0.0032 0.0382 0.0549
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.009 0.0157
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0382 0.0565
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.009 0.3182
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.014 0.2819 0.4165
Brugia malayi Calcitonin receptor-like protein seb-1 0.0157 0.3205 0.4639
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0017 0.0044 0.0065
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0049 0.0767 0.2721
Brugia malayi MH1 domain containing protein 0.0017 0.0055 0.0079
Onchocerca volvulus 0.0019 0.009 0.0125
Echinococcus multilocularis Smad4 0.0017 0.0055 0.0055
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0254 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0069 0.1218 0.575
Echinococcus multilocularis cathepsin L 0.0015 0.0013 0.0013
Echinococcus multilocularis cysteine protease 0.0026 0.0254 0.0254
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0015 0.0013 0.0046
Plasmodium falciparum mitochondrial import inner membrane translocase subunit TIM23, putative 0.0046 0.0702 0.7918
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0382 0.0554
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0015 0.0003 0.0003
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0382 0.0382
Schistosoma mansoni nuclear hormone receptor 0.0015 0.0003 0.0005
Plasmodium vivax vivapain-2 0.0026 0.0254 0.2872
Echinococcus multilocularis thioredoxin glutathione reductase 0.0044 0.0645 0.0645
Entamoeba histolytica protein kinase, putative 0.002 0.0107 0.3895
Schistosoma mansoni tar DNA-binding protein 0.0063 0.108 0.1596
Trypanosoma cruzi cruzipain precursor, putative 0.0026 0.0254 0.0903
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0835 0.1233
Mycobacterium tuberculosis Probable dehydrogenase 0.0098 0.1872 0.8837
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0254 0.0444
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0428 0.0633
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0382 0.0554
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0351 0.3959
Brugia malayi MH2 domain containing protein 0.0017 0.0055 0.0079
Echinococcus multilocularis calpain 0.002 0.0107 0.0107
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0026 0.0254 0.0364
Brugia malayi nuclear hormone receptor family member odr-7 0.0015 0.0003 0.0005
Brugia malayi Pre-SET motif family protein 0.0236 0.4989 0.7222
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0154 0.0154
Brugia malayi hypothetical protein 0.0015 0.0003 0.0005
Leishmania major cathepsin L-like protease 0.0026 0.0254 0.2089
Mycobacterium ulcerans aldehyde dehydrogenase 0.0069 0.1218 1
Toxoplasma gondii cathepsin CPL 0.0026 0.0254 0.2089
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0382 0.0382
Echinococcus granulosus calpain 7 C02 family 0.002 0.0107 0.0107
Brugia malayi Cathepsin L-like precursor 0.0026 0.0254 0.0368
Leishmania major cathepsin L-like protease 0.0026 0.0254 0.2089
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0098 0.1872 0.8837
Brugia malayi Cathepsin L-like precursor 0.0026 0.0254 0.0368
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0382 0.0554
Echinococcus granulosus muscleblind protein 0.018 0.3731 0.3731
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0026 0.0254 0.0444
Brugia malayi MH2 domain containing protein 0.0254 0.5387 0.7799
Brugia malayi hypothetical protein 0.0121 0.2403 0.3479
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0382 0.0382
Schistosoma mansoni tar DNA-binding protein 0.0063 0.108 0.1596
Brugia malayi cathepsin L-like precursor 0.0019 0.009 0.013
Echinococcus granulosus cathepsin l cysteine peptidase 0.0026 0.0254 0.0254
Plasmodium vivax glutathione reductase, putative 0.0043 0.0632 0.7137
Brugia malayi latrophilin 2 splice variant baaae 0.0107 0.2085 0.3018
Toxoplasma gondii mitochondrial import inner membrane translocase subunit TIM10, putative 0.0054 0.0886 0.7275
Onchocerca volvulus Cathepsin L homolog 0.0026 0.0254 0.0364
Brugia malayi TAR-binding protein 0.0063 0.108 0.1564
Leishmania major cathepsin L-like protease 0.0026 0.0254 0.2089
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0254 0.0444
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0382 0.0554
Schistosoma mansoni hypothetical protein 0.0173 0.3575 0.5282
Brugia malayi RNA binding protein 0.0063 0.108 0.1564
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0382 0.0554
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0107 0.038
Schistosoma mansoni aldehyde dehydrogenase 0.0069 0.1218 0.1799
Plasmodium vivax SET domain protein, putative 0.0034 0.0428 0.4834
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.033 0.2711
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0382 0.0565
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0015 0.0003 0.0003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0254 0.0444
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0382 0.0565
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.002 0.0107 0.038
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.002 0.0107 0.038
Echinococcus multilocularis hypothetical protein 0.002 0.0107 0.0107
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0382 0.0382
Trypanosoma cruzi cysteine proteinase, putative 0.0015 0.0013 0.0046
Loa Loa (eye worm) hypothetical protein 0.003 0.0351 0.0503
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0055 0.0055
Onchocerca volvulus 0.0026 0.0254 0.0364
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0069 0.1227 0.1227
Loa Loa (eye worm) RNA binding protein 0.0063 0.108 0.156
Schistosoma mansoni importin beta-1 0.003 0.033 0.0488
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0019 0.009 0.0319

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0355 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 7.9433 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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