Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | parathyroid hormone 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | galactosylceramidase | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K04588 secretin receptor, putative | Get druggable targets OG5_139196 | All targets in OG5_139196 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | integrin alpha ps | 0.0054 | 0.2422 | 0.2422 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.3815 | 0.5659 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0612 | 0.0908 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0626 | 0.0928 |
Schistosoma mansoni | hypothetical protein | 0.0076 | 0.3815 | 0.3815 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0016 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 1 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0035 | 0.1213 | 0.18 |
Echinococcus multilocularis | integrin alpha ps | 0.0054 | 0.2422 | 0.2422 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1213 | 0.18 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0035 | 0.1213 | 0.1213 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0031 | 0.0046 |
Schistosoma mansoni | integrin alpha | 0.0054 | 0.2422 | 0.2422 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1313 | 0.5 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0035 | 0.1213 | 0.18 |
Schistosoma mansoni | integrin alpha-ps | 0.0054 | 0.2422 | 0.2422 |
Brugia malayi | MH2 domain containing protein | 0.0122 | 0.6742 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.014 | 0.7877 | 0.7877 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0134 | 0.7541 | 0.7541 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0122 | 0.6742 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0122 | 0.6742 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0026 | 0.0626 | 0.0626 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.1313 | 0.1313 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.0612 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0612 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0035 | 0.1213 | 0.1213 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0111 | 0.6057 | 0.8984 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1213 | 0.1213 |
Schistosoma mansoni | integrin alpha-ps | 0.0028 | 0.0768 | 0.0768 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0612 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0076 | 0.3815 | 0.5659 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0612 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0037 | 0.1313 | 0.1313 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0054 | 0.2422 | 0.3593 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1213 | 0.1213 |
Echinococcus granulosus | integrin alpha 3 | 0.0026 | 0.0626 | 0.0626 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.4793 | 0.711 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0035 | 0.1213 | 0.1213 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1313 | 0.5 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.0612 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0035 | 0.1213 | 0.1213 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0768 | 0.114 |
Brugia malayi | hypothetical protein | 0.0037 | 0.1313 | 0.1948 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0111 | 0.6057 | 0.8984 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0037 | 0.1313 | 0.1313 |
Echinococcus granulosus | integrin alpha ps | 0.0054 | 0.2422 | 0.2422 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0768 | 0.114 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0612 | 0.0908 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.014 | 0.7877 | 0.7877 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0035 | 0.1213 | 0.1213 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0612 | 1 |
Echinococcus multilocularis | integrin alpha 3 | 0.0026 | 0.0626 | 0.0626 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0035 | 0.1213 | 0.18 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.0612 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0035 | 0.1213 | 0.1213 |
Echinococcus multilocularis | integrin alpha ps | 0.0026 | 0.0626 | 0.0626 |
Echinococcus multilocularis | geminin | 0.0173 | 1 | 1 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.0091 | 0.4793 | 0.711 |
Echinococcus granulosus | integrin alpha ps | 0.0026 | 0.0626 | 0.0626 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0111 | 0.6057 | 0.8984 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1313 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.6057 | 0.8984 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0037 | 0.1313 | 0.5 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0119 | 0.659 | 0.9775 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.1313 | 0.1313 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1213 | 0.1213 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0612 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1213 | 0.1213 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.4668 uM | PubChem BioAssay. A Novel Cell-Based Assay to Identify Small Molecules for B -Galactocerebrosidase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 19.9526 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 39.8107 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.